Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Aldosterone excess)
2,629 results
  • Infections and immunity: associations with obesity and related metabolic disorders. [Review]
    J Pathol Transl Med. 2023 Jan; 57(1):28-42.Ray A, Bonorden MJL, … Bishayee A
  • About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathologic…
  • New advances in endocrine hypertension: from genes to biomarkers. [Review]
    Kidney Int. 2023 Jan 13 [Online ahead of print]Fernandes-Rosa FL, Boulkroun S, … Zennaro MC
  • Hypertension (HT) is a major cardiovascular risk factor that affects 10% to 40% of the general population in an age-dependent manner. Detection of secondary forms of HT is particularly important because it allows the targeted management of the underlying disease. Among hypertensive patients, the prevalence of endocrine HT reaches up to 10%. Adrenal diseases are the most frequent cause of endocrin…
  • Pathophysiologic approach in genetic hypokalemia. [Review]
    Ann Endocrinol (Paris). 2023 Jan 10 [Online ahead of print]Blanchard A
  • The pathophysiology of genetic hypokalemia is close to that of non-genetic hypokalemia. New molecular pathways physiologically involved in renal and extrarenal potassium homeostasis have been highlighted. A physiological approach to diagnosis is illustrated here, with 6 cases. Mechanisms generating and sustaining of hypokalemia are discussed. After excluding acute shift of extracellular potassium…
  • Liddle syndrome. [Journal Article]
    Vnitr Lek. 2022 Winter; 68(E-8):8-11.Mareš Š, Filipovský J
  • Liddle syndrome is an inherited form of arterial hypertension with autosomal dominant pattern of inheritance. It is caused by activating mutation of genes coding of the epithelial sodium channel in distal nephron. Mutation leads to excessive reabsorbtion of sodium ions and volume expansion resulting in arterial hypertension. Antoher typical laboratory findings are hypokalaemia, low levels of seru…
  • Vascular and hormonal interactions in the adrenal gland. [Review]
    Front Endocrinol (Lausanne). 2022; 13:995228.Abdellatif AB, Fernandes-Rosa FL, … Zennaro MC
  • Primary aldosteronism is the most common form of secondary arterial hypertension, due to excessive aldosterone production from the adrenal gland. Although somatic mutations have been identified in aldosterone producing adenoma, the exact mechanisms leading to increased cell proliferation and nodule formation remain to be established. One hypothesis is that changes in vascular supply to the adrena…
  • Aldosterone as a Possible Contributor to Eye Diseases. [Journal Article]
    Endocrinology. 2022 12 19; 164(2)Higashide T, Hirooka K, … Sugiyama K
  • Aldosterone, an effector molecule of the renin-angiotensin-aldosterone system (RAAS), has been receiving more attention in the field of ophthalmology because of its possible role in the pathogenesis of various eye diseases or abnormalities; it may even become a target for their treatment. Primary aldosteronism, a typical model of a systemic aldosterone excess, may cause vision loss due to various…
  • The Entity of Connshing Syndrome: Primary Aldosteronism with Autonomous Cortisol Secretion. [Review]
    Diagnostics (Basel). 2022 Nov 13; 12(11)Carsote M
  • Connshing syndrome (CoSh) (adrenal-related synchronous aldosterone (A) and cortisol (C) excess) represents a distinct entity among PA (primary hyperaldosteronisms) named by W. Arlt et al. in 2017, but the condition has been studied for more than 4 decades. Within the last few years, this is one of the most dynamic topics in hormonally active adrenal lesions due to massive advances in steroids met…
  • Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction. [Journal Article]
    J Am Heart Assoc. 2022 12 06; 11(23):e027164.Hegyi B, Mira Hernandez J, … Bossuyt J
  • Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited. Diabetes and mineralocorticoid excess are common and important pathophysiological factors that may synergistically promote HFpEF. The authors aimed to develop a novel animal model of HFpEF that recapitulates key aspects of the complex human phen…
  • StatPearls: Hemodialysis [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MurdeshwarHimani N.HNGrant Government Medical CollegeAnjumFatimaFHofstra University, Zucker School of MedicineBOOK
  • The term dialysis is derived from the Greek words dia, meaning "through", and lysis meaning "loosening or splitting". It is a form of renal replacement therapy, where the kidney's role of filtration of the blood is supplemented by artificial equipment, which removes excess water, solutes, and toxins. Dialysis ensures maintenance of homeostasis (a stable internal environment) in people experiencin…
  • Neutrophil gelatinase-associated lipocalin as an immunomodulator in endocrine hypertension. [Review]
    Front Endocrinol (Lausanne). 2022; 13:1006790.Araos P, Amador CA
  • In recent studies, primary aldosteronism (PA) has been reported as the most common etiology for secondary hypertension of endocrine origin, accounting for approximately 10% of cases. In PA, excess aldosterone production can lead to deleterious effects at the cardiovascular (CV) and renal levels by activating mineralocorticoid receptors, which involves an increase in pro-inflammatory and pro-fibro…
  • Bone and mineral metabolism in patients with primary aldosteronism: A systematic review and meta-analysis. [Meta-Analysis]
    Front Endocrinol (Lausanne). 2022; 13:1027841.Wang A, Wang Y, … Lyu Z
  • CONCLUSIONS: Excess aldosterone was associated with decreased serum calcium, elevated urinary calcium, and elevated PTH levels; these effects may be enhanced by low serum 25-OHD levels. The risks of OP and fracture might be elevated in PA patients, especially unilateral PA patients, but could be reduced after medical treatment or adrenal surgery. In view, however, of the lack of BMD changes, such hypothesis needs to be tested in further studies.
  • Primary Aldosteronism Masked by Accessory Renal Arteries: A Case Report. [Case Reports]
    J Clin Med. 2022 Oct 25; 11(21)Yang C, Yang X, … Liu K
  • Primary aldosteronism (PA) is the most frequent form of secondary endocrine hypertension, which is characterized by excessive aldosterone secretion and suppressed renin. The currently recommended diagnostic algorithm is very clear, and the plasma aldosterone-to-renin ratio (ARR) is considered the first-line screening test. However, this indicator is influenced by many factors, some of which may c…
  • Apparent mineralocorticoid excess: comprehensive overview of molecular genetics. [Review]
    J Transl Med. 2022 11 03; 20(1):500.Lu YT, Zhang D, … Peng F
  • Apparent mineralocorticoid excess is an autosomal recessive form of monogenic disease characterized by juvenile resistant low-renin hypertension, marked hypokalemic alkalosis, low aldosterone levels, and high ratios of cortisol to cortisone metabolites. It is caused by defects in the HSD11B2 gene, encoding the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is primarily involved …
  • Thromboembolic Disease and Cardiac Thrombotic Complication in COVID-19: A Systematic Review. [Review]
    Metabolites. 2022 Sep 22; 12(10)Nappi F, Nappi P, … Avtaar Singh SS
  • The coronavirus 2019 pandemic has affected many healthcare systems worldwide. While acute respiratory distress syndrome (ARDS) has been well-documented in COVID-19, there are several cardiovascular complications, such as myocardial infarction, ischaemic stroke, and pulmonary embolism, leading to disability and death. The link between COVID-19 and increasing thrombogenicity potentially occurs due …
New Search Next