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3,848 results
  • Temperament clusters associate with anxiety disorder comorbidity in depression. [Journal Article]
  • JAJ Affect Disord 2018 Apr 23; 236:252-258
  • Paavonen V, Luoto K, … Kampman O
  • CONCLUSIONS: The patients' temperament profiles were assessed while displaying depressive symptoms, which may have affected results.Temperament clusters with unique dimensional profiles were specifically associated with different anxiety disorders in this study. These results suggest that TCI-R could offer a valuable dimensional method for predicting the risk of anxiety disorders in diverse depressed patients.
  • Antidepressants versus placebo for panic disorder in adults. [Review]
  • CDCochrane Database Syst Rev 2018 Apr 05; 4:CD010676
  • Bighelli I, Castellazzi M, … Barbui C
  • CONCLUSIONS: The identified studies comprehensively address the objectives of the present review.Based on these results, antidepressants may be more effective than placebo in treating panic disorder. Efficacy can be quantified as a NNTB of 7, implying that seven people need to be treated with antidepressants in order for one to benefit. Antidepressants may also have benefit in comparison with placebo in terms of number of dropouts, but a less favourable profile in terms of dropout due to adverse effects. However, the tolerability profile varied between different classes of antidepressants.The choice of whether antidepressants should be prescribed in clinical practice cannot be made on the basis of this review.Limitations in results include funding of some studies by pharmaceutical companies, and only assessing short-term outcomes.Data from the present review will be included in a network meta-analysis of psychopharmacological treatment in panic disorder, which will hopefully provide further useful information on this issue.
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