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Unbound Medicine.
(Alopecia areata)
5,554 results
  • Psychosocial impact of pediatric alopecia areata: A survey study. [Journal Article]
    Pediatr Dermatol. 2023 Feb 01 [Online ahead of print]Benton S, Bellefeuille G, … Hordinsky MK
  • This study, which aimed to identify distress by sites of hair loss and psychosocial stressors for a pediatric alopecia areata population, enrolled 50 patients (32 females, 18 males, ages 7-17 years) from pediatric dermatology clinics, including a monthly hair disease clinic. Patients completed a 47-question survey. Scalp hair loss was rated as often or always bothersome in 34.7%; eyebrow loss in …
  • Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. [Journal Article]
    PNAS Nexus. 2023 Jan; 2(1):pgac297.Tsai J, Gori S, … Garza LA
  • Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8+ T cells. Most patients present with patchy hair loss on the scalp that improves spontaneously or with topical and intralesional steroids, topical minoxidil, or topical immunotherapy. However, recurrence of hair loss is common, and patients with extensive disease may require treatment with…
  • The burden of alopecia areata: a scoping review focusing on quality of life, mental health and work productivity. [Review]
    J Eur Acad Dermatol Venereol. 2023 Jan 27 [Online ahead of print]Muntyanu A, Gabrielli S, … Netchiporouk E
  • Alopecia areata (AA) is a common inflammatory autoimmune disease of the hair which can have a significant negative impact on the quality of life (QoL), mental health, and productivity. The aim of this scoping review is to elucidate the burden of AA focusing on these three realms. Inclusion criteria included all original manuscripts with no restriction on study type or statistical method written i…
  • Alopecia areata and risk of common infections: a population-based cohort study. [Journal Article]
    Clin Exp Dermatol. 2022 Dec 01 [Online ahead of print]Messenger AG, Harries M, … de Lusignan S
  • CONCLUSIONS: The association between AA and common infection may represent a higher propensity of people with AA to engage with healthcare services (and thereby to have infections recorded), rather than a true association between AA and infection. Overall our findings suggest that AA is not associated with a clinically significantly increased or decreased incidence of common infections.
  • Gut microbiota in alopecia areata. [Journal Article]
    Postepy Dermatol Alergol. 2022 Dec; 39(6):1162-1170.Brzychcy K, Dróżdż I, … Lesiak A
  • CONCLUSIONS: This study describes, for the first time, the characteristics of the gut microbiome in AA patients and may provide new insight into the gut microbiome that may play a role in the development of AA.
  • Mitochondrial DNA copy number as a diagnostic marker and indicator of degree of severity in alopecia areata. [Journal Article]
    J Immunoassay Immunochem. 2023 Jan 22 [Online ahead of print]Shehata WA, Hammam MA, … Abdelsattar S
  • Alopecia areata (AA) is a disorder with several etiologies. The evidence suggests that the absolute copy number of mitochondrial deoxyribonucleic acid (mtDNA), as well as proportion of mutated mtDNA copies, determines disease onset. This study aims to quantify the relative index of the mtDNA copy number in patients with AA and healthy controls and correlate the results with the existing clinical …
  • Exploring Mast Cell-CD8 T Cell Interactions in Inflammatory Skin Diseases. [Review]
    Int J Mol Sci. 2023 Jan 13; 24(2)Chen Y, Griffiths CEM, Bulfone-Paus S
  • The skin is exposed to environmental challenges and contains skin-resident immune cells, including mast cells (MCs) and CD8 T cells that act as sentinels for pathogens and environmental antigens. Human skin MCs and their mediators participate in the maintenance of tissue homeostasis and regulate the recruitment and activity of immune cells involved in the pathogenesis of skin diseases. The cutane…
  • Association between the first exposure to general anesthesia and alopecia areata. [Journal Article]
    J Dermatol. 2023 Jan 18 [Online ahead of print]Lee H, Choi YW, … Choi JW
  • Alopecia areata (AA) is an autoimmune cutaneous disorder reported to be related to various immunologic diseases and psychiatric disorders. Some AA patients report the onset of patchy hair loss after surgeries under general anesthesia (GA). However, no large-scale studies have been conducted on the relationship between AA and GA. Thus, we aimed to evaluate whether exposure to GA is associated with…
  • Cutaneous manifestations of COVID-19 and COVID-19 vaccination. [Journal Article]
    J Dermatol. 2023 Jan 13 [Online ahead of print]Nakashima C, Kato M, Otsuka A
  • In December 2019, a new infectious pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China. Transmitted through respiratory droplets, SARS-CoV-2 is the causative pathogen of coronavirus disease 2019 (COVID-19). Although this new COVID-19 infection is known to cause primarily interstitial pneumonia and respiratory failure, it is often associated w…
  • Parry Romberg Syndrome in a Young Ghanaian: A Case Report and a Literature Review. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32287.Dzefi-Tettey K, Edzie EK, … Acheampong F
  • Parry Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is a very rare self-limiting disease, which affects the skin and subcutaneous tissues, underlying musculature, cartilage, and bony structures of one half of the face with a resultant hemiatrophy and alopecia areata. It presents in children and young adults, with a slow progression of the atrophy for several years, and the…
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