- Efficiently photocatalysis activation of peroxydisulfate by Fe-doped g-C3N5 for pharmaceuticals and personal care products degradation. [Journal Article]Environ Pollut. 2023 Jan 31 [Online ahead of print]EP
- Peroxydisulfate (PDS) based advanced oxidation processes (AOPs) are widely used for the degradation of pharmaceutical and personal care products (PPCP) in wastewater treatment. In this study, a Fe-doped g-C3N5 (Fe@g-C3N5) was synthesized as a photocatalyst for catalyzing the PDS-based AOPs to degrade tetracycline hydrochloride (TH) at pH 3 and Naproxen (NPX) at pH 7. The photocatalytic performanc…
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- Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups. [Review]ACS Appl Bio Mater. 2023 Feb 03 [Online ahead of print]AA
- The self-assembly and structural and functional properties of peptide conjugates containing bulky terminal aromatic substituents are reviewed with a particular focus on bioactivity. Terminal moieties include Fmoc [fluorenylmethyloxycarbonyl], naphthalene, pyrene, naproxen, diimides of naphthalene or pyrene, and others. These provide a driving force for self-assembly due to π-stacking and hydropho…
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- Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine. [Journal Article]Chem Pharm Bull (Tokyo). 2023; 71(2):148-153.CP
- This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensit…
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- Poly(lactic acid)/β-cyclodextrin based nanoparticles bearing ruthenium(II)-arene naproxen complex: preparation and characterization. Analytical validation for metal determination by Microwave-Induced Plasma Optical Emission Spectrometry. [Journal Article]J Microencapsul. 2023 Feb 01 [Online ahead of print]JM
- CONCLUSIONS: The NPs parameters are compatible with colloidally stable systems. The MIP-OES method showed to be simple, reliable and feasible to quantify indirectly the amount of the metallodrug-loaded into the PLA NPs.
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- Repurposing some of the Well-Known Non-Steroid Anti-Inflammatory Drugs [Nsaids] for Cancer Treatment. [Journal Article]Curr Top Med Chem. 2023 Jan 30 [Online ahead of print]CT
- Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is time-saving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing…
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- Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]BC
- Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
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- Chemical and biological tracers to identify source and transport pathways of septic system contamination to streams in areas with low permeability soils. [Journal Article]Sci Total Environ. 2023 Jan 26 [Online ahead of print]ST
- Septic systems are widely used in rural areas that lack centralized sewage treatment systems. Incomplete removal of domestic wastewater contaminants in septic systems can lead to leaching of nutrients (P and N), bacteria/viruses, and trace contaminants to surrounding groundwater and surface water. This study focuses on delineating the fate of wastewater contaminants in localities in which septic …
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- The design and evaluation of the antimicrobial activity of a novel conjugated penta-ultrashort antimicrobial peptide in combination with conventional antibiotics against sensitive and resistant strains of S. aureus and E. coli. [Journal Article]
- CONCLUSIONS: Naprolyginine could prove to be a promising candidate for antimicrobial drug development.
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- Fe3O4 supported UiO-66 (Zr) metal-organic framework for removal of drug contaminants from water: fuzzy logic modeling approach. [Journal Article]Environ Sci Pollut Res Int. 2023 Jan 24 [Online ahead of print]ES
- The increase in production and consumption of pharmaceuticals and personal care products causes environmental problems. In this study, naproxen and clofibric acid adsorption were studied using Fe3O4-supported UiO-66 (Zr) metal-organic framework (Mag-UiO-66). The adsorption processes were carried out in batch mode at pH value 3.0. The optimum adsorbent quantities, equilibrium periods, pseudo-first…
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- Embedding of Poorly Water-Soluble Drugs in Orodispersible Films-Comparison of Five Formulation Strategies. [Journal Article]
- The poor bioavailability of many newly developed active pharmaceutical ingredients (APIs) poses a major challenge in formulation development. To overcome this issue, strategies such as the preparation of amorphous solid dispersions (ASDs), and the application of the APIs in lipid nanocarriers or the wet-milling of the substances into nanoparticles have been introduced. In addition to an efficient…
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- Recent Advances in Asymmetric Catalysis Associated with B(C6F5)3. [Review]
- The prevalence and significance of asymmetric catalysis in the modern medicinal industry has been witnessed in recent years, which have already been used to manufacture the (S)-Naproxen and the (S)-Propranolol. With matched specificities such as the Lewis acidity and steric bulk, B(C6F5)3 has gained accelerating attention on its application in asymmetric catalysis of Diels-Alder cycloaddition rea…
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- Comparison of cardiorenal safety of nonsteroidal anti-inflammatory drugs in the treatment of arthritis: a network meta-analysis. [Journal Article]
- CONCLUSIONS: The NMA results showed that amtolmetin guacil was relatively safer, but it needs further investigation. Rofecoxib was associated with a higher incidence of cardiorenal adverse events, ibuprofen with a higher incidence of cardiovascular events and hypertension, and naproxen with a higher incidence of renal events and edema. Clinicians should weigh the efficacy of NSAIDs against renal and cardiovascular toxicity when prescribing NSAIDs for the treatment of arthritis.
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- Fully soluble polymeric foams for in-vial dried blood spot collection and analysis of acidic drugs by capillary electrophoresis. [Journal Article]Anal Chim Acta. 2023 Feb 08; 1241:340793.AC
- Polymeric foams tailor-made of polyvinylpyrrolidone (PVP) and carboxymethylcellulose/oxidized 6-carboxycellulose (CMC07/OC) composite were proposed as suitable sorbents for the collection and analysis of dried blood spots (DBSs). The PVP and CMC07/OC foams were easy to prepare, enabled collection of minute volumes of capillary blood, and blood drying at ambient temperature. The resulting foams we…
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- Clinician's dilemma: Naproxen-induced liver injury. [Case Reports]Indian J Pathol Microbiol. 2023 Jan-Mar; 66(1):168-170.IJ
- Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) in pediatric population, used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. It rarely causes clinically apparent liver injury in the adult population taking high doses of the drug over a prolonged period and is reported even rarer in pediatric population. We present a case of drug-induced liver inj…
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- Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis. [Journal Article]J Dent Res. 2023 Jan 11 [Online ahead of print]JD
- This study compares the effectiveness of pharmacological treatments to develop guidelines for the management of acute pain after tooth extraction. We searched Medline, EMBASE, CENTRAL, and US Clinical Trials registry on November 21, 2020. We included randomized clinical trials (RCTs) of participants undergoing dental extractions comparing 10 interventions, including acetaminophen, nonsteroidal an…
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- Biotinylated Pt(IV) prodrugs with elevated lipophilicity and cytotoxicity. [Journal Article]Dalton Trans. 2023 Jan 24; 52(4):866-871.DT
- A design of Pt(IV) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(IV) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic acid moiety and biotin as axial ligands. We have established that for Pt(IV) prodrugs with biotin and naproxen or stearate in axial position, the lipophilicity rather than biotin rece…
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- Synthesis of fluorescent artificial receptors with high specificity for simultaneous detection of non-steroidal anti-inflammatory drugs. [Journal Article]Food Chem. 2023 Jun 01; 410:135419.FC
- Development of multiple detection methods to monitor non-steroidal anti-inflammatory drugs (NSAIDs) in food is an effective way to protect human health. Here, we aimed to synthesize fluorescent artificial receptors by molecular imprinting technique to construct a simultaneous detection system targeting NSAIDs. Rhodamine B and fluorescein-functionalized silanes were employed as the fluorescence si…
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- Simultaneous Voltammetric Determination of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using a Modified Carbon Paste Electrode and Chemometrics. [Journal Article]
- This work presents the simultaneous quantification of four non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, diclofenac, naproxen, and aspirin, in mixture solutions, by a laboratory-made working electrode based on carbon paste modified with multi-wall carbon nanotubes (MWCNT-CPE) and Differential Pulse Voltammetry (DPV). Preliminary electrochemical analysis was performed using cyclic v…
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- N,N'-Diaryldihydrophenazines as a Sustainable and Cost-Effective Alternative to Precious Metal Complexes in the Photoredox-Catalyzed Alkylation of Aryl Alkyl Ketones. [Journal Article]
- An inexpensive and highly efficient metal-free alternative to commonly used Ru- and Ir-based catalysts was proposed. It was shown that the new 2,7-di-tert-butyl-5,10-bis(4-trifluoromethylphenyl)-5,10-dihydrophenazine outcompeted the iridium phenylpyridyl complex in photoredox activity in the alkylation of silyl enol ethers yielding aryl alkyl ketones. The reaction occurred under visible light irr…
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- Synthesis, In Vitro Anti-Inflammatory Activity, and HRMS Analysis of New Amphetamine Derivatives. [Journal Article]
- Herein, we report the obtaining of new hybrid molecules of amphetamine with different profens (amfens). The obtained amfens are characterized by their melting points, UV, 1H-, 13C-NMR, and HRMS spectra. A complete and detailed mass spectral analysis of the newly obtained derivatives of amphetamine with ibuprofen, flurbiprofen, ketoprofen, naproxen, and carprofen was performed. In vitro inhibition…
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- An Observational Study of Fixed Drug Eruption in A Tertiary Care Hospital in Bangladesh. [Journal Article]Mymensingh Med J. 2023 Jan; 32(1):49-53.MM
- Fixed drug eruption (FDE) is a distinctive pattern of cutaneous adverse drug reaction. Characteristically the eruption recurs at the same site on re exposure to the offending agent. Aim of this study was to evaluate and identification of the various offending drugs causing FDE which may help the physician to limit the associate complication regarding the drug. This observational cross sectional s…
- The effects of Lavandula angustifolia essential oil on analgesic effects and percutaneous absorption of naproxen sodium gel; an in vivo and in vitro study. [Journal Article]Clin Exp Pharmacol Physiol. 2022 Dec 27 [Online ahead of print]CE
- The percutaneous bioavailability of naproxen is low and several technologies have been utilized to overcome the problem. Although, some studies have reported the permeation-enhancing properties of natural essential oils, no research has reflected the effectiveness of Lavandula angustifolia essential oil (LAEO) on increasing the percutaneous absorption of naproxen sodium from a topical gel. Theref…
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- Novel management of granuloma formation secondary to dermal filler: A multi-modality approach. [Journal Article]J Cosmet Dermatol. 2022 Dec 25 [Online ahead of print]JC
- CONCLUSIONS: GFBR provides both a medical and aesthetic issue for these patients including mental distress, pain, and dysfunction, therefore having an effective treatment for GFBR will affect medical management of these patients, improving patient outcomes and satisfaction. Our proposed regimen for GFBR has been shown to be highly efficacious and safe for these patients, providing a significant improvement in both function and cosmesis of the area.
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- Influence of Hydrophobic and Hydrophilic Chain Length of CiEj Surfactants on the Solubilization of Active Pharmaceutical Ingredients. [Journal Article]Mol Pharm. 2022 Dec 24 [Online ahead of print]MP
- Up to 90% of all newly developed active pharmaceutical ingredients (APIs) are poorly water soluble, most likely also showing a low oral bioavailability. In order to increase the aqueous solubility of these APIs, surfactants are promising excipients to increase both solubility and consequently bioavailability (e.g., in lipid- and surfactant-based drug delivery systems). In this work, we investigat…
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- Current and emerging COX inhibitors for treating postoperative pain following oral surgery. [Journal Article]Expert Opin Pharmacother. 2023 Jan 04 [Online ahead of print]EO
- The numerous drugs in the NSAID class are often used to treat acute postoperative pain associated with oral surgery such as impacted third-molar extractions. These drugs are effective in this setting and dental pain studies often serve as models for acute pain relief and for registration of analgesics. With numerous cyclooxygenase (COX) inhibitors available as monotherapy, for use in combination …
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- Adsorption and Release Properties of Drug Delivery System Naproxen-SBA-15: Effect of Surface Polarity, Sodium/Acid Drug Form and pH. [Journal Article]
- Mesoporous silica SBA-15 was prepared via sol-gel synthesis and functionalized with different types of organosilanes containing various organic functional groups: (3-aminopropyl)triethoxysilane (SBA-15-NH2), (3-mercaptopropyl)triethoxysilane (SBA-15-SH), triethoxymethylsilane (SBA-15-CH3), triethoxyphenylsilane (SBA-15-Ph), and (3-isocynatopropyl)triethoxysilane (SBA-15-NCO). The prepared materia…
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- Cucurbituril-assisted sensitive fluorescence detection and quantitation of naproxen drug in wastewater samples: Guest-host characterization and HPLC investigation. [Journal Article]
- Sensitive spectrofluorometric and liquid chromatography with fluorescence detection methods have been developed for detection and determination of naproxen drug in the presence of cucurbit7uril (CB7). Fluorescence signals have been improved with the addition of CB7 to the drug aqueous solution. Fluorescence spectroscopy, mass spectrometry, 1H-NMR, and liquid chromatography with fluorescence detec…
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- Pea root responses under naproxen stress: changes in the formation of structural barriers in the primary root in context with changes of auxin and abscisic acid levels. [Journal Article]Ecotoxicology. 2023 Jan; 32(1):1-11.E
- Pharmaceuticals belong to pseudo-persistent pollutants because of constant entry into the environment and hazardous potential for non-target organisms, including plants, in which they can influence biochemical and physiological processes. Detailed analysis of results obtained by microscopic observations using fluorescent dyes (berberine hemisulphate, Fluorol Yellow 088), detection of phytohormone…
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- HPLC-Fluorescence Detection Method for Concurrent Estimation of Domperidone and Naproxen. Validation and Eco-Friendliness Appraisal Studies. [Journal Article]J Fluoresc. 2022 Dec 20 [Online ahead of print]JF
- This work demonstrates a simple and reliable HPLC method with fluorimetric detection for simultaneous estimation of domperidone (DOM) and naproxen (NAP). Successful chromatographic separation was accomplished using Inertsil ODS C18 column (5 μm, 4.6 × 150 mm) with gradient elution of the mobile phase consisting of 0.01 M phosphate buffer (pH 5.5) solution and acetonitrile. The gradient elution st…
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- [Treatment of sleep disturbances associated with chronic non-specific low back pain: results of prospective randomized multicenter open-label clinical trial]. [Randomized Controlled Trial]Zh Nevrol Psikhiatr Im S S Korsakova. 2022; 122(12):85-94.ZN
- CONCLUSIONS: Naproxen sodium 440 mg/diphenhydramine 50 mg combination demonstrated improvement in sleep maintenance (WASO) vs. naproxen sodium 550 mg and higher efficiency in average daily pain reduction compared with the comparison groups. The treatment was well tolerated There were no serious or unexpected adverse events reported in the study.
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