- A novel and alternative therapy for persistent allergic rhinitis via intranasal acupuncture: a randomized controlled trial. [Journal Article]Eur Arch Otorhinolaryngol. 2023 Jan 09 [Online ahead of print]EA
- CONCLUSIONS: Intranasal acupuncture has good efficacy and safety in the treatment of PAR. Moreover, VAS and RQLQ scores were much lower in the intranasal acupuncture group than in the Western medicine group, and acupuncture had an immediate impact, especially for improving nasal congestion, olfactory function and sleep.
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- Misdiagnosed centipede and scorpion poisoning characterized by delayed hypersensitivity reaction: A case report. [Case Reports]
- CONCLUSIONS: This case suggests that because oral Chinese medicine poisoning is rare, detailed collection of medical history is particularly important for poisoning diagnosis.
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- Effectiveness of traditional Chinese medicine preparations for facial seborrheic dermatitis: case reports. [Case Reports]
- Facial seborrheic dermatitis is a chronic skin condition that presents as erythematous scaly dermatitis and has a detrimental effect on the patient's quality of life. The purpose of this article is to present successful treatment of two male patients with face seborrheic dermatitis, one aged 50 and the other aged 56, who developed facial seborrheic dermatitis following facial erythema eruptions. …
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- Drug Repurposing Using Gene Co-Expression and Module Preservation Analysis in Acute Respiratory Distress Syndrome (ARDS), Systemic Inflammatory Response Syndrome (SIRS), Sepsis, and COVID-19. [Journal Article]
- SARS-CoV-2 infections are highly correlated with the overexpression of pro-inflammatory cytokines in what is known as a cytokine storm, leading to high fatality rates. Such infections are accompanied by SIRS, ARDS, and sepsis, suggesting a potential link between the three phenotypes. Currently, little is known about the transcriptional similarity between these conditions. Herein, weighted gene co…
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- Danggui Sini decoction treatment of refractory allergic cutaneous vasculitis: A case report. [Case Reports]World J Clin Cases. 2022 Nov 26; 10(33):12422-12429.WJ
- CONCLUSIONS: Danggui Sini decoction may be a promising oral treatment for ACV patients.
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- Effect of momethasone furoate combined with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis. [Journal Article]
- CONCLUSIONS: Both mometasone furoate combined with either loratadine or montelukast sodium had good effects in AR, while the first option had a faster inhibitory effect on inflammatory factors and a better protection of lung function in children.
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- Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness. [Journal Article]J Pharmacol Sci. 2022 Dec; 150(4):275-278.JP
- T cells play an essential role in the development of allergen-induced nasal hyperresponsiveness (NHR), a pathophysiological response in allergic rhinitis. The effects of histamine H1-receptor antagonists (antihistamines) on murine NHR models were investigated. Intragastric epinastine, fexofenadine, and loratadine administration suppressed allergen-induced immediate nasal response but not NHR in i…
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- UV-responsive fluorescent behavior of pharmaceuticals assessed by UV-induced fingerprint spectroscopy (UV-IFS). [Journal Article]Int J Pharm. 2022 Nov 25; 628:122289.IJ
- UV-induced fingerprint spectroscopy (UV-IFS), a new tool in a toolbox of analytical methods, is a powerful technique registering molecule-specific changes of fluorescence induced by UV irradiation. Analysis of fluorescence spectra of a sample prior and after UV irradiation enables an identification of a sample of a drug or pharmaceutics based on a comparison with signals of known standards. Moreo…
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- Possibility of drug-distribution measurement in the hair of drowned bodies: evaluation of drug stability in water-soaked hair using micro-segmental analysis. [Journal Article]
- In postmortem examinations, the drug analysis of hair is effective for revealing drug-use history. Additionally, a method to estimate the day of death using hair was previously developed by analyzing a single hair strand segmented at 0.4-mm intervals (micro-segmental hair analysis). However, for drowned bodies, drugs in the hair may be washed out due to soaking in water for extended periods. To e…
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- Preparation of Loratadine Orally Disintegrating Tablets by Semi-solid Extrusion 3D Printing. [Journal Article]Curr Drug Deliv. 2022 Oct 11 [Online ahead of print]CD
- CONCLUSIONS: Semi-solid extrusion of 3D printing technology was applied to prepare loratadine orally disintegrating tablets with customized drug content, which provides an alternative method for the research of customized preparation.
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- Persisting, unilateral tinnitus 22 days after first dose of an mRNA-based SARS-CoV-2 vaccine. [Case Reports]
- CONCLUSIONS: SARS-CoV-2 vaccination can be followed by unilateral persisting tinnitus, headache, and ear respectively facial pressure. Since steroids and anti-histamines had a beneficial effect, an immunological pathophysiology is quite likely.
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- Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation. [Journal Article]
- Loratadine (LORA), is a topical antihistamine utilized in the treatment of ocular symptoms of COVID-19. The study aimed to develop a Loratadine Nanostructured Lipid Carriers Ocugel (LORA-NLCs Ocugel), enhance its solubility, trans-corneal penetrability, and bioavailability. full-factorial design was established with 24 trials to investigate the impact of several variables upon NLCs properties. LO…
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- Effect of Loratadine Tablets in Combination with Other Drugs on Nasal Physiological Function and T Lymphocyte Subsets in Patients with Allergic Rhinitis. [Randomized Controlled Trial]
- CONCLUSIONS: Budesonide and loratadine are effective in improving patient efficacy, T lymphocyte subsets, and nasal physiological function, and are safer.
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- A Rheological Approach for Predicting Physical Stability of Amorphous Solid Dispersions. [Journal Article]J Pharm Sci. 2023 Jan; 112(1):204-212.JP
- Miscibility is an important indicator of physical stability against crystallization of amorphous solid dispersions (ASDs). Currently available methods for miscibility determination have both theoretical and practical limitations. Here we report a method of miscibility determination based on the overlap concentration, c*, which can be conveniently determined from the viscosity-composition diagram.…
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- Molecular Characterization of Estrogen Receptor Agonists during Sewage Treatment Processes Using Effect-Directed Analysis Combined with High-Resolution Full-Scan Screening. [Journal Article]Environ Sci Technol. 2022 09 20; 56(18):13085-13095.ES
- Endocrine-disrupting potential was evaluated during the sewage treatment process using in vitro bioassays. Aryl hydrocarbon receptor (AhR)-, androgen receptor (AR)-, glucocorticoid receptor (GR)-, and estrogen receptor (ER)-mediated activities were assessed over five steps of the treatment process. Bioassays of organic extracts showed that AhR, AR, and GR potencies tended to decrease through the …
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- Milk Oral Lyophilizates with Loratadine: Screening for New Excipients for Pediatric Use. [Journal Article]
- The development of suitable formulations for the pediatric population remains a challenging field with great advances reported every year in terms of excipients and technology. When developing pediatric formulations, the acceptability of medicines represents a key element to consider. For this reason, milk can be a widely accepted excipient with taste-masking properties and supplementary advantag…
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- Safety of fexofenadine and other second-generation oral antihistamines before and after the removal of the prescription requirement in Italy and other European countries: A real-world evidence study and systematic review. [Review]
- CONCLUSIONS: There was no difference in number of AEs reported for fexofenadine pre/post-OTC switch, indicating a similar safety profile. Spontaneous reporting systems are a valuable source of real-world data and support the OTC provision of oral antihistamines in Europe and fexofenadine in Italy, in addition to supporting the use of larger pack sizes in Italy.
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- Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer. [Journal Article]
- A high percentage of marketed drugs suffer from poor water solubility and require an appropriate technique to increase their solubility. This study aims to compare physically modified and unmodified gum polymers extracted from Ziziphus spina-christi fruits as solid dispersion carriers for some drugs. Taguchi Orthogonal Design (L9) was chosen for the screening and optimization of the solid dispers…
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- Plasma exchange treats severe intrahepatic cholestasis caused by dacomitinib: A case report. [Case Reports]
- CONCLUSIONS: Dacomitinib can induce severe intrahepatic cholestasis. It is considered that patients with intermediate metabolic CYP2D6 are susceptible to drug-induced liver injury caused by dacomitinib; plasma exchange may be an effective treatment.
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- [Effect of acupuncture and moxibustion on skin barrier function in guinea pigs with eczema of skin damp-heat accumulation]. [Journal Article]Zhongguo Zhen Jiu. 2022 Jul 12; 42(7):779-84.ZZ
- CONCLUSIONS: Acupuncture and moxibustion could improve the epidermal water metabolism and skin tissue morphology in guinea pigs with eczema of skin damp-heat accumulation. Its mechanism may be related to regulating inflammatory factors, up-regulating the expression of AQP3, and then repairing the skin barrier function.
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- Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial. [Randomized Controlled Trial]Pak J Pharm Sci. 2022 May; 35(3(Special)):919-922.PJ
- To investigate the efficacy of desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema. 100 patients with subacute eczema who were admitted in our hospital from June 2019 to June 2020 were selected according to the order of admission, and divided into experimental groups (n=50, using a single compound glycyrrhizin) and control group (n=50, using compound glyc…
- Anti-histamine effects of dipotassium glycyrrhizinate on lung fibroblasts, implicating its therapeutic mechanism for pulmonary fibrosis. [Journal Article]J Pharm Pharmacol. 2022 Sep 01; 74(9):1241-1250.JP
- CONCLUSIONS: This study provided the evidences that DG can inhibit histamine-induced effects on lung fibroblasts and promote apoptosis of abnormally activated lung fibroblasts, implicating its potential therapeutic mechanisms against PF development, also for those histamine-related diseases.
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- Clinical Efficacy of Tuomin Zhiti Decoction in Allergic Rhinitis. [Journal Article]
- Allergic rhinitis (AR) is a noninfectious inflammatory disease seriously affecting the quality of life. This study aimed to assess the efficacy of the Tuomin Zhiti decoction in allergic rhinitis and to provide a reference for clinical treatment. One hundred patients with AR treated in the Department of Otolaryngology of our hospital from January 2019 to December 2020 were recruited and assigned v…
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- Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery. [Journal Article]
- Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables affecting the fate of drugs after ingestion, and medication management of these patients requires a thorough and complex mechanistic analysis. The aim of this research was to study whether loratadine/desloratadine antiallergic treatment of bariatric patients is at risk of being ineffective due to impaire…
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- Effective RNAi in leukemia cells is enhanced by spermine-modified pullulan combined with desloratadine. [Journal Article]Carbohydr Polym. 2022 Sep 15; 292:119646.CP
- RNA interference is a very useful tool for clinical treatment as well as mechanistic studies of leukemia. However, leukemia cells are known as hard-to-transfected by non-virus carriers. The low capacity of endocytosis and lysosomal escape of synthetic carriers are two obstacles for successful RNAi in leukemia cells. In this work, we established a universal powerful strategy for mediating effectiv…
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- Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19. [Journal Article]
- Antihistamines have potent efficacy to alleviate COVID-19 (Coronavirus disease 2019) symptoms such as anti-inflammation and as a pain reliever. However, the pharmacological mechanism(s), key target(s), and drug(s) are not documented well against COVID-19. Thus, we investigated to decipher the most significant components and how its research methodology was utilized by network pharmacology. The li…
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- Loratadine, an antihistaminic drug, suppresses the proliferation of endometrial stromal cells by inhibition of TRPV2. [Journal Article]Eur J Pharmacol. 2022 Aug 05; 928:175086.EJ
- The transient receptor potential (TRP) channel TRPV2 is widely expressed in a variety of different cell types and tissues. However, elucidating the exact biological functions of TRPV2 is significantly hampered by the lack of selective pharmacological tools to modulate channel activity in vitro and in vivo. This study aimed to identify new compounds that modify TRPV2 activity via the use of a plat…
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- Effects of pharmaceuticals compounds and calcium on granulation, microbiology, and performance of anaerobic granular sludge systems. [Journal Article]Water Sci Technol. 2022 Jun; 85(11):3184-3195.WS
- Granular sludge is a promising biotechnology to treat sewage contaminated with pharmaceuticals due to its increased toxicity resistance. In this context, this study evaluated the potential of Ca2+ as a granulation precursor and how pharmaceutical compounds (loratadine, prednisone, fluconazole, fenofibrate, betamethasone, 17α-ethinyl estradiol, and ketoprofen) affect granulation. Continuous and in…
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- Occurrence and removal of drugs and endocrine disruptors in water supply systems in the metropolitan region of Belo Horizonte (Minas Gerais State, Brazil). [Journal Article]Environ Monit Assess. 2022 Jun 03; 194(7):473.EM
- This study evaluates both the occurrence and removal of 24 compounds, including drugs and endocrine disruptors, in 8 water treatment plants (WTP) located in the metropolitan region of Belo Horizonte (Minas Gerais State, Brazil). The compounds 4-nonylphenol, 4-octylphenol, 17α-ethinylestradiol, 17β-estradiol, acyclovir, bisphenol A, bezafibrate, caffeine, dexamethasone, diclofenac sodium, diltiaze…
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- The Impact of Bilastine on Symptoms of Allergic Rhinitis and Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [Meta-Analysis]Am J Rhinol Allergy. 2022 Sep; 36(5):684-694.AJ
- CONCLUSIONS: Bilastine safely improved TSS in hyper histaminic allergic conditions involving nasal symptoms in AR. It decreases the discomfort associated with the disease resulting in improving the QOL of the participants.
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