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1,021 results
  • Treatment of cryptosporidiosis: nitazoxanide yes, but we can do better. [Journal Article]
    Expert Rev Anti Infect Ther. 2022 Dec 26 [Online ahead of print]Caravedo MA, White AC
  • Cryptosporidiosis was initially recognized as an important cause of diarrhea in AIDS patients. It has been underdiagnosed in other populations. Recent studies have highlighted the importance of Cryptosporidium as a cause of diarrhea and malnutrition in young children in resource-poor countries and an emerging pathogen in organ-transplant recipients.
  • Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis. [Journal Article]
    R Soc Open Sci. 2022 Oct; 9(10):220428.Khalid H, Batool S, … Khan GM
  • Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is associated with severe dyspepsia and stomach pain. Here…
  • Electronic Structures and Reactivities of COVID-19 Drugs: A DFT Study. [Journal Article]
    Acta Chim Slov. 2022 Sep 26; 69(3):647-656.Aydogdu S, Hatipoglu A
  • These days, the world is facing the threat of pandemic Coronavirus Disease 2019 (COVID-19). Although a vaccine has been found to combat the pandemic, it is essential to find drugs for an effective treatment method against this disease as soon as possible. In this study, electronic and thermodynamic properties, molecular electrostatic potential (MEP) analysis, and frontier molecular orbitals (FMOs…
  • Nitazoxanide and COVID-19: A review. [Review]
    Mol Biol Rep. 2022 Nov; 49(11):11169-11176.Al-Kuraishy HM, Al-Gareeb AI, … Batiha GE
  • Coronavirus disease 2019 (COVID-19) is a current global illness triggered by severe acute respiratory coronavirus 2 (SARS-CoV-2) leading to acute viral pneumonia, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and cytokine storm in severe cases. In the COVID-19 era, different unexpected old drugs are repurposed to find out effective and cheap therapies against SARS-CoV-2. On…
  • In vivo evaluation of anticryptosporidial effects of wheat germ extracts in immunocompromised mice. [Journal Article]
    J Parasit Dis. 2022 Sep; 46(3):833-844.Abdelmaksoud HF, Osman EEA, … Naggar HME
  • Cryptosporidium species is a prime cause of diarrheal disease in individuals with competent immunity. In patients with compromised immunity, infections are more severe particularly in developing countries. Wheat germ oil was described to have antiparasitic effect. This study was done to evaluate the possible role of wheat germ extracts in Cryptosporidium parvum (C. parvum) infected immunocompromi…
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