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Unbound Medicine.
(Alpha glucosidase inhibitors)
7,648 results
  • Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges. [Review]
    Eur J Med Chem. 2023 Jan 17; 249:115119.Mushtaq A, Azam U, … Naseer MM
  • Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. It is a well-recognized multifactorial health problem contributes significantly to high mortality rates by causing serious health complications mainly related to cardiovascular diseases, kidney damage and neuropathy. The inhibition of α-glucosidase (enzyme that catalyses starch hydrolysis in the i…
  • α-Amylase and α-glucosidase inhibitors from the aerial parts of Chamaecrista pumila (Lam.) K. Larsen. [Journal Article]
    Nat Prod Res. 2023 Jan 20 [Online ahead of print]Bui Thi Thuy L, Vu Thanh B, … Nguyen Manh T
  • One new compound, 4,7-dihydroxy-2-hydroxymethyl-5,6-dimethoxyanthraquinone (1), along with eight known compounds (2-9) were isolated from the methanol extracts of the aerial parts of Chamaecrista pumila (Lam.) K. Larsen. Their chemical structure was determined based on spectroscopic data interpretation and comparison with the reported data. The inhibitory effects of them on α-amylase and α-glucos…
  • Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents. [Journal Article]
    Future Med Chem. 2023 Jan 16 [Online ahead of print]Asuquo IG, Solangi M, … Taha M
  • Background: Diabetes mellitus is a serious global health concern, and this is expected to impact more than 300 million people by 2025. The current study focuses on identifying substituted indolin-2-one-based inhibitors for two indispensable drug targets, α-amylase and α-glucosidase. Methods: The structures of synthetic compounds were confirmed by spectroscopic techniques and evaluated for enzyme …
  • Pyrazole scaffold-based derivatives: A glimpse of α-glucosidase inhibitory activity, SAR, and route of synthesis. [Review]
    Arch Pharm (Weinheim). 2023 Jan 08 [Online ahead of print]Firdaus JU, Siddiqui N, … Chandra K
  • The α-glucosidase is a validated target to develop drugs for treating type 2 diabetes mellitus. The existing α-glucosidase inhibitors have certain shortcomings related to side effects and route of synthesis. Accordingly, it is inevitable to develop new chemical templates as α-glucosidase inhibitors. Pyrazole derivatives have a special place in medicinal chemistry because of various biological act…
  • In Vitro Evaluation of Antidiabetic Potential of Cleistocalyx nervosum var. paniala Fruit Extract. [Journal Article]
    Plants (Basel). 2022 Dec 26; 12(1)Chukiatsiri S, Wongsrangsap N, … Choowongkomon K
  • Diabetes mellitus is a complex global public health condition. Medicinal plants are significant resources in the research of alternative new drug active compounds. Cleistocalyx nervosum var. paniala (C. nervosum) is an indigenous berry fruit widely grown in Southeast Asia. The fruit of C. nervosum exhibit various medicinal properties and health benefits. This study aimed to investigate antidiabet…
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