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(Age related macular degeneration)
28,056 results
  • Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models. [Journal Article]
  • IOInvest Ophthalmol Vis Sci 2018 Feb 01; 59(2):940-951
  • Crowley MA, Delgado O, … Liao SM
  • CONCLUSIONS: Systemic TLR stimulation and eye tissue injury induced time-dependent alternative complement pathway activation in the eye. Ocular complement levels were also gradually elevated during aging. An anti-FD antibody IVT potently inhibited LPS-induced complement activation in the posterior segment of the eye. This study provides insights into the dynamic profile of ocular complement activation, which is valuable for complement research in eye diseases and for developing complement therapeutics for AMD.
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