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737 results
  • Akathisia after chronic usage of synthetic cathinones: A case study. [Case Reports]
    Front Psychiatry. 2022; 13:1046486.Albert N, Catthoor K, Morrens M
  • CONCLUSIONS: The current case suggests that besides cocaine, amphetamines and methamphetamines, synthetic cathinones can also increase the risk for development of extrapyramidal symptoms such as akathisia. Especially a-PVP-analogs as used by the current patient and Pyrovalerone-analogs such as Methylenedioxypyrovalerone (MDPV) are very powerful dopamine reuptake-inhibitors which might lead to strong locomotor activation. Up to this day it remains very difficult to establish a guideline concerning the treatment of intoxication with synthetic cathinones or dependence thereof.
  • Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review. [Review]
    Brain Sci. 2022 Nov 14; 12(11)Lassi DLS, Malbergier A, … Castaldelli-Maia JM
  • CONCLUSIONS: There is a direct association between craving and cocaine use, underscoring craving as an important treatment target for promoting abstinence among persons with cocaine use disorder. Clonidine, fenfluramine and m-CPP showed to be promising medications for cocaine craving in the short-term treatment, and amphetamine, biperiden, carbamazepine, lisdexamfetamine, lorcaserin, methamphetamine, mirtazapine, pioglitazone, progesterone, guanfacine, levodopa, nefazodone in the long-term treatment.
  • Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms. [Journal Article]
    Neurosci Lett. 2022 09 25; 788:136840.Nelissen E, van Hagen BTJ, … Prickaerts J
  • Soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) signalling is important for healthy memory function and a healthy vascular system. Targeting sGC-cGMP signalling can therefore be a potential strategy to enhance memory processes. sGC can be targeted by using agonists, such as sGC stimulator riociguat. Therefore, this study aimed to target sGC using riociguat to investigate i…
  • Cholinergic models of memory impairment in animals and man: scopolamine vs. biperiden. [Journal Article]
    Behav Pharmacol. 2022 06 01; 33(4):231-237.Blokland A
  • Scopolamine has been used as a pharmacologic model for cognitive impairments in dementia and Alzheimer's disease. The validity of this model seems to be limited because findings in animals do not readily translate to novel treatments in humans. Biperiden is also a cholinergic deficit model for cognitive impairments but specifically blocks muscarinic M1 receptors. The effects of scopolamine and bi…
  • Misuse of Anticholinergic Medications: A Systematic Review. [Review]
    Biomedicines. 2022 Feb 01; 10(2)Chiappini S, Mosca A, … Di Giannantonio M
  • (1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, o…
  • Metoclopramide-induced Acute Dystonia Misdiagnosed as an Epileptic Seizure in a Lupus Patient. [Case Reports]
    J Epilepsy Res. 2021 Dec; 11(2):156-158.Emorinken A, Agbadaola OR
  • Acute dystonic reactions are the most prevalent extrapyramidal adverse effects associated with metoclopramide. It could be mistaken for a variety of other conditions, such as seizures, tetanus, and encephalitis, to name a few possibilities. We present a case of a 26-year-old female misdiagnosed as having an epileptic seizure who was rushed to the emergency unit with an involuntary bilateral upwar…
  • Metoclopramide induced acute dystonic reaction: A case report. [Case Reports]
    Ann Med Surg (Lond). 2022 Feb; 74:103248.Sheikh Hassan M, Ahmed Nor M
  • CONCLUSIONS: Metoclopramide can cause unpredictable acute dystonic reactions. This can be life-threatening and should be detected early. Extrapyramidal side effects should be monitored in patients on metoclopramide since a single dose can cause these symptoms. This case highlights an acute dystonic reaction following the administration of a metoclopromide injection.
  • [Sulpiride induced dystonia in a patient with Tourette syndrome. A stroke-mimicking presentation]. [Case Reports]
    Fortschr Neurol Psychiatr. 2022 Jan; 90(1-02):60-62.Abdelnaby R, Abosrea MA, … Elsayed M
  • We present a case of a 23-year-old male Caucasian patient admitted to the emergency department because of an acute onset of difficulty of articulation, weakness of the left arm, throat- and neck pain. An emergency CT & MRI of the brain showed no abnormalities. The Patient had started visiting a new neurologist three weeks before admission and received Sulpiride against Tourette syndrome (TS) in a…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Parkinson Disease Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Parkinson disease is a progressive neurological condition characterized by slowness and paucity of movement (bradykinesia), muscle rigidity, resting tremors, and disordered posture. The onset is typically in the 6th or 7th decade of life with slow progression to akinesia, severe tremors, physical disability and death within 10 to 25 years of initial symptoms. Parkinson disease is common and affec…
  • Selected Molecular Targets for Antiepileptogenesis. [Review]
    Int J Mol Sci. 2021 Sep 08; 22(18)Pawlik MJ, Miziak B, … Czuczwar SJ
  • The term epileptogenesis defines the usually durable process of converting normal brain into an epileptic one. The resistance of a significant proportion of patients with epilepsy to the available pharmacotherapy prompted the concept of a causative treatment option consisting in stopping or modifying the progress of epileptogenesis. Most antiepileptic drugs possess only a weak or no antiepileptog…
  • Bicaudal-C protein, a potential antidepressant target. [Review]
    Neuroreport. 2021 11 02; 32(16):1293-1298.Han Q, Jiang J, … Zhang J
  • Bicaudal-C protein is a highly conserved RNA binding protein, which contains K homology domains and sterile alpha motif domain. Genome-wide association study identified that Bicaudal-C protein was associated with depression. The expression of Bicaudal-C increased in depression patients, also increased expression of Bicaudal-C induces the behavior of depression. The decrease of synaptic plasticity…
  • [A toddler with status dystonicus due to medication]. [Case Reports]
    Ned Tijdschr Geneeskd. 2021 06 08; 165van Dooijeweert B, Verschuur AVD, … Jansen J
  • CONCLUSIONS: Treatment of SD encompasses elimination or treatment of the trigger, stabilization of vital functions, possible administration of sedatives and dystonia specific medication. Metoclopramide holds a relatively high risk for extrapyramidal complications (1-10%) and dystonia (0.1-1.5%), even within therapeutic range. The use of anti-emetics with less alarming side effect profiles, for example ondansetron, is recommended.
  • Childhood dystonic reactions in the middle Black Sea region. [Journal Article]
    Medicine (Baltimore). 2021 Jul 02; 100(26):e26465.Çirakli S
  • Acute dystonic reactions are a worrying reason for presentation to the pediatric emergency department and the pediatric neurology clinic in childhood. It must be diagnosed and treated quickly. The aim of this study was to examine the clinical presentations, etiological factors, and prognosis of patients presenting to our regional tertiary pediatric neurology clinic with a diagnosis of acute dysto…
  • Two decades of research towards a potential first anti-epileptic drug. [Randomized Controlled Trial]
    Seizure. 2021 Aug; 90:99-109.Benassi SK, Alves JGSM, … Mello LE
  • The basic mechanisms by which brain insults, such as trauma, stroke or status epilepticus produce epilepsy are not completely understood, and effective preventive measures and treatment are still not available in the clinical setting. Over the last 2 decades we have conducted several studies with animal models of epilepsy (rodents and non-human primates) and demonstrated that drugs that modify ne…
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