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1,138 results
  • Biochemical and immunochemical characterization of venoms from snakes of the genus Agkistrodon. [Journal Article]
    Toxicon X. 2019 Oct; 4:100013.Román-Domínguez L, Neri-Castro E, … Bénard-Valle M
  • In the present work, venoms from five species of the genus Agkistrodon were evaluated in terms of their enzymatic (Phospholipase A2 and caseinolytic) and biological (edema forming, hemorrhagic, procoagulant and lethal) effects. Horses were used to produce monovalent hyperimmune sera against each of three venoms (A. bilineatus, A. contortrix and A. piscivorus) and their neutralizing potency, expre…
  • Purification and characterization of Protein C activator from Agkistrodon acutus Venom. [Journal Article]
    Prep Biochem Biotechnol. 2020 Jun 01 [Online ahead of print]Sun Y, Bao PJ, Zhang GB
  • Protein C (PC) plays an important role in the balance of coagulation and anticoagulation. Thus, the detection of PC activity is diagnostically significant for patients with cardiovascular diseases. Presently, the key methods to detect PC activity are the chromogenic assay and activated partial thromboplastin time (APTT) test. PROTAC used in the chromogenic assay is isolated from Agkistrodon conto…
  • National Estimates of Noncanine Bite and Sting Injuries Treated in US Hospital Emergency Departments, 2011-2015. [Journal Article]
    South Med J. 2020 May; 113(5):232-239.Hareza D, Langley R, … King K
  • CONCLUSIONS: Various sources of bite and sting injuries had an outsized effect on injury rates and identify potential areas of focus for education and prevention programs to reduce the burden of these injuries on health and healthcare costs. The study describes the diversity of animal exposures based on a national sample of EDs. Noncanine bite and sting injuries significantly affect public health and healthcare resources. Priorities can be focused on animal sources with the most impact on bite and sting injury rates, healthcare costs, and disease burden.
  • Hemocoagulase agkistrodon can prevent bleeding and induce hypofibrinogenemia in hepatic disease cases . [Journal Article]
    Int J Clin Pharmacol Ther. 2020 Jun; 58(6):351-353.Lu S, Han M, … Liu C
  • Hemocoagulase is often used for hemostasis in patients with bleeding and hemorrhagic diseases, and to avoid or stanch bleeding after surgery. Herein, three patients with hepatic diseases suffering from hypofibrinogenemia were treated with hemocoagulase agkistrodon (HCA) in Peking University People's Hospital during September 2018. All the 3 patients were chronic hepatitis B patients: Patient 1 pr…
  • Comparison of Methods for Measuring Protein Concentration in Venom Samples. [Journal Article]
    Animals (Basel). 2020 Mar 08; 10(3)Bocian A, Sławek S, … Legáth J
  • Snake venom is an extremely interesting natural mixture of proteins and peptides, characterized by both high diversity and high pharmacological potential. Much attention has been paid to the study of venom composition of different species and also detailed analysis of the properties of individual components. Since proteins and peptides are the active ingredients in venom, rapidly developing prote…
  • AAVC-I promotes apoptosis of human oral squamous cell carcinoma through the mitochondrial pathway. [Journal Article]
    Int J Clin Exp Pathol. 2019; 12(10):3968-3974.Chai L, Huang T, … Deng C
  • This study aimed to explore the role and possible mechanism of component I from agkistrodon acutus venom (AAVC-I) in promoting the apoptosis of oral squamous cell carcinoma (OSCC). HN4 cells (a human OSCC cell line) were randomly divided into four experimental groups: low AAVC-I (2.5 μg/mL) group, medium AAVC-I (5 μg/mL) group and high AAVC-I (10 μg/mL) group, as well as control group (AAVC-I, 0 …
  • Presumed Copperhead Snakebite and Antivenom Administration in the Third Trimester. [Case Reports]
    Wilderness Environ Med. 2019 Dec; 30(4):446-449.Yano J, Zerden M, German B
  • Snake envenomation during pregnancy is an uncommon emergency with several potential complications associated with the poisoning and its treatment. This case discusses a 27-y-old gravida 3, para 1102 (3 total pregnancies, 1 term birth, 1 premature birth, 0 abortions, 2 living births, twins) at 36 wk gestation who was bitten by a presumed Agkistrodon contortrix (copperhead snake). She had worsening…
  • Drought-induced Suppression of Female Fecundity in a Capital Breeder. [Journal Article]
    Sci Rep. 2019 10 29; 9(1):15499.Smith CF, Schuett GW, … Davis MA
  • Human-induced global climate change is exerting increasingly strong selective pressures on a myriad of fitness traits that affect organisms. These traits, in turn, are influenced by a variety of environmental parameters such as temperature and precipitation, particularly in ectothermic taxa such as amphibians and reptiles. Over the past several decades, severe and prolonged episodes of drought ar…
  • StatPearls: Water Moccasin Snake Toxicity [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Thackston Derek D VCU Health Wills Brandon K. BK Virginia Commonwealth University BOOK
  • The water moccasin or cottonmouth, Agkistrodon piscivorus, is a semi-aquatic pit viper found throughout the Southeastern United States and into West Texas[1] Their two common names derive from the white-colored membranes in its mouth and living near sources of water. Cottonmouth snakes are part of the Crotalinae family of pit vipers which includes rattlesnakes and copperheads.  Like the other Nor…
  • Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents. [Journal Article]
    Comp Biochem Physiol C Toxicol Pharmacol. 2019 Dec; 226:108612.Mendes B, Almeida JR, … Miguel DC
  • Phospholipase A2 toxins present in snake venoms interact with biological membranes and serve as structural models for the design of small peptides with anticancer, antibacterial and antiparasitic properties. Oligoarginine peptides are capable of increasing cell membrane permeability (cell penetrating peptides), and for this reason are interesting delivery systems for compounds of pharmacological …
  • Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis. [Journal Article]
    Int J Mol Sci. 2019 Aug 21; 20(17)Huang J, Fan H, … Huang F
  • Snake venom contains large amounts of active proteins and peptides. In this study, a novel snake protein, metalloproteinase SP, was successfully isolated from the venom of Agkistrodon acutus by multi-gel chromatography. The isolated protein exhibits anti-platelet aggregation activity. Animal experiments showed that it exhibited defibration, anticoagulation, and antithrombotic effects and contribu…
  • [Experience of Professor Fan Yongsheng in treating arthralgia with insect drugs]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2019 Feb; 44(4):845-848.Wu GL, Li TY, Fan YS
  • National-level famous traditional Chinese medicine(TCM) doctor Professor Fan Yong-sheng has high-level accomplishments in the treatment of arthralgia. According to clinical diagnosis and dialectic,TCM with appropriate medicinal properties were flexibly applied,with a remarkable efficacy. Especially in the application of insect drugs,he has accumulated abundant clinical experience.According to the…
  • Functional recombinant single-chain variable fragment antibody against Agkistrodon acutus venom. [Journal Article]
    Exp Ther Med. 2019 May; 17(5):3768-3774.Zhang L, Cao Y, … Tian J
  • Agkistrodon acutus bites are conventionally treated with animal-derived antivenom, the use of which is limited due to allergic reactions and serum sickness. Thus in the present study, the genes of humanized antibodies produced in response to A. acutus venom were extracted from lymphocytes from patients bitten by A. acutus. A single-chain variable fragment (scFv) library against venom was construc…
  • Water relations of an insular pit viper. [Journal Article]
    J Exp Biol. 2019 05 07; 222(Pt 9)Sandfoss MR, Lillywhite HB
  • Colonization of novel habitats often requires plasticity or adaptation to local conditions. There is a critical need to maintain hydration in terrestrial environments having limited water. Atypical populations of Florida cottonmouth snakes, Agkistrodon conanti, inhabit continental islands with no permanent sources of fresh water. Here, we report investigations related to how these insular snakes …
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