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149 results
  • Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35. [Journal Article]
    Cell Discov. 2022 Dec 21; 8(1):135.Duan J, Liu Q, … Jiang Y
  • Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes Gs, Gi/o, and Gq/11, insufficient structural evidence is accessible to understand the coupling mechanism of G12/13 protein by GPCRs. Orphan receptor GPR35, which is predominantly expressed in the gastrointestinal t…
  • Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35 [Journal Article]
    Biomol Ther (Seoul). 2019 06 13 [Online ahead of print]Kim MJ, Park SJ, … Im DS
  • A previous pharmacogenomic analysis identified cromolyn, an anti-allergic drug, as an effective anti-fibrotic agent that acts on hepatocytes and stellate cells. Furthermore, cromolyn was shown to be a G protein-coupled receptor 35 (GPR35) agonist. However, it has not been studied whether anti-fibrotic effects are mediated by GPR35. Therefore, in this study, the role of GPR35 in hepatic fibrosis w…
  • Drugs and Lactation Database (LactMed): Lodoxamide [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Although no published data exist on the use of lodoxamide during lactation, maternal milk levels are likely to be very low after the use eye drops. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
  • Protective effect of lodoxamide on hepatic steatosis through GPR35. [Journal Article]
    Cell Signal. 2019 01; 53:190-200.Nam SY, Park SJ, Im DS
  • Although GPR35 is an orphan G protein-coupled receptor, synthetic agonists and antagonists have been developed. Recently, cromolyn, a mast cell stabilizer, was reported as an agonist of GPR35 and was shown to exhibit antifibrotic effects through its actions on hepatocytes and stellate cells. In this study, the role of GPR35 in hepatic steatosis was investigated using an in vitro model of liver X …
  • Vernal keratoconjunctivitis: a severe allergic eye disease with remodeling changes. [Review]
    Pediatr Allergy Immunol. 2014 Jun; 25(4):314-22.Vichyanond P, Pacharn P, … Leonardi A
  • Vernal keratoconjunctivitis (VKC) is an unusually severe sight-threatening allergic eye disease, occurring mainly in children. Conventional therapy for allergic conjunctivitis is generally not adequate for VKC. Pediatricians and allergists are often not familiar with the severe clinical symptoms and signs of VKC. As untreated VKC can lead to permanent visual loss, pediatric allergists should be a…
  • Immediate hypersensitivity elicits renin release from cardiac mast cells. [Journal Article]
    Int Arch Allergy Immunol. 2008; 146(1):71-5.Kano S, Tyler E, … Levi R
  • CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release. As renin is stored in human heart mast cells, allergic reactions could initiate renin release, leading to local angiotensin formation and hyperadrenergic dysfunction.
  • Optimal use of topical agents for allergic conjunctivitis. [Journal Article]
    BioDrugs. 1997 Oct; 8(4):250-64.Mösges R, Hassan HA, Wenzel MR
  • In recent years, there has been renewed interest in the topical treatment of allergic conjunctivitis, a disorder that is involved in the common red-eye syndrome. Topical treatment for rapid relief of symptoms is most often preferred by the patient, although physicians are more cautious with the choice of an agent that might worsen symptoms due to contact irritation induced by the substance or its…
  • Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness. [Review]
    Br J Gen Pract. 2004 Jun; 54(503):451-6.Owen CG, Shah A, … Sheikh A
  • CONCLUSIONS: Overall, these findings confirm the benefit of topical mast cell stabilisers and antihistamines over placebo for the treatment of allergic conjunctivitis. There is, however, insufficient evidence to recommend the use of one type of medication over another. Treatment preferences should therefore be based on convenience of use (with reduced frequency of instillation for some preparations), patient preference, and costs, especially as important side effects were not reported with any medication.
  • Seasonal allergic conjunctivitis. [Journal Article]
    Drugs Today (Barc). 1998 Mar; 34(3):259-65.Joss J, Craig T
  • Seasonal allergic conjunctivitis is rarely associated with permanent vision impairment; however, it is a relatively common condition that may compromise the quality of life of patients with this diagnosis. In extreme cases daily activities, including work, may be compromised. Numerous treatment options have become available for the relief of acute symptoms. Corticosteroids may be used for severe …
  • Ocular allergic disease. [Journal Article]
    Drugs Today (Barc). 1998 Nov; 34(11):957-71.Bhargava A, Jackson WB, El-Defrawy SR
  • Ocular allergy is a common condition that usually affects the conjunctiva of the eye and is therefore often referred to as allergic conjunctivitis. The severity of the disease can range from mild itching and redness, as seen in seasonal allergic conjunctivitis, to the more serious vision threatening forms of ocular allergy which affect the cornea, such as atopic keratoconjunctivitis. The pathogen…
  • Vernal keratoconjunctivitis in Thailand. [Randomized Controlled Trial]
    Asian Pac J Allergy Immunol. 2003 Mar; 21(1):25-30.Kosrirukvongs P, Vichyanond P, Wongsawad W
  • A prospective, cross-sectional and randomized cross-over study was conducted to study the clinical features and treatment outcome among Thai patients with vernal keratoconjunctivitis (VKC). History-taking and eye examinations were performed. Mild cases of VKC were given topical antihistamine four times daily. Moderate and severe cases of VKC were treated with topical lodoxamide four times a day. …
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