- Actinic lichen planopilaris: a new variant of lichen planopilaris triggered by ultraviolet radiation. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):158-160.CE
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- Psychosocial impact of pediatric alopecia areata: A survey study. [Journal Article]Pediatr Dermatol. 2023 Feb 01 [Online ahead of print]PD
- This study, which aimed to identify distress by sites of hair loss and psychosocial stressors for a pediatric alopecia areata population, enrolled 50 patients (32 females, 18 males, ages 7-17 years) from pediatric dermatology clinics, including a monthly hair disease clinic. Patients completed a 47-question survey. Scalp hair loss was rated as often or always bothersome in 34.7%; eyebrow loss in …
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- Effect of fractional laser alone or in combination on alopecia areata: A systematic review and meta-analysis. [Review]J Cosmet Dermatol. 2023 Jan 31 [Online ahead of print]JC
- CONCLUSIONS: Our results show that the use of fractional lasers can effectively treat alopecia areata.
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- Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. [Journal Article]
- Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8+ T cells. Most patients present with patchy hair loss on the scalp that improves spontaneously or with topical and intralesional steroids, topical minoxidil, or topical immunotherapy. However, recurrence of hair loss is common, and patients with extensive disease may require treatment with…
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- The burden of alopecia areata: a scoping review focusing on quality of life, mental health and work productivity. [Review]J Eur Acad Dermatol Venereol. 2023 Jan 27 [Online ahead of print]JE
- Alopecia areata (AA) is a common inflammatory autoimmune disease of the hair which can have a significant negative impact on the quality of life (QoL), mental health, and productivity. The aim of this scoping review is to elucidate the burden of AA focusing on these three realms. Inclusion criteria included all original manuscripts with no restriction on study type or statistical method written i…
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- Alopecia areata and risk of common infections: a population-based cohort study. [Journal Article]Clin Exp Dermatol. 2022 Dec 01 [Online ahead of print]CE
- CONCLUSIONS: The association between AA and common infection may represent a higher propensity of people with AA to engage with healthcare services (and thereby to have infections recorded), rather than a true association between AA and infection. Overall our findings suggest that AA is not associated with a clinically significantly increased or decreased incidence of common infections.
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- Prevalence and Odds of Depressive and Anxiety Disorders and Symptoms in Children and Adults With Alopecia Areata: A Systematic Review and Meta-analysis. [Journal Article]JAMA Dermatol. 2023 Jan 25 [Online ahead of print]JD
- CONCLUSIONS: In this systematic review and meta-analysis, the separate analyses showed that 7% to 17% of patients with AA had depressive or anxiety disorders that require psychiatric care, including specific medication. Additionally, more than one-third of patients had symptoms that are warning signs and that need monitoring because they can develop into disorders.
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- Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis. [Meta-Analysis]Acta Derm Venereol. 2023 Jan 25; 103:adv00855.AD
- The aim of this study was to compare the efficacy and safety of treatment with Janus kinase inhibitors for alopecia areata, measured by change in Severity of Alopecia Tool (SALT) score. A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines was performed using Medline, EMBASE and Cochrane library. All studies investigating the efficacy…
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- Exploring the Overlap Between Alopecia Areata and Major Depressive Disorder: Epidemiological and Genetic Perspectives. [Journal Article]J Eur Acad Dermatol Venereol. 2023 Jan 25 [Online ahead of print]JE
- CONCLUSIONS: As in previous research, AA patients showed an increased prevalence of MDD. The present analyses suggest that genetic overlap may be confined to the MHC region, which is implicated in immune function. More detailed investigation is required to refine understanding of how the MHC is involved in the development of AA and MDD comorbidity.
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- Global, regional, and national burden of alopecia areata and its associated diseases, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019. [Journal Article]Eur J Clin Invest. 2023 Jan 24 [Online ahead of print]EJ
- CONCLUSIONS: The burden of AA was prominent in females, young adults, high socio-demographic countries, and North Americans. The study corroborates sex- and region-specific implications and public health measures for AA and its associated burdens. These epidemiological data on AA burden can guide future research efforts, prevention strategies, and allocation of resources.
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- Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study. [Journal Article]Clin Exp Dermatol. 2022 Nov 30 [Online ahead of print]CE
- CONCLUSIONS: People with AA have an increased burden of atopic and autoimmune comorbidity. This supports previous work suggesting that both T helper cell (Th)1 and Th2 immune responses may be implicated in the pathogenesis of AA.
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- Factors influencing alopecia areata treatment decisions: A qualitative assessment. [Journal Article]
- CONCLUSIONS: Patients with AA face various challenges including medical uncertainty and lack of information. Patients need trustworthy and accessible sources of information regarding their treatment that also take into consideration their preferences and values.
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- Gut microbiota in alopecia areata. [Journal Article]
- CONCLUSIONS: This study describes, for the first time, the characteristics of the gut microbiome in AA patients and may provide new insight into the gut microbiome that may play a role in the development of AA.
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- A retrospective study of oral tofacitinib therapy for alopecia areata. [Case Reports]An Bras Dermatol. 2023 Jan 20 [Online ahead of print]AB
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- Mitochondrial DNA copy number as a diagnostic marker and indicator of degree of severity in alopecia areata. [Journal Article]J Immunoassay Immunochem. 2023 Jan 22 [Online ahead of print]JI
- Alopecia areata (AA) is a disorder with several etiologies. The evidence suggests that the absolute copy number of mitochondrial deoxyribonucleic acid (mtDNA), as well as proportion of mutated mtDNA copies, determines disease onset. This study aims to quantify the relative index of the mtDNA copy number in patients with AA and healthy controls and correlate the results with the existing clinical …
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- Long-term patient-reported perception and experience of methylprednisolone pulse with or without methotrexate in alopecia areata: a French retrospective single-center cohort. [Letter]J Eur Acad Dermatol Venereol. 2023 Jan 22 [Online ahead of print]JE
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- Cross-specialty identification of the JAK1 inhibitor trial agent filgotinib as a potential therapy for alopecia areata. [Journal Article]Br J Dermatol. 2022 Nov 25 [Online ahead of print]BJ
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- Exploring Mast Cell-CD8 T Cell Interactions in Inflammatory Skin Diseases. [Review]
- The skin is exposed to environmental challenges and contains skin-resident immune cells, including mast cells (MCs) and CD8 T cells that act as sentinels for pathogens and environmental antigens. Human skin MCs and their mediators participate in the maintenance of tissue homeostasis and regulate the recruitment and activity of immune cells involved in the pathogenesis of skin diseases. The cutane…
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- Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches. [Review]
- Alopecia areata (AA) is a dermatological condition characterized by non-scarring hair loss. Exact etiopathogenesis of AA is still unknown although it is known that several factors contribute to the collapse of the hair-follicle (HF)-immune-privileged (IP) site. Oxidative stress (OS) plays an important role in skin diseases. The aim of this review was to clarify the role of OS in AA pathogenesis a…
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- Prevalence and Incidence of Vitiligo and Associated Comorbidities: A Nationwide Population-based Study in Korea. [Journal Article]Clin Exp Dermatol. 2023 Jan 19 [Online ahead of print]CE
- CONCLUSIONS: The incidence and prevalence of vitiligo are increasing, particularly among younger patients in Korea. In addition, various comorbidities are associated with vitiligo. Therefore, if vitiligo patients present extracutaneous symptoms, physicians should consider the possibility of other comorbid diseases.
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- Pediatric alopecia areata following COVID-19 infection. [Letter]J Cosmet Dermatol. 2023 Jan 18 [Online ahead of print]JC
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- Association between the first exposure to general anesthesia and alopecia areata. [Journal Article]J Dermatol. 2023 Jan 18 [Online ahead of print]JD
- Alopecia areata (AA) is an autoimmune cutaneous disorder reported to be related to various immunologic diseases and psychiatric disorders. Some AA patients report the onset of patchy hair loss after surgeries under general anesthesia (GA). However, no large-scale studies have been conducted on the relationship between AA and GA. Thus, we aimed to evaluate whether exposure to GA is associated with…
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- Hair loss after drug reaction with eosinophilia and systemic symptoms (DRESS): A multicentric retrospective case series. [Journal Article]J Dermatol. 2023 Jan 17 [Online ahead of print]JD
- Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous drug adverse reaction characterized by various cutaneous and systemic manifestations. However, reports on the various patterns of alopecia after DRESS are lacking. Thus, we aimed to describe cases of alopecia after DRESS and review the literature. This multicentric retrospective study reviewed the records of 182 p…
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- Activated Platelet Rich Plasma versus Non-Activated Platelet Rich Plasma in the Treatment of Alopecia Areata. [Journal Article]
- CONCLUSIONS: Data obtained in our research confirm that PRP is safe, effective, and well tolerated by patients as a treatment modality for alopecia areata. Besides, such a method is cost-effective as there is no need for any expensive tools for preparation and it can be done in outpatient clinics. Also, activation of PRP prior to injection is not mandatory as there was no statistically significant difference between both groups.
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- Global Guidelines in Dermatology Mapping Project (GUIDEMAP): a systematic review of alopecia areata clinical practice guidelines. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):100-107.CE
- CONCLUSIONS: We found a limited number of AA CPGs, all of which had significant methodological deficiencies. We encourage guideline development groups to use validated checklists/tools to develop reliable and trustworthy CPGs.
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- Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib-A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata. [Journal Article]Dermatol Ther (Heidelb). 2023 Jan 13 [Online ahead of print]DT
- Alopecia areata (AA) is a cell-mediated autoimmune disease in which a cytotoxic T-cell response against hair follicles occurs. AA has been demonstrated to frequently co-exist with atopic dermatitis (AD), and the coincidence of atopy predisposes to a more severe course of the disease. To date, therapeutic options in AA, especially in the pediatric population, are mainly limited to corticosteroids,…
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- Cutaneous manifestations of COVID-19 and COVID-19 vaccination. [Journal Article]J Dermatol. 2023 Jan 13 [Online ahead of print]JD
- In December 2019, a new infectious pathogen named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China. Transmitted through respiratory droplets, SARS-CoV-2 is the causative pathogen of coronavirus disease 2019 (COVID-19). Although this new COVID-19 infection is known to cause primarily interstitial pneumonia and respiratory failure, it is often associated w…
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- Parry Romberg Syndrome in a Young Ghanaian: A Case Report and a Literature Review. [Case Reports]
- Parry Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is a very rare self-limiting disease, which affects the skin and subcutaneous tissues, underlying musculature, cartilage, and bony structures of one half of the face with a resultant hemiatrophy and alopecia areata. It presents in children and young adults, with a slow progression of the atrophy for several years, and the…
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