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(Altered mental status)
3,610 results
  • Cefepime-induced encephalopathy (CIE): Neural mass modeling of triphasic wave-like generalized periodic discharges with a high negative component (Tri-HNC). [Journal Article]
  • PCPsychiatry Clin Neurosci 2018 Oct 29
  • Tamune H, Hamamoto Y, … Yamamoto N
  • CONCLUSIONS: Since CIE is iatrogenic and continues unless cefepime is stopped, early recognition is crucial. Physicians should be vigilant about altered mental status, pain, and verbal changes in patients taking cefepime. Tri-HNC on EEG can expedite the diagnosis of CIE, and the association between Tri-HNC and CIE suggested that an excitatory and inhibitory (E/I) imbalance due to the dysfunction of GABAergic interneurons was the underlying mechanism. This modeling may offer a new method of investigating disorders related to GABAergic dysfunction. This article is protected by copyright. All rights reserved.
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