- Nascent geographic atrophy as a predictor of type 3 MNV development. [Journal Article]Ophthalmol Retina. 2023 Feb 01 [Online ahead of print]OR
- CONCLUSIONS: As nascent GA may precede the development of exudative type 3 MNV, the detection of nascent GA in eyes with AMD may warrant closer surveillance in order to identify early exudative type 3 MNV warranting treatment.
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- Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration. [Journal Article]Gene. 2023 Feb 01 [Online ahead of print]GENE
- This study aimed to investigate the effect and mechanism of levodopa (L-DOPA) in the treatment of age-related macular degeneration (AMD). A wet AMD cell model was created via CoCl2 treatment of ARPE-19 cells. The cytoprotective effects of L-DOPA in the model were determined using CCK-8, flow cytometry, TUNEL, qPCR, and ELISA assays. Subsequently, circRNA sequencing and bioinformatics analysis wer…
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- Seven-year outcome after 1-year fixed regimen of intravitreal aflibercept injections followed by pro re nata treatment for neovascular age-related macular degeneration. [Journal Article]Graefes Arch Clin Exp Ophthalmol. 2023 Feb 03 [Online ahead of print]GA
- CONCLUSIONS: BCVA was maintained for 7 years in nAMD eyes after 1-year fixed regimen of IVA, essentially followed by PRN regimen, but sometimes followed by agent switching, PDT, or vitrectomy, without severe drug-induced complications. Thus, early diagnosis and treatment of nAMD are essential for maintaining good long-term BCVA, even in eyes with relatively poor baseline vision.
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- Ocular health screening among care-center residents with disabilities: a smartphone adaptive fundus camera cross-sectional study. [Journal Article]Eur Rev Med Pharmacol Sci. 2023 Jan; 27(2):620-627.ER
- CONCLUSIONS: Screening for ocular health with a novel smartphone-adapted fundus camera revealed significantly higher rates of various ocular diseases in care center disabled residents. Given technological progress, remote control method-assisted ocular exams appear to be potentially feasible and clinically beneficial. This could allow trained allied health personnel to perform ocular health screenings without the need to transport a disabled person to the hospital. Thus, diagnosis and follow-up of various chronic ocular diseases may be properly organized.
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- Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases. [Journal Article]Int J Retina Vitreous. 2023 Feb 02; 9(1):9.IJ
- CONCLUSIONS: CCT demonstrates color and contrast deficits for multiple retinal diseases with differing pathophysiology. Further prospective studies of CCT in other disease states and with larger samples sizes is warranted.
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- Effects of Systemic Drugs on the Development and Progression of Age-Related Macular Degeneration. [Review]Surv Ophthalmol. 2023 Jan 30 [Online ahead of print]SO
- Age-related macular degeneration (AMD) is the leading cause of severe loss of central vision among people over 50. The pathophysiology of the disease is multifactorial and can be attributed to genetics, aging, inflammation, environmental factors, and lifestyle factors including smoking, diet, obesity, and alcohol consumption. While there is no treatment for dry AMD, the current standard treatment…
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- Multimodal Retinal Imaging Reveals New Pathogenic Insights in Central Areolar Choroidal Dystrophy: A Case Series. [Journal Article]Retin Cases Brief Rep. 2022 Aug 25 [Online ahead of print]RC
- CONCLUSIONS: Multimodal imaging can reveal new pathogenic insights in CACD. Of notice, NIR-AF and OCT-A are able to detect RPE hypopigmentation and choriocapillaris rarefaction, respectively, since the earliest stages of the disease.
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- Long-term Morphological Changes in Macular Neovascularization under Aflibercept Treatment with a Treat-and-Extend Regimen. [Journal Article]Retina. 2022 Nov 17 [Online ahead of print]R
- CONCLUSIONS: MNV expanded and showed vascular maturation under aflibercept treatment with a T&E regimen. The smaller the MNV at baseline, the greater is its expansion in 2 years.
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- Spatial pattern of retinal pigment epithelium tear development and progression after anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration. [Journal Article]Retin Cases Brief Rep. 2022 Nov 28 [Online ahead of print]RC
- CONCLUSIONS: The location of CNVM in PED determines the spatial pattern of RPE tear development and progression and helps to predict the visual outcome after RPE tears.
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- Characterization of Macular Neovascularization in Bietti's Crystalline Dystrophy Using Multimodal Imaging Modalities. [Journal Article]Retina. 2022 Dec 08 [Online ahead of print]R
- CONCLUSIONS: MNV was demonstrated to be a common complication secondary to BCD. The lesions were typical type 2 MNV of varied activities possibly associated with the degrees of the primary degeneration. Choriocapillaris hypoperfusion might participate in MNV development.
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- Advantages of Optical Coherence Tomography as a High Dynamic Range Imaging Modality in Subretinal Hyperreflective Material. [Journal Article]Retina. 2022 Dec 14 [Online ahead of print]R
- CONCLUSIONS: Contrast-enhanced OCT images enabled us to classify SHRM according to its reflectivity showing groups with different disappearance rates, visual acuity improvement and outer retinal layer disruption. This easy to access tool may be helpful as a prognostic factor in neovascular AMD cases.
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- Quantified anastomotic areas of neovascularization as factors associated with frequent recurrence in neovascular age-related macular degeneration. [Journal Article]Retina. 2022 Dec 14 [Online ahead of print]R
- CONCLUSIONS: The quantitative characteristics of the anastomotic areas in the MNV might indicate the need for IVIs in nAMD patients.
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- PATTERNS OF SUBRETINAL AND/OR INTRARETINAL FLUID RECURRENCE IN PATIENTS WHO RECEIVED AS-NEEDED RANIBIZUMAB THERAPY IN THE HARBOR TRIAL. [Journal Article]Retina. 2022 Dec 20 [Online ahead of print]R
- CONCLUSIONS: Although the location of SRF and/or IRF were equally distributed at baseline, recurrent fluid was typically centrally located. We identified a subgroup of eyes exhibiting fluid recurrence in a different location than at baseline, potentially indicating new choroidal neovascularization.
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- Sustained Biweekly Aflibercept For Refractory Neovascular Age-Related Macular Degeneration: The Prospective TRISTAR Study. [Journal Article]Retina. 2022 Dec 26 [Online ahead of print]R
- CONCLUSIONS: In patients with refractory NVAMD-related SRF, sustained biweekly IAIs resulted in significant functional and anatomic improvements during biweekly dosing. These gains, however, were lost upon return to monthly dosing. These findings suggest that efforts to reduce refractory SRF in NVAMD with biweekly dosing may provide added benefit compared with standard of care treatment if biweekly dosing is sustained.
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- RISK OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN PATIENTS WITH CENTRAL SEROUS CHORIORETINOPATHY: A Nationwide Cohort Study. [Journal Article]Retina. 2023 Jan 02 [Online ahead of print]R
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- Fundus autofluorescence in Extensive Macular Atrophy with Pseudodrusen (EMAP) and Diffuse Trickling Geographic Atrophy (DTGA). [Journal Article]Retina. 2023 Jan 02 [Online ahead of print]R
- CONCLUSIONS: Our study found that EMAP and DTGA cannot be effectively differentiated on fundus autofluorescence: in both diseases, the macular atrophic area has a major vertical axis, fringed borders, and fast progression.
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- Management of recurrent optic disc pit-associated maculopathy with human amniotic membrane graft in a pediatric case. [Case Reports]Indian J Ophthalmol. 2023 Feb; 71(2):674.IJ
- Optic disc pit-associated maculopathy (ODP-M) is a rare presentation in children. Therefore, only a few pediatric cases successfully managed have been reported in the literature. This video shows successful management of ODP-M with human amniotic membrane graft in a pediatric case presenting with recurrence with intraoperative optical coherence tomography (OCT).
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- Effect of dexamethasone implant on intraocular cytokines in diabetic macular edema. [Journal Article]Indian J Ophthalmol. 2023 Feb; 71(2):363-368.IJ
- CONCLUSIONS: Our study suggests that dexamethasone acts more on IC than VEGF in DME. This is significant in the first 3 months with a rebound effect on IL-6 after 3 months. Our study also suggests that repeat injection of DEX in DME should be done at 3 months to prevent deterioration of visual acuity (VA) and worsening of CMT.
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- Visual acuity and causes of central visual loss in the adult Danish population 2020-2022. Results from the FORSYN study. [Journal Article]Acta Ophthalmol. 2023 Feb 01 [Online ahead of print]AO
- CONCLUSIONS: Recent advances in the therapy of chorioretinal vascular diseases have been paralleled with a reduction in central vision loss secondary to exudative AMD and diabetic retinopathy in Denmark. The demographic development can be expected to increase the demand for treatments of vision-threatening diseases that mainly affect older persons.
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- Switching to brolucizumab: injection intervals and visual, anatomical and safety outcomes at 12 and 18 months in real-world eyes with neovascular age-related macular degeneration. [Journal Article]Int J Retina Vitreous. 2023 Feb 01; 9(1):8.IJ
- CONCLUSIONS: This real-world study demonstrates that injection intervals may be significantly extended with maintained vision and reduced CMT in nAMD eyes switching to brolucizumab therapy from other anti-VEGFs.
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- Proliferative diabetic retinopathy and diabetic macular edema are two factors that increase macrophage-like cell density characterized by en face optical coherence tomography. [Journal Article]BMC Ophthalmol. 2023 Feb 01; 23(1):46.BO
- CONCLUSIONS: SS-OCTA is a non-invasive and simple method for the characterization of MLCs at the VRI. PDR and DME are two factors that increase MLC density. MLC density also correlated with VD.
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- Prevalence of visual impairment in older people living with dementia and its impact: a scoping review. [Review]BMC Geriatr. 2023 Feb 01; 23(1):63.BG
- CONCLUSIONS: VI is common in older people living with dementia and is associated with negative impacts on those with dementia and their caregivers. However, heterogeneity between studies in terms of setting and method for assessing and defining VI make it difficult to compare findings among studies. Further research is needed, particularly assessing the impact on caregivers.
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- Quantitative multimodal imaging of extensive macular atrophy with pseudodrusen and geographic atrophy with diffuse trickling pattern. [Journal Article]
- To compare clinical and imaging characteristics of extensive macular atrophy with pseudodrusen-like appearance (EMAP) versus diffuse-trickling geographic atrophy (DTGA) and non-diffuse-trickling geographic atrophy (nDTGA) phenotypes of age-related macular degeneration. Prospective, observational study performed in the Ophthalmology Department of IRCCS San Raffaele Hospital between January 2015 an…
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- Safety and efficacy of an artificial intelligence-enabled decision tool for treatment decisions in neovascular age-related macular degeneration and an exploration of clinical pathway integration and implementation: protocol for a multi-methods validation study. [Journal Article]BMJ Open. 2023 Feb 01; 13(2):e069443.BO
- Neovascular age-related macular degeneration (nAMD) management is one of the largest single-disease contributors to hospital outpatient appointments. Partial automation of nAMD treatment decisions could reduce demands on clinician time. Established artificial intelligence (AI)-enabled retinal imaging analysis tools, could be applied to this use-case, but are not yet validated for it. A primary qu…
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- Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro. [Journal Article]J Photochem Photobiol B. 2023 Jan 24; 240:112654.JP
- Long-term light exposure, especially in the spectrum of blue light, frequently causes excessive oxidative stress in dry age-related macular degeneration (AMD). Here, to gain insight into the underlying mechanism, we focused on mitochondrial dynamics alterations under long-term exposure to blue light in mouse and retinal cells. Six-month-old C57BL/6 mice were exposed to blue light (450 nm, 800 lx)…
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- Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events. [Journal Article]Sci Transl Med. 2023 Feb; 15(681):eabq5241.ST
- In October 2019, Novartis launched brolucizumab, a single-chain variable fragment molecule targeting vascular endothelial growth factor A, for the treatment of neovascular age-related macular degeneration. In 2020, rare cases of retinal vasculitis and/or retinal vascular occlusion (RV/RO) were reported, often during the first few months after treatment initiation, consistent with a possible immun…
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- Repeatability of Quantitative Autofluorescence Imaging in a Multicenter Study Involving Patients With Recessive Stargardt Disease 1. [Multicenter Study]Transl Vis Sci Technol. 2023 Feb 01; 12(2):1.TV
- CONCLUSIONS: Real-life test-retest variability of qAF is higher in this set of data than previously reported in single center settings. With improved operator training and by selecting the better of two recordings for evaluation, qAF serves as a useful method for assessing changes in autofluorescence signal.
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- The Injection Practice Patterns of Retina Specialists in Managing Exudative Age-Related Macular Degeneration: A Retrospective Study. [Journal Article]
- CONCLUSIONS: Despite similar baseline criteria for injections by the retina specialists, different anti-VEGF injection regimens were practiced resulting in variations in BCVA and CMT outcomes. This suggests a need in establishing a universally adoptable injection regimen with possible integration of the confounding factors to reduce burden on both patients and retina specialists.
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- PRMT5 is a therapeutic target in choroidal neovascularization. [Journal Article]
- Ocular neovascular diseases including neovascular age-related macular degeneration (nvAMD) are widespread causes of blindness. Patients' non-responsiveness to currently used biologics that target vascular endothelial growth factor (VEGF) poses an unmet need for novel therapies. Here, we identify protein arginine methyltransferase 5 (PRMT5) as a novel therapeutic target for nvAMD. PRMT5 is a well-…
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- An ensemble of deep convolutional neural networks is more accurate and reliable than board-certified ophthalmologists at detecting multiple diseases in retinal fundus photographs. [Journal Article]Br J Ophthalmol. 2023 Jan 31 [Online ahead of print]BJ
- CONCLUSIONS: We developed a deep learning model and found that it could more accurately and reliably classify four categories of fundus images compared with board-certified ophthalmologists. This work provides proof-of-principle that an algorithm is capable of accurate and reliable recognition of multiple retinal diseases using only fundus photographs.
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