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2,298 results
  • Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression. [Journal Article]
  • PPhytomedicine 2018 Nov 15; 50:19-24
  • Allegra M, De Cicco P, … Ianaro A
  • CONCLUSIONS: In conclusion, we demonstrated that indicaxanthin represents a novel phytochemical able to significantly inhibit human melanoma cell proliferation in vitro and to impair tumor progression in vivo. When considering the resistance of melanoma to the current therapeutical approach and the very limited number of phytochemicals able to partially counteract it, our findings may be of interest to explore indicaxanthin potential in further and more complex melanoma studies in combo therapy, i.e. where different check points of melanoma development are targeted.
  • Treatment of DVT with rivaroxaban and its potential to prevent the post-thrombotic syndrome. [Journal Article]
  • IAInt Angiol 2018 Nov 20
  • Antignani PL, Allegra C, Fareed J
  • CONCLUSIONS: Our results suggest that rivaroxaban could have a pro-fibrinolytic effect not only on recent thrombus but also on organized thrombus that results in a complete recanalization of affected veins. It is proposed that this lytic effect will preserve venous valve structure and lead to a reduction of incidence of post-thrombotic syndrome in rivaroxaban treated patients.
  • Drug-drug interactions of P-gp substrates unrelated to CYP metabolism. [Journal Article]
  • CDCurr Drug Metab 2018 10 03
  • Akamine Y, Yasui-Furukori N, Uno T
  • CONCLUSIONS: Our manuscript concludes that the PK changes of the DDIs among P-gp drugs unrelated to CYP metabolism are less likely to be serious, and it appears to be convincing that the absences of clinical effects caused to the PK changes by the P-gp inducers is predominant compared with the excessive effects caused to those by the P-gp inhibitors.
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