- Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects. [Journal Article]BMC Pharmacol Toxicol. 2023 Feb 03; 24(1):7.BP
- CONCLUSIONS: The test ezetimibe tablet and Ezetrol® were determined to be bioequivalent under both fasting and fed conditions in Chinese people.
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- Primary extranodal soft tissue Lennert lymphoma (lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified): a case report and review of the literature. [Journal Article]Diagn Pathol. 2023 Feb 03; 18(1):12.DP
- Lennert lymphoma (LeL) is a rare variant of peripheral T-cell lymphoma, not otherwise specified (PTCL/NOS) that is rich in epithelioid histiocytes. LeL may pose great diagnostic and therapeutic challenges to the pathologist and clinician. Primary extranodal soft tissue LeL is even rarer and has not been reported. Herein, we report a case of LeL arising from soft tissue.A 65-year-old male presente…
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- A tablet-based game for the assessment of visual motor skills in autistic children. [Journal Article]NPJ Digit Med. 2023 Feb 03; 6(1):17.ND
- Increasing evidence suggests that early motor impairments are a common feature of autism. Thus, scalable, quantitative methods for measuring motor behavior in young autistic children are needed. This work presents an engaging and scalable assessment of visual-motor abilities based on a bubble-popping game administered on a tablet. Participants are 233 children ranging from 1.5 to 10 years of age …
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- Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis. [Journal Article]Int J Pharm. 2023 Feb 01 [Online ahead of print]IJ
- The objective of the present study was to confirm the usefulness of BioGIT data in the evaluation of the impact of dose and/or formulation on early exposure after oral administration of immediate release or enabling products of low solubility active pharmaceutical ingredients (APIs) with a glass of water in the fasted state. BioGIT experiments were performed with four APIs: Compound Α (tablet, th…
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- Exploration of parent-reported family meal dinner characteristics to inform a definition of family meals. [Journal Article]Appetite. 2023 Feb 01 [Online ahead of print]A
- CONCLUSIONS: Parents expect family meals to take place at home around a table/counter, with homemade food prepared by the caregivers, and most family members gathered enjoying a conversation without other distractions. Study findings indicated that parents endorse specific characteristics as key for defining what counts as a family meal. These findings can be used by clinicians as recommendations for improving one's family meal experience and by future research as the basis for intervening on family meal characteristics and standardization of a definition of family meals.
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- Evaluation of acceptability, safety and continuation rates of centchroman as post-abortion nonsteroidal contraceptive pill. [Journal Article]Contraception. 2023 Jan 31 [Online ahead of print]C
- CONCLUSIONS: Centchroman is safe, effective, has good acceptance and continuation rate post-abortion with infrequent menstrual cycles as the main limiting factor for its continuation.
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- Deciphering in vivo metabolic profile and pharmacological mechanisms of Jitongning Tablet for the treatment of Ankylosing spondylitis. [Journal Article]J Pharm Biomed Anal. 2023 Jan 25; 227:115271.JP
- Jitongning tablet (JTNT) is a Traditional Chinese Medicine (TCM) prescription used for the treatment of Ankylosing spondylitis (AS). Currently, it is in phase II clinical trial (NCT03932019) for patients with active axial Spondyloarthritis (axSpA), showing great promise for the treatment of AS. However, the potential material basis and the underlying mechanisms for JTNT to treat AS remain elusive…
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- [Clinical research of acupuncture therapy combined with domperidone in treatment of diabetic gastroparesis of liver stagnation and spleen deficiency]. [Journal Article]Zhen Ci Yan Jiu. 2023 Jan 25; 48(1):88-94.ZC
- CONCLUSIONS: Shuanggu yitong acupuncture therapy combined with domperidone remarkably relieves the clinical symptoms and improves the gastric emptying rate, effectively reduces motilin and gastrin and regulates oxidative stress and inflammatory responses in the patients with DGP of liver stagnation and spleen deficiency.
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- Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial. [Journal Article]Front Microbiol. 2023; 14:1108762.FM
- Several in vitro and in vivo studies have evaluated the effect of probiotics on oral health; however, human clinical studies are still limited. Therefore, this study aimed to examine the effects of Weissella cibaria Chonnam Medical University (CMU)-containing tablets on halitosis. This randomized, double-blinded, placebo-controlled study included 100 adults with halitosis (age, 20-70 years). The …
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- Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial. [Journal Article]Front Immunol. 2023; 14:1073788.FI
- CONCLUSIONS: Administration of sublingual PMBL tablets during the grass pollen season proves to have a high efficacy in alleviating SAR symptoms in children sensitized to grass pollen allergens. Th1-like γδT cells may be used as potential markers for SAR severity in children.
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- Public-private partnership to rapidly strengthen and scale COVID-19 response in Western Kenya. [Journal Article]Front Public Health. 2022; 10:837215.FP
- CONCLUSIONS: We demonstrate feasibility of rapidly increasing the public health sector COVID-19 response through coordinated private sector efforts in an African setting. Our PPP intervention in Kisumu, Kenya was based on a joint testing strategy and demonstrated that semi-real time digitalization of patient trajectories can gain significant efficiencies, linking public and private healthcare efforts, increasing transparency, support better quality health services and informing policy makers to target interventions.
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- The acceptability and utility of Indigenous youth health assessments: a narrative systematic review. [Journal Article]Aust J Prim Health. 2023 Feb 03 [Online ahead of print]AJ
- CONCLUSIONS: There is insufficient evidence to make firm conclusions about the benefits of health assessments; however, health assessments can be useful for detecting new diagnoses and concerns regarding social determinants of health, and social and emotional wellbeing. Future development of Indigenous youth health assessments needs to involve Indigenous youth's perspectives and interpretations of health.
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- Use, marketing, and appeal of oral nicotine products among adolescents, young adults, and adults. [Journal Article]Addict Behav. 2023 Jan 27; 140:107632.AB
- CONCLUSIONS: This study provides a foundation for estimating use, behaviors, flavors, and marketing influence of oral nicotine products in the US and globally. Adolescent and young adult use of oral nicotine products and likelihood of buying products when exposed to marketing highlights the need for expanded tobacco use surveillance, marketing regulations, and counter marketing and educational efforts.
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- Interdisciplinary Collaboration Among Nursing and Computer Science to Refine a Pharmacogenetics Clinical Decision Support Tool Via Mobile Application. [Journal Article]Comput Inform Nurs. 2022 Oct 14 [Online ahead of print]CI
- In previous work, a prototype clinical decision support mobile application was created that accepts a patient's genomic profile information and provides information and rationale for the prescription of certain oncology medications. The response to the instrument was overwhelmingly positive by healthcare providers in the oncology field who tested the instrument. This article reports on the interd…
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- A Case of Multifocal Lymphangioendotheliomatosis With Thrombocytopenia and Changes in Coagulopathy. [Journal Article]J Pediatr Hematol Oncol. 2022 Nov 21 [Online ahead of print]JP
- Multifocal lymphangioendotheliomatosis with thrombocytopenia is a rare disease characterized by progressive multiple vascular lesions and is accompanied by thrombocytopenia. The precise diagnosis of this disease is frequently difficult because of the heterogeneity of the clinical symptoms. We report a case of a male infant who presented with severe thrombocytopenia induced by local inflammation. …
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- Discharge Prescribing Protocol Decreases Opioids in Circulation and Does Not Increase Refills after Colorectal Surgery. [Journal Article]Dis Colon Rectum. 2022 Dec 08 [Online ahead of print]DC
- CONCLUSIONS: Patients took significantly fewer opioids than were prescribed. Our protocol limited over-prescribing and resulted in fewer opioids in the community without opportunity costs such as increased refills. Long-term studies are needed to assess the effects on persistent opioid use after surgery. See Video Abstract at http://links.lww.com/DCR/C93.
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- Effectiveness of vaginal estriol with lactobacilli on urinary symptoms in postmenopausal women: a randomized-controlled trial. [Journal Article]Menopause. 2023 Jan 04 [Online ahead of print]M
- CONCLUSIONS: A 1-month course of vaginal E3/L does not appear to improve LUTS in PMW.
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- Real world use of dolutegravir two drug regimens. [Journal Article]AIDS. 2023 Jan 16 [Online ahead of print]AIDS
- CONCLUSIONS: Majority of experience is in DTG/3TC stable switch. Minority ofpatients developed side-effects. Low number of virological failures, one developed INIresistance. Viral failure associated with MTR, commensurate with trial data showing nofailure with resistance if DTG/3TC STR used. Overall DTG-2DR demonstrates high efficacy in real-world setting.
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- Limited health risks in performing drug reconstitution and handling tasks in pharmacies - results of an occupational risk assessment study. [Journal Article]J Occup Environ Med. 2023 Jan 16 [Online ahead of print]JO
- CONCLUSIONS: Occupational exposure during routine handling of drugs can occur, but the risks vary greatly with the nature and duration of the tasks.
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- [What is the real price of SOP and OTC drugs? Pilot study on paracetamol]. [Journal Article]Epidemiol Prev. 2023 Jan-Apr; 47(1-2):In press.EP
- CONCLUSIONS: wide and homogeneous distribution of unbranded products from different holders is available throughout the country. These products have significantly lower prices than branded packages, and they also have heavy discounts applied (up to 70%, with minimum price per tablet going as low as 0.05 euros). However, contrary to what these premises might lead one to think, consumption is concentrated on the branded packages having the highest prices. For proper information to citizens and trade associations, it is important for the media to bring awareness of the real savings opportunities available nationwide for products of frequent and widespread use, such as the case of paracetamol 500 mg.
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- Development and Evaluation of Self-Emulsifying Drug-Delivery System-Based Tablets for Simvastatin, a BCS Class II Drug. [Journal Article]
- CONCLUSIONS: Using commonly available excipients and machinery, SEDDS-based tablets with better dissolution profile and bioavailability can be prepared by direct compression. These S-SEDDSs could be a better alternative to conventional tablets of simvastatin.
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- Alternate day versus daily oral iron for treatment of iron deficiency anemia: a randomized controlled trial. [Journal Article]
- Oral iron is the mainstay of treating iron deficiency anemia. Recent studies indicate better fractional iron absorption with alternate day supplementation. However, the optimal supplementation strategy is unclear. We compared effectiveness of daily versus alternate day supplementation of oral iron for treatment of iron deficiency anemia. This double blind, active control, randomized controlled tr…
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- [Meta-analysis and GRADE evaluation of Guanxinning Tablets in treatment of angina pectoris of coronary heart disease]. [Meta-Analysis]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):247-255.ZZ
- This study aims to evaluate the efficacy and safety of Guanxinning Tablets+conventional western medicine in the treatment of angina pectoris of coronary heart disease, and provide evidence-based references for clinical medication. Retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, randomized controlled trial(RCT) about Guanxinning Tablets for the treatment of angina pec…
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- Quality Evaluation of Humidified Magnesium Oxide Tablet Formulations with Respect to Disintegration Time Prolongation. [Journal Article]Chem Pharm Bull (Tokyo). 2023; 71(2):165-174.CP
- In the present study, we conducted a detailed evaluation of the effects of humidification on the quality of five types of commercial magnesium oxide (MgO) tablet formulations. When near-IR spectroscopy was performed, a peak derived from the first overtone of the stretching vibration of the hydroxyl group was observed at approximately 7200 cm-1 in a humidified MgO tablet formulation. To visually e…
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- Feasible spectrofluorimetric approach for the ultrasensitive determination of lomefloxacin based on synergistic effects of micellization and metal complexation. [Journal Article]Spectrochim Acta A Mol Biomol Spectrosc. 2023 Jan 30; 292:122399.SA
- The purpose of the present work was to establish a fast and convenient strategy for lomefloxacin analysis using a fluorimetric approach. The methodology was based on the complex formation of the drug with aluminum ion to give a product having high fluorescence. Adding sodium dodecyl sulfate led to further boosting the intensity of fluorescence which was recorded at 429 nm after excitation at 332 …
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- Suboptimal lopinavir exposure in infants on rifampicin treatment receiving double-dosed or semi-superboosted lopinavir/ritonavir: time for a change. [Journal Article]J Acquir Immune Defic Syndr. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: Double-dosed or semi-superboosted LPV/r for infants aged 1-12 months receiving rifampicin resulted in substantial proportions of subtherapeutic LPV levels. There is an urgent need for data on alternative antiretroviral regimens in infants with HIV/TB co-infection, including twice-daily dolutegravir.
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- Gamification to Support Adherence to a Therapeutic Ambylopia Treatment for Children: Retrospective Study Using a Focal Ambient Visual Acuity Stimulation Game. [Journal Article]JMIR Pediatr Parent. 2023 Feb 01; 6:e32282.JP
- CONCLUSIONS: FAVAS 2020, with improved gamification aspect as well as tablet computer functionality, increased adherence significantly compared to the earlier version of FAVAS 2015, indicating that FAVAS 2020 could be an effective approach to support adherence to amblyopia treatment.
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- Patient-Reported Outcome Measures and Their Clinical Applications in Dermatology. [Journal Article]
- With more disease- and symptom-specific measures available and research pointing to increased usefulness, patient-reported outcome measures (PROMs) can be routinely used in clinical care. PROMs increase efficiency in healthcare, improve the clinician-patient relationship, and increase patient satisfaction with their care. PROMs can be administered before, during, and after clinic visits using pap…
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- Green synthesis of CQDs for determination of iron and isoniazid in pharmaceutical formulations. [Journal Article]Anal Methods. 2023 Jan 31 [Online ahead of print]AM
- Camphor leaves were used as the precursor for the hydrothermal synthesis of carbon quantum dots. The preparation method is simple and rapid, and the raw material is environmentally friendly and easy to obtain. Without additional modification, the carbon quantum dots were used as fluorescent probes for the sensitive and selective detection of Fe3+ and isoniazid at different excitation wavelengths.…
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- LC-MS Compatible Chromatographic Method for Quantification of Potential Organic Impurities of Elagolix Sodium in Tablet Dosage Form with Identification of Major Degradation Products. [Journal Article]J AOAC Int. 2023 Jan 31 [Online ahead of print]JA
- CONCLUSIONS: Forced degradation study suggests that the developed method is specific and stability- indicating and can be used for related substance analysis of Elagolix drug substance and its dosage forms.
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