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40,430 results
  • A comprehensive evaluation of stable expression "hot spot" in the ScltI gene of Chinese hamster ovary cells. [Journal Article]
    Appl Microbiol Biotechnol. 2023 Jan 27 [Online ahead of print]Ding X, Chen Y, … Li H
  • The Chinese hamster ovary (CHO) cell is the most widely used biopharmaceutical expression system, but its long-term expression is unstable. This issue can be effectively addressed by site-specific integration of exogenous genes into the genome. Therefore, exogenous protein sites with stable expression in the CHO cell genome must be identified. CRISPR/Cas9 technology was used in this study to inte…
  • Explanation of inconsistencies in the determination of human serum albumin thermal stability. [Journal Article]
    Int J Biol Macromol. 2023 Jan 23; 232:123379.Nemergut M, Sedláková D, … Sedlák E
  • Thermal denaturation of human serum albumin has been the subject of many studies in recent decades, but the results of these studies are often conflicting and inconclusive. To clarify this, we combined different spectroscopic and calorimetric techniques and performed an in-depth analysis of the structural changes that occur during the thermal unfolding of different conformational forms of human s…
  • Albumin-based drug carrier targeting urokinase receptor for cancer therapy. [Journal Article]
    Int J Pharm. 2023 Jan 22 [Online ahead of print]Li H, Wang Z, … Huang M
  • Urokinase plasminogen activator receptor (uPAR) is a key participant in extracellular proteolysis, tissue remodeling and cell motility. uPAR overexpresses in most solid tumors and several hematologic malignancies, but has low levels on normal tissues, thus is advocated as a molecular target for cancer therapy. One of the obstacles for the evaluation of uPAR targeting agents in preclinical study i…
  • Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins. [Journal Article]
    ACS Biomater Sci Eng. 2023 Jan 24 [Online ahead of print]Jagrosse ML, Agredo P, … Nilsson BL
  • Protein-based therapeutics have emerged as next-generation pharmaceutical agents for oncology, bone regeneration, autoimmune disorders, viral infections, and other diseases. The clinical application of protein therapeutics has been impeded by pharmacokinetic and pharmacodynamic challenges including off-target toxicity, rapid clearance, and drug stability. Strategies for the localized and sustaine…
  • Albumin-fused long-acting FGF21 analogue for the treatment of non-alcoholic fatty liver disease. [Journal Article]
    J Control Release. 2023 Jan 20 [Online ahead of print]Chikamatsu M, Watanabe H, … Maruyama T
  • Non-alcoholic fatty liver disease (NAFLD) currently affects about 25% of the world's population, and the numbers continue to rise as the number of obese patients increases. However, there are currently no approved treatments for NAFLD. This study reports on the evaluation of the therapeutic effect of a recombinant human serum albumin-fibroblast growth factor 21 analogue fusion protein (HSA-FGF21)…
  • Zinc Substituted Myoglobin-Albumin Fusion Protein: A Photosensitizer for Cancer Therapy. [Journal Article]
    Chemistry. 2023 Jan 23 [Online ahead of print]Yamada T, Morita Y, … Komatsu T
  • Myoglobin combined with human serum albumin (Mb-HSA) can be produced using yeast Pichia pastoris as a host strain, with secretion into the culture medium. This Mb-HSA fusion protein possesses identical O2 binding affinity to that of naked Mb. The Mb unit is reconstituted with a zinc(II) protoporphyrin IX, yielding (zinc substituted Mb)-HSA, ZnMb-HSA. The photophysical property and singlet O2 gene…
  • Analysis of malnutrition factors for inpatients with chronic kidney disease. [Journal Article]
    Front Nutr. 2022; 9:1002498.Xi WZ, Wu C, … Cao YH
  • CONCLUSIONS: Gender, age, weight loss, reduced food intake, serum ALB expression were independently associated with malnutrition in patients with chronic kidney disease, Hence, the medical staff should take timely and effective nutrition intervention for the patients with malnutrition, delay the renal function damage of patients with CKD and improve the quality of life of patients. Inpatients with CKD, especially women, should increase their dietary intake, maintain normal weight and improve their nutritional status.
  • Construction of diagnostic prediction model for Wilson's disease. [Journal Article]
    Front Surg. 2022; 9:1065053.Wang Y, Li Y, … Song Z
  • CONCLUSIONS: ALT, AST, AKP, ALB, UA, Ca, and P are independent predictors of Wilson's disease, and can be used as early predictors. Based on the nomogram prediction model, the optimal threshold was determined to be 0.698, which was an important reference index for judging Wilson's disease. Compared with the Leipzig score, the nomogram prediction model has a relatively high sensitivity and specificity and has a good clinical application value.
  • Multiple protein patterned surface plasmon resonance biochip for the detection of Human Immunoglobulin-G. [Journal Article]
    J Biophotonics. 2023 Jan 22 [Online ahead of print]Kashyap R, Boro PR, … Mondal B
  • A portable surface plasmon resonance (SPR) measurement prototype integrated with a multiple protein-patterned SPR biochip is introduced for label-free and selective detection of Human Immunoglobulin-G (H-IgG). The polyclonal anti Human Immunoglobulin-G antibodies derived from goat, rabbit and mouse were immobilized through polydimethylsiloxane (PDMS) microchannels to fabricate the patterened SPR …
  • Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy. [Journal Article]
    Adv Sci (Weinh). 2023 Jan 22 [Online ahead of print]He L, Zhao J, … Chen T
  • Low persistence, metabolic dysfunction in microenvironment, and tumor-derived immunosuppression of Natural killer (NK) cells in patients are greatly limited the successful clinical application of NK cell-based cancer immunotherapy. Interestingly, herein that human serum albumin-encapsulated black phosphorus quantum dots (BPQDs@HSA) can effectively augment antitumor efficacy of clinical patients-d…
  • BSA-stabilized silver nanoclusters for efficient photoresponsive colorimetric detection of chromium(VI). [Journal Article]
    Anal Bioanal Chem. 2023 Jan 21 [Online ahead of print]Yuan Z, Li Z, … Lu Y
  • Hexavalent chromium is a highly toxic substance, which will pose a serious threat to human life and health and the entire ecosystem. Therefore, it is crucial to establish a simple and rapid detection method for hexavalent chromium. In this work, we fabricated bovine serum albumin-stabilized silver nanocluster (BSA-Ag13 NC) which exhibited photoresponsive oxidase-like activity, catalyzing the oxid…
  • PFC@O2 Targets HIF-1α to Reverse the Immunosuppressive TME in OSCC. [Journal Article]
    J Clin Med. 2023 Jan 10; 12(2)Lan Z, Zou KL, … Yu GT
  • As a typical hallmark of solid tumors, hypoxia affects the effects of tumor radiotherapy, chemotherapy, and photodynamic therapy. Therefore, targeting the hypoxic tumor microenvironment (TME) is a promising treatment strategy for cancer therapy. Here, we prepared an Albumin Human Serum (HSA)-coated perfluorocarbon (PFC) carrying oxygen (PFC@O2) to minimize OSCC hypoxia. The results showed that PF…
  • Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications. [Journal Article]
    Int J Mol Sci. 2023 Jan 16; 24(2)Smolarkiewicz-Wyczachowski A, Kaczmarek H, … Ziegler-Borowska M
  • The work is devoted to preparing and characterizing the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy. Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting. These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIP…
  • Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins. [Journal Article]
    Int J Mol Sci. 2023 Jan 12; 24(2)Talaj JA, Zielinski K, Bujacz A
  • Free drug concentration in the blood sera is crucial for its appropriate activity. Serum albumin, the universal blood carrier protein, is responsible for transporting drugs and releasing them into the bloodstream. Therefore, a drug's binding to SA is especially important for its bioavailability and it is a key problem in the drug design process. In this paper, we present crystal structures of thr…
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