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Unbound Medicine.
(Alcohol withdrawal)
17,621 results
  • A challenging case of lumbar vertebral burst fracture with alcohol withdrawal delirium: A case report. [Journal Article]
    Medicine (Baltimore). 2023 Jan 20; 102(3):e32712.Koizumi K, Uehara M, … Takahashi J
  • CONCLUSIONS: We encountered a patient with severe delirium tremens developing several days after thoraco-lumbar fusion surgery. Prompt internal fixation successfully treated the spinal injury and prevented neurological damage. It may also be necessary to consider treatment strategies for patients with a background of heavy alcohol consumption in consideration of delirium tremens and other symptoms of alcohol withdrawal.
  • Opioid Use Disorder from Poppy Seed Tea Use: A Case Report. [Journal Article]
    Am J Case Rep. 2023 Jan 26; 24:e938675.Kauppila GR, Eagen KV
  • BACKGROUND Unwashed or unprocessed poppy seeds may be an underrecognized substance that can lead to dependence, abuse, and an opioid use disorder. Poppy seeds can be purchased in an unwashed or unprocessed form, and these seeds can be contaminated with the opium alkaloids morphine, codeine, and thebaine on their surfaces. Poppy seeds that are commercially available, such as those used for baking …
  • Chalcones: Potential Chemotherapeutic Compounds and Educational Tools for Closing the Loop in STEM. [Journal Article]
    Acc Chem Res. 2023 Jan 25 [Online ahead of print]Russell AE, Gines BR
  • ConspectusThe study discussed herein describes the synthesis of halogenated chalcones as potential chemotherapeutics. The synthesis work was conducted by undergraduate students participating in an Organic Chemistry II laboratory course at Tuskegee University, while the biological assays were conducted by students enrolled in a Molecular Biology I laboratory course. Chalcones were synthesized via …
  • Seasonality and Delirium Tremens in Hospitalized Patients with Alcohol Dependence Syndrome. [Journal Article]
    Eur Addict Res. 2023 Jan 23 [Online ahead of print]Pribék IK, Kádár BK, … Andó B
  • CONCLUSIONS: The present study revealed that spring, especially March is a critical period in temperate climate zone regarding DT. This can be interpreted as a late winter effect since the temperature is lower in this month compared to other spring months. Furthermore, higher age and the occurrence of comorbid somatic disorders can be considered as risk factors in case of DT. These results support the need of further clinical studies to better understand the impact of seasonality on DT.
  • Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice. [Journal Article]
    Front Pharmacol. 2022; 13:1074633.Alper K, Cange J, … Vinod KY
  • The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder (AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice administered saline or psilocybin intraperitoneally as a single dose of 0.1, 0.5, 1.0 or 2.0 mg/kg and provided 20% ethanol utilizing a two-bottle choice alcohol drinking paradig…
  • Caffeine Delays Ethanol-Induced Sedation in Drosophila. [Journal Article]
    Biology (Basel). 2022 Dec 30; 12(1)Tremblay S, Zeng Y, … Ahmad ST
  • Caffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagonist and thus acts as a stimulant. Conversely, ethanol is a sedative because it promotes GABAergic n…
  • Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder. [Journal Article]
    Neuropsychopharmacology. 2023 Jan 20 [Online ahead of print]Macedo GC, Kreifeldt M, … Contet C
  • Alcohol use disorders can be driven by negative reinforcement. Alterations of the microtubule cytoskeleton have been associated with mood regulation in the context of depression. Notably, MAP4343, a pregnenolone derivative known to promote tubulin assembly, has antidepressant properties. In the present study, we tested the hypothesis that MAP4343 may reduce excessive alcohol drinking in a mouse m…
  • Acute Alcoholic Hallucinosis: A Review. [Review]
    Psychopathology. 2023 Jan 19 [Online ahead of print]Skryabin VY, Martinotti G, … Zastrozhin MS
  • Acute alcoholic hallucinosis is a psychotic disorder characterized by a predominance of auditory hallucinations with delusions and affective symptoms in the clinical picture. Classically, it develops as part of the alcohol withdrawal syndrome. The prevalence of acute alcoholic hallucinosis ranks second among alcohol-related psychoses after alcohol delirium. The study aimed to systematize the scie…
  • Reduction in caffeine withdrawal after open-label decaffeinated coffee. [Journal Article]
    J Psychopharmacol. 2023 Jan 11 [Online ahead of print]Mills L, Lee JC, … Colagiuri B
  • CONCLUSIONS: It appears as if open-label placebo caffeine (i.e. decaf) can reduce caffeine withdrawal symptoms, even when people do not hold a conscious expectancy it will do so. There may be ways to integrate open-label placebo procedures into clinical interventions for drug dependence without violating informed consent.
  • Confusion of Alcohol Craving With Food Hunger in Alcohol-Dependent Individuals Entering In-Patient Drug Treatment. [Journal Article]
    Alcohol Alcohol. 2023 Jan 09 [Online ahead of print]Czarnecki D, Ziółkowski M, … Kułak-Bejda A
  • CONCLUSIONS: Alcohol-dependent persons who confuse alcohol craving with pre-meal hunger differ from those who do not confuse these hunger pangs in terms of feeling stronger alcohol craving and more frequent occurrence of symptoms accompanying the feeling of alcohol craving during pre-meal hunger. At the start of treatment for alcohol withdrawal, alcohol-dependent individuals who report confusing alcohol cravings with pre-meal hunger are less confident of maintaining abstinence. This is relevant to treatment. The role of possible confounders (depressive symptoms, cognitive and educational deficiency) could not be elucidated definitively.
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