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208,978 results
  • MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition. [Journal Article]
    J Exp Clin Cancer Res. 2023 Feb 03; 42(1):40.Hsiao SY, Weng SM, … Chang JY
  • CONCLUSIONS: In this study, we determined that miR-455-5p was associated with lymph node metastasis and clinical invasion, leading to poor outcomes in patients with OSCC. MiR-455-5p promoted oral cancer cell migration and invasion and induced epithelial-to-mesenchymal transition (EMT). We also identified a new biomarker, PDZK1IP1 (MAP17), that was targeted by miR-455-5p. PDZK1IP1 knockdown led to migration, metastasis, EMT, and increased transforming growth factor-β signaling in OSCC. In addition, miR-455-5p overexpression and PDZK1IP1 inhibition promoted collective OSCC cell migration. According to data from the Cancer Genome Atlas database and the NCKU-OrCA-40TN data set, miR-455-5p and PDZK1IP1 are positively and negatively correlated, respectively, with partial EMT score. High miR-455-5p expression was associated with high vimentin levels and low MAP17 H-scores. The patients with low MAP17 expression had higher rates of disease recurrence than did patients with high MAP17 expression, especially for patients with clinical invasion risk factors and low MAP17 expression. These results suggest that miR-455-5p suppresses PDZK1IP1 expression and mediates OSCC progression. MiR-455-5p and PDZK1IP1 may therefore serve as key biomarkers and be involved in regulating partial EMT in OSCC cells. PDZK1IP1 expression may also serve as an independent factor that impacts outcomes in patients with clinical risk factors for recurrence.
  • Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings. [Journal Article]
    Sci Rep. 2023 Feb 03; 13(1):2014.Doherty C, Byrne CV, … Thomason HA
  • Microbial growth within a wound often manifests as biofilms, which can prevent healing and is difficult to eradicate. Novel silver dressings claim to combat wound infection, but anti-biofilm efficacy and effects on healing independent of infection are often unclear. Using in vitro and in vivo S. aureus and P. aeruginosa biofilm models, we report the efficacy of a dressing which produces Ag1+ ions…
  • Recent advances in carboxymethyl chitosan-based materials for biomedical applications. [Review]
    Carbohydr Polym. 2023 Apr 01; 305:120555.Geng Y, Xue H, … Liu G
  • Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at physiological pH limits its use in systems requiring higher dissolving ability and a suitable drug release rate. Besides, CS can result in fast drug re…
  • Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair. [Journal Article]
    Carbohydr Polym. 2023 Apr 01; 305:120545.Cao S, Bi Z, … Chen J
  • Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through t…
  • Between therapy effect and false-positive result in animal experimentation. [Journal Article]
    Biomed Pharmacother. 2023 Feb 01; 160:114317.Sosnowski P, Sass P, … Sachadyn P
  • Despite the animal models' complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therap…
  • Regulation and role of calcium in cellular senescence. [Journal Article]
    Cell Calcium. 2023 Jan 27; 110:102701.Martin N, Zhu K, … Bernard D
  • Cellular senescence is a state of stable cell proliferation arrest accompanied by a distinct secretory program impacting the senescent cell microenvironment. This phenotype can be induced by many stresses, including telomere shortening, oncogene activation, oxidative or genotoxic stress. Cellular senescence plays a key role in the organism throughout life, with beneficial effects at a young age f…
  • Single-session repair of multiple pressure ulcers in non-ambulatory patients. [Journal Article]
    J Wound Care. 2023 Feb 02; 32(2):109-115.Aysal BK, Nisanci M
  • CONCLUSIONS: Multiple PUs can be repaired in one session using gluteus maximus musculocutaneous flaps in immobile patients. Based on the fact that the gluteus maximus is an essential muscle for ambulation, our approach can only be used in the treatment of patients with irreversible paraplegia or tetraplegia. When all prerequsities are met, the amount of blood loss and operation duration are acceptable, and returning the patient to a wound-free state can be achieved more quickly compared to multi-session repairs. Air-fluidised beds are vital tools for accomplishing single session repairs of multiple PUs. The data shows that the approach is safe and can be used in patients with multiple PUs.
  • Quality of life of patients with venous leg ulcers treated by a one-stop clinic. [Journal Article]
    J Wound Care. 2023 Feb 02; 32(2):122-128.Rook B, Koedijk J, … de Jong EE
  • CONCLUSIONS: The introduction of a one-stop clinic led to better insight and awareness among staff of patients' symptoms and complaints. More focus and time should be given to patient-oriented symptoms, which was highly appreciated by patients in this study. This could eventually lead to a reduction in the impairing effects of VLUs on patients' lives and healthcare costs due to fewer visits to the hospital.
  • Perioperative Medication Management in Elective Plastic Surgery Procedures. [Journal Article]
    J Craniofac Surg. 2023 Feb 03 [Online ahead of print]Chaya BF, Rodriguez Colon R, … Saadeh PB
  • CONCLUSIONS: The perioperative medication management in elective plastic surgery procedures remains a complex and multidisciplinary process. It is important to manage these patients in a case-by-case manner and to consult a specialist when necessary. Careful medication reconciliation is essential to decrease the likelihood of adverse outcomes and interactions with perioperative anesthetics.
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