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(Alkylating agents )
130,025 results
  • Emerging Cellular Therapies for Glioblastoma Multiforme. [Review]
  • CCureus 2018 Mar 11; 10(3):e2305
  • Choi PJ, Tubbs RS, Oskouian RJ
  • Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, mak...
  • Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs. [Journal Article]
  • CCCancer Cell Int 2018; 18:69
  • Haas B, Klinger V, … Eckstein N
  • CONCLUSIONS: Temozolomide treatment naive and TMZ resistant GBM biopsies show a distinct activation pattern of the MEK/ERK and PI3K signaling cascades indicating a role of these pathways in resistance development. Both pathways are also activated in GBM cell lines, however, only the PI3K pathway seems to play a crucial role in resistance to alkylating agents and might serve as drug target for chemosensitization.
  • Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases. [Journal Article]
  • DDiseases 2018 May 03; 6(2)
  • Mazzaro C, Maso LD, … Pozzato G
  • CONCLUSIONS: From our data, antiviral therapy is the first-line therapy in HCV-related MC, whereas steroids, alkylating agents and Rituximab should be considered as a second-line therapy. Given the heterogeneity of the disease, the role of these different therapeutic strategies should be checked in randomized controlled trials.
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