- Use of a neural network-based prediction method to calculate the therapeutic dose in boron neutron capture therapy of patients with glioblastoma. [Journal Article]Med Phys. 2023 Jan 17 [Online ahead of print]MP
- CONCLUSIONS: This study proposes a 3D dose prediction method based on 3D-UNET architecture in BNCT, and the feasibility of this method is demonstrated. Results indicate that the method can remarkably reduce the time required for calculation and ensure the accuracy of the predicted 3D therapeutic dose-effect. This work is expected to promote the clinical development of BNCT in the future.
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- Exploring the Physical and Biological Aspects of BNCT with a Carboranylmethylbenzo[b]acridone Compound in U87 Glioblastoma Cells. [Journal Article]
- Boron neutron capture therapy (BNCT) is a re-emerging technique for selectively killing tumor cells. Briefly, the mechanism can be described as follows: after the uptake of boron into cells, the thermal neutrons trigger the fission of the boron atoms, releasing the α-particles and recoiling lithium particles and high-energy photons that damage the cells. We performed a detailed study of the react…
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- DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT). [Review]Enzymes. 2022; 51:65-78.E
- Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (10B) compound via intravenous injection or infusion, and when 10B is sufficiently accumulated in the tumor, neutron beams containing epithermal neutrons as the main component are irradiated. Epithermal neutrons lose energy in the body and be…
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- In situ investigation of the formation mechanism of α-Bi2Rh nanoparticles in polyol reductions. [Journal Article]Dalton Trans. 2022 Nov 21; 51(45):17405-17415.DT
- The synthesis of intermetallic phases formed from elements with very different melting points is often time and energy consuming, and in extreme cases the evaporation of a reactant may even prevent formation completely. An alternative, facile synthesis approach is the reduction of metal salts in the polyol process, which requires only moderate temperatures and short reaction times. In addition, t…
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- SYNTHESIS OF LIF:MG,TI NANOPARTICLES BY CO-PRECIPITATION METHOD AND EVALUATION OF INCREASING THE 5A/5 RATIO IN ALPHA AND GAMMA RADIATION. [Journal Article]Radiat Prot Dosimetry. 2023 Jan 04; 199(1):1-10.RP
- The peak 5 in LiF: Mg, Ti includes sub-peaks 5a and 5b, which occur at the temperatures lower and higher than that of peak 5, respectively. Peak 5a in LiF:Mg,Ti occurs due to the localized recombination of trapping/luminescence center (TC/LC), in which the electron is released from the electron trap by obtaining energy from heat and recombines through the tunneling phenomenon with a hole located …
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- On the effectiveness of proton boron fusion therapy (PBFT) at cellular level. [Journal Article]
- The present work introduced a framework to investigate the effectiveness of proton boron fusion therapy (PBFT) at the cellular level. The framework consisted of a cell array generator program coupled with PHITS Monte Carlo package with a dedicated terminal-based code editor that was developed in this work. The framework enabled users to model large cell arrays with normal, all boron, and random b…
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- Systems Biology Approach to Investigate Biomarkers, Boron-10 Carriers, and Mechanisms Useful for Improving Boron Neutron Capture Therapy. [Journal Article]Cancer Biother Radiopharm. 2022 Oct 21 [Online ahead of print]CB
- Systems biology approach, carried out with high-throughput omics technologies, has become a fundamental aspect of the study of complex diseases like cancer. It can molecularly characterize subjects, physiopathological conditions, and interactions, allowing a precise description, to reach personalized medicine. In particular, proteomics, typically performed with liquid chromatography coupled to ma…
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- Production cross sections of samarium-153 and -145 via alpha-particle-induced reactions on natural neodymium. [Journal Article]Appl Radiat Isot. 2022 Sep; 187:110345.AR
- Production cross sections of 153,145Sm via alpha-particle-induced reactions on natNd were measured up to 23 MeV. The stacked-foil activation technique and high-resolution gamma-ray spectrometry were adopted for the measurement. The obtained cross sections were compared with the literature data and the TENDL-2019 and TENDL-2021 values. Physical thick target yields of the two radionuclides were der…
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- A Review of Boron Neutron Capture Therapy: Its History and Current Challenges. [Review]
- External beam, whether with photons or particles, remains as the most common type of radiation therapy. The main drawback is that radiation deposits dose in healthy tissue before reaching its target. Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when 10B is irradiated with low-energy (0.0025 eV) thermal neutrons. The resulting 10B(n,α)7Li ca…
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- Effect of boron compounds on the biological effectiveness of proton therapy. [Journal Article]Med Phys. 2022 Sep; 49(9):6098-6109.MP
- CONCLUSIONS: Treatment with 11 B, at concentrations of 80.4 ppm from BSH or 86.9 ppm from BPA, had no effect on the biological effectiveness of proton beams in DU145 prostate cancer cells. Our results agree with published theoretical calculations indicating that the contribution of alpha particles from such reactions to the total absorbed dose and biological effectiveness is negligible. We also found that BSH radiosensitized DU145 cells to X-rays, low-LET protons, and high-LET protons but that the radiosensitization was not related to DNA damage.
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- Effects of combining some theoretical models in the cross-section calculations of some alpha-induced reactions for natSb. [Journal Article]Appl Radiat Isot. 2022 Aug; 186:110255.AR
- In cases where it is not possible to obtain the cross-section values experimentally due to various factors, the importance of obtaining them with theoretical models has been explained in many studies available in the literature. In this context, the comparison of the cross-section values obtained by using the theoretical models with the experimental data will also be very beneficial for updating …
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- Revealing the crystal phases of primary particles formed during the coprecipitation of iron oxides. [Journal Article]Chem Commun (Camb). 2022 May 10; 58(38):5749-5752.CC
- The mechanistic investigation of the coprecipitation formation of iron oxides has been a long-standing challenge due to the rapid reaction kinetics and high complexity of iron hydrolysis reactions. Although a few studies have suggested that the coprecipitation of iron oxide nanoparticles follows a non-classic route through inter-particle attachment, the compositions of the primary particles remai…
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- Production cross sections of 52Mn in alpha-particle-induced reactions on natural vanadium. [Journal Article]Appl Radiat Isot. 2022 Jun; 184:110204.AR
- Activation cross sections of alpha-particle-induced reactions on natural vanadium were measured. The production cross sections of 54, 52gMn, 51Cr, 48V, and 47, 46gSc were determined up to 50 MeV. The stacked-foil activation technique and high-resolution gamma-ray spectrometry were used. The experimental results were compared with previous experimental data and theoretical calculations in the TEND…
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- New method for production of 155Tb via 155Dy by irradiation of natGd by medium energy alpha particles. [Journal Article]Nucl Med Biol. 2022 Mar-Apr; 106-107:52-61.NM
- CONCLUSIONS: The developed method allows the production of therapeutic amounts of 155Tb with acceptable radionuclidic purity without the need for isotopically enriched materials. The amount of 155Tb is sufficient for its use in Auger therapy, as well as for preclinical studies of the suitability of SPECT preparations in laboratory animals. Nevertheless, to obtain higher activities, a longer irradiation time and a higher projectile current are proposed. The 153Tb radionuclide present in the final preparation has a shorter half-life than the target radionuclide, and its hard γ-lines have a probability of emission of less than 1%, from which it can be concluded that the negative effect will not be significant. However, a product of this purity and type of contamination requires additional testing for toxicity in living organisms. The final sample also includes a certain amount of 157Tb (T1/2 = 71 a, the only γ-line 54.5 keV Iγ = 0.0084%), which will complicate the labeling conditions. Thus, more research is needed in the labeling area. It should be noted that the use of gadolinium enriched in the 155Gd or 156Gd nuclide as a target will help not only reduce the amount of impurities but also increase the yield of 155Tb.
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- First optical observation of 10B-neutron capture reactions using a boron-added liquid scintillator for quality assurance in boron neutron capture therapy. [Journal Article]Radiol Phys Technol. 2022 Mar; 15(1):37-44.RP
- 10B-neutron capture was observed optically using a boron-added liquid scintillator. Trimethyl borate was dissolved in a commercially available liquid scintillator at natural boron concentrations of approximately 1 wt% and 0.25 wt%. The boron-added liquid scintillator was placed in a phantom quartz bottle and irradiated by thermal neutrons (~ 105 n/[cm2 s]) for 150, 300, and 600 s. The luminescenc…
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- Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with 10B-Borocaptate Sodium (BSH) and 10B-Paraboronophenylalanine (BPA). [Review]
- Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly from the 10B(n, α7Li reaction. BNCT can minimize the dose to normal tissues, but it must be performed within the tolerable range of normal tissues. …
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- Technical note: Monte Carlo study of the mechanism of proton-boron fusion therapy. [Journal Article]
- CONCLUSIONS: Our findings do not support the theory that an alpha particle-based mechanism is responsible for the enhanced biological effectiveness of proton-boron fusion therapy. We conclude that any enhanced biological effect seen in experimental studies was not caused by fusion reactions between protons and 11 B nuclei. However, it is necessary to reproduce the past experiments that indicated significant dose enhancement.
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- The basis and advances in clinical application of boron neutron capture therapy. [Review]
- Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclear reaction that occurs when 10B capture low-energy thermal neutrons to yield high-linear energy transfer (LE…
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- Targeted Alpha Particle Therapy Remodels the Tumor Microenvironment and Improves Efficacy of Immunotherapy. [Journal Article]
- CONCLUSIONS: Combining TAT and ACT seems to transiently remodel the cold TME, improving ACT efficiency. The immune response then leads to the establishment of other tumor cell resistance mechanisms.
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- Advances in the Chemistry of Astatine and Implications for the Development of Radiopharmaceuticals. [Journal Article]
- ConspectusAstatine (At) is the rarest on Earth of all naturally occurring elements, situated below iodine in the periodic table. While only short-lived isotopes (t1/2 ≤ 8.1 h) are known, 211At is the object of growing attention due to its emission of high-energy alpha particles. Such radiation is highly efficient to eradicate disseminated tumors, provided that the radionuclide is attached to a ca…
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- Development of a DNA damage model that accommodates different cellular oxygen concentrations and radiation qualities. [Journal Article]
- CONCLUSIONS: We developed a DNA damage model to evaluate the oxygen effect and provide evidence that a reaction-kinetic model of DNA-derived radicals induced by ionizing radiation suffices to explain the observed oxygen effects. Therefore, the DICOLDD model is a powerful tool for the analysis of cellular responses at different OCs after exposure to different types of radiation.
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- The Proton-Boron Reaction Increases the Radiobiological Effectiveness of Clinical Low- and High-Energy Proton Beams: Novel Experimental Evidence and Perspectives. [Journal Article]
- Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose to the tumor target but is generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) is a novel approach aimed at enhancing proton biological effectiveness. PBCT exploits a nuclear fusion reaction between low-energy protons and …
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- First spatially resolved measurements of the D-3He α-particle source with the upgraded JET gamma-ray camera. [Journal Article]Rev Sci Instrum. 2021 May 01; 92(5):053529.RS
- The Joint European Torus (JET) gamma-ray camera has been recently upgraded with the installation of new gamma-ray detectors, based on LaBr3(Ce) scintillation crystals, which add spectroscopic capability to the existing system allowing measurements with good energy resolution (5% at 0.622 MeV), a dynamic range from hundreds of keV up to about 30 MeV, and high counting rate capabilities of MCps. Fi…
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- Aqueous-phase fates of α-alkoxyalkyl-hydroperoxides derived from the reactions of Criegee intermediates with alcohols. [Journal Article]
- In the atmosphere, carbonyl oxides known as Criegee intermediates are produced mainly by ozonolysis of volatile organic compounds containing C[double bond, length as m-dash]C double bonds, such as biogenic terpenoids. Criegee intermediates can react with OH-containing species to produce labile organic hydroperoxides (ROOHs) that are taken up into atmospheric condensed phases. Besides water, alcoh…
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- Radioimmunotherapy with an 211 At-labeled anti-tissue factor antibody protected by sodium ascorbate. [Journal Article]
- Tissue factor (TF), the trigger protein of the extrinsic blood coagulation cascade, is abundantly expressed in various cancers including gastric cancer. Anti-TF monoclonal antibodies (mAbs) capable of targeting cancers have been successfully applied to armed antibodies such as antibody-drug conjugates (ADCs) and molecular imaging probes. We prepared an anti-TF mAb, clone 1084, labeled with astati…
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- Synthesis and preliminary evaluation of 211At-labeled inhibitors of prostate-specific membrane antigen for targeted alpha particle therapy of prostate cancer. [Journal Article]
- CONCLUSIONS: Compared with the first generation compound [211At]DCABzL, several of the novel 211At-labeled PSMA ligands exhibited markedly improved stability in vivo and higher tumor-to-normal tissue ratios. [211At]GV-620 has the most promising characteristics and warrants further evaluation as a targeted radiotherapeutic for prostate cancer.
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- Alpha emitting nuclides for targeted therapy. [Review]
- Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives s…
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- Glioma Stem-Like Cells Can Be Targeted in Boron Neutron Capture Therapy with Boronophenylalanine. [Journal Article]
- As glioma stem cells are chemo- and radio-resistant, they could be the origins of recurrent malignant glioma. Boron neutron capture therapy (BNCT) is a tumor-selective particle radiation therapy. 10B(n,α)7Li capture reaction produces alpha particles whose short paths (5-9 µm) lead to selective killing of tumor cells. P-boronophenylalanine (BPA) is a chemical compound used in clinical trials for B…
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- Radiofrequency at 2.45 GHz increases toxicity, pro-inflammatory and pre-apoptotic activity caused by black carbon in the RAW 264.7 macrophage cell line. [Journal Article]
- Environmental factors such as air pollution by particles and/or electromagnetic fields (EMFs) are studied as harmful agents for human health. We analyzed whether the combined action of EMF with fine and coarse black carbon (BC) particles induced cell damage and inflammatory response in RAW 264.7 cell line macrophages exposed to 2.45 GHz in a gigahertz transverse electromagnetic (GTEM) chamber at …
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- Colocalization of tracks from boron neutron capture reactions and images of isolated cells. [Journal Article]Appl Radiat Isot. 2021 Jan; 167:109353.AR
- In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with i…
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