- The management of alcohol use disorder in the emergency department, is it time for version 2.0? [Editorial]CJEM. 2023 Feb 07 [Online ahead of print]CJEM
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- Falsely elevated thyroid hormone levels associated with fibrin interference in patients receiving oral anticoagulant therapy. [Journal Article]Ann Clin Biochem. 2023 Feb 07 [Online ahead of print]AC
- CONCLUSIONS: We report two patients receiving warfarin with falsely elevated thyroid hormone levels caused by fibrin interference resembling central hyperthyroidism for the first time. Our retrospective study suggests that the medication status of oral anticoagulants should be considered when evaluating thyroid function tests.
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- Simultaneous co-Photocatalytic CO2 Reduction and Ethanol Oxidation towards Synergistic Acetaldehyde Synthesis. [Journal Article]Angew Chem Int Ed Engl. 2023 Feb 07 [Online ahead of print]AC
- Photocatalytic conversion of CO2 is of great interest but it often suffers sluggish oxidation half reaction and undesired by-products. Here, we report for the first the simultaneous co-photocatalytic CO2 reduction and ethanol oxidation towards one identical value-added CH3CHO product on a rubidium and potassium co-modified carbon nitride (CN-KRb). The CN-KRb offers a record photocatalytic activit…
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- Rapid and chronic ethanol tolerance are composed of distinct memory-like states in Drosophila. [Journal Article]J Neurosci. 2023 Feb 07 [Online ahead of print]JN
- Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here, we characterize three distinct forms of ethanol tolerance in male Drosophila: rapid, chronic, and repeated. Rapid tolerance is composed of two short-lived memory-like states, one that is labile and one that i…
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- [Role of IRE1 in autophagy induced by vitamin E succinate in human gastric cancer cell]. [Journal Article]Wei Sheng Yan Jiu. 2023 Jan; 52(1):109-114.WS
- CONCLUSIONS: VES may participate in the regulation of autophagy in gastric cancer cells by upregulating IRE1 pathway.
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- Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. [Journal Article]Gut. 2023 Mar; 72(3):581-589.Gut
- CONCLUSIONS: The LS thresholds identified in this study may be useful for risk stratification of NASH patients with advanced fibrosis.
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- [Not Available]. [Journal Article]Salud Publica Mex. 2023 Jan 02; 65(1, ene-feb):1-9.SP
- CONCLUSIONS: La prevalencia de IS durante la pandemia por Covid-19 fue elevada; se discute la relevancia de los DS estructurales e intermedios que influyen en la IS.
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- An Eye Tracking Investigation of Young People's Gaze Behaviour to Gambling and Non-Gambling Moving Adverts. [Journal Article]Eur Addict Res. 2023 Feb 07 [Online ahead of print]EA
- CONCLUSIONS: Our findings demonstrate that young people's craving for gambling can be predicted based on their eye movements to video clips of gambling advertisements and that certain features of gambling advertisements may be more appealing to some group of viewers, particularly those with high craving for gambling.
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- Using Direct and Indirect Estimates for Alcohol-Attributable Mortality: A Modelling Study Using the Example of Lithuania. [Journal Article]Eur Addict Res. 2023 Feb 07 [Online ahead of print]EA
- CONCLUSIONS: As all indirect estimates were markedly lower than direct estimates, current overall relative risks and price elasticities should be re-evaluated. In particular, global estimates should be replaced by new regional estimates based on cohort studies.
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- Self-Assembly of Glycerol-Amphiphilic Janus Dendrimers Amplifies and Indicates Principles for the Selection of Stereochemistry by Biological Membranes. [Journal Article]J Am Chem Soc. 2023 Feb 07 [Online ahead of print]JA
- The principles for the selection of the stereochemistry of phospholipids of biological membranes remain unclear and continue to be debated. Therefore, any new experiments on this topic may help progress in this field. To address this question, three libraries of constitutional isomeric glycerol-amphiphilic Janus dendrimers (JDs) with nonsymmetric homochiral, racemic, and symmetric achiral branchi…
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- Clot-Targeted Antithrombotic Liposomal Nanomedicine Containing High Content of H2O2-Activatable Hybrid Prodrugs. [Journal Article]ACS Appl Mater Interfaces. 2023 Feb 07 [Online ahead of print]AA
- Liposomes have been extensively explored as drug carriers, but their clinical translation has been hampered by their low drug-loading content and premature leakage of drug payloads. It was reasoned that vesicle-forming prodrugs could be incorporated into the lipid bilayer at a high molar fraction and therefore serve as a therapeutic agent as well as a structural component in liposomal nanomedicin…
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- Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis. [Journal Article]Diabetes. 2023 Feb 07 [Online ahead of print]D
- High-throughput proteomics allow researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic responses to an intravenous glucose tolerance test (IVGTT) to identify novel protein contributors to glucose homeostasis and diabetes risk. We tested 4,776 SomaScan® pr…
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- Controlled Release of H2S from Biomimetic Silk Fibroin-PLGA Multilayer Electrospun Scaffolds. [Journal Article]Biomacromolecules. 2023 Feb 07 [Online ahead of print]B
- The possibility of incorporating H2S slow-release donors inside biomimetic scaffolds can pave the way to new approaches in the field of tissue regeneration and anti-inflammatory treatment. In the present work, GYY4137, an easy-to-handle commercially available Lawesson's reagent derivative, has been successfully incorporated inside biomimetic silk fibroin-based electrospun scaffolds. Due to the in…
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- Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation. [Journal Article]J Med Chem. 2023 Feb 07 [Online ahead of print]JM
- GPR88 is an orphan G protein-coupled receptor mainly expressed in the brain, whose endogenous ligand has not yet been identified. To elucidate GPR88 functions, our group has developed RTI-13951-33 (1b) as the first in vivo active GPR88 agonist, but its poor metabolic stability and moderate brain permeability remain to be further optimized. Here, we report the design, synthesis, and pharmacologica…
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- Impact of adverse drug reactions on the outcomes of tuberculosis treatment. [Journal Article]PLoS One. 2023; 18(2):e0269765.Plos
- CONCLUSIONS: Substance use was associated with unfavorable outcomes, highlighting the need for better strategies to reduce this habit. In contrast, ADRs were associated with favorable outcomes. Attention to the occurrence of ADR in PLHIV is essential, especially regarding hepatotoxicity in those with high immunosuppression.
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- Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer. [Journal Article]J Med Chem. 2023 Feb 07 [Online ahead of print]JM
- The development of orally bioavailable, furanopyrimidine-based double-mutant (L858R/T790M) EGFR inhibitors is described. First, selectivity for mutant EGFR was accomplished by replacing the (S)-2-phenylglycinol moiety of 12 with either an ethanol or an alkyl substituent. Then, the cellular potency and physicochemical properties were optimized through insights from molecular modeling studies by im…
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- Evaluation of free radical quenching, anti-inflammatory activity together with anticancer potential of Lychnis coronaria and characterization of novel molecules from its extract through high resolution-liquid chromatography mass spectrometry coupled to structural biochemistry approach. [Journal Article]J Biomol Struct Dyn. 2023 Feb 07 [Online ahead of print]JB
- Lychnis coronaria, a perennial (herbaceous) belonging to Caryophyllaceae has been traditionally used for treating different complications. However, the free radical scavenging effect, anti-inflammatory activity and anticancer property of methanolic extract of this plant has not been addressed. Most importantly, the chemical constituents present in the extract of Lychnis coronaria responsible for …
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- Adipose-targeted SWELL1 deletion exacerbates obesity and age-related non-alcoholic fatty liver disease. [Journal Article]JCI Insight. 2023 Feb 07 [Online ahead of print]JI
- Healthy expansion of adipose tissue is critical for the maintenance of metabolic health - providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently store lipid can result in lipodystrophy and contribute to nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. LRRC8a/SWELL1 functionally e…
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- Direct and Indirect Predictors of Medication Adherence With Bipolar Disorder: Path Analysis. [Journal Article]JMIR Form Res. 2023 Feb 07; 7:e44059.JF
- CONCLUSIONS: Alcohol misuse did not predict perceived cognitive failures. Nor did age predict medication adherence or cognitive failures. This is noteworthy given the 51-year age range of participants. That is, persons in their 20s with BD reported similar levels of medication adherence and perceived cognitive failures as those in their 60s. This suggests that perceived cognitive loss is a facet of adult life with BD, in contrast to the assumption that accelerated cognitive aging with BD begins in midlife.
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- Modifiable Risk Factor Score and Fecundability in a Preconception Cohort in Singapore. [Journal Article]JAMA Netw Open. 2023 Feb 01; 6(2):e2255001.JN
- CONCLUSIONS: Results of this study revealed the co-occurrence of multiple modifiable risk factors for lowered fecundability and a substantially higher conception rate among participants with no or minimal risk factors. The risk assessment scoring system proposed is a simple and potentially useful public health tool for mitigating risks and guiding those who are trying to conceive.
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- Syndemic Profiles and Sexual Health Risks Among Sexually Exploited Adolescent Girls in Taiwan: A Latent Class Analysis. [Journal Article]Arch Sex Behav. 2023 Feb 07 [Online ahead of print]AS
- Sexually exploited adolescent girls are disproportionately affected by adverse psychosocial conditions, such as intra-familial child physical and sexual abuse, extra-familial violence and sexual assault, alcohol and drug use, and suicide. Syndemic theory suggests that these adverse psychosocial or syndemic conditions are concentrated and co-occurring in socially marginalized populations, includin…
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- Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases. [Journal Article]Chem Res Toxicol. 2023 Feb 07 [Online ahead of print]CR
- Benign and malignant prostatic diseases are common, costly, and burdensome; moreover, they share fundamental underlying molecular processes. Several ubiquitous contaminants may perturb these processes, possibly via peroxisome proliferator-activated receptor (PPAR) signaling, but the role of environmental exposures─particularly mixtures─in prostatic diseases is undefined. In the present study, non…
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- Comparison of the effects of 2 frequencies of application of photobiomodulation on facial rejuvenation: Controlled, randomized, and double-blind clinical trial. [Journal Article]Medicine (Baltimore). 2023 Feb 03; 102(5):e32514.M
- Skin aging is an irreversible, slow and progressive process, mainly influenced by age, but also by external factors such as ultraviolet radiation, smoking, and alcohol, among others. It is increasingly common to look for procedures that slow down skin aging by limiting or hiding its effects on appearance. Studies have shown the benefits of photobiomodulation (PBM) for the skin, especially with th…
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- Precorneal retention time of ocular lubricants measured with fluorophotometry in healthy dogs. [Journal Article]Vet Ophthalmol. 2023 Feb 07 [Online ahead of print]VO
- CONCLUSIONS: This study established normative data for the retention time of common lubricants on the ocular surface of dogs, which may be used to guide clinicians with their choice of lubricant and frequency of administration.
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- Extraction Optimization and Antioxidant Activities of Ethanol Extract of the Brown Roll-Rim Mushroom Paxillus involutus (Agaricomycetes). [Journal Article]Int J Med Mushrooms. 2023; 25(2):67-75.IJ
- Box Behnken design (BBD) was used to optimize the extraction of Paxillus involutus (EPI) in ethanol. The optimum extraction conditions were as follows: temperature 45°C; solid:liquid ratio 1:35; time 5 h. Under these conditions, the yield of EPI was 13.57%. The antioxidant activity of EPI was evaluated in vitro, and DPPH free radical scavenging, ABTS free radical scavenging, and hydroxyl free rad…
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- Cross-linked enzyme aggregates of fusion enzymes in microaqueous organic media. [Journal Article]Chembiochem. 2023 Feb 07 [Online ahead of print]C
- Baeyer-Villiger Monooxygenases (BVMOs) are attractive for selectively oxidizing various ketones using oxygen into valuable esters and lactones. However, the application of BVMOs is restrained by cofactor-dependency and enzyme instability combined with waterrelated downsides such as low substrate loadings, low oxygen capacity, and water-induced side reactions. Herein, we described a redox-neutral …
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- Assessment of proline function in higher plants under extreme temperatures. [Review]Plant Biol (Stuttg). 2023 Feb 07 [Online ahead of print]PB
- Climate change and abiotic stress factors are the key players in crop losses around the globe. Among the different stresses, extreme temperatures (heat and cold) disturb plant growth and development, reduces productivity, and in severe cases, leads to plant death. The plants have developed numerous strategies to safeguard themselves against the detrimental impact of temperature stress. Exposure t…
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- Two new diarylheptanoids from the green walnut husks of Juglans mandshurica Maxim. [Journal Article]Nat Prod Res. 2023 Feb 07 [Online ahead of print]NP
- Chemical investigation on the 95% ethanol extract of green walnut husks of Juglans mandshurica Maxim. led to the isolation of two new diarylheptanoid compounds, including Juglanin K (1) and Myricananin I (2), together with ten known compounds (3-13). Their structures were elucidated by extensive analyses of comprehensive spectroscopic methods. The isolated compounds were evaluated for their antib…
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- Association between psychomotor function and ALDH2 genotype after consuming barley shochu: A randomized crossover trial. [Journal Article]Clin Transl Sci. 2023 Feb 07 [Online ahead of print]CT
- Sustained exposure to acetaldehyde, the major metabolite of ethanol, may influence psychomotor performance even after the breath ethanol level significantly drops several hours following ethanol consumption. We examined the relationship between psychomotor function and changes in exhaled ethanol and acetaldehyde concentrations after consuming a low dose (0.33 g/kg) of barley shochu, a traditional…
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- Anaeropeptidivorans aminofermentans gen. nov., sp. nov., a mesophilic proteolytic salt-tolerant bacterium isolated from a laboratory-scale biogas fermenter, and emended description of Clostridium colinum. [Journal Article]Int J Syst Evol Microbiol. 2022 Dec; 72(12)IJ
- An anaerobic bacterial strain, designated strain M3/9T, was isolated from a laboratory-scale biogas fermenter fed with maize silage supplemented with 5 % wheat straw. Cells were straight, non-motile rods, which stained Gram-negative. Optimal growth occurred between 30 and 40°C, at pH 7.5-8.5, and up to 3.9 % (w/v) NaCl was tolerated. When grown on peptone from casein and soymeal, strain M3/9T pro…
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