A 76-year-old man presented with a tracheal tumor associated with severe respiratory obstruction. A tracheotomy was performed due to respiratory failure. F-fluorodeoxyglucose (FDG) -positron emission tomography/computed tomography revealed an abnormal accumulation of FDG (maximum standardized uptake value: 16) in the trachea. A histopathological examination of the tracheal biopsy revealed extranodal NK/T-cell lymphoma, nasal type (ENKL). He was treated with concurrent radiotherapy (50 Gy) for the tracheal tumor and three courses of two-thirds dose ofdexamethasone, etoposide, ifosfamide, and carboplatin. Although the tumor responded remarkably well to this therapy, the patient died of an ENKL recurrence in the lungs and liver 11 months post therapy.

Silicone airway stents are extremely useful for both temporary or long-term management of upper airway obstruction, especially in the proximal half of the trachea and in the subglottic region. They cannot migrate are well tolerated, relatively easy to manage, durable, and generally cause little or no injury to the underlying airway mucosa. They are particularly important as part of the management of subglottic strictures. For patients with postintubation tracheal or laryngotracheal stenosis they can be used to temporize for periods up to a year or two, until the patients' condition is optimal for proceeding with a resection or reconstruction.

Basic airway management in both the pediatric and adult populations includes assessing and managing airway patency, oxygen delivery, and ventilation. All efforts should be taken to maintain a patient’s airway via non-invasive methodology unless indications for invasive airway management are apparent. Non-invasive airway supplementation includes passive oxygenation (nasal cannula, non-rebreather, among others), bag-valve-mask (BVM), non-invasive positive pressure ventilation (BVM with positive-pressure valve, CPAP, BIPAP), and supraglottic airways (King Tube, LMA. among others). Invasive airway management involves establishing a secure airway and placing patients on a ventilator via intubation (nasal or endotracheal), needle jet ventilation (in pediatric patients younger than 8 years old, cricothyroidotomy in pediatric patients older than 8 years old, and adults), and tracheostomy. Proper airway management begins by looking at the patient visually for trauma, obesity, cervical collar, macroglossia, among other factors to determine the type of airway approach best suited for each patient. Most important is positioning via the head tilt-chin lift maneuver, which involves extending the patient’s neck by putting one hand on the forehead and the other hand on the neck to allow for the extension of the head in relation to the neck. This maneuver puts the patient into sniffing position, with the nose pointed upward and forward. Then a chin lift can be performed by taking the hand from underneath the neck to underneath the chin (mandible) and lifting the mandible until the teeth barely touch. Another airway positioning method involves the jaw thrust maneuver, which is safer in potential cervical spinal cord injury patients. This method involves maintaining the spine in a neutral position and grabbing the sides of the angle of the mandible and lifting it forward to lift the jaw and open the airway. There are some differences between the pediatric and adult populations. For example, the large occiput of the pre-pubescent pediatric patient can lead to too much flexion of the neck and can cause tracheal obstruction. This is addressed by utilizing the head tilt-chin lift maneuver, but care must be taken to avoid overextension in the pediatric population as it can cause airway obstruction due to a weak trachea in the pediatric patient. However, the head tilt-chin lift may not be adequate to maintain a patent airway, and the jaw thrust maneuver may need to be employed to prevent the pediatric, large, floppy tongue from obstructing the airway. Once properly positioned, the rescuer has the best shot at delivering effective breaths either via mouth to mouth or BVM. If there is continued difficulty at delivering breaths, then airway adjuncts like an oral pharyngeal airway (OPA) device or nasopharyngeal airway (NPA) can be useful for maintaining a patent airway to allow delivery of breaths in an unresponsive patient. NPA devices can be useful at maintaining the airway in an awake patient as well, which is beneficial if intubation is not the goal, intubation needs to be delayed, or an awake intubation is necessary. NPA devices are plastic hollow or soft rubber tubes that a healthcare provider can utilize to help with patient oxygenation and ventilation when the patient is difficult to oxygenate or ventilate via BVM, for example. NPAs are passed into the nose and pass through to the posterior pharynx. NPAs do not cause patients to gag and are, therefore, the best airway adjunct route in an awake patient and the better choice in a semiconscious patient that may not tolerate an OPA due to the gag reflex. NPAs are also helpful when a patient's mouth is difficult to open, for example, if there are angioedema, trismus, or other factors. While NPAs are airway adjuncts for difficult patient ventilation and oxygenation, they only act as a bridge to either an eventually stabilized patient that is breathing without aid or a patient that requires a secure airway via endotracheal or nasotracheal (NT) intubation. The NT route for intubation was the preferred route among critical care and emergency physicians up until several decades ago. However, today, the majority of clinicians prefer the endotracheal route for intubation as it has been shown to have better results and fewer complications. Some of the complications of NT intubation include sinusitis, nasal structure destruction due to localized pressure and decreased perfusion of nasal cartilage, and local abscesses. Furthermore, NT intubation requires narrow tubes making pulmonary toilet very difficult due to the increased airway resistance. However, there are clear advantages to NT intubation. NT intubation can be performed in the sitting position, which is valuable, especially in the pre-hospital setting when needing to intubate a patient in acutely decompensated heart failure that cannot lay flat. Other advantages include the patient’s inability to bite or manipulate the tube, better patient tolerance, decrease salivation, and better access to patient oral care. In addition, the NT tube is much more stable as it has the entire nasal tract holding it in place versus the endotracheal tube that flops out the mouth and can easily dislodge or become right mainstemmed. NT intubation can be performed blind or with a flexible bronchoscope. Blind NT intubation is difficult and requires expertise and skill. However, when indicated, can be a very useful skill both in the prehospital and hospital setting. Blind NT intubation decreases the need for neck movement and mouth opening, but can only be done in the awake and ventilating patient. NT intubation via a flexible bronchoscope also requires lots of expertise and skill, and it is useless if there is blood, vomitus, or fluid that will obscure the bronchoscopes camera.

Development of effective rescue countermeasures for toxic inhalational industrial chemicals, such as methyl isocyanate (MIC), has been an emerging interest. Nonetheless, current methods for studying toxin-induced airway injuries are limited by cost, labor time, or accuracy, and only provide indirect or localized information. Optical Coherence Tomography (OCT) endoscopic probes have previously been used to visualize the 3-D airway structure. However, gathering such information in small animal models, such as rat airways after toxic gas exposure, remains a challenge due to the required probe size necessary for accessing the small, narrow, and partially obstructed tracheas. In this study, we have designed a 0.4 mm miniature endoscopic probe and investigated the structural changes in rat trachea after MIC inhalation. An automated 3D segmentation algorithm was implemented so that anatomical changes, such as tracheal lumen volume and cross-sectional areas, could be quantified. The tracheal region of rats exposed to MIC by inhalation showed significant airway narrowing, especially within the upper trachea, as a result of epithelial detachment and extravascular coagulation within the airway. This imaging and automated reconstruction technique is capable of rapid and minimally-invasive identification of airway obstruction. This method can be applied to large-scale quantitative analysis of in vivo animal models.

Chondrosarcoma is a cancer of cartilage cells, and despite being a common primary bone tumor, tracheal chondrosarcoma is rare with only 18 cases reported in the literature prior to mid-2016. A 60-year-old gentleman presented with progressively increasing cough, severe stridor, and production of phlegm for approximately 2 years. On admission to our tertiary care hospital, he developed complete obstructive apnea within an hour, and was intubated. A tracheal biopsy was performed, followed by resection. Histopathology confirmed chondrosarcoma of the trachea. The patient tolerated the procedure very well and is currently symptom-free on follow-up, with no signs of recurrence.