- Graham-Little-Piccardi-Lasseur Syndrome: A Case Report. [Journal Article]J Drugs Dermatol. 2023 Feb 01; 22(2):210-216.JD
- Graham-Little Piccardi-Lasseur syndrome is a rare dermatosis that affects the hair follicles throughout the body and often presents with a progressive cicatricial alopecia of the scalp that is unresponsive to medical therapy. While treatment options are limited, prompt recognition through a careful physical exam aided by dermoscopy can facilitate early intervention. Here we present a patient with…
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- Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine-like procedures for rhesus macaques (Macaca mulatta). [Journal Article]J Med Primatol. 2023 Feb 06 [Online ahead of print]JM
- CONCLUSIONS: Pair-housed macaques exhibited less of some undesirable behaviors (e.g., self-clasping) and experienced less diarrhea than single-housed subjects; however, no significant differences in cortisol levels or alopecia measures were found. The demonstrated beneficial effects of pair housing for rhesus macaques following intrafacility transfer and adjustment suggest pairing upon arrival at a new facility will bolster animal welfare.
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- Pathology and pathogenesis of cutaneous lesions in beef cattle associated with buffalo fly infestation. [Journal Article]Front Vet Sci. 2022; 9:971813.FV
- Haematobia irritans exigua, commonly known as buffalo fly, is the major hematophagous ectoparasite of north Australian cattle herds. Lesions associated with buffalo fly infestation are generally alopecic, hyperkeratotic, or scab encrusted wounds with variable hemorrhagic ulceration. Buffalo flies can transmit a filarial nematode, Stephanofilaria sp., which has been implicated in the pathogenesis …
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- Editorial: Advances in evaluation and management of hair loss disorders. [Editorial]Front Med (Lausanne). 2023; 10:1131286.FM
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- Hydroxychloroquine for granuloma annulare: A case report on secondary hair growth in alopecia universalis. [Case Reports]SAGE Open Med Case Rep. 2023; 11:2050313X231152066.SO
- Alopecia areata is an autoimmune disease resulting in non-scarring hair loss. Alopecia areata can progress to become alopecia totalis (loss of hair from the entire scalp) or alopecia universalis (loss of hair form the entire body), with the progression estimated to range from 7% to 30%. There are no universally proven therapies that both induce and sustain remission, and furthermore, the course o…
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- Postmenopausal Hyperandrogenism due to Ovarian Hyperthecosis. [Case Reports]Case Rep Obstet Gynecol. 2023; 2023:2783464.CR
- Ovarian hyperthecosis or ovarian stromal hyperplasia is a non-neoplastic functional disorder resulting from the presence of luteinized thecal cells within a hyperplastic ovarian stroma. The condition is more common in postmenopausal women than in those of reproductive age and leads to substantial clinical and laboratory alterations, principally androgenetic alopecia, progressive hirsutism, and el…
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- Van der Woude Syndrome and Alopecia Areata – more than a fortuitous association? [Case Reports]Actas Dermosifiliogr. 2023 Feb 03 [Online ahead of print]AD
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- Alopecia as an emerging adverse event to CGRP monoclonal antibodies: Cases Series, evaluation of FAERS, and literature review. [Journal Article]Cephalalgia. 2023 Feb; 43(2):3331024221143538.C
- CONCLUSIONS: Most events were reported in women and non-serious. The potential mechanism of alopecia with drugs targeting calcitonin gene-related peptide or its receptor possibly includes disruptions in the microvascular circulation and other homeostatic mechanisms.
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- Hair regrowth boosting via minoxidil cubosomes: Formulation development, in vivo hair regrowth evaluation, histopathological examination and confocal laser microscopy imaging. [Journal Article]Int J Pharm. 2023 Jan 31 [Online ahead of print]IJ
- Minoxidil has been used as an effective and cost-efficient topical treatment for androgenic alopecia. However, due to its poor water solubility, commercially available formulations contain alcohol and propylene glycol in a concentration that causes skin reactions such as irritation and dryness. Therefore, nanotechnology-based formulations can offer an alternative that might increase penetration a…
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- Scalp Biopsy Influences Diagnostic Accuracy and Treatment in Black Women with Alopecia: A Retrospective Study. [Journal Article]J Am Acad Dermatol. 2023 Jan 31 [Online ahead of print]JA
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- Chemotherapy: how to reduce its adverse effects while maintaining the potency? [Review]Med Oncol. 2023 Feb 03; 40(3):88.MO
- Chemotherapy is one of the widely used anticancer treatments that involves the use of powerful cytotoxic drugs to stop tumor growth by targeting rapidly dividing cells through various mechanisms, which will be elucidated in this review. Introduced during the early twentieth century, chemotherapy has since lengthened the longevity of innumerable cancer patients. However, the increase in lifespan i…
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- Trace element zinc and skin disorders. [Review]
- Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except f…
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- Amelioration of trichotillomania with onabotulinumtoxinA for chronic migraine. [Case Reports]BMJ Case Rep. 2023 Feb 02; 16(2)BC
- We report a case of a woman in her 30s who struggled with a life-long history of trichotillomania (TTM; hair-pulling disorder), which was unsuccessfully treated with behavioural therapy and selective serotonin reuptake inhibitors. In addition to TTM, our patient had a history of chronic migraine which brought her to our clinic, and treatment with onabotulinumtoxinA (OBTA) was initiated per the Ph…
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- Actinic lichen planopilaris: a new variant of lichen planopilaris triggered by ultraviolet radiation. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):158-160.CE
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- "Efficacy of Platelet-Rich Plasma Plus Basic Fibroblast Growth Factor on the Treatment of Androgenic Alopecia". [Journal Article]Plast Reconstr Surg. 2022 Dec 06 [Online ahead of print]PR
- CONCLUSIONS: PRPF can be a safe and valuable form of AGA treatment, and has proven to be more effective than PRP.
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- Autologous Platelet-Rich Plasma Treatment for Androgenic Alopecia: A Systematic Review and Meta-analysis of Clinical Trials on Patient Safety, Efficacy and Outcomes. [Journal Article]Plast Reconstr Surg. 2022 Dec 19 [Online ahead of print]PR
- CONCLUSIONS: Autologous PRP significantly improves alopecia in select patients. Future research should focus on optimizing PRP treatment protocols and minimizing possible adverse reactions.
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- Infantile vitiligo and alopecia in immunodysregulation polyendocrinopathy enteropathy X-linked syndrome. [Case Reports]Pediatr Dermatol. 2023 Feb 02 [Online ahead of print]PD
- Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is characterized by failure to thrive, severe chronic diarrhea, neonatal type 1 diabetes or thyroiditis, and eczematous dermatitis. We report a patient with infantile onset IPEX syndrome who developed vitiligo, alopecia, and chronic diarrhea. Awaiting stem cell transplant, he had multiple episodes of sepsis and succumbed at th…
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- [Clinical effect and influencing factors of pegylated interferon alfa-2a and entecavir monotherapy among children with HBeAg-positive chronic hepatitis B based on a real-world study]. [Journal Article]Zhonghua Gan Zang Bing Za Zhi. 2022 Oct 20; 30(10):1056-1062.ZG
- Objective: To compare the efficacy, safety, and influencing factors among children with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B (CHB) who received short-term therapy with pegylated interferon alfa-2a (Peg-IFNα-2a) or continuous therapy with entecavir (ETV). Methods: Quantitative data were compared using analysis of variance to compare the differences between groups. Enume…
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- Tuberculosis mimicking the onset of systemic lupus erythematosus flare: Case based review. [Case Reports]Int J Rheum Dis. 2023 Feb 01 [Online ahead of print]IJ
- CONCLUSIONS: TB stimulated the production of autoantibodies, with shared affinity for mycobacteria and human antigens, which may have led to lupus mimickers.
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- Psychosocial impact of pediatric alopecia areata: A survey study. [Journal Article]Pediatr Dermatol. 2023 Feb 01 [Online ahead of print]PD
- This study, which aimed to identify distress by sites of hair loss and psychosocial stressors for a pediatric alopecia areata population, enrolled 50 patients (32 females, 18 males, ages 7-17 years) from pediatric dermatology clinics, including a monthly hair disease clinic. Patients completed a 47-question survey. Scalp hair loss was rated as often or always bothersome in 34.7%; eyebrow loss in …
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- ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth. [Journal Article]Br J Pharmacol. 2023 Jan 31 [Online ahead of print]BJ
- CONCLUSIONS: Taken together, our study unraveled that ISX9 could activate Wnt/β-catenin signaling by potentiating the association between LRP6 and Axin1, and may be a promising therapeutic agent for alopecia treatment.
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- Genetic epidemiology of Woodhouse-Sakati Syndrome in the Greater Middle East region and beyond: a systematic review. [Review]
- CONCLUSIONS: This systematic review highlights the molecular basis and clinical manifestations of WSS globally, including the GME region, where the disease is prevalent due to consanguinity. Additional studies are now needed to understand the genotype-phenotype correlation for different DCAF17 variants and their impact on the phenotypic heterogeneity observed in WSS patients.
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- Erythroderma with total scarring alopecia. [Case Reports]BMJ Case Rep. 2023 Jan 31; 16(1)BC
- A woman in her 50s presented with total scarring ulcerated alopecia evolving for 10 years, and a recent budding tumour on the lower lip. Clinical examination revealed an associated exfoliated and infiltrated erythroderma with ulcerated cutaneous tumours of the legs, palmoplantar hyperkeratosis, hepatosplenomegaly and diffuse lymphadenopathies.Dermatoscopy of the scalp, leg tumours and infiltrated…
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- Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta-analysis. [Review]J Cosmet Dermatol. 2023 Jan 31 [Online ahead of print]JC
- CONCLUSIONS: Our results show that the use of fractional lasers can effectively treat alopecia areata.
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- An umbrella review of the use of platelet-rich plasma in the treatment of androgenetic alopecia. [Review]J Cosmet Dermatol. 2023 Jan 31 [Online ahead of print]JC
- CONCLUSIONS: PRP treatment for androgenetic alopecia is effective, and we recommend the following: (1) a PRP volume of at least 0.05 ml/cm2 , preferably 0.1 ml/cm2 ; (2) at least three consecutive treatments at an interval of 1 month; (3) intensive therapy is beneficial and can be provided from 3 to 6 months after continuous treatment; (4) objective indicators such as hair diameter, hair count; (5) long-term follow-up.
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- Excess KLHL24 impairs skin wound healing by degradation of vimentin. [Journal Article]J Invest Dermatol. 2023 Jan 27 [Online ahead of print]JI
- Start codon mutations in ubiquitin ligase Kelch-like protein 24 (KLHL24) lead to a gain-of-function mutant KLHL24-ΔN28, which mediates the excessive degradation of keratin 15, desmin, and keratin 14, resulting in alopecia, cardiopathy, and epidermolysis bullosa syndrome (ACES). ACES patients normally present atrophic scars after wounds heal, which is rare in KRT14-related epidermolysis bullosa (E…
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- Folliculitis decalvans has a heterogeneous microbiological signature and impaired immunological response. [Journal Article]Dermatology. 2023 Jan 30 [Online ahead of print]D
- CONCLUSIONS: FD hair follicles have a specific heterogenous follicular bacterial microbiota signature. Additionally, these patients seem to have an impaired immunological response.
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- A Proactive Approach to Prevent Hematopoietic Exhaustion During Cancer Chemotherapy in Older Patients: Temporary Cell-Cycle Arrest. [Review]Drugs Aging. 2023 Jan 30 [Online ahead of print]DA
- Age is associated with the decline of multiple organ systems. In older patients, hematological toxicities associated with chemotherapy are often dose limiting, impairing dose intensity and treatment efficacy. Contrary to the classical path using growth factors to activate tissue regeneration, a novel strategy is emerging to prevent chemotherapy toxicity that involves temporary cell-cycle arrest o…
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- Dermoscopic Findings of Alopecia in Patients with Hypothyroidism. [Journal Article]
- CONCLUSIONS: Regarding the promising results of this study, we could detect possible dermoscopic signs of inflammation in hypothyroid patients with hair loss. Further investigations are needed because there is a shortage of evidence on this novel diagnostic method.
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