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Unbound Medicine.
(Alu Cap)
40 results
  • Chemical approaches for structure and function of RNA in postgenomic era. [Journal Article]
    J Nucleic Acids. 2012; 2012:369058.Ro-Choi TS, Choi YC
  • In the study of cellular RNA chemistry, a major thrust of research focused upon sequence determinations for decades. Structures of snRNAs (4.5S RNA I (Alu), U1, U2, U3, U4, U5, and U6) were determined at Baylor College of Medicine, Houston, Tex, in an earlier time of pregenomic era. They show novel modifications including base methylation, sugar methylation, 5'-cap structures (types 0-III) and se…
  • A differential sequencing-based analysis of the C. elegans noncoding transcriptome. [Journal Article]
    RNA. 2012 Apr; 18(4):626-39.Xiao T, Wang Y, … Chen R
  • Noncoding RNAs are increasingly being recognized as important players in eukaryote biology. However, despite major efforts in mapping the Caenorhabditis elegans transcriptome over the last couple of years, nonpolyadenylated and intermediate-size noncoding RNAs (is-ncRNAs) are still incompletely explored. We have combined an enzymatic approach with full-length RNA-Seq of is-ncRNAs in C. elegans. A…
  • Diversity of contactin mRNA in human brain tumors. [Journal Article]
    Mol Carcinog. 2006 Oct; 45(10):774-85.Rome C, Loiseau H, … Couillaud F
  • In order to address the molecular signature of human glioma, we investigated the polymorphism of 5'UTR of the mRNA of Contactin, an adhesion molecule which plays a role in the invasive behavior of these tumors. Contactin mRNA is identified by RT-PCR and a strategy based on rapid amplification of cDNA ends (RACE) reveals different 5'UTRs resulting from both an alternative use of two types of leade…
  • Promoter and transcription start site of human and rabbit butyrylcholinesterase genes. [Journal Article]
    J Biol Chem. 1994 Aug 19; 269(33):20829-37.Jbilo O, Toutant JP, … Lockridge O
  • Two kilobase segments of the 5'-untranslated regions of the human and rabbit butyrylcholinesterase (BCHE) genes were characterized. The sequences shared extensive identity except for a 333-base pair (bp) Alu repeat present only in human BCHE. One single transcription start site was found in both genes with the techniques of primer extension, amplification of the 5'-end of mRNA, and RNase protecti…
  • Structure and organization of the human S-adenosylmethionine decarboxylase gene. [Journal Article]
    J Biol Chem. 1992 Sep 15; 267(26):18915-23.Marić SC, Crozat A, Jänne OA
  • Genomic clones for the S-adenosylmethionine (AdoMet) decarboxylase gene were isolated from a human chromosome 6 DNA library. In addition, polymerase chain reaction and specific primers were used to amplify fragments from chromosomal DNA covering exonic regions not found in the screening of DNA libraries with AdoMet decarboxylase cDNA. The gene encompasses at least 22 kilobases of chromosome 6 DNA…
  • Structure of the gorilla alpha-fetoprotein gene and the divergence of primates. [Journal Article]
    Genomics. 1991 Jan; 9(1):60-72.Ryan SC, Zielinski R, Dugaiczyk A
  • The sequence of the gorilla alpha-fetoprotein gene, including 869 base pairs of the 5' flanking region and 4892 base pairs of the 3' flanking region (24,607 in total), was determined from two overlapping lambda phage clones. The sequence extends 18,846 base pairs from the Cap site to the polyadenylation site, and it reveals that the gene is composed of 15 exons, which are symmetrically placed wit…
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