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2,785 results
  • Do CAR-T and Allogeneic Stem Cell Transplant Both Have a Place in Lymphoid Neoplasms? [Review]
    Int J Mol Sci. 2023 Jan 05; 24(2)Martino M, Canale FA, … Allegra A
  • Allogeneic stem cell transplantation (allo-SCT) represented the first immunotherapy to treat hematologic malignancies: it has been considered as a cure for the disease and never as an approach to extend the life of patients. The success of allo-SCT derives both from the ability to treat patients with intensive chemoradiotherapy and from the potent graft-versus-leukemia effects mediated by donor i…
  • Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging. [Review]
    Int J Mol Sci. 2022 Dec 26; 24(1)Pojero F, Aiello A, … Allegra M
  • Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative h…
  • Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias. [Review]
    Cancers (Basel). 2022 Dec 26; 15(1)Allegra A, Petrarca C, … Gangemi S
  • Until now, morphological assessment with an optical or electronic microscope, fluorescence in situ hybridization, DNA sequencing, flow cytometry, polymerase chain reactions, and immunohistochemistry have been employed for leukemia identification. Nevertheless, despite their numerous different vantages, it is difficult to recognize leukemic cells correctly. Recently, the electrochemical evaluation…
  • Cigarette Smoke Extract Induces p38 MAPK-Initiated, Fas-Mediated Eryptosis. [Journal Article]
    Int J Mol Sci. 2022 Nov 25; 23(23)Restivo I, Attanzio A, … Allegra M
  • Eryptosis is a physiological mechanism for the clearance of senescent or damaged erythrocytes by phagocytes. Excessive eryptosis is stimulated under several pathologies and associated with endothelial injury and thrombosis. Cigarette smoke (CS) is an established risk factor for vascular diseases and cigarette smokers have high-levels of eryptotic erythrocytes. This study, for the first time, inve…
  • The Impact of Curcumin on Immune Response: An Immunomodulatory Strategy to Treat Sepsis. [Review]
    Int J Mol Sci. 2022 Nov 25; 23(23)Allegra A, Mirabile G, … Gangemi S
  • Primary and secondary immunodeficiencies cause an alteration in the immune response which can increase the rate of infectious diseases and worsened prognoses. They can also alter the immune response, thus, making the infection even worse. Curcumin is the most biologically active component of the turmeric root and appears to be an antimicrobial agent. Curcumin cooperates with various cells such as…
  • StatPearls: Fexofenadine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)CraunKari L.KLMclaren Oakland Hosp, MS College OMSchuryMark P.MPMcLaren OaklandBOOK
  • Fexofenadine is a medication used in the management and treatment of allergic rhinitis and chronic urticaria. It is a second-generation antihistamine. This activity outlines the indications, action, and contraindications for fexofenadine as a valuable agent in treating allergic rhinitis and chronic urticaria. This activity will highlight the mechanism of action, adverse event profile, and other k…
  • Atezolizumab plus tivozanib for immunologically cold tumor types: the IMMCO-1 trial. [Review]
    Future Oncol. 2022 Nov 18 [Online ahead of print]Ramnaraign BH, Lee JH, … Chatzkel JA
  • Immune checkpoint inhibitor therapy represents a significant advance in cancer care. The interaction between PD-1 and PD-L1 induces immune tolerance and the inhibition of this interaction is an effective treatment strategy for numerous malignancies. Despite its demonstrated potential, immunotherapy is not clinically effective in immunogenically 'cold' tumors such as pancreatic cancer, prostate ca…
  • Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. [Journal Article]
    Pharmaceuticals (Basel). 2022 Oct 12; 15(10)Lagard C, Vodovar D, … Mégarbane B
  • Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study's aim was to identify the mechanisms involved in tramadol-induced seizures in overdose in rats. The investigations included (1) the effects of specific pretreatments on…
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