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Unbound Medicine.
(Allopurinol)
11,220 results
  • DNA methylation of ITGB2 contributes to allopurinol hypersensitivity. [Journal Article]
    Clin Immunol. 2023 Feb 02 [Online ahead of print]Liu Y, Wang CW, … Lu QJ
  • CONCLUSIONS: Our study uncovers differentially methylated genes between allopurinol-induced SCAR patients and tolerant controls with positive or negative HLA-B*58:01 allele and provides the novel epigenetic marker that improves the prediction accuracy of genetic testing for prevention of allopurinol-induced SCAR.
  • [Anti-hyperuricemia activity and its mechanism of flavonoid extract from saffron floral bio-residues]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):148-159.Chen N, Li H, … Yang B
  • A hyperuricemic rat model induced by adenine and ethambutol was established to investigate the anti-hyperuricemia activity and its mechanism of the flavonoid extract from saffron floral bio-residues. Sixty-seven SD rats were randomly divided into control group, model group, positive control group, and flavonoid extract groups(with 3 doses), respectively, and each group contained 11 or 12 rats. Th…
  • Etoricoxib Induced Toxic Epidermal Necrolysis in a case of Systemic Lupus Erythematosus: A Case Report. [Case Reports]
    JNMA J Nepal Med Assoc. 2022 Sep 01; 60(253):811-814.Pandey A, Parajuli S, … Dongol A
  • Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are associated with a high risk of toxic epidermal necrolysis. It is also associated …
  • A Case of Feline Leishmaniosis with Panniculitis. [Case Reports]
    Case Rep Vet Med. 2023; 2023:8864790.Matralis D, Papadogiannaki I, … Papadogiannakis E
  • Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania and transmitted mainly by the bite of sand fly vectors. Cats are infected with at least 6 species of Leishmania. Significant associations have been found between feline leishmaniosis and coinfections mainly with FIV and/or FeLV. A 7-year-old castrated male, domestic short-haired cat was presented with unknown history…
  • The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2. [Journal Article]
    Antioxidants (Basel). 2023 Jan 05; 12(1)Higa Y, Hiasa M, … Abe M
  • Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical inducer of antioxidants, which is bound and repressed by a kelch-like ECH-associated prot…
  • Optimizing adherence to allopurinol for gout: patients' perspectives. [Journal Article]
    Br J Clin Pharmacol. 2023 Jan 06 [Online ahead of print]Spragg JCJ, Michael TJF, … Stocker SL
  • CONCLUSIONS: Patient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation and discontinuation. Strategies that inform patients of their urate control and provide accurate medical advice have the potential to improve adherence to allopurinol.
  • Skin reaction with Eosinophilia and Systemic Symptoms after lenalidomide in peritoneal Dialysis. [Case Reports]
    G Ital Nefrol. 2022 Oct 31; 39(5)Cazzato S, Fontana F, … Alfano G
  • The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a fatal and immune-mediated idiosyncratic drug reaction, with symptoms of fever, skin eruptions (that involves more than half of the body surface), facial oedema and hematological disorders, all presenting within the latent period following drug intake. Effects can also be seen on multiple organs, most notably hepatitis…
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