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Unbound Medicine.
(Allergic disorders)
428,689 results
  • [Evaluation of immunotoxicitiy in biomedical research and development]. [Journal Article]
    Biol Aujourdhui. 2022; 216(3-4):167-181.Nguyen C, Jordheim LP
  • Immunotoxicology aims at studying toxic effects of any substance on the immune system and its functions. In its various fields of application, this science is dependent on regulatory texts and guidelines. Studies are based on in vitro, ex vivo and in vivo techniques and are observational or functional allowing the identification of a toxic effect and its underlying mechanisms, respectively. Here,…
  • Vitamin D for the management of asthma. [Review]
    Cochrane Database Syst Rev. 2023 Feb 06; 2(2):CD011511.Williamson A, Martineau AR, … Griffiths CJ
  • CONCLUSIONS: In contrast to findings of our previous Cochrane Review on this topic, this updated review does not find evidence to support a role for vitamin D supplementation or its hydroxylated metabolites to reduce risk of asthma exacerbations or improve asthma control. Participants with severe asthma and those with baseline 25(OH)D concentrations < 25 nmol/L were poorly represented, so further research is warranted here. A single study investigating effects of calcidiol yielded positive results, so further studies investigating effects of this metabolite are needed.
  • Erythema nodosum leprosum with genital ulceration - A rare and interesting case report. [Case Reports]
    Indian J Sex Transm Dis AIDS. 2022 Jul-Dec; 43(2):194-195.Rupan A, Sivanu S, Nirmaladevi P
  • Erythema nodosum leprosum (ENL) is a type III hypersensitivity phenomenon seen in the lepromatous spectrum of leprosy. Involvement of external genitalia is very rare, and genital mucosal involvement is still rare. We report a 39-year-old man with episodic fever, red raised skin lesions predominantly in the lower extremities, and painful genital ulcers for 1-month duration. Genital examination rev…
  • Vestibular Hypersensitivity in Patients with Chronic Noise Exposure. [Journal Article]
    Indian J Otolaryngol Head Neck Surg. 2022 Dec; 74(Suppl 3):3957-3964.Bayat A, Jafarzadeh S, … Pourbakht A
  • It has been demonstrated that high-intensity noise exposure adversely affects the human balance function. The Tullio phenomenon (TP) refers to sound-induced imbalance which is resulted from hypersensitivity of vestibular end organs to normal acoustic stimuli. Although different etiologies have been attributed to TP, evidence on the role of excessive noise exposure in the development of this sympt…
  • Interleukin-18 and IL-18BP in inflammatory dermatological diseases. [Review]
    Front Immunol. 2023; 14:955369.Wang X, Wang L, … He G
  • Interleukin (IL)-18, an interferon-γ inducer, belongs to the IL-1 family of pleiotropic pro-inflammatory factors, and IL-18 binding protein (IL-18BP) is a native antagonist of IL-18 in vivo, regulating its activity. Moreover, IL-18 exerts an influential function in host innate and adaptive immunity, and IL-18BP has elevated levels of interferon-γ in diverse cells, suggesting that IL-18BP is a neg…
  • The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors. [Review]
    Front Immunol. 2022; 13:1109938.Zhan X, Li Q, … Bai Z
  • NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Once activated, NLRP3 initiates the inflammasome assembly together with the adaptor ASC and the effector caspase-1, leading to caspase-1 activation and subsequent cleava…
  • Allergic Rhinitis in Preschoolers: A Systematic Review of Diagnostics. [Review]
    Am J Rhinol Allergy. 2023 Feb 05 [Online ahead of print]Diniz AF, Ribeiro JA, … Sarinho ES
  • CONCLUSIONS: There are no defined criteria for the diagnosis of allergic rhinitis in preschool children. Nasal cytology, serum specific IgE and immediate hypersensitivity skin test were the most used tests. A reliable diagnostic criterion in this age group is necessary so that in the future it is possible to propose a diagnostic algorithm for allergic rhinitis in preschool children.
  • [Eosinophilic bronchitis: update and review]. [Journal Article]
    Zhonghua Jie He He Hu Xi Za Zhi. 2023 Feb 12; 46(2):192-196.Zhan WZ, Lai KF
  • Eosinophilic bronchitis (EB) is a common cause of chronic cough, which shares similar airway eosinophilic inflammation with asthma, however, there is no airway hyperresponsiveness and airflow obstruction. The mechanism of the different phenotype between EB and asthma remains unclear. The differences in the location of airway inflammation, the level of inflammatory mediators, the imbalance of impo…
  • [Influencing factors of poor treatment adherence in uncontrolled asthma patients in China]. [Journal Article]
    Zhonghua Jie He He Hu Xi Za Zhi. 2023 Feb 12; 46(2):121-127.Wang WY, Lin JT, … Liu HG
  • Objective: To evaluate the influencing factors of poor treatment adherence in patients with uncontrolled asthma in China. Methods: From April 2017 to April 2018, all asthma patients with uncontrolled asthma and poor compliance in 32 third-class hospitals in 28 provinces and cities of China mainland included in the "National Mobile Asthma Assessment and Management Project" were selected as the sub…
  • Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions. [Review]
    J Allergy Clin Immunol. 2023 Feb; 151(2):289-300.e4.Gibson A, Deshpande P, … Phillips EJ
  • Severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) cause significant morbidity and mortality and impede new drug development. HLA class I associations with SJS/TEN and drug reaction with eosinophilia and systemic symptoms/d…
  • Cardiovascular disease in asthma patients: from mechanisms to therapeutic implications. [Journal Article]
    Kardiol Pol. 2023 Feb 05 [Online ahead of print]Cazzola M, Hanania NA, … Matera MG
  • Cardiovascular disease (CVD) is often associated with asthma, and asthma patients have an increased risk of CVD mortality. Our understanding of the bidirectional risk of CVD and asthma has been based on several observational studies. However, the specific pathogenetic mechanisms underlying the development of cardiovascular comorbidities in patients with asthma have not yet been fully determined. …
  • Autoimmunity and hernia mesh: fact or fiction? [Review]
    Hernia. 2023 Feb 04 [Online ahead of print]Jisova B, Wolesky J, … East B
  • CONCLUSIONS: There is little evidence that the use of polypropylene mesh can lead to autoimmunity. A large number of potential triggers of autoimmunity along with the genetic predisposition to autoimmune disease and the commonality of hernia, make a cause and effect difficult to unravel at present. Biomaterials cause foreign body reactions, but a chronic foreign body reaction does not indicate autoimmunity, a common misunderstanding in the literature.
  • Giant-Cell Myocarditis, Cardiac Sarcoidosis, and Orthotopic Heart Transplantation. [Case Reports]
    Am J Cardiol. 2023 Mar 01; 190:131-135.Roberts WC, Hasson L, Hassan MH
  • Described herein are 2 patients diagnosed clinically as "giant cell myocarditis." Both had short clinical courses (∼ 2 months) before lifesaving orthotopic heart transplantation (OHT). Examination of the hearts disclosed multiple widespread yellow lesions in the ventricular walls. The short clinical courses in these 2 patients are quite different from cardiac sarcoidosis, which typically has cour…
  • DNA methylation of ITGB2 contributes to allopurinol hypersensitivity. [Journal Article]
    Clin Immunol. 2023 Feb 02 [Online ahead of print]Liu Y, Wang CW, … Lu QJ
  • CONCLUSIONS: Our study uncovers differentially methylated genes between allopurinol-induced SCAR patients and tolerant controls with positive or negative HLA-B*58:01 allele and provides the novel epigenetic marker that improves the prediction accuracy of genetic testing for prevention of allopurinol-induced SCAR.
  • Jak out of the box -targeting BTK, siglec-8, & Jak1 in food allergy. [Review]
    Ann Allergy Asthma Immunol. 2023 Feb 02 [Online ahead of print]Berin C
  • There has been rapid growth in the field of IgE-mediated food allergy therapeutics, with one FDA-approved therapy in 2020 and several others in various stages of investigation. Oral immunotherapy is the approach with the longest track record of study, and provides desensitization for most individuals undertaking therapy. However, therapy must be maintained for continued clinical protection, and s…
  • Regulatory Module WRKY33-ATL31-IRT1 Mediates Cadmium Tolerance in Arabidopsis. [Journal Article]
    Plant Cell Environ. 2023 Feb 04 [Online ahead of print]Zhang C, Tong C, … Cao S
  • Cadmium (Cd) is one of the most dangerous environmental pollutants among heavy metals, and threatens food safety and human health by accumulating in plant sink tissues. Here, we report a novel regulatory cascade that profoundly influences Cd tolerance in Arabidopsis. Phenotypic analysis showed that an insertional knockdown mutation at the Arabidopsis Tóxicos en Levadura 31 (ATL31) locus resulted …
  • Dynamics of high hydrostatic pressure resistance development in RpoS-deficient Escherichia coli. [Journal Article]
    Food Res Int. 2023 Feb; 164:112280.Gayán E, Wang Z, … Aertsen A
  • High hydrostatic pressure (HHP) treatment is one of the most widely accepted non-thermal food processing methods, but HHP-resistance development in pathogenic or spoilage bacteria might compromise the safety and stability of HHP-treated foods. Charting the possible routes and mechanisms of HHP resistance development in foodborne bacteria is therefore essential to anticipate or prevent the appeara…
  • Diagnostic approach and grading scheme for canine allergic conjunctivitis. [Journal Article]
    BMC Vet Res. 2023 Feb 03; 19(1):35.Delgado E, Gomes É, … Lourenço AM
  • CONCLUSIONS: The triad hyperemia, chemosis and ocular pruritus, already known in human medicine to be a reliable way of diagnosing human allergic conjunctivitis, also proved to be important in cAC Mild forms of the disease may pass unnoticed, ocular pruritus being hard to assess in canine patients.The proposed standardized diagnostic approach and novel grading scheme for cAC may be of value for both veterinary ophthalmologists and dermatologists, as well as general practitioners.
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