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(Ala Cort)
83,494 results
  • Acute Spontaneous Bilateral Adrenal Hemorrhage Presenting as Hyponatremia. [Case Reports]
    Cureus. 2022 Dec; 14(12):e33060.Chippa VM, Chenna S, … Candula N
  • Bilateral adrenal hemorrhage is a very unusual cause of severe adrenal insufficiency and hyponatremia. It can result from trauma, infections, or antiphospholipid antibody syndrome and can be fatal if not diagnosed and treated early. Here, we present a 58-year-old Caucasian man with fatigue, altered sensorium, bradycardia, and hypotension. He denied any abdominal pain, recent trauma, or anti-plate…
  • Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells. [Journal Article]
    Tissue Eng Part C Methods. 2023 Jan 31 [Online ahead of print]Burdis R, Kronemberger GS, Kelly DJ
  • Engineering clinically relevant musculoskeletal tissues at a human scale is a considerable challenge. Developmentally inspired scaffold-free approaches for engineering cartilage tissues have shown great promise in recent years, enabling the generation of highly biomimetic tissues. Despite the relative success of these approaches, the absence of a supporting scaffold or hydrogel creates challenges…
  • Akutt binyrebarksvikt hos et barn. [Journal Article]
    Tidsskr Nor Laegeforen. 2023 Jan 31; 143(2)Holmberg NH, Haagensen AL
  • CONCLUSIONS: Acute adrenal crisis is a rare primary presentation of adrenal insufficiency, especially in the paediatric population. It is an important differential diagnosis of shock and has high morbidity and mortality.
  • Thyroid hormone dynamics of Tharparkar and Sahiwal cattle during induced heat stress. [Journal Article]
    Trop Anim Health Prod. 2023 Jan 30; 55(1):57.Anjali , Vk G, … Singh G
  • Thyroid hormones and Cortisol level are the essential biomarkers in the assessment of stress condition. This study was done to estimate the metabolic hormonal profile of Tharparkar and Sahiwal during heat stress condition. The experiment was conducted on two groups consisting of Tharparkar and Sahiwal animals (5 in each group) and the experimental period comprised a 7-day acclimatization period, …
  • Outcome of COVID-19 infections in patients with adrenal insufficiency and excess. [Journal Article]
    Endocr Connect. 2023 Jan 01 [Online ahead of print]Nowotny HF, Bryce J, … Reisch N
  • CONCLUSIONS: This European multicentric questionnaire is the first to collect data on the outcome of COVID-19 infection in patients with adrenal gland disorders. It suggests good clinical outcome in case of duly dose adjustments and emphasizes the importance of patient education on sick day rules.
  • Urinary cortisol is lower in pregnant women with higher pre-pregnancy BMI. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:1014574.Hohman EE, Smyth JM, … Savage JS
  • CONCLUSIONS: Although women with obesity reported higher perceived stress, they had lower urinary cortisol than women with normal BMI, and gestation-related increases in cortisol were similar across weight groups and unrelated to perceived stress, suggesting that physiological factors that drive increases in cortisol as pregnancy may outweigh effects of stress and adiposity.
  • Immune checkpoint inhibitor-mediated hypophysitis: no place like home. [Journal Article]
    Clin Med (Lond). 2023 Jan; 23(1):81-84.Cooksley T, Knight T, … Adam S
  • Ambulatory emergency care forms a fundamental part of the strategy of trying to ensure safe and sustainable acute care services. Immune checkpoint inhibitor(ICI)-mediated hypophysitis is an important life-threatening complication of therapy. Patients presenting with clinical features and findings consistent with ICI-mediated hypophysitis were considered in the current study. In the absence of sev…
  • Reporting of Social Determinants of Health in Pediatric Sepsis Studies. [Journal Article]
    Pediatr Crit Care Med. 2023 Jan 25 [Online ahead of print]Menon K, Sorce LR, … Pediatric Sepsis Definition Taskforce are as follows
  • CONCLUSIONS: We found overall low reporting of SDOH and marked variability in categorizations and definitions of SDOH variables. Consistent and standardized reporting of SDOH in pediatric sepsis studies is needed to understand the role these factors play in the development and severity of sepsis, to compare and extrapolate study results between settings and to implement policies aimed at improving socioeconomic conditions related to sepsis.
  • Influence of sex on the requirement for and outcomes following late postnatal corticosteroid treatment. [Journal Article]
    Eur J Pediatr. 2023 Jan 24 [Online ahead of print]Lee R, Kostina E, … Greenough A
  • There remains a disparity between the outcomes of male and female prematurely born infants. Our aim was to assess the influence of sex on the requirement for late (> 7 days) postnatal corticosteroid (PNS) treatment and the outcomes following treatment. A retrospective whole population study of infants born at less than 28 weeks of gestation in all neonatal units in England between 2014 and 2018. …
  • ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma. [Case Reports]
    Eur J Endocrinol. 2022 Dec 01; 187(6):K39-K45.Kitamura T, Blinder AR, … Tagami T
  • Due to its rarity, biochemical and histologic characteristics of androgen and glucocorticoid co-secreting adrenocortical adenomas are largely unknown. Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion. In this study, we investigated serum steroid profiles using liquid chromatography-tandem mass spectrometry (LC-MS/MS) an…
  • [Steroid profiling characteristics in pediatrc adrenal diseases]. [Journal Article]
    Probl Endokrinol (Mosk). 2022 Nov 03; 68(6):110-120.Yanar EA, Makazan NV, … Peterkova VA
  • CONCLUSIONS: Results of our study steroid profiling can be used as additional differential diagnosis method in patients with adrenocortical adenomas with or without hormonal hyperproduction (ACTH-independent Cushing syndrome and incidentaloma). Further studies are needed to identify steroid markers for subtyping pediatric adrenal diseases.
  • Evaluation of hydrocortisone as a strain-dependent growth-regulator of Porphyromonasgingivalis. [Journal Article]
    Anaerobe. 2023 Jan 18; 80:102698.Klomp T, Jahr H, … Conrads G
  • CONCLUSIONS: HC could reduce the incubation time when isolating P. gingivalis from clinical samples and could boost low biomass cultivations especially during their lag-phase. The growth-modulating effect might be via modulation of virulence factors/quorum sensing gene expression or by reactive oxygen species(ROS)-capturing during early stages of bacterial growth. Further experiments are necessary to explain the mechanism behind our observations.
  • Adrenal Dysfunction in Mitochondrial Diseases. [Review]
    Int J Mol Sci. 2023 Jan 06; 24(2)Corkery-Hayward M, Metherell LA
  • Cortisol is central to several homeostatic mechanisms including the stress and immune response. Adrenal insufficiency and impaired cortisol production leads to severe, potentially fatal disorders. Several fundamental stages of steroidogenesis occur within the mitochondria. These dynamic organelles not only contribute ATP for steroidogenesis, but also detoxify harmful by-products generated during …
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