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Unbound Medicine.
(Allergic Bronchopulmonary Aspergillosis ABPA )
2,814 results
  • Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals. [Journal Article]
    J Fungi (Basel). 2023 Jan 06; 9(1)Moss RB
  • Allergic asthma has traditionally been treated with inhaled and systemic glucocorticosteroids. A continuum of allergic fungal airways disease associated with Aspergillus fumigatus colonization and/or atopic immune responses that encompasses fungal asthma, severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis is now recognized along a phenotypic severity spectrum of T…
  • Updated estimation of the burden of fungal disease in Vietnam. [Journal Article]
    Mycoses. 2022 Dec 23 [Online ahead of print]Duong TN, Le MH, … Nguyen BT
  • CONCLUSIONS: The number of patients with mycoses in Vietnam is likely underestimated due to a lack of local data and limited diagnostic capacity, but at least 2.5% of the population might have some form of serious fungal disease.
  • Successful treatment with dupilumab for mucus plugs in severe asthma. [Case Reports]
    Respirol Case Rep. 2023 Jan; 11(1):e01074.Anai M, Yoshida C, … Sakagami T
  • A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long-acting beta-2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bro…
  • Allergic bronchopulmonary aspergillosis with endobronchial signs: Two cases. [Case Reports]
    Tuberk Toraks. 2022 Dec; 70(4):392-396.Öz M, Karnak D
  • Pulmonary aspergillosis may be classified under three categories depending on whether the patient is atopic or immunocompromised: invasive, chronic necrotizing, and allergic bronchopulmonary aspergillosis (ABPA), which is an immunological pulmonary disorder caused by hypersensitivity to Aspergillus spp., manifesting with poorly controlled asthma. ABPA is diagnosed using major and minor criteria. …
  • [Expert consensus on the diagnosis and treatment of allergic bronchopulmonary aspergillosis(2022 update)]. [Journal Article]
    Zhonghua Jie He He Hu Xi Za Zhi. 2022 Dec 12; 45(12):1169-1179.Asthma Group of Chinese Thoracic Society
  • As an allergic lung disease caused by Aspergillus species, allergic bronchopulmonary aspergillosis(ABPA) is manifested by asthma and recurrent lung infiltrates, often with signs of bronchiectasis. ABPA is not uncommon, but under-diagnosis/misdiagnosis and inappropriate management are common in clinical practice, due to the varied manifestations, inconsistent diagnostic criteria, and the need of c…
  • Subcutaneous entomophthoromycosis in an immunocompetent individual: a localised forearm swelling. [Case Reports]
    BMJ Case Rep. 2022 Dec 01; 15(12)Katari Gopalakrishanan V, Murali M, … Essaki M
  • A man in his 80s with no known comorbidities presented with diffuse swelling on the dorsal aspect of his right forearm for 3 months. Clinical features were suggestive of soft tissue sarcoma of the right forearm. A high resolution CT scan of the thorax showed allergic bronchopulmonary aspergillosis associated with mild mediastinal lymphadenopathy. MRI of the right upper limb showed a suspicious ne…
  • Allergic Bronchopulmonary Mycosis Complicated with Lung Adenocarcinoma. [Case Reports]
    Intern Med. 2022; 61(23):3563-3568.Ohnishi H, Sakai Tsuji K, … Yokoyama A
  • Chest computed tomography (CT) of a 76-year-old woman with bronchial asthma showed multiple lung nodules with high CT densities that were compatible with high-attenuation mucoid (HAM) impactions characteristic of allergic bronchopulmonary mycosis (ABPM). Follow-up chest CT revealed increased sizes of multiple lung nodules. However, a left upper lobe nodule showed lower CT density than the other H…
  • ABPA sans asthma: an entity to remember. [Case Reports]
    BMJ Case Rep. 2022 Nov 25; 15(11)Nair AA, Vimala LR, … Gupta R
  • A male patient in his 20s presented with a cough and a small volume of haemoptysis that lasted a year. He had no other constitutional symptoms and a respiratory examination was suggestive of a consolidation. A chronic infection, such as tuberculosis, was suspected. The routine evaluation showed peripheral eosinophilia with raised serum total IgE. Sputum examination for tuberculosis was negative; …
  • Mucoid impaction of the bronchi (MIB) in a young man with no previous history of hypersensitivity. [Case Reports]
    Radiol Case Rep. 2023 Jan; 18(1):416-420.Askari E, Soltani K, … Yaghmaei S
  • Mucoid impaction of the bronchi (MIB) is a specific form of proximal bronchiectasis characterized by obstruction and dilation of bronchi usually presented with thick mucoid plug. MIB mostly occurs as the manifestation of a hypersensitivity state in patients with bronchial asthma or in association with allergic bronchopulmonary aspergillosis (ABPA) and clinical overlap between MIB and ABPA can occ…
  • Antifungal chemotherapies and immunotherapies for the future. [Review]
    Parasite Immunol. 2022 Nov 20 [Online ahead of print]Armstrong-James D
  • Human fungal pathogens cause a broad plethora of infections, spanning cutaneous dermatophytoses to invasive infections in immunocompromised hosts. As eukaryotic pathogens are capable of morphotype switching, they present unique challenges both for drug development and the immunological response. Whilst current antifungal therapies are limited to the orally available triazoles, intravenous echonoc…
  • Post-transplant Schizophyllum commune abscess in a pediatric patient with chronic granulomatous disease. [Case Reports]
    J Infect Chemother. 2023 Feb; 29(2):219-222.Yada Y, Shiraishi A, … Ohga S
  • Schizophyllum commune is a widely distributed basidiomycete fungus that occasionally causes sinusitis or allergic bronchopulmonary mycosis. The invasive infection mostly occurs in immunocompromised adults. The number of reports on S. commune infection have increased in this decade due to the expansion of diagnostic techniques and awareness in clinical practice. However, S.commune infection in pat…
  • Benralizumab in the management of rare primary eosinophilic lung diseases. [Review]
    Allergy Asthma Proc. 2022 11 01; 43(6):494-500.Griscti Soler D, Bennici A, … Ricciardi L
  • Background: Eosinophils have a double-edged role in the human body, being essential in important physiologic functions but whose presence is conspicuous in a variety of diseases characterized by a T2 inflammation phenotype. Eosinophils are exquisitely sensitive to corticosteroids, and the latter have, until recently, represented the cornerstone of treatment of eosinophilic diseases. However, most…
  • Treatments of refractory eosinophilic lung diseases with biologics. [Review]
    Allergol Int. 2023 Jan; 72(1):31-40.Asano K, Suzuki Y, … Kamide Y
  • Biologics targeting the molecules associated with type 2 inflammation have significantly improved the outcomes of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Chronic eosinophilic airway/lung diseases including chronic eosinophilic pneumonia, allergic bronchopulmonary aspergillosis/mycosis, eosinophilic bronchitis, and eosinophilic granulomatosis…
  • Significance and Potential Role of Eosinophils in Non-Cystic Fibrosis Bronchiectasis. [Journal Article]
    J Allergy Clin Immunol Pract. 2022 Oct 30 [Online ahead of print]Guan WJ, Oscullo G, … Martinez-Garcia MA
  • Bronchiectasis is a complex and heterogeneous disease with a myriad of pulmonary and extrapulmonary etiologies. Bronchiectasis has a predominantly neutrophilic inflammatory profile. However, eosinophilic inflammation has also been documented in both the airways and the systemic circulation. Various diseases (eg, asthma, allergic bronchopulmonary aspergillosis, chronic rhinosinusitis with nasal po…
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