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566,719 results
  • Changes in structural and functional properties of whey protein cross-linked by polyphenol oxidase. [Journal Article]
    Food Res Int. 2023 Feb; 164:112377.Yang R, Shao H, … Chen H
  • The natural whey protein is unstable, to achieve more efficient utilization, the functional properties of whey protein were modified by changing its structure, and enzymatic cross-linking is one of the common methods in dairy products to change the functional characterization. This study was conducted with objective to evaluate the structural and functional of whey protein which was cross-linked …
  • Dynamics of high hydrostatic pressure resistance development in RpoS-deficient Escherichia coli. [Journal Article]
    Food Res Int. 2023 Feb; 164:112280.Gayán E, Wang Z, … Aertsen A
  • High hydrostatic pressure (HHP) treatment is one of the most widely accepted non-thermal food processing methods, but HHP-resistance development in pathogenic or spoilage bacteria might compromise the safety and stability of HHP-treated foods. Charting the possible routes and mechanisms of HHP resistance development in foodborne bacteria is therefore essential to anticipate or prevent the appeara…
  • Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs. [Journal Article]
    Adv Sci (Weinh). 2023 Feb 03 [Online ahead of print]Lei H, Zeng T, … Zhou X
  • Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one-step introduction of diacylation linkers and azide groups on the 2'-OH of RNA is advance. Selected from eight phosphine reagents, it is found that 2-(diphenylphosphino)ethylamine has excellent performance in reducing azides via a Staudinger reduction to obtain the original RNA. I…
  • Is there a role for microbiome-based approach in common variable immunodeficiency? [Review]
    Clin Exp Med. 2023 Feb 03 [Online ahead of print]Poto R, Laniro G, … Varricchi G
  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown…
  • Treatable Traits in Airway Disease: From Theory to Practice. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]Agusti A, Gibson PG, McDonald VM
  • Chronic airway diseases such as asthma and chronic obstructive pulmonary disease are prevalent and complex conditions that often coexist in the same patient. To address this complexity in clinical practice, and to move forward toward personalized and precision medicine of airway diseases, a strategy based on the identification and treatment of so-called "treatable traits" (TTs) has been proposed.…
  • Optimisation of the quality of care for patients with severe asthma: ASfarMA project. [Journal Article]
    Eur J Hosp Pharm. 2023 Feb 03 [Online ahead of print]Muñoz-García M, Martínez-Barros H, … González-De-Olano D
  •  Severe asthma has an important impact on patients and healthcare resources. Recently, the new specific treatments have defined a new scenario in which person-focused care and specialist multidisciplinary teams are necessary. Our Severe Asthma Unit (SAU) started the ASfarMA project along with an external human-centered design company to understand patients' vision of their illness, treatment, and…
  • Inhalational lung diseases. [Journal Article]
    Radiologia (Engl Ed). 2022 Dec; 64 Suppl 3:290-300.Prieto Fernandez A, Palomo Antequera B, … Mesa Alvarez AM
  • The term inhalational lung disease comprises a group of entities that develop secondary to the active aspiration of particles. Most are occupational lung diseases. Inhalational lung diseases are classified as occupational diseases (pneumoconiosis, chemical pneumonitis), hypersensitivity pneumonitis, and electronic-cigarette-associated lung diseases. The radiologic findings often consist of nonspe…
  • Endpoints and outcomes following immunotherapy for food allergy: What is meaningful for patients? [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]Lloyd M, Patel N, … Tang ML
  • Multiple novel interventions for food allergy are currently at various stages of development with the goal of reducing or eliminating allergic reactions. However, the relative success of these therapeutics in achieving meaningful, long-term improvements to patients' lives is difficult to determine as there is currently very limited understanding of the degree of alignment between clinical trial e…
  • Digital Antibiotic Allergy Decision Support Tool Improves Management of Beta Lactam Allergies. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]Dunham TB, Gardner RM, … Liu AY
  • CONCLUSIONS: A point-of-care clinical decision tool provides allergist-designed guidance to non-allergists and is a scalable system for addressing antibiotic allergies, irrespective of allergist availability. This tool encouraged appropriate antibiotic use in low- and medium-risk situations and increased caution in high-risk situations. A digital support tool should be considered in quality improvement and antibiotic stewardship efforts.
  • Trends and variation in pediatric anaphylaxis care from 2016-2022. [Journal Article]
    J Allergy Clin Immunol Pract. 2023 Feb 01 [Online ahead of print]Dribin TE, Neuman MI, … Michelson KA
  • CONCLUSIONS: ED visits for anaphylaxis increased during the study period, but hospitalization rates were low. Substantial variation exists between EDs regarding the use of anaphylaxis therapies, supporting the need for future research to evaluate the efficacy of these medications.
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