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45,268 results
  • Protein S Deficiency with Recurrent Deep Vein Thrombosis and Post Thrombotic Syndrome: A Case Report. [Journal Article]
    JNMA J Nepal Med Assoc. 2022 Oct 01; 60(254):892-894.Neupane S, Pudasaini P, … Subedi B
  • Protein S is a vitamin K-dependent protein that acts as a break in secondary hemostasis by inactivating activated factor V and activated factor VIII. We report a case of a 40 years old male who had the first episode of deep vein thrombosis of the left lower limb 10 years back, which despite treatment, reoccurred 3 months later in the bilateral lower limb. Thrombophilic screening showed severe pro…
    Georgian Med News. 2022 NovTsiourantani F, Koutouzis M, … Politou M
  • The laboratory detection of factors that participate in coagulation mechanisms in patients with coronary heart disease may lead to important findings regarding the contribution of endothelial function to atherosclerotic lesions of coronary arteries. The main purpose of this study was to investigate the role of high-sensitivity C-reactive protein (hs-CRP), von Willebrand factor (vWF) activity, thr…
  • Therapeutic potential of fetal liver cells transplantation in hemophilia A mice. [Journal Article]
    Haematologica. 2023 Jan 26 [Online ahead of print]Merlin S, Akula S, … Follenzi A
  • Hemophilia A (HA) cell therapy approaches in pediatric individuals require suitable factor (F)VIII-producing cells for stable engraftment. Liver sinusoidal endothelial cells (LSEC) and hematopoietic stem cells (HSC) have been demonstrated to be suitable for the treatment of adult HA-mice. However, after transplantation in busulfan (BU)-conditioned newborn mice, adult LSEC/HSC cannot efficiently e…
  • Acquired Hemophilia A In Adults: A Multicenter Study from Turkey. [Journal Article]
    Indian J Hematol Blood Transfus. 2023 Jan; 39(1):107-115.Arslan Davulcu E, Demirci Z, … Şahin F
  • Acquired hemophilia A (AHA) is a rare disease caused by autoantibodies inhibiting factor VIII (FVIII) activity. Although the conditionis usually idiopathic, there may be other underlying diseases. Treatment consists of two steps: treatment of acute bleeding and immunosuppression. In this multicenter study, we aimed to demonstrate the clinical characteristics, management details, and survival of A…
  • The relative risk of ischemic cerebrovascular accident in patients with Von Willebrand disease. [Journal Article]
    J Investig Med. 2023 Jan 25 [Online ahead of print]Olagunju A, Mihyawi N, … Yeneneh BT
  • Cerebrovascular accident (CVA) is one of the leading causes of death in the United States. Von Willebrand factor plays an important role in platelet activation and adhesion. It remains unclear whether Von Willebrand disease (vWD) is associated with a decreased risk of developing CVA. The study aimed to compare the relative risk (RR) of CVA in patients with and without vWD. We queried the National…
  • COVID-19-associated myocardial injury: A case report. [Case Reports]
    ESC Heart Fail. 2023 Jan 24 [Online ahead of print]Tadokoro T, Ohta-Ogo K, … Tashiro H
  • Coronavirus disease 2019 (COVID-19) is often accompanied by pneumonia and can be fatal. We report a case of COVID-19-associated myocardial injury mimicking fulminant myocarditis. Endomyocardial biopsy revealed numerous von Willebrand factor-rich microthrombi with small myocardial necrotic areas, complement deposits in small vessels/microthrombi, and macrophage-predominant interstitial infiltratio…
  • Gene therapy for hemophilia: looking beyond factor expression. [Review]
    Exp Biol Med (Maywood). 2023 Jan 23 [Online ahead of print]Yamaguti-Hayakawa GG, Ozelo MC
  • Hemophilia A (factor VIII [FVIII] deficiency) and hemophilia B (factor IX [FIX] deficiency) are the X-linked recessive bleeding disorders that clinically manifest with recurrent bleeding, predominantly into muscles and joints. In its severe presentation, when factor activity is less than 1% of normal, hemophilia presents with spontaneous musculoskeletal bleeds and may progress to debilitating chr…
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