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26,186 results
  • Graham-Little-Piccardi-Lasseur Syndrome: A Case Report. [Journal Article]
    J Drugs Dermatol. 2023 Feb 01; 22(2):210-216.Celen A, Lo Sicco K, … Weed J
  • Graham-Little Piccardi-Lasseur syndrome is a rare dermatosis that affects the hair follicles throughout the body and often presents with a progressive cicatricial alopecia of the scalp that is unresponsive to medical therapy. While treatment options are limited, prompt recognition through a careful physical exam aided by dermoscopy can facilitate early intervention. Here we present a patient with…
  • Postmenopausal Hyperandrogenism due to Ovarian Hyperthecosis. [Case Reports]
    Case Rep Obstet Gynecol. 2023; 2023:2783464.Metzker LS, Ferreira LAC, … Filho AC
  • Ovarian hyperthecosis or ovarian stromal hyperplasia is a non-neoplastic functional disorder resulting from the presence of luteinized thecal cells within a hyperplastic ovarian stroma. The condition is more common in postmenopausal women than in those of reproductive age and leads to substantial clinical and laboratory alterations, principally androgenetic alopecia, progressive hirsutism, and el…
  • Chemotherapy: how to reduce its adverse effects while maintaining the potency? [Review]
    Med Oncol. 2023 Feb 03; 40(3):88.Brianna , Lee SH
  • Chemotherapy is one of the widely used anticancer treatments that involves the use of powerful cytotoxic drugs to stop tumor growth by targeting rapidly dividing cells through various mechanisms, which will be elucidated in this review. Introduced during the early twentieth century, chemotherapy has since lengthened the longevity of innumerable cancer patients. However, the increase in lifespan i…
  • Trace element zinc and skin disorders. [Review]
    Front Med (Lausanne). 2022; 9:1093868.Zou P, Du Y, … Cao Y
  • Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except f…
  • Amelioration of trichotillomania with onabotulinumtoxinA for chronic migraine. [Case Reports]
    BMJ Case Rep. 2023 Feb 02; 16(2)Engel ER, Ham JA
  • We report a case of a woman in her 30s who struggled with a life-long history of trichotillomania (TTM; hair-pulling disorder), which was unsuccessfully treated with behavioural therapy and selective serotonin reuptake inhibitors. In addition to TTM, our patient had a history of chronic migraine which brought her to our clinic, and treatment with onabotulinumtoxinA (OBTA) was initiated per the Ph…
  • Infantile vitiligo and alopecia in immunodysregulation polyendocrinopathy enteropathy X-linked syndrome. [Case Reports]
    Pediatr Dermatol. 2023 Feb 02 [Online ahead of print]Lee WQ, Leong KF
  • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is characterized by failure to thrive, severe chronic diarrhea, neonatal type 1 diabetes or thyroiditis, and eczematous dermatitis. We report a patient with infantile onset IPEX syndrome who developed vitiligo, alopecia, and chronic diarrhea. Awaiting stem cell transplant, he had multiple episodes of sepsis and succumbed at th…
  • Psychosocial impact of pediatric alopecia areata: A survey study. [Journal Article]
    Pediatr Dermatol. 2023 Feb 01 [Online ahead of print]Benton S, Bellefeuille G, … Hordinsky MK
  • This study, which aimed to identify distress by sites of hair loss and psychosocial stressors for a pediatric alopecia areata population, enrolled 50 patients (32 females, 18 males, ages 7-17 years) from pediatric dermatology clinics, including a monthly hair disease clinic. Patients completed a 47-question survey. Scalp hair loss was rated as often or always bothersome in 34.7%; eyebrow loss in …
  • Erythroderma with total scarring alopecia. [Case Reports]
    BMJ Case Rep. 2023 Jan 31; 16(1)Karrakchou B, Fliti A, … Senouci K
  • A woman in her 50s presented with total scarring ulcerated alopecia evolving for 10 years, and a recent budding tumour on the lower lip. Clinical examination revealed an associated exfoliated and infiltrated erythroderma with ulcerated cutaneous tumours of the legs, palmoplantar hyperkeratosis, hepatosplenomegaly and diffuse lymphadenopathies.Dermatoscopy of the scalp, leg tumours and infiltrated…
  • An umbrella review of the use of platelet-rich plasma in the treatment of androgenetic alopecia. [Review]
    J Cosmet Dermatol. 2023 Jan 31 [Online ahead of print]Li C, Pan L, … Zhang L
  • CONCLUSIONS: PRP treatment for androgenetic alopecia is effective, and we recommend the following: (1) a PRP volume of at least 0.05 ml/cm2 , preferably 0.1 ml/cm2 ; (2) at least three consecutive treatments at an interval of 1 month; (3) intensive therapy is beneficial and can be provided from 3 to 6 months after continuous treatment; (4) objective indicators such as hair diameter, hair count; (5) long-term follow-up.
  • Excess KLHL24 impairs skin wound healing by degradation of vimentin. [Journal Article]
    J Invest Dermatol. 2023 Jan 27 [Online ahead of print]Liu Y, Cui J, … Yang Y
  • Start codon mutations in ubiquitin ligase Kelch-like protein 24 (KLHL24) lead to a gain-of-function mutant KLHL24-ΔN28, which mediates the excessive degradation of keratin 15, desmin, and keratin 14, resulting in alopecia, cardiopathy, and epidermolysis bullosa syndrome (ACES). ACES patients normally present atrophic scars after wounds heal, which is rare in KRT14-related epidermolysis bullosa (E…
  • Dermoscopic Findings of Alopecia in Patients with Hypothyroidism. [Journal Article]
    Int J Endocrinol Metab. 2022 Oct; 20(4):e128938.Gharaei Nejad K, Motamed B, … Molaei A
  • CONCLUSIONS: Regarding the promising results of this study, we could detect possible dermoscopic signs of inflammation in hypothyroid patients with hair loss. Further investigations are needed because there is a shortage of evidence on this novel diagnostic method.
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