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2,950 results
  • Comparative efficacy of antihypertensive drugs in dogs: a systematic review. [Journal Article]
    Top Companion Anim Med. 2022 May 28 [Online ahead of print]Choi HI, Kim J, … Kim HJ
  • Systemic arterial hypertension is a health condition causing target organ damage (TOD) in dogs. Early and effective treatment is essential to prevent hypertensive emergencies and to reduce the risk of TOD. This study investigated the diseases underlying hypertension and compared the short-term efficacy of antihypertensive drugs in dogs. We evaluated the medical records of client-owned dogs treate…
  • Minimal Change Disease in an Adult: A Case Report. [Case Reports]
    JNMA J Nepal Med Assoc. 2022 Apr 15; 60(248):399-401.Neupane S, Pudasaini P, … Roka K
  • Minimal change disease is an important cause of nephrotic syndrome in children, however, few cases are seen among adults. There is very little literature regarding the occurrence of minimal change disease in adults. We reported a case of a 63-year-old male who presented with the complaint of swelling around the eyes mostly during the morning for 18 days and frothing of urine for 7 days. On examin…
  • QT shortening: a proarrhythmic safety surrogate measure or an inappropriate indicator of it? [Journal Article]
    Curr Med Res Opin. 2022 Jun 14 [Online ahead of print]Tanti A, Micallef B, … Borg JJ
  • CONCLUSIONS: From a regulatory perspective one cannot refute the possibility of a clinically relevant risk from QT shortening through the current testing requirements. Lack of further investigations into any potential morphological changes to the AP, or APD90 shortening beyond a specified threshold in our opinion does not fully exclude the possibility of proarrhythmic effects of active substances.
  • Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells. [Journal Article]
    Int J Mol Sci. 2022 May 04; 23(9)Caputo I, Caroccia B, … Rossi GP
  • Blockers of the renin-angiotensin system (RAS) have been reported to increase the angiotensin converting enzyme (ACE)2, the cellular receptor of SARS-CoV-2, and thus the risk and course of COVID-19. Therefore, we investigated if angiotensin (Ang) II and RAS blockers affected ACE2 expression and SARS-CoV-2 infectivity in human epithelial bronchial Calu-3 cells. By infectivity and spike-mediated ce…
  • Novel Therapies for Alport Syndrome. [Review]
    Front Med (Lausanne). 2022; 9:848389.Chavez E, Rodriguez J, … Fornoni A
  • Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria and progressive kidney failure. It is characterized by a defective glomerular basement membrane caused by mutations in type IV collagen genes COL4A3/A4/A5 which result in defective type IV collagen α3, α4, or α5 chains, respectively. Alport syndrome has three different patterns of inheritance: X-linked, aut…
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