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  • Modified release paracetamol overdose: a prospective observational study (ATOM-3). [Journal Article]
  • CTClin Toxicol (Phila) 2018 Feb 16; :1-10
  • Chiew AL, Isbister GK, … Buckley NA
  • CONCLUSIONS: Drug regulatory authorities are considering restrictions on MR paracetamol preparations. Following an acute MR paracetamol overdose, this study found that many patients had a persistently elevated paracetamol concentrations, many required prolonged treatment and some developed liver injury despite early acetylcysteine treatment. Furthermore, activated charcoal and increased acetylcysteine did not appear to significantly alter the risk of liver injury. Hence, research into better treatment strategies is required.
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