- White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment. [Journal Article]Biomater Res. 2023 Feb 03; 27(1):6.BR
- CONCLUSIONS: Casein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.
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- MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition. [Journal Article]J Exp Clin Cancer Res. 2023 Feb 03; 42(1):40.JE
- CONCLUSIONS: In this study, we determined that miR-455-5p was associated with lymph node metastasis and clinical invasion, leading to poor outcomes in patients with OSCC. MiR-455-5p promoted oral cancer cell migration and invasion and induced epithelial-to-mesenchymal transition (EMT). We also identified a new biomarker, PDZK1IP1 (MAP17), that was targeted by miR-455-5p. PDZK1IP1 knockdown led to migration, metastasis, EMT, and increased transforming growth factor-β signaling in OSCC. In addition, miR-455-5p overexpression and PDZK1IP1 inhibition promoted collective OSCC cell migration. According to data from the Cancer Genome Atlas database and the NCKU-OrCA-40TN data set, miR-455-5p and PDZK1IP1 are positively and negatively correlated, respectively, with partial EMT score. High miR-455-5p expression was associated with high vimentin levels and low MAP17 H-scores. The patients with low MAP17 expression had higher rates of disease recurrence than did patients with high MAP17 expression, especially for patients with clinical invasion risk factors and low MAP17 expression. These results suggest that miR-455-5p suppresses PDZK1IP1 expression and mediates OSCC progression. MiR-455-5p and PDZK1IP1 may therefore serve as key biomarkers and be involved in regulating partial EMT in OSCC cells. PDZK1IP1 expression may also serve as an independent factor that impacts outcomes in patients with clinical risk factors for recurrence.
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- Adipose-derived stem cell spheroid-laden microbial transglutaminase cross-linked gelatin hydrogel for treating diabetic periodontal wounds and craniofacial defects. [Journal Article]Stem Cell Res Ther. 2023 Feb 03; 14(1):20.SC
- CONCLUSIONS: ADsp-mTG accelerated diabetic oral mucosal wound healing, and osteogenically pretreated ADsp-mTG promoted diabetic osseous defect regeneration, proving that ADsp-mTG facilitated diabetic periodontal wound healing and craniofacial osseous defect regeneration.
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- Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma. [Journal Article]Funct Integr Genomics. 2023 Feb 04; 23(1):56.FI
- CONCLUSIONS: Let-7c-5p has been proved to suppress HCC by down-regulating immune-related CDCA8, which will help understand the pathogenesis of HCC and develop drugs for its treatment.
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- Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings. [Journal Article]Sci Rep. 2023 Feb 03; 13(1):2014.SR
- Microbial growth within a wound often manifests as biofilms, which can prevent healing and is difficult to eradicate. Novel silver dressings claim to combat wound infection, but anti-biofilm efficacy and effects on healing independent of infection are often unclear. Using in vitro and in vivo S. aureus and P. aeruginosa biofilm models, we report the efficacy of a dressing which produces Ag1+ ions…
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- Comparative study between platelet-rich plasma (PRP) and mechanically emulsified fat grafts in management of chronic wounds. [Journal Article]Asian J Surg. 2023 Feb 01 [Online ahead of print]AJ
- CONCLUSIONS: Both PRP and mechanically emulsified fat grafts were found to be efficient treatment modalities in management of chronic "non-healing" wounds. But mechanically emulsified fat grafts represent a better treatment method for chronic wounds.
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- Recent advances in carboxymethyl chitosan-based materials for biomedical applications. [Review]Carbohydr Polym. 2023 Apr 01; 305:120555.CP
- Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at physiological pH limits its use in systems requiring higher dissolving ability and a suitable drug release rate. Besides, CS can result in fast drug re…
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- Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair. [Journal Article]Carbohydr Polym. 2023 Apr 01; 305:120545.CP
- Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through t…
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- Tailoring and application of a multi-responsive cellulose nanofibre-based 3D nanonetwork wound dressing. [Journal Article]Carbohydr Polym. 2023 Apr 01; 305:120542.CP
- The rapid loss of drugs and the weak curative effects due to cyclical urination are the main reasons why wound heal with difficulty after bladder tumour resection. Here, a bioinspired cellulose nanofibre (CNF)-based magnetic 3D nanonetwork wound dressing with excellent tissue adhesion and biocompatibility is designed by the assembly of pH- and near infrared-responsive CNF nanoskeletons, magnetic …
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- PDGF and VEGF-releasing bi-layer wound dressing made of sodium tripolyphosphate crosslinked gelatin-sponge layer and a carrageenan nanofiber layer. [Journal Article]Int J Biol Macromol. 2023 Feb 01 [Online ahead of print]IJ
- The use of dressings is one of the most common methods for wound treatment. Since most single-layer dressings cannot mimic the hierarchical structure of the skin well, multi-layer dressings have been considered. In this study, a bilayer dressing was fabricated using a gelatin sponge layer cross-linked with sodium tripolyphosphate (Gel-STPP) and a layer of carrageenan nanofibers containing platele…
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- Injectable, self-healing, transparent, and antibacterial hydrogels based on chitosan and dextran for wound dressings. [Journal Article]Int J Biol Macromol. 2023 Feb 01 [Online ahead of print]IJ
- One major shortcoming of biopolymeric based wound dressing so far is the lack of an integrated multi-functional system that could provide suitable mechanical strength, fast self-healing, transparency, antibacterial and antioxidant effects. Benefiting from the dynamic and rapid reaction between glycidyl trimethyl ammonium chloride-graft- chitosan (QCS) and aldehyde-dextran (ODex) under physiologic…
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- A multifunctional hydrogel loaded with two nanoagents improves the pathological microenvironment associated with radiation combined with skin wounds. [Journal Article]Acta Biomater. 2023 Jan 31 [Online ahead of print]AB
- Persistent oxidative stress and recurring waves of inflammation with excessive reactive oxygen species (ROS) and free radical accumulation could be generated by radiation. Exposure to radiation in combination with physical injuries such as wound trauma would produce a more harmful set of medical complications, which was known as radiation combined with skin wounds (RCSWs). However, little attenti…
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- Multi-crosslinked hydrogels with strong wet adhesion, self-healing, antibacterial property, reactive oxygen species scavenging activity, and on-demand removability for seawater-immersed wound healing. [Journal Article]Acta Biomater. 2023 Jan 31 [Online ahead of print]AB
- In general, seawater-immersed wounds are associated with tissue necrosis, infection, prolonged healing period, and high mortality because of high salinity, hyperosmosis, and the presence of various pathogenic bacteria in seawater. However, current wound dressings can hardly achieve strong and stable wet adhesion and antibacterial properties, thus limiting their application to seawater-immersed wo…
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- Does the Choice of Preparation Protocol for Platelet-Rich Fibrin Have Consequences for Healing and Alveolar Ridge Preservation After Tooth Extraction? A Meta-Analysis. [Review]J Oral Maxillofac Surg. 2023 Jan 31 [Online ahead of print]JO
- CONCLUSIONS: This study confirms that PRF is associated with reduced postoperative complications but indicates that preparation protocol influences clinical outcomes. S-PRF and CGF protocols appear to be superior for several outcome parameters.
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- Between therapy effect and false-positive result in animal experimentation. [Journal Article]Biomed Pharmacother. 2023 Feb 01; 160:114317.BP
- Despite the animal models' complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therap…
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- Regulation and role of calcium in cellular senescence. [Journal Article]Cell Calcium. 2023 Jan 27; 110:102701.CC
- Cellular senescence is a state of stable cell proliferation arrest accompanied by a distinct secretory program impacting the senescent cell microenvironment. This phenotype can be induced by many stresses, including telomere shortening, oncogene activation, oxidative or genotoxic stress. Cellular senescence plays a key role in the organism throughout life, with beneficial effects at a young age f…
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- Effects of sericin and egg white on the inflammation of damaged skin in mice. [Journal Article]Biomed Mater. 2023 Feb 03 [Online ahead of print]BM
- CONCLUSIONS: A sericin and EW hybrid solution can effectively shorten the time needed for wound healing and reduce inflammation-related indicators in mice, making it a promising candidate for wound dressing.
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- METTL13 promotes nasopharyngeal carcinoma progression through regulating ZEB1/TPT1 axis. [Journal Article]J Gene Med. 2023 Feb 03 [Online ahead of print]JG
- CONCLUSIONS: In summary, METTL13 up-regulated ZEB1, which facilitated the transcriptional activation of TPT1, ultimately promoting NPC growth and metastasis, providing a potential therapeutic strategy of NPC treatment.
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- Knockdown of CD44 inhibits proliferation, migration, and invasiveness in hepatocellular carcinoma cells by modulating CXCR4/Wnt/β-Catenin Axis. [Journal Article]Acta Biochim Pol. 2023 Feb 03 [Online ahead of print]AB
- CONCLUSIONS: Interference with the expression of CD44 significantly inhibits the invasion and metastasis in the HCC cell line, Huh7. Furthermore, CD44 was found to regulate the expression of MMP-2, MMP-9, CXCL12, CXCR4 and Wnt/β-catenin signal pathway.
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- Negative pressure sealing drainage with antibiotic bone cement for the treatment of skin and soft tissue defects in the older population with bone exposure. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):104-108.JW
- CONCLUSIONS: VSD combined with antibiotic bone cement in the treatment of skin and soft tissue defects of the extremities with bone exposure in the older population has a high survival rate of skin grafts and good wound healing. It is worthy of clinical application.
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- Circumcision wound dressing with octylcyanoacrylate tissue adhesive. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):116-120.JW
- CONCLUSIONS: Tissue adhesive dressing is an acceptable alternative to paraffin gauze dressing for circumcision wounds. This option should be offered to all patients undergoing circumcision.
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- Topical oxygen therapy in acute traumatic musculoskeletal wounds of the foot and ankle. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):92-97.JW
- CONCLUSIONS: TOT appears to be a promising and cost-effective alternative in the management of traumatic wounds. However, future studies with larger sample sizes and control groups for comparison are needed to establish the benefit of TOT in acute traumatic musculoskeletal wounds.
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- Single-session repair of multiple pressure ulcers in non-ambulatory patients. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):109-115.JW
- CONCLUSIONS: Multiple PUs can be repaired in one session using gluteus maximus musculocutaneous flaps in immobile patients. Based on the fact that the gluteus maximus is an essential muscle for ambulation, our approach can only be used in the treatment of patients with irreversible paraplegia or tetraplegia. When all prerequsities are met, the amount of blood loss and operation duration are acceptable, and returning the patient to a wound-free state can be achieved more quickly compared to multi-session repairs. Air-fluidised beds are vital tools for accomplishing single session repairs of multiple PUs. The data shows that the approach is safe and can be used in patients with multiple PUs.
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- Staples versus sutures wound closure in hip and knee arthroplasty: a prospective cohort study. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):98-103.JW
- CONCLUSIONS: In THR and TKR, there was no significant difference between either vertical mattress nylon sutures or staples primary skin closure in terms of wound complications and patient satisfaction in this study. The decision on wound closure method should be based on the availability of resources in the institution/country.
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- Evaluation of a five-layer hydrocellular polyurethane foam dressing across wound care settings in southern Europe. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):68-73.JW
- CONCLUSIONS: The T3 programme is a highly successful method of training delivery and practice improvement across a variety of healthcare settings in southern Europe, helping support HCP engagement and ongoing development in challenging times during the Covid-19 pandemic. The programme can be adapted considering the needs of different HCPs and payor and/or healthcare systems.
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- Quality of life of patients with venous leg ulcers treated by a one-stop clinic. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):122-128.JW
- CONCLUSIONS: The introduction of a one-stop clinic led to better insight and awareness among staff of patients' symptoms and complaints. More focus and time should be given to patient-oriented symptoms, which was highly appreciated by patients in this study. This could eventually lead to a reduction in the impairing effects of VLUs on patients' lives and healthcare costs due to fewer visits to the hospital.
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- The role of proinflammatory cytokines in the detection of early pressure ulcer development: a systematic review. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):83-91.JW
- CONCLUSIONS: It is not yet certain that monitoring proinflammatory cytokines represents a noninvasive method that could potentially direct preventative measures to those who are identified as at high risk for developing PUs. IL-1α potentially may be elevated for other health conditions, not just PUs. Future studies are therefore recommended.
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- Performance of portable objective wound assessment tools: a systematic review. [Journal Article]J Wound Care. 2023 Feb 02; 32(2):74-82.JW
- CONCLUSIONS: Based on the presented evidence, 2D-based portable wound assessment devices were the most studied and demonstrated good performance. Further studies are required for 3D and application-based measurement instruments.
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- Perioperative Medication Management in Elective Plastic Surgery Procedures. [Journal Article]J Craniofac Surg. 2023 Feb 03 [Online ahead of print]JC
- CONCLUSIONS: The perioperative medication management in elective plastic surgery procedures remains a complex and multidisciplinary process. It is important to manage these patients in a case-by-case manner and to consult a specialist when necessary. Careful medication reconciliation is essential to decrease the likelihood of adverse outcomes and interactions with perioperative anesthetics.
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- Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model. [Journal Article]J Mol Endocrinol. 2023 Feb 01 [Online ahead of print]JM
- Dysfunction in key cellular organelles has been linked to diabetic complications. This study intended to investigate the alterations in the unfolded protein response (UPR), autophagy, and mitochondrial function, which are part of the endoplasmic reticulum (ER) stress response, in wound healing under diabetes conditions. Wound healing mouse models were used to evaluate the UPR, autophagy, mitochon…
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