- Greater ecologically-assessed positive experiences predict heightened sex hormone concentrations across two-weeks in older adults. [Journal Article]J Gerontol B Psychol Sci Soc Sci. 2023 Jan 28 [Online ahead of print]JG
- CONCLUSIONS: These findings suggest that sex hormones may be a pathway linking positive experiences to health in older adults.
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- Controlled ovarian hyperstimulation parameters are not associated with de novo chromosomal abnormality rates and clinical pregnancy outcomes in preimplantation genetic testing. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1080843.FE
- CONCLUSIONS: The rate of de novo chromosomal abnormalities was found to increase with maternal or paternal age. COH parameters were found to not influence the incidence of de novo chromosomal abnormalities or clinical pregnancy outcomes.
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- Multiple statistical models reveal specific volatile organic compounds affect sex hormones in American adult male: NHANES 2013-2016. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1076664.FE
- CONCLUSIONS: This study is an academic illustration of the association between VOCs exposure and sex hormones, suggesting that exposure to VOCs might be associated with sex hormone metabolic disorder in American adult males.
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- Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis. [Journal Article]Front Cardiovasc Med. 2022; 9:1062460.FC
- CONCLUSIONS: Overall, these results further suggest a more androgenic sex profile (higher free T and lower SHBG) is associated with a less favorable adipokine pattern. These findings may provide mechanistic insight into the interplay between sex hormones, adipokines, and CVD risk.
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- Elevated baseline LH/FSH ratio is associated with poor ovulatory response but better clinical pregnancy and live birth in Chinese women with PCOS after ovulation induction. [Journal Article]Heliyon. 2023 Jan; 9(1):e13024.H
- CONCLUSIONS: Elevated baseline LH/FSH ratio in women with PCOS was associated with poor ovulatory response, but women were more likely to achieve clinical pregnancy and live birth than women with normal LH/FSH. It suggests LH and FSH in women with PCOS may play a role in successful pregnancy despite of negative impact in ovulation.
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- Hormone-sleep interactions predict cerebellar connectivity and behavior in aging females. [Journal Article]Psychoneuroendocrinology. 2023 Jan 25; 150:106034.P
- Sex hormones fluctuate over the course of the female lifespan and are associated with brain health and cognition. Thus, hormonal changes throughout female adulthood, and with menopause in particular, may contribute to sex differences in brain function and behavior. Further, sex hormones have been correlated with sleep patterns, which also exhibit sex-specific impacts on the brain and behavior. As…
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- G-protein coupled estrogen receptor (GPER1) activation promotes synaptic insertion of AMPA receptors and induction of chemical LTP at hippocampal temporoammonic-CA1 synapses. [Journal Article]Mol Brain. 2023 Jan 28; 16(1):16.MB
- It is well documented that 17β estradiol (E2) regulates excitatory synaptic transmission at hippocampal Shaffer-collateral (SC)-CA1 synapses, via activation of the classical estrogen receptors (ERα and ERβ). Hippocampal CA1 pyramidal neurons are also innervated by the temporoammonic (TA) pathway, and excitatory TA-CA1 synapses are reported to be regulated by E2. Recent studies suggest a role for …
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- Biotransformation of bisphenol A in vivo and in vitro by laccase-producing Trametes hirsuta La-7: Kinetics, products, and mechanisms. [Journal Article]Environ Pollut. 2023 Jan 25 [Online ahead of print]EP
- Bisphenol A (BPA) is a ubiquitous endocrine disruptor that poses adverse human health risks. Herein, biotransformation kinetics, products, and mechanisms of BPA undergoing a laccase-producing Trametes hirsuta La-7 metabolism were for the first time reported. Strain La-7 could completely biotransform ≤0.5 mmol·L-1 BPA within 6 d in vivo. Notably, its extracellular crude laccase solution (ECLS) and…
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- Oxytocin enhances progesterone production with upregulation of BMP-15 activity by granulosa cells. [Journal Article]Biochem Biophys Res Commun. 2023 Jan 23; 646:103-109.BB
- To elucidate the reproductive role of oxytocin (OXT) in ovarian steroidogenesis and its functional interaction with bone morphogenetic proteins (BMPs), the effects of OXT on ovarian steroidogenesis were investigated by utilizing primary culture of rat granulosa cells and human granulosa KGN cells. Here we revealed that the OXT receptor was expressed in both rat and human granulosa cells and that …
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- Obesity is associated with alterations in antral follicle dynamics in eumenorrheic women. [Journal Article]Hum Reprod. 2023 Jan 27 [Online ahead of print]HR
- CONCLUSIONS: Eumenorrheic women with obesity display evidence of suppressed antral follicle dynamics as judged by fewer recruitment events, selectable follicles, and anovulatory dominant follicles, as well as lower anti-Müllerian hormone (AMH) concentrations and an increased prevalence of luteal phase defects.This study was limited to an assessment of antral follicle dynamics and cannot inform on earlier stages of folliculogenesis. This study was observational and cannot address causation between obesity and altered antral follicle dynamics. Lastly, the data cannot be extrapolated to account for reduced fecundity and fertility in obesity.The increasing global prevalence of obesity necessitates an understanding of the mechanisms that underlie obesity-related adverse reproductive health outcomes. Eumenorrheic women with obesity demonstrate altered ovarian antral follicle and endocrine dynamics compared to their counterparts without obesity. The degree to which abnormal granulosa cell assembly and/or activity underlie the suboptimal luteinization and subfertility requires further investigation.
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- [Estradiol regulates the expression of plasma membrane Ca2+-ATPase isoform 2 in inner ear of rats]. [Journal Article]Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec 07; 57(12):1484-1490.ZE
- Objective: To observe the effects of estradiol on expression of plasma membrane Ca2+-ATPase isoform 2 in inner ear of rats. Methods: Twenty-five Three-months-old female Sprague-Dawley rats were randomly and equally divided into five groups by random number table mathod,with five rats in each group. Animals in Sham group were sham-operated while others were bilateral ovariactmized. One month after…
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- [Susceptibility and mechanism of sodium salicylate-induced tinnitus model in low estrogen rats]. [Journal Article]Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec 07; 57(12):1479-1483.ZE
- Objective: The susceptibility of tinnitus rats with low estrogen level induced by sodium salicylate and the changes of tumor necrosis factor α (TNF-α) in serum were observed to investigate the relationship between tinnitus occurrence and estrogen level. Methods: Forty-two healthy female Wistar rats were randomly divided into control group(n=6), normal group(n=6), sham operation group(n=6) and ova…
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- Molecular and cellular mechanisms underlying brain region-specific endocannabinoid system modulation by estradiol across the rodent estrus cycle. [Journal Article]Prog Mol Biol Transl Sci. 2023; 195:27-45.PM
- Neurological crosstalk between the endocannabinoid and estrogen systems has been a growing topic of discussion over the last decade. Although the main estrogenic ligand, estradiol (E2), influences endocannabinoid signaling in both male and female animals, the latter experiences significant and rhythmic fluctuations in E2 as well as other sex hormones. This is referred to as the menstrual cycle in…
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- Exploration of the effect of simultaneous removal of EDCs in the treatment process of different types of wastewater. [Journal Article]Water Sci Technol. 2023 Jan; 87(2):436-453.WS
- The SPE-HPLC-MS/MS method was used to investigate the concentration distribution of nine types of estrogens in 18 locations of pollution source along the Jiuzhou River belonging to river systems in Guangdong province and Guangxi Zhuang autonomous region in China, and the estrogenic activity and potential ecological risks were evaluated by calculating the estradiol equivalency (EEQ). The results s…
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- Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway. [Journal Article]Immun Inflamm Dis. 2023 Jan; 11(1):e754.II
- CONCLUSIONS: We highlighted that extracellular histone H3 facilitated lipopolysaccharides-induced HUVEC ferroptosis via activating ROS/JNK pathway, and such an effect could be antagonized by E2.
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- Ethanol potentiates FSH action in ovarian granulosa cells. [Journal Article]J Endocrinol. 2023 Jan 01 [Online ahead of print]JE
- There are many previous reports on the effects of ethanol on physiological function, including reports of elevated blood estrogen levels in women who drank alcohol. However, the mechanism of ethanol's effects on ovarian functions, such as follicle development and hormone secretion, hasn't been fully clarified. Therefore, in this study, we investigated the impacts of ethanol on these phenomena and…
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- Genetic variation reveals the influence of steroid hormones on the risk of retinal neurodegenerative diseases. [Journal Article]
- It is difficult to get evidence from randomized trials of a causal relationship between steroid hormones produced by the adrenal gland and gonad and retinal neurodegenerative disorders (RND). In this study, genetic variations of aldosterone (Aldo), androstenedione (A4), progesterone (P4), hydroxyprogesterone (17-OHP), and testosterone/17β-estradiol (T/E2) were obtained from genome-wide associatio…
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- Intraovarian Administration of Autologous Menstrual Blood Derived-Mesenchymal Stromal Cells in Women with Premature Ovarian Failure. [Journal Article]Arch Med Res. 2023 Jan 24 [Online ahead of print]AM
- CONCLUSIONS: According to the findings of this study, administration of Men-MSCs improved ovarian function and menstrual restoration in some POF patients.
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- Studying paraben-induced estrogen receptor- and steroid hormone-related endocrine disruption effects via multi-level approaches. [Journal Article]Sci Total Environ. 2023 Jan 23 [Online ahead of print]ST
- Increasing concerns have been raised on the health risks of parabens in the regard of their widespread applications and potential endocrine disrupting activities. In this study, four typical parabens, including methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), and butyl paraben (BuP) were systematically investigated for their estrogen receptor- and steroid hormone-related endocrine…
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- Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study. [Journal Article]Drug Alcohol Depend. 2023 Jan 18; 244:109781.DA
- CONCLUSIONS: Testosterone and estradiol levels are altered in males and females with AD distinctly regardless of current drinking frequency. SHBG may play a critical role in these associations.
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- Gut Microbial Succession Patterns and Metabolic Profiling during Pregnancy and Lactation in a Goat Model. [Journal Article]Microbiol Spectr. 2023 Jan 26 [Online ahead of print]MS
- The maternal gut microbiome affects the duration of pregnancy, delivery, and lactation. It also coordinates the stability of maternal metabolism by regulating and modulating inflammatory cytokines and reproductive hormones. This has been shown in several species; however, the situation in ruminants remains a black box. Here, we aimed to elucidate the relationship between the hindgut microbiota, m…
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- Surrogate fostering of mice prevents prenatal estradiol-induced insulin resistance via modulation of the microbiota-gut-brain axis. [Journal Article]Front Microbiol. 2022; 13:1050352.FM
- Prenatal and early postnatal development are known to influence future health. We previously reported that prenatal high estradiol (HE) exposure induces insulin resistance in male mice by disrupting hypothalamus development. Because a foster dam can modify a pup's gut microbiota and affect its health later in life, we explored whether surrogate fostering could also influence glucose metabolism in…
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- Hormonal abnormalities in alexithymia. [Journal Article]Front Psychiatry. 2022; 13:1070066.FP
- Alexithymia is a personality trait characterized by difficulties in emotion recognition and regulation that is associated with deficits in social cognition. High alexithymia levels are considered a transdiagnostic risk factor for a range of psychiatric and medical conditions, including depression, anxiety, and autism. Hormones are known to affect social-emotional cognition and behavior in humans,…
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- Use of male-to-female sex reversal as a welfare scoring system in the protandrous farmed gilthead sea bream (Sparus aurata). [Journal Article]Front Vet Sci. 2022; 9:1083255.FV
- Gilthead sea bream is a highly cultured marine fish throughout the Mediterranean area, but new and strict criteria of welfare are needed to assure that the intensification of production has no negative effects on animal farming. Most welfare indicators are specific to a given phase of the production cycle, but others such as the timing of puberty and/or sex reversal are of retrospective value. Th…
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- GYNAECOMASTIA APPEARED THREE DAYS AFTER STARTING METHIMAZOLE. [Journal Article]Acta Endocrinol (Buchar). 2022 Jul-Sep; 18(3):398-400.AE
- We reported that in a 29-year-old male patient with hyperthyroidism, bilateral breast swelling appeared in three days after starting methimazole and gradually aggravated. Several days later, a small amount of transparent liquid could be squeezed out from bilateral mammary glands. Breast ultrasound confirmed gynaecomastia. The level of testosterone, estradiol and luteinizing hormone increased. Aft…
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- Poly(vinylidene fluoride) membrane with immobilized TiO2 for degradation of steroid hormone micropollutants in a photocatalytic membrane reactor. [Journal Article]J Hazard Mater. 2023 Jan 20; 447:130832.JH
- The lack of effective technologies to remove steroid hormones (SHs) from aquatic systems is a critical issue for both environment and public health. The performance of a flow-through photocatalytic membrane reactor (PMR) with TiO2 immobilized on a photostable poly(vinylidene fluoride) membrane (PVDF-TiO2) was evaluated in the context of SHs degradation at concentrations from 0.05 to 1000 µg/L und…
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- The effect of Cornus mas fruit extract on vasomotor symptoms and sex hormones in postmenopausal women: a randomized, double-blind, clinical trial. [Journal Article]Menopause. 2023 Feb 01; 30(2):201-207.M
- CONCLUSIONS: It has been found that the extract of C mas fruit has a favorable effect on vasomotor symptoms, sex hormones, and related complications in women experiencing menopausal symptoms.
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- Do correlates of white matter features differ between older men and women living with human immunodeficiency virus? [Journal Article]Menopause. 2023 Feb 01; 30(2):149-155.M
- CONCLUSIONS: Although sexually dimorphic interactions of reproductive hormones and total white matter volume were demonstrated, our study findings do not support a role for sex-based differences in reproductive hormones as predictive correlates of WMH in a small sample of older PLWH.
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- Sex-moderated relationship between the 2D:4D ratio and circulating hormones in an adult Ghanaian population. [Journal Article]
- The second-to-fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D ratio or the right-left difference (Dr-l) are said to be negative and positive correlates, respectively, of circulating testosterone and estrogen in both adult males and females. However, previous studies on the subject have reported mixed results. This study aimed to determine the sex-moderate…
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- Salivary crystallization pattern: a possible unconventional tool for timing of insemination and early pregnancy diagnosis in zebu cows. [Journal Article]J Dairy Res. 2023 Jan 25 [Online ahead of print]JD
- The present study assessed if salivary crystallization pattern (ferning pattern formed as a result of the higher levels of salt content in the dried sample) could be used for estrus detection and for diagnosis of pregnancy/non-pregnancy in dairy cows. Saliva and blood samples were collected from non-pregnant cycling cows (Sahiwal breed; n = 20) on alternate days from the day of estrus till next e…
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