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(Albutein)
40,456 results
  • Discovery and characterization of hydroxylysine O-glycosylation in an engineered IL-2 fusion protein. [Journal Article]
    Protein Expr Purif. 2023 Feb 01 [Online ahead of print]Zhu Y, Liu J, … Liu H
  • In the present study, an engineered interleukin-2 (IL-2) fusion protein consisting of an anti-human serum albumin nanobody linked by ASTKG and a (G4S)2 linker to IL-2 was constructed. Liquid chromatography-mass spectrometry (LC-MS) characterization was performed on the intact molecule and at the peptide level. The liquid chromatography-mass spectrometry molecular mass analysis for the engineered …
  • Label-free biosensing of lignans for therapeutics using engineered model surfaces. [Journal Article]
    Int J Biol Macromol. 2023 Feb 01 [Online ahead of print]Péter B, Majoros B, … Horvath R
  • The label-free interaction analysis of macromolecules and small molecules has increasing importance nowadays, both in diagnostics and therapeutics. In the blood vascular system, human serum albumin (HSA) is a vital globular transport protein with potential multiple ligand binding sites. Characterizing the binding affinity of compounds to HSA is essential in pharmaceutics and in developing new com…
  • Autoxidation of ascorbate mediates lysine N-pyrrolation. [Journal Article]
    Free Radic Res. 2023 Feb 01 [Online ahead of print]Yoshitake J, Shibata T, … Uchida K
  • Protein N-pyrrolation, which converts lysine residues to Nε-pyrrole-L-lysine (pyrK), is a naturally-occurring covalent modification. The pyrrolated proteins have a unique property of binding to DNA-staining agessnts, such as SYBR Green I (SG), and anti-DNA antibodies, suggesting a physiologically relevant modification that gives rise to DNA mimic protein. These properties of pyrrolated protein ar…
  • Noninvasive, continuous fluorescence monitoring of bilirubin photodegradation. [Review]
    Phys Chem Chem Phys. 2023 Jan 27 [Online ahead of print]Perkov S, Gorin D
  • Nowadays phototherapy is widely used for treatment of various diseases. However, efficient application of phototherapy requires an understanding of light interactions with main endogenous chromophores (e.g., hemoglobin, bilirubin, and water) in tissue. In particular, bilirubin is the target chromophore in the treatment of neonatal jaundice, which is the most common disease affecting up to 80% of …
  • Dysregulation of metalloproteins in ischemic heart disease patients with systolic dysfunction. [Journal Article]
    Int J Biol Macromol. 2023 Jan 28; 232:123435.Khan N, Ullah J, … Musharraf SG
  • Ischemic heart disease (IHD) is the leading cause of mortality worldwide. Metalloproteins have been linked to human health and diseases. The molecular functions of metalloproteins in IHD is not well understood and require further exploration. The objective of this study was to find out the role of metalloproteins in the pericardial fluid of IHD patients having normal (EF > 45) and impaired (EF < …
  • Closed-loop vasculature network design for bioprinting large, solid tissue scaffolds. [Journal Article]
    Biofabrication. 2023 Jan 30 [Online ahead of print]Kumar H, Dixit K, … Kim K
  • Vascularization is an indispensable requirement for fabricating large solid tissues and organs. The natural vasculature derived from medical imaging modalities for large tissues and organs are highly complex and convoluted. However, the present bioprinting capabilities limit the fabrication of such complex natural vascular networks. Simplified bioprinted vascular networks, on the other hand, lack…
  • Explanation of inconsistencies in the determination of human serum albumin thermal stability. [Journal Article]
    Int J Biol Macromol. 2023 Jan 23; 232:123379.Nemergut M, Sedláková D, … Sedlák E
  • Thermal denaturation of human serum albumin has been the subject of many studies in recent decades, but the results of these studies are often conflicting and inconclusive. To clarify this, we combined different spectroscopic and calorimetric techniques and performed an in-depth analysis of the structural changes that occur during the thermal unfolding of different conformational forms of human s…
  • Albumin-based drug carrier targeting urokinase receptor for cancer therapy. [Journal Article]
    Int J Pharm. 2023 Jan 22; 634:122636.Li H, Wang Z, … Huang M
  • Urokinase plasminogen activator receptor (uPAR) is a key participant in extracellular proteolysis, tissue remodeling and cell motility. uPAR overexpresses in most solid tumors and several hematologic malignancies, but has low levels on normal tissues, thus is advocated as a molecular target for cancer therapy. One of the obstacles for the evaluation of uPAR targeting agents in preclinical study i…
  • Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins. [Journal Article]
    ACS Biomater Sci Eng. 2023 Jan 24 [Online ahead of print]Jagrosse ML, Agredo P, … Nilsson BL
  • Protein-based therapeutics have emerged as next-generation pharmaceutical agents for oncology, bone regeneration, autoimmune disorders, viral infections, and other diseases. The clinical application of protein therapeutics has been impeded by pharmacokinetic and pharmacodynamic challenges including off-target toxicity, rapid clearance, and drug stability. Strategies for the localized and sustaine…
  • Albumin-fused long-acting FGF21 analogue for the treatment of non-alcoholic fatty liver disease. [Journal Article]
    J Control Release. 2023 Jan 20 [Online ahead of print]Chikamatsu M, Watanabe H, … Maruyama T
  • Non-alcoholic fatty liver disease (NAFLD) currently affects about 25% of the world's population, and the numbers continue to rise as the number of obese patients increases. However, there are currently no approved treatments for NAFLD. This study reports on the evaluation of the therapeutic effect of a recombinant human serum albumin-fibroblast growth factor 21 analogue fusion protein (HSA-FGF21)…
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