Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
(Alpha particles radiation reactions from)
316 results
  • DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT). [Review]
    Enzymes. 2022; 51:65-78.Kondo N
  • Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (10B) compound via intravenous injection or infusion, and when 10B is sufficiently accumulated in the tumor, neutron beams containing epithermal neutrons as the main component are irradiated. Epithermal neutrons lose energy in the body and be…
  • In situ investigation of the formation mechanism of α-Bi2Rh nanoparticles in polyol reductions. [Journal Article]
    Dalton Trans. 2022 Nov 21; 51(45):17405-17415.Smuda M, Ströh J, … Doert T
  • The synthesis of intermetallic phases formed from elements with very different melting points is often time and energy consuming, and in extreme cases the evaporation of a reactant may even prevent formation completely. An alternative, facile synthesis approach is the reduction of metal salts in the polyol process, which requires only moderate temperatures and short reaction times. In addition, t…
  • On the effectiveness of proton boron fusion therapy (PBFT) at cellular level. [Journal Article]
    Sci Rep. 2022 10 27; 12(1):18098.Shahmohammadi Beni M, Islam MR, … Watabe H
  • The present work introduced a framework to investigate the effectiveness of proton boron fusion therapy (PBFT) at the cellular level. The framework consisted of a cell array generator program coupled with PHITS Monte Carlo package with a dedicated terminal-based code editor that was developed in this work. The framework enabled users to model large cell arrays with normal, all boron, and random b…
  • A Review of Boron Neutron Capture Therapy: Its History and Current Challenges. [Review]
    Int J Part Ther. 2022 Summer; 9(1):71-82.Jin WH, Seldon C, … Giap HB
  • External beam, whether with photons or particles, remains as the most common type of radiation therapy. The main drawback is that radiation deposits dose in healthy tissue before reaching its target. Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when 10B is irradiated with low-energy (0.0025 eV) thermal neutrons. The resulting 10B(n,α)7Li ca…
  • Effect of boron compounds on the biological effectiveness of proton therapy. [Journal Article]
    Med Phys. 2022 Sep; 49(9):6098-6109.Manandhar M, Bright SJ, … Sawakuchi GO
  • CONCLUSIONS: Treatment with 11 B, at concentrations of 80.4 ppm from BSH or 86.9 ppm from BPA, had no effect on the biological effectiveness of proton beams in DU145 prostate cancer cells. Our results agree with published theoretical calculations indicating that the contribution of alpha particles from such reactions to the total absorbed dose and biological effectiveness is negligible. We also found that BSH radiosensitized DU145 cells to X-rays, low-LET protons, and high-LET protons but that the radiosensitization was not related to DNA damage.
  • Revealing the crystal phases of primary particles formed during the coprecipitation of iron oxides. [Journal Article]
    Chem Commun (Camb). 2022 May 10; 58(38):5749-5752.Mao Y, Zhang Z, … Gu N
  • The mechanistic investigation of the coprecipitation formation of iron oxides has been a long-standing challenge due to the rapid reaction kinetics and high complexity of iron hydrolysis reactions. Although a few studies have suggested that the coprecipitation of iron oxide nanoparticles follows a non-classic route through inter-particle attachment, the compositions of the primary particles remai…
  • Production cross sections of 52Mn in alpha-particle-induced reactions on natural vanadium. [Journal Article]
    Appl Radiat Isot. 2022 Jun; 184:110204.Gantumur D, Aikawa M, … Haba H
  • Activation cross sections of alpha-particle-induced reactions on natural vanadium were measured. The production cross sections of 54, 52gMn, 51Cr, 48V, and 47, 46gSc were determined up to 50 MeV. The stacked-foil activation technique and high-resolution gamma-ray spectrometry were used. The experimental results were compared with previous experimental data and theoretical calculations in the TEND…
  • New method for production of 155Tb via 155Dy by irradiation of natGd by medium energy alpha particles. [Journal Article]
    Nucl Med Biol. 2022 Mar-Apr; 106-107:52-61.Moiseeva AN, Aliev RA, … Unezhev VN
  • CONCLUSIONS: The developed method allows the production of therapeutic amounts of 155Tb with acceptable radionuclidic purity without the need for isotopically enriched materials. The amount of 155Tb is sufficient for its use in Auger therapy, as well as for preclinical studies of the suitability of SPECT preparations in laboratory animals. Nevertheless, to obtain higher activities, a longer irradiation time and a higher projectile current are proposed. The 153Tb radionuclide present in the final preparation has a shorter half-life than the target radionuclide, and its hard γ-lines have a probability of emission of less than 1%, from which it can be concluded that the negative effect will not be significant. However, a product of this purity and type of contamination requires additional testing for toxicity in living organisms. The final sample also includes a certain amount of 157Tb (T1/2 = 71 a, the only γ-line 54.5 keV Iγ = 0.0084%), which will complicate the labeling conditions. Thus, more research is needed in the labeling area. It should be noted that the use of gadolinium enriched in the 155Gd or 156Gd nuclide as a target will help not only reduce the amount of impurities but also increase the yield of 155Tb.
  • Technical note: Monte Carlo study of the mechanism of proton-boron fusion therapy. [Journal Article]
    Med Phys. 2022 Jan; 49(1):579-582.Meyer HJ, Titt U, Mohan R
  • CONCLUSIONS: Our findings do not support the theory that an alpha particle-based mechanism is responsible for the enhanced biological effectiveness of proton-boron fusion therapy. We conclude that any enhanced biological effect seen in experimental studies was not caused by fusion reactions between protons and 11 B nuclei. However, it is necessary to reproduce the past experiments that indicated significant dose enhancement.
  • The basis and advances in clinical application of boron neutron capture therapy. [Review]
    Radiat Oncol. 2021 Nov 07; 16(1):216.He H, Li J, … Wang J
  • Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclear reaction that occurs when 10B capture low-energy thermal neutrons to yield high-linear energy transfer (LE…
  • Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals. [Journal Article]
    Acc Chem Res. 2021 Aug 05 [Online ahead of print]Guérard F, Maingueneau C, … Galland N
  • ConspectusAstatine (At) is the rarest on Earth of all naturally occurring elements, situated below iodine in the periodic table. While only short-lived isotopes (t1/2 ≤ 8.1 h) are known, 211At is the object of growing attention due to its emission of high-energy alpha particles. Such radiation is highly efficient to eradicate disseminated tumors, provided that the radionuclide is attached to a ca…
  • Alpha emitting nuclides for targeted therapy. [Review]
    Nucl Med Biol. 2021 01; 92:228-240.Hatcher-Lamarre JL, Sanders VA, … Francesconi LC
  • Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives s…
  • Colocalization of tracks from boron neutron capture reactions and images of isolated cells. [Journal Article]
    Appl Radiat Isot. 2021 Jan; 167:109353.Postuma I, Sommi P, … Altieri S
  • In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with i…
New Search Next