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(Alkylating agents)
144,150 results
  • Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis. [Journal Article]
    Int Immunopharmacol. 2023 Jan; 114:109595.Wu Q, Chen X, … Zheng H
  • Methotrexate (MTX) is used to treat rheumatoid arthritis, acute leukemia, and psoriasis. MTX can cause certain side effects, such as myelosuppression, while the exact mechanism of myelosuppression caused by MTX is unknown. Notch signaling pathway has been considered to be essential to regulate hematopoietic stem cell (HSC) regeneration and homeostasis, thus contributing to bone marrow hematopoies…
  • Synthesis and antiproliferative activities of steroidal lactam conjugates bearing a new nitrogen mustard. [Journal Article]
    Eur J Med Chem. 2023 Jan 21; 249:115133.Sflakidou E, Dalezis P, … Sarli V
  • Alkylating agents are potent anticancer compounds that exert their anticancer properties through the inhibition of cell replication and transcription leading to cell death. Despite the numerous benefits, these agents also have serious drawbacks such as their high toxicity and low specificity towards cancer cells. As previously reported by our group, conjugation of alkylating agents with azasteroi…
  • Investigation of the female infertility risk associated with anti-cancer therapy. [Review]
    Clin Transl Oncol. 2023 Jan 23 [Online ahead of print]Lavafian A, Pezeshki PS, Rezaei N
  • Female infertility is a significant health issue worldwide with a rising incidence. Anti-cancer therapy is one of the most important reasons for increasing infertility. Although anti-cancer treatment increases the rate of survival, it decreases the quality of life through its side effects. The most substantial side effects are sexual dysfunction and infertility. Breast cancer is the most common c…
  • The dual role of DNA repair protein MGMT in cancer prevention and treatment. [Review]
    DNA Repair (Amst). 2023 Jan 14; 123:103449.Bai P, Fan T, … Zhong R
  • Alkylating agents are genotoxic chemicals that can induce and treat various types of cancer. This occurs through covalent bonding with cellular macromolecules, in particular DNA, leading to the loss of functional integrity under the persistence of modifications upon replication. O6-alkylguanine (O6-AlkylG) adducts are proposed to be the most potent DNA lesions induced by alkylating agents. If not…
  • Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. [Review]
    Pharmaceutics. 2022 Dec 26; 15(1)Zlotos DP, Kronenberger T, Laufer SA
  • Hormone-dependent cancers, such as certain types of breast cancer are characterized by over-expression of estrogen receptors (ERs). Anticancer drug conjugates combining ER ligands with other classes of anticancer agents may not only benefit from dual action at both anti-cancer targets but also from selective delivery of cytotoxic agents to ER-positive tumor cells resulting in less toxicity and ad…
  • ProNGF Expression and Targeting in Glioblastoma Multiforme. [Journal Article]
    Int J Mol Sci. 2023 Jan 13; 24(2)Marsland M, Dowdell A, … Hondermarck H
  • Glioblastoma multiforme (GBM) is the most lethal adult brain cancer. Temozolomide (TMZ), the standard chemotherapeutic drug used in GBM, has limited benefit and alternate therapies are needed to improve GBM treatment. Nerve growth factor (NGF) and its precursor proNGF are increasingly recognized as stimulators of human tumor progression. The expression and stimulatory effect of NGF on GBM cell gr…
  • The use of flow cytometry for diagnosis and immunophenotyping in chronic lymphocytic leukemia in a dog: Clinical case report. [Case Reports]
    Open Vet J. 2022 Nov-Dec; 12(6):868-876.Sánchez-Solé R, Pedreira G, … Serdio PP
  • CONCLUSIONS: The combination of the immunophenotyping test, the myelogram, and the hematological and biochemical profile confirmed the presence of T-CLL in our patient. Flow cytometry, increasingly used in veterinary medicine, allowed us to confirm the diagnosis of CLL originating in cytotoxic T lymphocytes in our patient, through the presence of positive staining of primary antibodies specific for the canine species CD45, CD3, CD5, and CD8 and the absence of staining for CD4, CD21, and CD34.
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