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Unbound Medicine.
(Aluminum toxicity in osteomalacia)
153 results
  • Aluminium toxicosis: a review of toxic actions and effects. [Review]
    Interdiscip Toxicol. 2019 Oct; 12(2):45-70.Igbokwe IO, Igwenagu E, Igbokwe NA
  • Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or t…
  • Aluminium utensils: Is it a concern? [Review]
    Natl Med J India. 2019 Jan-Feb; 32(1):38-40.Gupta YK, Meenu M, Peshin SS
  • Aluminium utensils are ubiquitous in Indian households and other developing countries. Concerns have recently been raised on the pathological effects of aluminium on the human body, due to its leaching from utensils with long-term use, which has been associated with certain clinical conditions such as anaemia, dementia and osteo-malacia. While some studies suggest that cooking in utensils or alum…
  • Aluminum toxicity to bone: A multisystem effect? [Review]
    Osteoporos Sarcopenia. 2019 Mar; 5(1):2-5.Klein GL
  • Aluminum (Al) is the third most abundant element in the earth's crust and is omnipresent in our environment, including our food. However, with normal renal function, oral and enteral ingestion of substances contaminated with Al, such as antacids and infant formulae, do not cause problems. The intestine, skin, and respiratory tract are barriers to Al entry into the blood. However, contamination of…
  • Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review. [Review]
    Biol Trace Elem Res. 2019 Mar; 188(1):60-67.Esparza JL, Gómez M, Domingo JL
  • Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can …
  • Multifocal osteonecrosis secondary to occupational exposure to aluminum. [Case Reports]
    Acta Ortop Bras. 2017 May-Jun; 25(3):103-106.Assunção JH, Malavolta EA, … Ferreira AA
  • Multifocal osteonecrosis is a rare disease; chronic use of corticosteroids is considered the main risk factor. Patients with chronic renal failure can develop aluminum toxicity, which can lead to osteomalacia and encephalopathy. An association between osteonecrosis and aluminum toxicity has been reported among patients with dialytic renal insufficiency. Occupational exposure to aluminum rarely ca…
  • Various musculoskeletal manifestations of chronic renal insufficiency. [Review]
    Clin Radiol. 2013 Jul; 68(7):e397-411.Lim CY, Ong KO
  • Musculoskeletal manifestations in chronic renal insufficiency are caused by complex bone metabolism alterations, now described under the umbrella term of chronic kidney disease mineral- and bone-related disorder (CKD-MBD), as well as iatrogenic processes related to renal replacement treatment. Radiological imaging remains the mainstay of disease assessment. This review aims to illustrate the radi…
  • How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale. [Review]
    Cell Biol Toxicol. 2013 Apr; 29(2):75-84.Han S, Lemire J, … Appanna VD
  • Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and …
  • Hepatic response to aluminum toxicity: dyslipidemia and liver diseases. [Review]
    Exp Cell Res. 2011 Oct 01; 317(16):2231-8.Mailloux RJ, Lemire J, Appanna VD
  • Aluminum (Al) is a metal toxin that has been implicated in the etiology of a number of diseases including Alzheimer's, Parkinson's, dialysis encephalopathy, and osteomalacia. Al has been shown to exert its effects by disrupting lipid membrane fluidity, perturbing iron (Fe), magnesium, and calcium homeostasis, and causing oxidative stress. However, the exact molecular targets of aluminum's toxicit…
  • Metabolic bone diseases during long-term total parenteral nutrition. [Review]
    J Endocrinol Invest. 2007; 30(6 Suppl):54-9.Acca M, Ragno A, … D'Erasmo E
  • Long-term total parenteral nutrition (TPN) is a procedure commonly applied to patients with advanced forms of intestinal malabsorption. Among TPN complications, bone metabolic diseases, such as osteoporosis and osteomalacia, are a common finding. Initially considered to be a manifestation of aluminium toxicity which followed massive contamination with the element of the solutions used in TPN, met…
  • [Nutrition-related bone disease]. [Review]
    Nihon Rinsho. 2006 Sep; 64(9):1707-11.Hirota K, Hirota T
  • Bone disorders clearly related to nutrition are osteomalacia and osteoporosis. Osteomalacia is caused by a deficiency of vitamin D or a disturbance of its metabolism. Dietary deficiency of phosphate or excess of aluminum or cadmium will also cause osteomalacia. Osteoporosis is associated with low intake of calcium and other nutrients. Dietary copper deficiency might stimulate bone metabolism and …
  • Aluminum toxicity elicits a dysfunctional TCA cycle and succinate accumulation in hepatocytes. [Journal Article]
    J Biochem Mol Toxicol. 2006; 20(4):198-208.Mailloux RJ, Hamel R, Appanna VD
  • Aluminum (Al), a known environmental toxicant, has been linked to a variety of pathological conditions such as dialysis dementia, osteomalacia, Alzheimer's disease, and Parkinson's disease. However, its precise role in the pathogenesis of these disorders is not fully understood. Using hepatocytes as a model system, we have probed the impact of this trivalent metal on the aerobic energy-generating…
  • Blast from the past: the aluminum's ghost on the lanthanum salts. [Review]
    Curr Med Chem. 2005; 12(14):1631-6.Canavese C, Mereu C, … Aime S
  • Hyperphosphatemia is a common serious complication of chronic renal diseases, which needs appropriate continuous treatment in order to avoid ominous side effects. Therefore, oral chelating agents able to avoid phosphate absorption by the gut are mandatory. In the past, Aluminium salts, and more recently Calcium and Magnesium salts, and a synthetic resin polyallylamine hydrochloride have been empl…
  • [Osteomalacia and vitamin D deficiency in hemodialyzed patients]. [Review]
    Clin Calcium. 2004 Sep; 14(9):42-5.Tahara H
  • Aluminum accumulation in plasma and tissues is a well-described complication among patients undergoing hemodialysis. Although the ratio of aluminum-induced osteomalacia has been decreasing year by year, there are still considerably many problems in such patients. Sources of aluminum now include food, drugs, and cooking tools. Besides, iron and strontium accumulations also induce osteomalacia. Ear…
  • Improving outcomes in hyperphosphataemia. [Review]
    Nephrol Dial Transplant. 2004 Mar; 19 Suppl 1:i14-8.De Broe ME, D'Haese PC, Lanthanum Study Group
  • Preclinical studies have shown that lanthanum has a very high phosphate-binding capacity at gastrointestinal pH, while clinical trials have shown lanthanum carbonate to be an effective, well-tolerated phosphate binder for the treatment of hyperphosphataemia in patients with end-stage renal disease. Optimization of bone health is an important issue in these patients, and, based on theoretical grou…
  • Aluminum as a toxicant. [Review]
    Toxicol Ind Health. 2002 Aug; 18(7):309-20.Becaria A, Campbell A, Bondy SC
  • Although aluminum is the most abundant metal in nature, it has no known biological function. However, it is known that there is a causal role for aluminum in dialysis encephalopathy, microcytic anemia, and osteomalacia. Aluminum has also been proposed to play a role in the pathogenesis of Alzheimer's disease (AD) even though this issue is controversial. The exact mechanism of aluminum toxicity is…
  • Safety of new phosphate binders for chronic renal failure. [Review]
    Drug Saf. 2003; 26(15):1093-115.Loghman-Adham M
  • Phosphate (Pi) retention is a common problem in patients with chronic kidney disease, particularly in those who have reached end-stage renal disease (ESRD). In addition to causing secondary hyperparathyroidism and renal osteodystrophy, recent evidence suggests that, in ESRD patients, high serum phosphorus concentration and increased calcium and phosphorous (Ca x P) product are associated with vas…
  • Aluminium in over-the-counter drugs: risks outweigh benefits? [Review]
    Drug Saf. 2003; 26(14):1011-25.Reinke CM, Breitkreutz J, Leuenberger H
  • In the early 1970s, aluminium toxicity was first implicated in the pathogenesis of clinical disorders in patients with chronic renal failure involving bone (renal osteomalacia) or brain tissue (dialysis encephalopathy). Before that time the toxic effects of aluminium ingestion were not considered to be a major concern because absorption seemed unlikely to occur. Meanwhile, aluminium toxicity has …
  • Parathyroid hormone-independent osteoclastic resorptive bone disease: a new variant of adynamic bone disease in haemodialysis patients. [Journal Article]
    Nephrol Dial Transplant. 2002 Apr; 17(4):620-4.Gal-Moscovici A, Popovtzer MM
  • CONCLUSIONS: We describe patients undergoing chronic haemodialysis with static and dynamic bone forming parameters, indistinguishable from that of ABD, but differing from the classic ABD by the presence of increased osteoclastic bone resorption. The suppressed PTH levels in this subgroup suggests that factors other than PTH activate osteoclasts in some patients on chronic haemodialysis. Uraemic cytokines and/or toxic metabolites, including beta-microglobulin, may be involved in this disorder. The precise nature of this bone abnormality remains to be defined by further studies.
  • Strontium overload and toxicity: impact on renal osteodystrophy. [Review]
    Nephrol Dial Transplant. 2002; 17 Suppl 2:30-4.Cohen-Solal M
  • Although the prevalence of aluminium-related bone diseases has declined, osteomalacia still persists at a low prevalence. The redistribution of bone disease prevalence corresponds to evolving regimens in the treatment of renal disease. Studies have demonstrated an association between the accumulation of strontium in bone and the presence of osteomalacia. The uptake of strontium has been shown to …
  • Aluminium and bone disease in chronic renal failure. [Review]
    Nephrol Dial Transplant. 2002; 17 Suppl 2:21-4.Malluche HH
  • Aluminium is absorbed by the intestines and is rapidly transported into bone, where it disrupts mineralization and bone cell growth and activity. Its toxicities result in or exacerbate painful forms of renal osteodystrophy, most notably adynamic bone disease and osteomalacia, but also other forms of the disease. Because aluminium is sequestered in bone for long periods, its toxic effects are cumu…
  • The role of trace elements in uraemic toxicity. [Review]
    Nephrol Dial Transplant. 2002; 17 Suppl 2:2-8.Vanholder R, Cornelis R, … Lameire N
  • Although most research on uraemic toxicity has focused on the retention or removal of organic solutes, subtle changes in the concentration of inorganic compounds are also of importance because these compounds may have significant clinical consequences. Potential clinical implications include increased risk of cancer, cardiovascular disease, immune deficiency, anaemia, renal function impairment an…
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