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(Ala Scalp)
58 results
  • Daylight Photodynamic Therapy for Actinic Keratoses. [Review]
  • AJAm J Clin Dermatol 2018 May 11
  • Morton CA, Braathen LR
  • Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, b...
  • Photodynamic Therapy Effectively Treats Actinic Keratoses Without Pre-Illumination Incubation Time. [Case Reports]
  • JDJ Drugs Dermatol 2017 Mar 01; 16(3):275-278
  • Gandy J, Labadie B, … Zachary C
  • CONCLUSIONS: During PDT, the photosensitizer aminolevulinic acid (ALA), or in Europe methyl aminolevulinate (MAL), is utilized as a synthetic precursor that preferentially accumulates in dysplastic cells. The precursor then converts to PpIX via the heme pathway and causes apoptosis of the cells when excited, most commonly by either blue-violet (400-430 nm) or red (630-635 nm) light. Shorter incubation times are associated with reduced pain because less PpIX will have accumulated in the treated tissue by the start of the exposure to the light. The doubling of the light exposure time allows comparable levels of the photosensitizing molecule to accumulate and be activated so as to produce an equivalent reaction. The associated reduction in pain along with a more convenient treatment schedule makes this PDT protocol more tolerable and convenient to some patients.</p> <p><em>J Drugs Dermatol. 2017;16(3):275-278.</em></p>.
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