- A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma. [Journal Article]J Asthma Allergy. 2023; 16:173-182.JA
- CONCLUSIONS: In Chinese adults with severe asthma defined by the use of conventional maintenance medication regimens, the prevalence of Th2 inflammation is comparable to that reported from other ethnic populations. Those with both eosinophil count ≥300 cell/mm3 and high IgE levels >150 IU/mL had a higher rate of uncontrolled asthma compared with those without a combination of these features.
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- Infliximab-Induced Non-specific Interstitial Pneumonitis in a Patient With Ulcerative Colitis (UC). [Case Reports]Cureus. 2022 Dec; 14(12):e33064.C
- Infliximab belongs to the family of tumor necrosis factor (TNF) alpha inhibitors and since its development, it has revolutionized treatment for both rheumatological diseases and inflammatory bowel disease (IBD). In IBD specifically, it has shown to result in symptomatic, endoscopic, and histological remission which is why it is one of the most widely used treatments for moderate to severe IBD. Wh…
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- Hereditary Angioedema with Normal C1 Inhibitor: US Survey of Prevalence and Provider Practice Patterns. [Journal Article]J Allergy Clin Immunol Pract. 2023 Jan 28 [Online ahead of print]JA
- CONCLUSIONS: This survey data provides estimates of HAE-nl-C1INH prevalence in the US, and current diagnosis and management strategies. Results may be useful for the development of studies to assess treatment efficacy and safety, and potentially improve diagnosis and management of this patient population.
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- Asthma in pregnancy. [Journal Article]Allergy Asthma Proc. 2023 Jan 01; 44(1):24-34.AA
- Background: Asthma is a frequent and potentially life-threatening disease that complicates many pregnancies. There are extensive data with regard to the diagnosis and treatment of asthma during pregnancy. Medical providers require an up-to-date summary of the critical aspects of asthma management during pregnancy. Objective: This review aimed to summarize the available data from clinical trials, …
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- Serum Sickness Reaction Post-MMRV Vaccination in a Pediatric Patient. [Case Reports]Isr Med Assoc J. 2023 Jan; 25(1):72-74.IM
- The Need for Required Stock Epinephrine in All Schools: A Work Group Report of the AAAAI Adverse Reactions to Foods Committee. [Journal Article]J Allergy Clin Immunol Pract. 2023 Jan 27 [Online ahead of print]JA
- Epinephrine is the first line of treatment for anaphylaxis which can occur outside a medical setting in community environments like schools. Patients with diagnosed IgE-mediated food allergy at risk of anaphylaxis are prescribed self-injectable epinephrine and given an individualized anaphylaxis action plan. As students, such patients/families provide their school with completed medication forms,…
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- Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice. [Journal Article]Phytomedicine. 2023 Jan 13; 111:154673.P
- CONCLUSIONS: Our work might be the first to report that MAOB not MAOA is selectively overexpressed in the spinal cord and DRG tissues of PIPN mice, and all findings have highly addressed the potency of selective MAOB inhibitor in the amelioration of PIPN-like pathology and highlighted the potential of Khe in treating PTX-induced side effects.
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- Combating chlorhexidine allergy in perioperative setting. [Journal Article]Med J Malaysia. 2023 Jan; 78(1):126-127.MJ
- Chlorhexidine is labelled as hidden allergen as the health care professionals (HCPs) are unaware of the wide range of products containing chlorhexidine. Adverse events from chlorhexidine allergy can be reduced by appropriate perioperative management especially heeding on positive history during preoperative assessment, awareness regarding this hidden allergen, and educating HCPs on possible chlor…
- Management of patients with suspected or confirmed antibiotic allergy. Executive summary of guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC). [Practice Guideline]Enferm Infecc Microbiol Clin (Engl Ed). 2023 Jan 25 [Online ahead of print]EI
- Suspected or confirmed antibiotic allergy is a frequently encountered clinical circumstance that influences antimicrobial prescribing and often leads to the avoidable use of less efficacious and/or more toxic or costly drugs than first-line antimicrobials. Optimizing antimicrobial therapy in patients with antibiotic allergy labels has become one of the priorities of antimicrobial stewardship prog…
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- Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air® approach. [Journal Article]
- MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organis…
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- Etoricoxib Induced Toxic Epidermal Necrolysis in a case of Systemic Lupus Erythematosus: A Case Report. [Case Reports]
- Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are associated with a high risk of toxic epidermal necrolysis. It is also associated …
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- Clinical outcomes of dose modification during pirfenidone treatment for IPF: A nationwide post-marketing surveillance study. [Journal Article]
- Background: Pirfenidone, an antifibrotic medication approved for the treatment of idiopathic pulmonary fibrosis (IPF), often requires dose reduction owing to adverse events. In this study, we evaluated if pirfenidone's reduced dose has any impact on clinical outcomes in patients with IPF. Methods: We used the data of a prospective post-marketing study of pirfenidone conducted at 10 hospitals in S…
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- Evaluation of the Efficacy and Safety of Romosozumab (Evenity) for the Treatment of Osteoporotic Vertebral Compression Fracture in Postmenopausal Women: A Systematic Review and Meta-analysis of Randomized Controlled Trials (CDM-J). [Journal Article]Pharmacoepidemiol Drug Saf. 2023 Jan 26 [Online ahead of print]PD
- CONCLUSIONS: Our meta-analysis revealed the evident advantages of romosozumab in the treatment of osteoporosis and low BMD in postmenopausal women and increased risks of hypersensitivity and injection site reactions. This article is protected by copyright. All rights reserved.
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- FEATURES OF MANAGEMENT OF AUTOIMMUNE THYROIDITIS IN CHILDREN: A CASE REPORT. [Case Reports]Georgian Med News. 2022 NovGM
- The article reflects the main links of pathogenesis and diagnostic criteria for autoimmune thyroiditis (AIT) and subclinical hypothyroidism as well as presents formulated features of signs and symptoms, diagnosis, and therapy of this disease in children. Here, we present a case report of an adolescent patient with AIT that was treated with L-thyroxine. The feature of this case was the development…
- Antiepileptic drug-induced hypersensitivity syndrome with liver function abnormality and fever as the first manifestation: A case report. [Case Reports]
- CONCLUSIONS: DRESS syndrome is a rare but life-threatening hypersensitivity reaction. The mortality will be very high if it's not diagnosed and treated timely. This paper presents a successful case of methylprednisolone plus intravenous immunoglobulin therapy, which provides a stronger evidence for the future diagnosis and treatment of the disease.
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- Delayed cutaneous hypersensitivity reactions following the use of infliximab or adalimumab in patients with coronavirus disease 2019. [Journal Article]J Med Virol. 2023 Jan 26 [Online ahead of print]JM
- CONCLUSIONS: Based on the FAERS database, we profiled delayed cutaneous hypersensitivity reactions related to infliximab or adalimumab application in patients with COVID-19 with more points of occurrences, clinical characteristics, and prognosis. This article is protected by copyright. All rights reserved.
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- An advanced in vitro human mucosal immune model to predict food sensitizing allergenicity risk: A proof of concept using ovalbumin as model allergen. [Journal Article]Front Immunol. 2022; 13:1073034.FI
- CONCLUSIONS: This in vitro coculture model combines multiple key events involved in allergic sensitization from epithelial cell to mast cell, which can be applied to study the allergic mechanism and sensitizing capacity of proteins.
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- Posttranscriptional Regulation of Gene Expression Participates in the Myelin Restoration in Mouse Models of Multiple Sclerosis: Antisense Modulation of HuR and HuD ELAV RNA Binding Protein. [Journal Article]Mol Neurobiol. 2023 Jan 25 [Online ahead of print]MN
- Neuropathic pain is the most difficult-to-treat pain syndrome in multiple sclerosis. Evidence relates neuropathic pain to demyelination, which often originates from unresolved neuroinflammation or altered immune response. Posttranscriptional regulation of gene expression might play a fundamental role in the regulation of these processes. The ELAV RNA-binding proteins HuR and HuD are involved in t…
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- Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis. [Journal Article]mBio. 2023 Jan 25 [Online ahead of print]MBIO
- Enzymes involved in rescuing stalled ribosomes and recycling translation machinery are ubiquitous in bacteria and required for growth. Peptidyl tRNA drop-off is a type of abortive translation that results in the release of a truncated peptide that is still bound to tRNA (peptidyl tRNA) into the cytoplasm. Peptidyl tRNA hydrolase (Pth) recycles the released tRNA by cleaving off the unfinished pept…
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- Comparison of cyclosporine and systemic corticosteroid for treating drug reaction with eosinophilia and systemic symptoms syndrome: A retrospective 20-year single-centre study in South Korea. [Journal Article]Australas J Dermatol. 2023 Jan 25 [Online ahead of print]AJ
- CONCLUSIONS: Cyclosporine was discovered to be clinically effective in DRESS syndrome and this study suggests that cyclosporine could be a feasible primary therapeutic option for DRESS syndrome.
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- The efficacy of a novel smart watch on medicine adherence and symptom control of allergic rhinitis patients: Pilot study. [Journal Article]
- CONCLUSIONS: This pilot study showed that the application of smart watches in patients with AR was associated with improved medication adherence and symptom control. Furthermore, the reliability of self-reported medication usage was limited.
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- Risks and safety of biologics: A practical guide for allergists. [Review]
- Biologic agents are a rapidly expanding class of medications, and several options are now available for the management of allergic and immunologic disorders. The risks of biologic therapy need to be understood in order to adequately counsel patients and appropriately monitor for potential adverse events. We sought to provide a comprehensive review of the risks and adverse effects reported for the…
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- Clinical aspects of severe cutaneous adverse reactions caused by beta-lactam antibiotics: A study from the Korea SCAR registry. [Journal Article]
- CONCLUSIONS: Among antibiotic-induced SCAR, clinical features were different depending on whether the culprit drug was a beta-lactam antibiotic or SCAR type. The poor prognosis was related to SJS-TEN overlap, TEN type, and carbapenem as the culprit drug.
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- Chronic Spontaneous Urticaria in Hong Kong: Clinical Characteristics, Real-World Practice and Implications for COVID-19 Vaccination. [Journal Article]Allergy Asthma Immunol Res. 2023 Jan; 15(1):32-42.AA
- CONCLUSIONS: A dedicated immunologist-led Urticaria Clinic may effectively improve CSU management and outcomes in Hong Kong.
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- Heteroatoms (B, N, S) doped quantum dots as potential drug delivery system for isoniazid: insight from DFT, NCI, and QTAIM. [Journal Article]
- Toxicity in drug includes target toxicity, immune hypersensitivity and off target toxicity. Recently, advances in nanotechnology in the areas of drug delivery have help reduce toxicity and enhance drug solubility and deliver drugs to target sites more efficiently. In this study, we present a novel heteroatom functionalized quantum dot (QD-NBC and QD-NBS) as an effective drug delivery system for i…
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- Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice. [Randomized Controlled Trial]
- CONCLUSIONS: This study highlights the positive effects of the ALABAMA behavioural intervention for both patients and clinicians.
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- DRESS/DiHS syndrome induced by Propylthiouracil: a case report. [Case Reports]
- CONCLUSIONS: Propylthiouracil is a rare cause of the DRESS/DiHS syndrome, which typically consists of severe dermatitis and various degrees of internal organ involvement. We want to emphasize through this severe case that DRESS/DiHS syndrome should be promptly recognized to hasten recovery.
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- Real-world evaluation of asthma reliever therapy among continuous users of asthma maintenance medication in Japan: A retrospective cohort study using a claims database. [Journal Article]Respir Investig. 2023 Jan 21; 61(2):164-171.RI
- CONCLUSIONS: There is a relatively low prevalence of SABA overuse among asthmatic patients in Japan. ICS/LABA therapy, treatment steps, allergic rhinitis, chronic sinusitis, and asthma management are associated with a decreased risk of SABA overuse. Further studies are needed to investigate the association between SABA overuse and asthma exacerbation and mortality.
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- Adapting adaptive design methods to accelerate adoption of a digital asthma management intervention. [Journal Article]Transl Behav Med. 2023 Jan 23 [Online ahead of print]TB
- Investigators conducting translational research in real-world settings may experience changes that create challenges to the successful completion of the trial as well as post-trial adoption and implementation. Adaptive designs support translational research by systematically adapting content and methods to meet the needs of target populations, settings and contexts. This manuscript describes an a…
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- Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats. [Journal Article]J Vis Exp. 2023 Jan 06JV
- The tibial neuroma transposition (TNT) is a rat model in which allodynia at the neuroma site (tibial nerve) can be independently evaluated from allodynia at the plantar surface of the hind paw innervated by the intact sural nerve. This TNT model is suitable to test therapies for neuroma pain, such as the potential superiority of certain surgical therapies that are already used in the clinic, or t…
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