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Unbound Medicine.
(Alcoholism)
1,128,098 results
  • Rapid and chronic ethanol tolerance are composed of distinct memory-like states in Drosophila. [Journal Article]
    J Neurosci. 2023 Feb 07 [Online ahead of print]Larnerd C, Adhikari P, … Wolf FW
  • Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here, we characterize three distinct forms of ethanol tolerance in male Drosophila: rapid, chronic, and repeated. Rapid tolerance is composed of two short-lived memory-like states, one that is labile and one that i…
  • [Not Available]. [Journal Article]
    Salud Publica Mex. 2023 Jan 02; 65(1, ene-feb):1-9.Gómez-García JA, Rivera-Rivera L, … Tejadilla-Orozco DI
  • CONCLUSIONS: La prevalencia de IS durante la pandemia por Covid-19 fue elevada; se discute la relevancia de los DS estructurales e intermedios que influyen en la IS.
  • Controlled Release of H2S from Biomimetic Silk Fibroin-PLGA Multilayer Electrospun Scaffolds. [Journal Article]
    Biomacromolecules. 2023 Feb 07 [Online ahead of print]Liguori A, Petri E, … Focarete ML
  • The possibility of incorporating H2S slow-release donors inside biomimetic scaffolds can pave the way to new approaches in the field of tissue regeneration and anti-inflammatory treatment. In the present work, GYY4137, an easy-to-handle commercially available Lawesson's reagent derivative, has been successfully incorporated inside biomimetic silk fibroin-based electrospun scaffolds. Due to the in…
  • Impact of adverse drug reactions on the outcomes of tuberculosis treatment. [Journal Article]
    PLoS One. 2023; 18(2):e0269765.Sant Anna FM, Araújo-Pereira M, … Rolla VC
  • CONCLUSIONS: Substance use was associated with unfavorable outcomes, highlighting the need for better strategies to reduce this habit. In contrast, ADRs were associated with favorable outcomes. Attention to the occurrence of ADR in PLHIV is essential, especially regarding hepatotoxicity in those with high immunosuppression.
  • Adipose-targeted SWELL1 deletion exacerbates obesity and age-related non-alcoholic fatty liver disease. [Journal Article]
    JCI Insight. 2023 Feb 07 [Online ahead of print]Gunasekar SK, Heebink J, … Sah R
  • Healthy expansion of adipose tissue is critical for the maintenance of metabolic health - providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently store lipid can result in lipodystrophy and contribute to nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. LRRC8a/SWELL1 functionally e…
  • Direct and Indirect Predictors of Medication Adherence With Bipolar Disorder: Path Analysis. [Journal Article]
    JMIR Form Res. 2023 Feb 07; 7:e44059.Cohen B, Sixsmith A, … O'Rourke N
  • CONCLUSIONS: Alcohol misuse did not predict perceived cognitive failures. Nor did age predict medication adherence or cognitive failures. This is noteworthy given the 51-year age range of participants. That is, persons in their 20s with BD reported similar levels of medication adherence and perceived cognitive failures as those in their 60s. This suggests that perceived cognitive loss is a facet of adult life with BD, in contrast to the assumption that accelerated cognitive aging with BD begins in midlife.
  • Modifiable Risk Factor Score and Fecundability in a Preconception Cohort in Singapore. [Journal Article]
    JAMA Netw Open. 2023 Feb 01; 6(2):e2255001.Loy SL, Ku CW, … Chan JKY
  • CONCLUSIONS: Results of this study revealed the co-occurrence of multiple modifiable risk factors for lowered fecundability and a substantially higher conception rate among participants with no or minimal risk factors. The risk assessment scoring system proposed is a simple and potentially useful public health tool for mitigating risks and guiding those who are trying to conceive.
  • Cross-linked enzyme aggregates of fusion enzymes in microaqueous organic media. [Journal Article]
    Chembiochem. 2023 Feb 07 [Online ahead of print]Vernet G, Ma Y, … Kara S
  • Baeyer-Villiger Monooxygenases (BVMOs) are attractive for selectively oxidizing various ketones using oxygen into valuable esters and lactones. However, the application of BVMOs is restrained by cofactor-dependency and enzyme instability combined with waterrelated downsides such as low substrate loadings, low oxygen capacity, and water-induced side reactions. Herein, we described a redox-neutral …
  • Assessment of proline function in higher plants under extreme temperatures. [Review]
    Plant Biol (Stuttg). 2023 Feb 07 [Online ahead of print]Raza A, Charagh S, … Varshney RK
  • Climate change and abiotic stress factors are the key players in crop losses around the globe. Among the different stresses, extreme temperatures (heat and cold) disturb plant growth and development, reduces productivity, and in severe cases, leads to plant death. The plants have developed numerous strategies to safeguard themselves against the detrimental impact of temperature stress. Exposure t…
  • Two new diarylheptanoids from the green walnut husks of Juglans mandshurica Maxim. [Journal Article]
    Nat Prod Res. 2023 Feb 07 [Online ahead of print]Zhou YY, Liu NY, … Kuang HX
  • Chemical investigation on the 95% ethanol extract of green walnut husks of Juglans mandshurica Maxim. led to the isolation of two new diarylheptanoid compounds, including Juglanin K (1) and Myricananin I (2), together with ten known compounds (3-13). Their structures were elucidated by extensive analyses of comprehensive spectroscopic methods. The isolated compounds were evaluated for their antib…
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