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Unbound Medicine.
(Alpha adrenoceptor blocking agents)
2,709 results
  • A literature perspective on the pharmacological applications of yohimbine. [Review]
    Ann Med. 2022 12; 54(1):2861-2875.Jabir NR, Firoz CK, … Tabrez S
  • Introduction: Phytochemicals have garnered much attention because they are useful in managing several human diseases. Yohimbine is one such phytochemical with significant pharmacological potential and could be exploited for research by medicinal chemists. It is an indole alkaloid obtained from various natural/synthetic sources.Aims and Results: The research on yohimbine started early, and its use…
  • Adrenergic Control of Primo Tissue Size in Rats. [Journal Article]
    J Acupunct Meridian Stud. 2022 Feb 28; 15(1):25-36.Shen Y, Kim YJ, Ryu PD
  • CONCLUSIONS: Adrenergic signaling controls hyperplastic changes in the organ surface PVS in rats. These findings may explain the morphological dynamics of the PVS tissues proposed by Bong Han Kim and further clarify the pathophysiological roles of the PVS.
  • Deleterious effects of levamisole, a cocaine adulterant, in rabbit aorta. [Journal Article]
    Vascul Pharmacol. 2022 06; 144:106992.Guerra-Ojeda S, Marchio P, … Vila JM
  • Levamisole, a veterinary anthelmintic drug, is one of the most widely used and dangerous cocaine adulterants. Like cocaine, levamisole acutely blocks noradrenaline reuptake but with much less potency, although its vascular effects are not well known. In this study, we evaluated the vascular effects of levamisole and cocaine in rabbit aortic rings used for isometric recording of tension in organ b…
  • A Review of Antipsychotics and Priapism. [Review]
    Sex Med Rev. 2021 07; 9(3):464-471.Hwang T, Shah T, Sadeghi-Nejad H
  • CONCLUSIONS: Clinicians should educate patients treated with antipsychotics about the potential for priapism and its sequelae including permanent erectile dysfunction. Appropriate patient education will raise awareness, encourage early reporting, and help reduce the long-term consequences associated with priapism through early intervention. Hwang T, Shah T,Sadeghi-NejadH. A Review of Antipsychotics and Priapism. Sex Med Rev 2021;9:464-471.
  • Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes. [Journal Article]
    Biochem Pharmacol. 2020 12; 182:114263.Fusi F, Mugnai P, … Sgaragli G
  • Seventeen compounds, rather selective, direct or indirect inhibitors and activators of PKA, PKG, and PKC, were analysed for effects on vascular CaV1.2 channel current (ICa1.2) by using the patch-clamp technique in single rat tail artery myocytes. The aim was to investigate how PKs regulate ICa1.2 and disclose any unexpected modulation of CaV1.2 channel function by these agents. The cAMP analogues…
  • Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome. [Journal Article]
    Eur J Pharmacol. 2020 Nov 15; 887:173565.Nozu T, Miyagishi S, … Okumura T
  • An impaired gut barrier, possibly leading to visceral hypersensitivity has been recently recognized to be one of the pivotal pathophysiology of irritable bowel syndrome (IBS). We previously showed that lipopolysaccharide (LPS), corticotropin-releasing factor (CRF), and repeated water avoidance stress (WAS) induce visceral hypersensitivity and colonic hyperpermeability via pro-inflammatory cytokin…
  • Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue. [Journal Article]
    Exp Neurol. 2020 11; 333:113428.Irvine KA, Sahbaie P, … Clark JD
  • Chronic pain is one of the most challenging and debilitating symptoms to manage after traumatic brain injury (TBI), yet the underlying mechanisms remain elusive. The disruption of normal endogenous pain control mechanisms has been linked to several forms of chronic pain and may play a role in pain after TBI. We hypothesized therefore that dysfunctional descending noradrenergic and serotonergic pa…
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