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Unbound Medicine.
(Altitude sickness)
5,165 results
  • Flying to high-altitude destinations: is the risk of acute mountain sickness greater? [Journal Article]
    J Travel Med. 2023 Jan 25 [Online ahead of print]Burtscher J, Swenson ER, … Burtscher M
  • CONCLUSIONS: Due to the short time span in going from low to high altitude, reduced acclimatization likely is the main reason for a higher AMS risk when travelling to high altitude destinations by flight. To avoid frustrating travel experiences and health risks, appropriate and timely medical advice on how to prepare for air travel to high-altitude is of vital importance. Effective preparation options include the use of modern pre-acclimatization strategies and pharmacological prophylaxis by acetazolamide or dexamethasone, or even considering alternate itineraries with more gradual ascent.
  • Molecular Mechanisms of High-Altitude Acclimatization. [Review]
    Int J Mol Sci. 2023 Jan 15; 24(2)Mallet RT, Burtscher J, … Burtscher M
  • High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric hypoxia and curtail the development of HAIs. The understanding of these mechanisms is essential to optimize hypoxic acclimatization for efficient prophylaxis and treatment of HAIs. This review aims to link outcomes of m…
  • [Incidence and risk factors of acute mountain sickness in grid construction personnel working at plateau]. [Journal Article]
    Zhonghua Yi Xue Za Zhi. 2023 Jan 31; 103(4):278-286.Zhang YJ, Zhou HZW, … Wang SF
  • Objective: To analyze the incidence and risk factors of acute mountain sickness (AMS) in grid construction personnel working at plateau. Methods: A total of 10 956 plateau construction personnel of Ali Network Project from January 1, 2019 to December 31, 2020 were included. Baseline information (including age, sex, body mass index, developmental and nutritional status, relevant clinical indicator…
  • Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia. [Journal Article]
    Platelets. 2023 Dec; 34(1):2157381.Wang Z, Tenzing N, … Cui S
  • High-altitude polycythemia (HAPC) can occur in individuals who are intolerant to high-altitude hypoxia. In patients with HAPC, erythrocytosis is often accompanied by a decrease in platelet count. Chronic hypoxia can increase the incidence of arteriovenous thrombosis and the risk of bleeding during antithrombotic treatment due to thrombocytopenia; therefore, understanding the cause of thrombocytop…
  • Sleep loss effects on physiological and cognitive responses to systemic environmental hypoxia. [Review]
    Front Physiol. 2022; 13:1046166.Fabries P, Gomez-Merino D, … Chennaoui M
  • In the course of their missions or training, alpinists, but also mountain combat forces and mountain security services, professional miners, aircrew, aircraft and glider pilots and helicopter crews are regularly exposed to altitude without oxygen supplementation. At altitude, humans are exposed to systemic environmental hypoxia induced by the decrease in barometric pressure (<1,013 hPa) which dec…
  • High altitude pulmonary edema in children: A systematic review. [Journal Article]
    Pediatr Pulmonol. 2022 Dec 23 [Online ahead of print]Ucrós S, Aparicio C, … Ivy D
  • CONCLUSIONS: R-HAPE was the most common HAPE subtype; HAPE peak age was found between 6 and 10 years of age; HAPE was more frequent in males and was rare in children under 2 years old; associated HAPE structural abnormalities were more common in C-HAPE than in R-HAPE.
  • Cardiovascular Risk Profiles and Pre-Existing Health Conditions of Trekkers in the Solu-Khumbu Region, Nepal. [Journal Article]
    Int J Environ Res Public Health. 2022 12 07; 19(24)Haunolder M, Apel C, … Küpper T
  • CONCLUSIONS: The results of earlier studies in the Annapurna region should be revalidated. Every trekker to the Himalayas should consult a physician prior to departure, ideally a travel medicine specialist. Preventative measures and education on AMS warrant special attention. Travellers with heart disease or with a pronounced cardiovascular risk profile should be presented to an internal medicine professional. Travel plans must be adjusted individually, especially with respect to adequate acclimatisation time and no physical overloading. With these and other precautions, trekking at high altitudes is generally safe and possible, even with significant pre-existing health conditions. Trekking can lead to invaluable personal experiences. Since organized groups are limited in their flexibility to change their itinerary, individual trekking or guided tours in small groups should be preferred.
  • Magnetic Resonance Imaging Evaluation of Suspected High-Altitude Cerebral Edema in Patients from High Altitude. [Journal Article]
    J Nepal Health Res Counc. 2022 Nov 02; 20(2):354-360.Karki DB, Gurung G, Ghimire RK
  • CONCLUSIONS: Typical magnetic resonance imaging features of cytotoxic edema in corpus callosum and microhemorrhage in the patients with High Altitude Cerebral Edema further support the findings in other similar studies. T2 white matter hyperintensities in deep, subcortical or periventricular location and lacunar infarcts could be seen in High Altitude Cerebral Edema. Normal magnetic resonance imaging of the brain is not infrequent.
  • Respiratory tract infection: an unfamiliar risk factor in high-altitude pulmonary edema. [Journal Article]
    Brief Funct Genomics. 2022 Dec 10 [Online ahead of print]Choudhary R, Kumari S, … Mishra A
  • The dramatic changes in physiology at high altitude (HA) as a result of the characteristic hypobaric hypoxia condition can modify innate and adaptive defense mechanisms of the body. As a consequence, few sojourners visiting HA with mild or asymptomatic infection may have an enhanced susceptibility to high-altitude pulmonary edema (HAPE), an acute but severe altitude sickness. It develops upon rap…
  • Initial Treatment of High-Altitude Pulmonary Edema: Comparison of Oxygen and Auto-PEEP. [Journal Article]
    Int J Environ Res Public Health. 2022 Dec 03; 19(23)Tannheimer M, Lechner R
  • CONCLUSIONS: The well-established therapies of HAPE are always the option of choice, if available, and should be started as soon as possible. The advantage of Auto-PEEP is its all-time availability. It improves SpO2 nearly as well as 3 L/min oxygen and furthermore has a positive effect on oxygenation lasting for approximately 120 min after stopping. Auto-PEEP treatment does not appear inferior to oxygen treatment, at least in this cross-case comparison. Its immediate application after diagnosis probably plays an important role here.
  • StatPearls: Chokes [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)HexdallEric J.EJDuke Regional HospitalCooperJeffrey S.JSUniversity of Nebraska Medical CenterBOOK
  • Chokes, or pulmonary decompression sickness, is a rare but severe manifestation of decompression sickness (DCS) that can be rapidly fatal even with appropriate treatment.
  • Physiological benefits of Akkermansia muciniphila under high-altitude hypoxia. [Review]
    Appl Microbiol Biotechnol. 2023 Jan; 107(1):1-8.Mishra KP, Bakshi J
  • When sojourners visit to high altitude, various symptoms may appear in the body including gastrointestinal symptoms such as poor appetite or nausea, vomiting, and incapacitating. The gastrointestinal tract is a key organ involved in the development of acute mountain sickness (AMS). The intestinal epithelial lining is covered by mucus layer. Mucosal barrier is considered as first line of protectio…
  • Genetics of High-Altitude Pulmonary Edema. [Review]
    Heart Fail Clin. 2023 Jan; 19(1):89-96.Eichstaedt CA, Benjamin N, … Grünig E
  • High-altitude pulmonary edema (HAPE) is the main cause of nontraumatic death at high altitude. HAPE development is not only related to the mode and speed of ascent and the maximum altitude reached, but also individual susceptibility plays an important role. In susceptible individuals, hypoxic pulmonary vasoconstriction leads to exaggerated elevated pulmonary arterial pressures and capillary leaka…
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