- Effect of colchicine and aspirin given together in patients with moderate COVID-19. [Journal Article]Contemp Clin Trials Commun. 2023 Jan 21 [Online ahead of print]CC
- CONCLUSIONS: It was evident from CT scan scores that the treatment group has shown significant improvement in the reduction of inflammation and other COVID-19 symptoms as compared to the control group. The fall in Ferritin, Hs-CRP and D-Dimer level after treatment were indicative of improvement in internal inflammatory response of body in COVID-19 disease. As increased troponin levels indicate some degree of heart damage, the fall in troponin levels indicated that test treatment improved heart health in COVID-19 patients.
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- Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren's syndrome. [Review]Front Immunol. 2022; 13:1094278.FI
- Sjögren's syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren's syndrome, the causes of the disease are as yet unknown and treatments remain largely ineffective, with established therapeutic interventions being limited to use of saliva substitutes with mode…
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- A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. [Journal Article]PNAS Nexus. 2022 May; 1(2):pgac059.PN
- MEK inhibitors are among the most successful molecularly targeted agents used as cancer therapeutics. However, to treat cancer more efficiently, resistance to MEK inhibitor-induced cell death must be overcome. Although previous genetic approaches based on comprehensive gene expression analysis or RNAi libraries led to the discovery of factors involved in intrinsic resistance to MEK inhibitors, a …
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- Isolation, identification, biological characteristics, and antifungal efficacy of sodium bicarbonate combined with natamycin on Aspergillus niger from Shengzhou nane (Prunus salicina var. taoxingli) fruit. [Journal Article]Front Microbiol. 2022; 13:1075033.FM
- The fungi causing fruit rot were isolated from symptomatic Shengzhou nane (Prunus salicina var. taoxingli) fruit and were identified as Aspergillus niger by biological characteristics and molecular analysis of the internal transcribed spacer region (rDNA-ITS) and translation elongation factor-1α (TEF-1α) sequences. Optimal growth conditions for A. niger were 30°C, pH 5.0-6.0, and fructose and pep…
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- Adverse drug reactions in an ageing PopulaTion (ADAPT) study: Prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients. [Journal Article]Front Pharmacol. 2022; 13:1029067.FP
- Background: Older people experience greater morbidity with a corresponding increase in medication use resulting in a potentially higher risk of adverse drug reactions (ADRs). Objectives: The aim of this study was to; 1) determine the prevalence and characteristics of ADR-related hospital admissions among older patients (≥65 years) in Ireland; and 2) identify the risk factors associated with ADR-r…
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- An oviduct glycan increases sperm lifespan by diminishing ubiquinone and production of reactive oxygen species. [Preprint]bioRxiv. 2023 Jan 08B
- Sperm storage by females after mating for species-dependent periods is used widely among animals with internal fertilization to allow asynchrony between mating and ovulation. Many mammals store sperm in the lower oviduct where specific glycans on epithelial cells retain sperm to form a reservoir. Binding to oviduct cells suppresses sperm intracellular Ca 2+ and increases sperm longevity. We inves…
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- Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]BC
- Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
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- Low-Dose Heparin Infusion as Venous Thromboembolism Chemoprophylaxis in Patients With Blunt Cerebrovascular Injury. [Journal Article]J Surg Res. 2023 Jan 27; 286:1-7.JS
- CONCLUSIONS: Low dose heparin infusion is frequently used as an initial treatment of BCVI. In injured patients with BCVI, a low dose heparin infusion is associated with a low rate of VTE, comparable to injured patients without BCVI that received standard VTE chemoprophylaxis.
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- Hypertensive disorders of pregnancy pre- and post-aspirin guideline publication in individuals with pre-gestational diabetes mellitus. [Journal Article]Am J Obstet Gynecol MFM. 2023 Jan 25 [Online ahead of print]AJ
- CONCLUSIONS: Delivery post-USPSTF aspirin guideline publication was associated with higher rates of hypertensive disorders of pregnancy and preterm birth in a population of individuals with diabetes mellitus. It is unknown whether patient or practitioner factors, or other changes in obstetric care, contributed to these findings.
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- Hsp90 protected chicken primary myocardial cells from heat-stress injury by inhibiting oxidative stress and calcium overload in mitochondria. [Journal Article]Biochem Pharmacol. 2023 Jan 25 [Online ahead of print]BP
- Severe heat stress can cause human and animal heart failure and sudden death, which is an important issue of public health worldwide. Our previous studies in animals showed that myocardial cells injury was critical in the above process, and Hsp90 induction has a definite anti-myocardial injury effect, especially through aspirin (ASA). But the mechanism has not been fully clarified. In this study,…
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- Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial. [Journal Article]Lancet. 2023 Jan 25 [Online ahead of print]Lct
- CONCLUSIONS: In adult kidney transplant recipients, correction of metabolic acidosis by treatment with sodium bicarbonate over 2 years did not affect the decline in estimated GFR. Thus, treatment with sodium bicarbonate should not be generally recommended to preserve estimated GFR (a surrogate marker for graft function) in kidney transplant recipients with chronic kidney disease who have metabolic acidosis.
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- Rechargeable films for protection of dry foods: A sustainable method for covalent grafting of β-cyclodextrin-thymol complex on PET/viscose platform. [Journal Article]Food Chem. 2023 Jan 23; 412:135560.FC
- Rechargeable materials for the effective protection of dry food products were developed. β-cyclodextrin-thymol inclusion complex was covalently grafted on a solid platform of polyethylene terephthalate-viscose using either traditional cross-linker of epichlorohydrin, or natural cross-linker of citric acid. A correlation between the grafting method and physicochemical properties, loading capacity …
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- Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68. [Journal Article]J Investig Med. 2023 Jan 10 [Online ahead of print]JI
- The molecular mechanisms of opium action with regard to coronary artery disease (CAD) have not yet been determined. The aim of this study was to evaluate the effect of opium on the expression of scavenger receptors including CD36, CD68, and CD9 tetraspanin in monocytes and the plasma levels of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), malondialdehyde (MDA), and nitric oxide m…
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- Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. [Journal Article]Pharmacol Res Perspect. 2023 Feb; 11(1):e01056.PR
- The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15-LOX-derived metabolites (15-oxylipins); however, whether 15-LOX is in the platelet or is required for the formation of 15-oxylipins remains unclear. This study seeks to elucidate…
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- Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES). [Journal Article]Stroke Vasc Neurol. 2023 Jan 27 [Online ahead of print]SV
- CONCLUSIONS: The INSPIRES trial will assess the efficacy and safety of intensive antiplatelet therapy and immediate intensive statin therapy begun within 72 hours of onset in decreasing the recurrent stroke at 90 days in patients with acute mild ischaemic stroke or high-risk TIA of intracranial or extracranial atherosclerosis origin.
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- Aspirin use during pregnancy may be a potential risk for postpartum hemorrhage and increased blood loss: A systematic review and meta-analysis. [Review]Am J Obstet Gynecol MFM. 2023 Jan 24 [Online ahead of print]AJ
- CONCLUSIONS: Aspirin use during pregnancy is a potential risk for postpartum hemorrhage and do slightly increase the amount of postpartum blood loss. Without denying the combined value of aspirin, our conclusions raise alarm for clinicians to postpartum hemorrhage in women using aspirin during pregnancy.
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- Utilization of Transport Data to Decrease Unnecessarily Repeated Laboratory Tests. [Journal Article]Pediatr Emerg Care. 2023 Jan 24 [Online ahead of print]PE
- CONCLUSIONS: Although there were some statistically significant differences between the laboratory value sets, it is arguable whether there are any clinically significant differences between them.Based on our failure to show a clinically significant difference between laboratory values drawn during transportation and those drawn immediately upon presentation to the institution, repeating laboratory draws after transportation do not add value to a patient's care trajectory. We should therefore rely on the laboratory values that were drawn from our transportation teams as part of the continuum of patient care.
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- Incidence, predictors, and short-term outcomes of acute kidney injury in children with diabetic ketoacidosis: a systematic review. [Review]Pediatr Nephrol. 2023 Jan 27 [Online ahead of print]PN
- CONCLUSIONS: AKI developed in almost half of the DKA episodes, and every fourth DKA episode was associated with severe AKI. The recovery rate from DKA-associated AKI appears to be high; however, further studies are needed to assess the exact impact of AKI on long-term outcomes.
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- The effects of enteric-coated sodium bicarbonate supplementation on 2 km rowing performance in female CrossFit® athletes. [Journal Article]Eur J Appl Physiol. 2023 Jan 27 [Online ahead of print]EJ
- CONCLUSIONS: Ingesting a 0.3 g·kg-1 BM dose of enteric-coated SB improves 2 km rowing performance in female athletes. The improvement is directly related to the extracellular buffering capacity even when blood [HCO3-] does not change ≥ 5.0 mmol⋅L-1.
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- Comprehensive fruit quality assessment and identification of aroma-active compounds in green pepper (Capsicum annuum L.). [Journal Article]
- The wrinkled pepper (Capsicum annuum L.) is a type of chili pepper domesticated in northwestern China, with a characteristic flavor. Fifteen wrinkled and four smooth-skinned pepper varieties were evaluated for morphology, texture, color, nutrients, capsaicinoids, and volatile compounds at the mature fruit stage. The sensory evaluation showed wrinkled pepper was superior to smooth pepper in textur…
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- Efficacy and safety of concomitant use of proton pump inhibitors with aspirin-clopidogrel dual antiplatelet therapy in coronary heart disease: A systematic review and meta-analysis. [Systematic Review]
- Background: Proton pump inhibitors (PPIs) are usually prescribed to prevent gastrointestinal (GI) complications in patients receiving dual antiplatelet therapy (DAPT). This systematic review and meta-analysis aimed to explore the efficacy and safety of the concomitant use of PPIs with aspirin-clopidogrel DAPT in patients with Coronary heart disease (CHD). Method: The PubMed, Embase, Cochrane Libr…
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- Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery aneurysms (CAA) in Kawasaki disease (KD): the KD CAA prevention (KD-CAAP) trial protocol. [Journal Article]
- CONCLUSIONS: Several recent studies have indicated that coronary complications associated with KD across Europe are much higher than early trials of IVIG had initially suggested. KD-CAAP directly addresses this issue by exploring the therapeutic benefit of adjunctive corticosteroids in unselected KD cases. If we find that corticosteroids prevent CAA and are safe, this is a cheap and widely available intervention that could be implemented immediately for the benefit of children.
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- Effective, safe and efficient porcine model of Forrest Ib bleeding gastric and colonic ulcers. [Journal Article]Indian J Gastroenterol. 2023 Jan 26 [Online ahead of print]IJ
- CONCLUSIONS: We have demonstrated the effectiveness and safety of a porcine GI bleeding model utilizing IV heparin anticoagulation and either hybrid ESD or EMR-C techniques to create oozing-type bleeding ulcers in the stomach and colon with customizable size.
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- Antithrombotic treatment after stroke due to intracerebral haemorrhage. [Review]
- CONCLUSIONS: We did not identify beneficial or hazardous effects of short-term prophylactic dose parenteral anticoagulation and long-term oral antiplatelet therapy after ICH on important outcomes. Although there was a significant reduction in MACE and all major occlusive vascular events after long-term treatment with therapeutic dose oral anticoagulation for atrial fibrillation after ICH, the pooled estimates were imprecise, the certainty of evidence was only moderate, and effects on other important outcomes were uncertain. Large RCTs with a low risk of bias are required to resolve the ongoing dilemmas about antithrombotic treatment after ICH.
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- Antithrombotic treatment for retinal vein occlusion: a systematic review and meta-analysis. [Journal Article]J Thromb Haemost. 2022 Dec 22 [Online ahead of print]JT
- CONCLUSIONS: Anticoagulant therapy was associated with higher visual acuity improvement and fewer recurrent RVO events than antiplatelet therapy, at the cost of an acceptable proportion of bleeding complications.
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- Combined metabolomic and transcriptomic analysis reveals key components of OsCIPK17 overexpression improves drought tolerance in rice. [Journal Article]Front Plant Sci. 2022; 13:1043757.FP
- Oryza Sativa is one of the most important food crops in China, which is easily affected by drought during its growth and development. As a member of the calcium signaling pathway, CBL-interacting protein kinase (CIPK) plays an important role in plant growth and development as well as environmental stress. However, there is no report on the function and mechanism of OsCIPK17 in rice drought resist…
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- Association of globulin concentrations with prognosis in horses with lymphoma. [Journal Article]Front Vet Sci. 2022; 9:1086010.FV
- Lymphoma is the most common hemopoietic neoplasia in horses. Common clinicopathologic abnormalities in equine lymphoma include hyperglobulinemia, hypoalbuminemia, hyperfibrinogenemia, anemia, thrombocytopenia and lymphocytosis. Hypoglobulinemia has been reported in other species with lymphoma, however it has not been well-described in horses. The objectives of this study were to examine the preva…
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- Clinical effectiveness of sodium bicarbonate therapy on mortality for septic patients with acute moderate lactic acidosis. [Journal Article]Front Pharmacol. 2022; 13:1059285.FP
- Objective: This study aimed to explore the effectiveness of sodium bicarbonate (SB) administration on mortality in septic patients with acute moderate lactic acidosis (MLA). Methods: The large ICU database (MIMIC-IV) was retrospectively analyzed. Patients with sepsis and acute MLA were identified. Propensity score analysis (PSA) was performed to explain baseline differences in the probability of …
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- Secondary prevention of antithrombotic therapy in patients with stable cardiovascular disease at high ischemic risk: A network meta-analysis of randomized controlled trials. [Systematic Review]Front Cardiovasc Med. 2022; 9:1040473.FC
- CONCLUSIONS: The present network meta-analysis suggests that clopidogrel or ticagrelor monotherapy may be recommended first in this cohort of SCVD at high ischemic risk. But clopidogrel plus aspirin or rivaroxaban plus aspirin can still be considered for use in patients with recurrent MACEs.
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- Efficacy and safety outcomes of long-term anti-thrombotic treatment of chronic coronary artery disease: A systematic review and network meta-analysis. [Systematic Review]Front Cardiovasc Med. 2022; 9:1016390.FC
- CONCLUSIONS: The rivaroxaban regimen appeared to be the preferred long-term anti-thrombotic regimen in preventing all-cause mortality. Our available results tend to support the efficacy of extended anti-thrombotic therapy consisting of prasugrel in lowering MI incidence compared to the other strategies, without increased risk of bleeding. However, additional large-scale direct clinical trials are needed to further determine the adequate long-term anti-thrombotic regimens for treating chronic coronary syndrome.
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