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(Alkaline phosphatase increased)
20,757 results
  • Burosumab Therapy in Children with X-Linked Hypophosphatemia. [Journal Article]
  • NEJMN Engl J Med 2018 05 24; 378(21):1987-1998
  • Carpenter TO, Whyte MP, … Portale AA
  • CONCLUSIONS: In children with X-linked hypophosphatemia, treatment with burosumab improved renal tubular phosphate reabsorption, serum phosphorus levels, linear growth, and physical function and reduced pain and the severity of rickets. (Funded by Ultragenyx Pharmaceutical and Kyowa Hakko Kirin; ClinicalTrials.gov number, NCT02163577 ; EudraCT number, 2014-000406-35 ).
  • Rituximab is Ineffective for Treatment of Fatigue in Primary Biliary Cholangitis: A phase-2 Randomised Controlled Trial. [Journal Article]
  • HepHepatology 2018 May 23
  • Khanna A, Jopson L, … Jones DE
  • CONCLUSIONS: Rituximab was safe over the 12 month study period but showed no evidence of effectiveness for the treatment of fatigue in PBC. Anaerobic threshold improvement was seen; potentially linking AMA with muscle bioenergetics dysfunction, however, this was not related to improvement in fatigue. Rituximab had some evidence of a beneficial effect on alkaline phosphatase levels in this largely UDCA-responding, early disease stage cohort. This article is protected by copyright. All rights reserved.
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