- The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention. [Review]
- AAlcohol 2018 Mar 20; 69:15-24
- Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early ge...
Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981 Science paper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career. She explored and discovered numerous mechanisms of alcohol's effects on the embryo, as well as describing several genetic factors that can modify susceptibility to developmental alcohol exposure. She did not restrict her research to the face and brain; her lab described in intricate detail the effects of developmental alcohol exposure on many different organs, including the heart, ears, kidneys, and limbs. In addition to her research, and in conjunction with NIAAA and the National Organization on Fetal Alcohol Syndrome (NOFAS), Kathy developed several FASD prevention curricula that are still in use today. Finally, as part of her drive to eradicate FAS and FASD, Kathy labored tirelessly with public policy makers to change how FASD is viewed by the public, how FASD is identified in affected individuals, and how FASD is studied by researchers. While no article could fully cover Kathy's contributions to FASD research and prevention, or her other contributions to embryology and teratology, this review will attempt to illustrate some of the highlights of Kathy's remarkable career.
- The long and latent road to autoimmunity. [Editorial]
- CMCell Mol Immunol 2018 Mar 22
- [Hepatocellular carcinoma: Increase in incidence or future plague?] [Review]
- BCBull Cancer 2018 Mar 19
- Hepatocellular carcinoma is the third most frequent cause of cancer death worldwide, particularly in Asia and Africa. Most cases complicate an underlying liver cirrhosis due to hepatitis B or C chron...
Hepatocellular carcinoma is the third most frequent cause of cancer death worldwide, particularly in Asia and Africa. Most cases complicate an underlying liver cirrhosis due to hepatitis B or C chronic virus infection or alcoholic abuse. But, following the current epidemics of obesity and type 2 diabetes, it appears that these diseases, associated in metabolic syndrome, are responsible for non alcoholic fatty liver disease at risk of HCC frequently before the stage of cirrhosis. Recent hypotheses consider that in the near future, cancer deaths due to HCC will overpass in USA those due to breast or colorectal cancers. Governments should develop policies to prevent obesity, type 2 diabetes and the metabolic syndrome as well as fight against alcoholism and hepatitis B and C virus infections.
- Analysis of the relationship between interleukin polymorphisms within miRNA-binding regions and alcoholic liver disease. [Journal Article]
- RCRev Clin Esp 2018 Mar 19
- CONCLUSIONS: Our study describes, for the first time, the expected frequencies of certain polymorphisms within miRNA-binding sites in alcoholic patients with and without ALD. Further studies should be developed to clarify the potential relevance of these polymorphisms in alcoholism and ALD development.
- Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure. [Journal Article]
- EElife 2018 Mar 22; 7
- Despite its being historically conceptualized as a motor expression site, emerging evidence suggests the ventral pallidum (VP) plays a more active role in integrating information to generate motivati...
Despite its being historically conceptualized as a motor expression site, emerging evidence suggests the ventral pallidum (VP) plays a more active role in integrating information to generate motivation. Here, we investigated whether rat VP cue responses would encode and contribute similarly to the vigor of reward-seeking behaviors trained under Pavlovian versus instrumental contingencies, when these behavioral responses consist of superficially similar locomotor response patterns but may reflect distinct underlying decision-making processes. We find that cue-elicited activity in many VP neurons predicts the latency of instrumental reward seeking, but not of Pavlovian response latency. Further, disruption of VP signaling increases the latency of instrumental but not Pavlovian reward seeking. This suggests that VP encoding of and contributions to response vigor are specific to the ability of incentive cues to invigorate reward-seeking behaviors upon which reward delivery is contingent.
- Clinical and microbiologic characteristics of pleuro-pulmonary infection due to Streptococcus intermedius. [Journal Article]
- RERev Esp Quimioter 2018 Mar 22
- The clinical and microbiological characteristics of pleuro-pulmonary infection (PPI) caused by Streptococcus intermedius is described, including 6 cases in the literature and 9 cases handled at the p...
The clinical and microbiological characteristics of pleuro-pulmonary infection (PPI) caused by Streptococcus intermedius is described, including 6 cases in the literature and 9 cases handled at the present centre. Out of the 15 patients, 12 were male; mean age at diagnosis was 62.06 ± 15 years. Twelve had risk factors for S. intermedius infection such as alcoholism in 5 (35.7%) patients, periodontal disease in 3 (24.6%) cases, chronic obstructive pulmonary disease in 3 (24.6%), and diabetes mellitus in 2 (14.2%). Cough was present in 12 (80%) patients and chest pain and dyspnea in 9 (60%). The mean diagnosis interval was 34 days. The diagnosis was obtained from pleural fluid aspirate in 13 (86.6%) cases and from biopsy/tissue samples in 2. The most frequently antimicrobials used for treatment were ceftriaxone + levofloxacin. Ten patients cured with a combination of medical and surgical treatment and 2 patients died as a consequence of infection. The incidence of PPI caused by S. intermedius is increasing in our health area; drainage along with antibiotic therapy is recommended for treatment.
- Depression in the wives of convicted men: prevalence and associated factors. [Journal Article]
- RBRev Bras Enferm 2018; 71(suppl 1):538-545
- CONCLUSIONS: It is the responsibility of the nurse with the multidisciplinary health team to invest in health promotion and prevention actions against these risk factors that were associated with depression in this population.
- Wellness interventions for anesthesiologists. [Journal Article]
- COCurr Opin Anaesthesiol 2018 Mar 19
- CONCLUSIONS: Burnout is a pathological syndrome that is triggered by constant levels of high stress. A combination of individual efforts as well as structural interventions can help to increase wellbeing in physicians.
- A Confirmatory Factor Analysis of the Smoking and Weight Eating Episodes Test (SWEET). [Journal Article]
- IJInt J Behav Med 2018 Mar 20
- CONCLUSIONS: The present study provides evidence in support of the validity and reliability of scores on the SWEET as a multidimensional measure of smoking for appetite, weight, and body-related concerns in male and female daily cigarette smokers.
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- [The development of prevention of alcoholic addiction on the basis of analysis of medical social risk factors and prognostic modeling]. [Journal Article]
- PSProbl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2016 Jul-Aug; 24(5):266-72
- The alcohol addiction is one of most actual medical social problems of modern society. The medical biological and social hygienic risk factors play significant role in its development. As a result of...
The alcohol addiction is one of most actual medical social problems of modern society. The medical biological and social hygienic risk factors play significant role in its development. As a result of that, actual priority is attached to development of methodology and implementation of screening program with the purpose of analyzing medical social characteristics of examined contingent, forming of risk groups and administrating of adequate preventive curative preventive measures. The developed program included 74 questions to patient and 6 items of decision of physician. The mentioned program was applied as a basis of medical social survey comprising samples of 418 patients with alcoholism (main group) and 402 patients without this pathology (control group). The digital data base was organized. To support possibility of joint statistical processing of values of analyzed medical social characteristics all qualitative indices based on expertise evaluations were represented in digital expression. The methods of mathematical statistics were applied to explore significance of leading medical social risk factors. These factors were used as a foundation of developing mathematical models permitting to forecast individual level of possibility of development of alcohol addiction and health of patients. The established risk factors and results of prognostic modeling were proposed to be implemented in process of preventive examinations with the purpose of identification of persons with high risk of development of alcohol addiction and administer curative preventive measures. The results of approbation organized in two industrial enterprises of the Voronezhskaia oblast and screening of patients without narcological or psychiatric diagnosis visited Voronezhskii clinical narcological dispensary with purpose of obtaining resolution about absence of narcological diseases, confirm effectiveness of proposed approach.