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137 results
  • NF-κB: A Druggable Target in Acute Myeloid Leukemia. [Review]
    Cancers (Basel). 2022 Jul 21; 14(14)Di Francesco B, Verzella D, … Zazzeroni F
  • Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy that relies on highly heterogeneous cytogenetic alterations. Although in the last few years new agents have been developed for AML treatment, the overall survival prospects for AML patients are still gloomy and new therapeutic options are still urgently needed. Constitutive NF-κB activation has been reported in around 40% of A…
  • EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player? [Review]
    Front Oncol. 2022; 12:933922.Di Vito Nolfi M, Vecchiotti D, … Zazzeroni F
  • Drug resistance is a major impediment to patient survival and remains the primary cause of unsuccessful cancer therapy. Drug resistance occurs in many tumors and is frequently induced by chemotherapy which triggers a defensive response both in cancerous and cancer-associated cells that constitute the tumor microenvironment (TME). Cell to cell communication within the TME is often mediated by extr…
  • Ultrasound-Based Method for the Identification of Novel MicroRNA Biomarkers in Prostate Cancer. [Journal Article]
    Genes (Basel). 2021 10 28; 12(11)Cornice J, Capece D, … Zazzeroni F
  • The detection of circulating microRNA (miRNA)-based biomarkers represents an innovative, non-invasive method for the early detection of cancer. However, the low concentration of miRNAs released in body fluids and the difficult identification of the tumor site have limited their clinical use as effective cancer biomarkers. To evaluate if ultrasound treatment could amplify the release of extracellu…
  • Emerging Role of isomiRs in Cancer: State of the Art and Recent Advances. [Review]
    Genes (Basel). 2021 09 20; 12(9)Zelli V, Compagnoni C, … Tessitore A
  • The advent of Next Generation Sequencing technologies brought with it the discovery of several microRNA (miRNA) variants of heterogeneous lengths and/or sequences. Initially ascribed to sequencing errors/artifacts, these isoforms, named isomiRs, are now considered non-canonical variants that originate from physiological processes affecting the canonical miRNA biogenesis. To date, accurate IsomiRs…
  • Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy. [Journal Article]
    Front Public Health. 2020; 8:594789.Fischietti M, Fratini E, … Alesse E
  • Low radiation doses can affect and modulate cell responses to various stress stimuli, resulting in perturbations leading to resistance or sensitivity to damage. To explore possible mechanisms taking place at an environmental radiation exposure, we set-up twin biological models, one growing in a low radiation environment (LRE) laboratory at the Gran Sasso National Laboratory, and one growing in a …
  • Leptin in Tumor Microenvironment. [Review]
    Adv Exp Med Biol. 2020; 1259:89-112.Angelucci A, Clementi L, Alesse E
  • Leptin is a hormone that plays a major role as mediator of long-term regulation of energy balance, suppressing food intake, and stimulating weight loss. More recently, important physiological roles other than controlling appetite and energy expenditure have been suggested for leptin, including neuroendocrine, reparative, reproductive, and immune functions. These emerging peripheral roles let hypo…
  • Life, death, and autophagy in cancer: NF-κB turns up everywhere. [Review]
    Cell Death Dis. 2020 03 30; 11(3):210.Verzella D, Pescatore A, … Zazzeroni F
  • Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review di…
  • Applications of Next Generation Sequencing to the Analysis of Familial Breast/Ovarian Cancer. [Review]
    High Throughput. 2020 Jan 10; 9(1)Zelli V, Compagnoni C, … Tessitore A
  • Next generation sequencing (NGS) provides a powerful tool in the field of medical genetics, allowing one to perform multi-gene analysis and to sequence entire exomes (WES), transcriptomes or genomes (WGS). The generated high-throughput data are particularly suitable for enhancing the understanding of the genetic bases of complex, multi-gene diseases, such as cancer. Among the various types of tum…
  • NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond. [Review]
    Semin Cell Dev Biol. 2020 02; 98:118-128.Capece D, Verzella D, … Zazzeroni F
  • NF-κB plays a pivotal role in oncogenesis. This transcription factor is best known for promoting cancer cell survival and tumour-driving inflammation. However, several lines of evidence support a crucial role for NF-κB in governing energy homeostasis and mediating cancer metabolic reprogramming. Mitochondria are central players in many metabolic processes altered in cancer. Beyond their bioenerge…
  • GADD45β Loss Ablates Innate Immunosuppression in Cancer. [Journal Article]
    Cancer Res. 2018 03 01; 78(5):1275-1292.Verzella D, Bennett J, … Franzoso G
  • T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumor-associated inflammation and T-cell trafficking into tumors. In various models of solid cancers refractory to immunotherapies, including hepatocellular carcinoma and ovarian adenoc…
  • Next-generation sequencing: recent applications to the analysis of colorectal cancer. [Review]
    J Transl Med. 2017 Dec 08; 15(1):246.Del Vecchio F, Mastroiaco V, … Tessitore A
  • Since the establishment of the Sanger sequencing method, scientists around the world focused their efforts to progress in the field to produce the utmost technology. The introduction of next-generation sequencing (NGS) represents a revolutionary step and promises to lead to massive improvements in our understanding on the role of nucleic acids functions. Cancer research began to use this innovati…
  • Cancer secretome and inflammation: The bright and the dark sides of NF-κB. [Review]
    Semin Cell Dev Biol. 2018 06; 78:51-61.Capece D, Verzella D, … Zazzeroni F
  • Tumour promoting inflammation is widely recognized as a hallmark of cancer. The source of this chronic inflammation in cancer has been ascribed to the progressive activation over time of immune cells, mostly of the innate arm of the immune system. However, recent evidence has shown that chronic inflammation may also derive, at least in part, from senescent cells. Hence, due to the prominent role …
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