- Changes in structural and functional properties of whey protein cross-linked by polyphenol oxidase. [Journal Article]Food Res Int. 2023 Feb; 164:112377.FR
- The natural whey protein is unstable, to achieve more efficient utilization, the functional properties of whey protein were modified by changing its structure, and enzymatic cross-linking is one of the common methods in dairy products to change the functional characterization. This study was conducted with objective to evaluate the structural and functional of whey protein which was cross-linked …
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- Contribution of five major apple polyphenols in reducing peanut protein sensitization and alleviating allergencitiy of peanut by changing allergen structure. [Journal Article]Food Res Int. 2023 Feb; 164:112297.FR
- Peanuts are prone to trigger allergic reactions with high mortality rate. There is currently no effective way to prevent peanut allergy. In order to reduce the allergy risk of peanuts, it's significant to reduce sensitization of peanut prior to ingestion. In this study, the effects of five major apple polyphenols (epicatechin, phlorizin, rutin, chlorogenic acid, and catechin) -peanut protein on t…
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- Dynamics of high hydrostatic pressure resistance development in RpoS-deficient Escherichia coli. [Journal Article]Food Res Int. 2023 Feb; 164:112280.FR
- High hydrostatic pressure (HHP) treatment is one of the most widely accepted non-thermal food processing methods, but HHP-resistance development in pathogenic or spoilage bacteria might compromise the safety and stability of HHP-treated foods. Charting the possible routes and mechanisms of HHP resistance development in foodborne bacteria is therefore essential to anticipate or prevent the appeara…
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- Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs. [Journal Article]Adv Sci (Weinh). 2023 Feb 03 [Online ahead of print]AS
- Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one-step introduction of diacylation linkers and azide groups on the 2'-OH of RNA is advance. Selected from eight phosphine reagents, it is found that 2-(diphenylphosphino)ethylamine has excellent performance in reducing azides via a Staudinger reduction to obtain the original RNA. I…
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- Erroneous detection of desensitization doses in the prevention of hypersensitivity reactions. [Journal Article]BMC Res Notes. 2023 Feb 03; 16(1):12.BR
- CONCLUSIONS: Desensitization algorithms may benefit from using concepts from signal processing theory in order to avoid hypersensitivity reactions.
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- Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens. [Journal Article]Clin Mol Allergy. 2023 Feb 03; 21(1):1.CM
- CONCLUSIONS: The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.
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- Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data. [Journal Article]Malar J. 2023 Feb 03; 22(1):42.MJ
- CONCLUSIONS: Carriage of malaria parasites over the months-long dry season in Mali is most likely in the older, more exposed and more immune children. These children may act as super-spreaders facilitating the fast spread of parasites at the beginning of the next transmission season.
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- Is there a role for microbiome-based approach in common variable immunodeficiency? [Review]Clin Exp Med. 2023 Feb 03 [Online ahead of print]CE
- Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown…
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- Smoking, but not use of complementary and alternative medicine predicts residual functional disability in patients with inflammatory arthritis on biologic disease-modifying anti-rheumatic drugs: Results from the Singapore National Biologics Register. [Journal Article]Int J Rheum Dis. 2023 Feb 03 [Online ahead of print]IJ
- CONCLUSIONS: CAM use was not associated with high mHAQ at 6 months. Smoking was an independent predictor of residual functional disability at 6 months, even after adjusting for age, comorbidity and baseline mHAQ. Greater emphasis on smoking cessation may improve long-term functional outcomes in IA patients on bDMARDs.
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- Treatable Traits in Airway Disease: From Theory to Practice. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- Chronic airway diseases such as asthma and chronic obstructive pulmonary disease are prevalent and complex conditions that often coexist in the same patient. To address this complexity in clinical practice, and to move forward toward personalized and precision medicine of airway diseases, a strategy based on the identification and treatment of so-called "treatable traits" (TTs) has been proposed.…
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- Acquired susceptibility to autoimmune diseases in pediatric patients with Escherichia coli infection: A population-matched retrospective cohort study. [Journal Article]J Autoimmun. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: Our cohort study indicates that E.coli infection was significantly associated with increased susceptibility to autoimmune diseases, even after adjusting for different factors. Thus, among environmental factors, a previous history of E.coli infection could be a predisposing risk factor in the development of autoimmune diseases.
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- FLG mutations, eczema control, and respiratory symptom at one-year-old in early-onset atopic dermatitis infants (PACI-ON cohort study). [Letter]J Dermatol Sci. 2023 Jan 25 [Online ahead of print]JD
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- Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle. [Journal Article]Gut. 2023 Feb 03 [Online ahead of print]Gut
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- Optimisation of the quality of care for patients with severe asthma: ASfarMA project. [Journal Article]Eur J Hosp Pharm. 2023 Feb 03 [Online ahead of print]EJ
- Severe asthma has an important impact on patients and healthcare resources. Recently, the new specific treatments have defined a new scenario in which person-focused care and specialist multidisciplinary teams are necessary. Our Severe Asthma Unit (SAU) started the ASfarMA project along with an external human-centered design company to understand patients' vision of their illness, treatment, and…
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- Inhalational lung diseases. [Journal Article]Radiologia (Engl Ed). 2022 Dec; 64 Suppl 3:290-300.R
- The term inhalational lung disease comprises a group of entities that develop secondary to the active aspiration of particles. Most are occupational lung diseases. Inhalational lung diseases are classified as occupational diseases (pneumoconiosis, chemical pneumonitis), hypersensitivity pneumonitis, and electronic-cigarette-associated lung diseases. The radiologic findings often consist of nonspe…
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- Biologics in Eosinophilic Gastrointestinal Disease Treatment: A new frontier. [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):155-156.AA
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- Pediatric research studies: The Yin and the Yang. [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):153-154.AA
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- Cow's milk formula each day may keep milk allergy away. [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):151-152.AA
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- Lupin allergy: Another member of the peanut gallery? [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):149-150.AA
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- Does improved indoor air quality lead to better asthma control? [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):147-148.AA
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- Drug allergy biomarkers: Are we there yet? [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):145-146.AA
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- Best of drug and vaccine allergy 2022. [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):143-144.AA
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- Allergy immunotherapy: Literature Review 2022. [Editorial]Ann Allergy Asthma Immunol. 2023 Feb; 130(2):137-138.AA
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- Endpoints and outcomes following immunotherapy for food allergy: What is meaningful for patients? [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- Multiple novel interventions for food allergy are currently at various stages of development with the goal of reducing or eliminating allergic reactions. However, the relative success of these therapeutics in achieving meaningful, long-term improvements to patients' lives is difficult to determine as there is currently very limited understanding of the degree of alignment between clinical trial e…
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- Real-World Safety Analysis of Preschool Tree Nut Oral Immunotherapy. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: Preschool TN-OIT in a real-world, multicenter setting appears safe and tolerable, with results comparable to our previously reported P-OIT findings.
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- Digital Antibiotic Allergy Decision Support Tool Improves Management of Beta Lactam Allergies. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: A point-of-care clinical decision tool provides allergist-designed guidance to non-allergists and is a scalable system for addressing antibiotic allergies, irrespective of allergist availability. This tool encouraged appropriate antibiotic use in low- and medium-risk situations and increased caution in high-risk situations. A digital support tool should be considered in quality improvement and antibiotic stewardship efforts.
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- Differences in Hypersensitivity Reactions to Iodinated Contrast Media: Analysis of the FDA Adverse Event Reporting System Database (FAERS). [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: Different ICMs exhibited diverse profiles regarding HSRs, which could be further affected by age, sex or geographical area. Prospective studies are required for patient safety.
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- Trends and variation in pediatric anaphylaxis care from 2016-2022. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: ED visits for anaphylaxis increased during the study period, but hospitalization rates were low. Substantial variation exists between EDs regarding the use of anaphylaxis therapies, supporting the need for future research to evaluate the efficacy of these medications.
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- Racial and Ethnic Disparities in Allergen Immunotherapy Prescription for Allergic Rhinitis. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: In the United States, differences in SCIT prescription exist between Black, and Hispanic patients relative to White patients. Barriers to treatment should be explored and mitigated.
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- Long-term immune reconstitution in ADA-deficient patients treated with elapegademase: a real-world experience. [Journal Article]J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]JA
- CONCLUSIONS: REVCOVI® is effective for the management of ADA-SCID.
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