- A multi-epitope vaccine GILE against Echinococcus Multilocularis infection in mice. [Journal Article]
- The objective of this study is to construct a multi-epitope vaccine GILE containing B-cell and T-cell epitopes against Echinococcus Multilocularis (E. multilocularis) infection based on the dominant epitopes of E. multilocularis EMY162, LAP, and GLUT1.
- PMC Free PDF
- Cerebral Alveolar Echinococcosis. [Case Reports]N Engl J Med. 2023 Feb 02; 388(5):453.NEJM
- Publisher Full Text (DOI)
- Case Report: Amphotericin B and Mefloquine as a Salvage Treatment of Alveolar Echinococcosis. [Case Reports]Am J Trop Med Hyg. 2023 Jan 30 [Online ahead of print]AJ
- Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therapy, there are no alternatives. Here, we present a patient with advanced alveolar echinococcosis who …
- Publisher Full Text (DOI)
- Real-time multiplex PCR for human echinococcosis and differential diagnosis. [Journal Article]
- Molecular identification of rare human infectious pathogens appears to be one of the most relevant current methods for rapid diagnosis and management of patients. PCR techniques, in particular real-time quantitative PCR, are best suited for the detection of DNA from the pathogens, even at low concentrations. Echinococcosis infections are due to helminths of the Echinococcus genus, with closely re…
- PMC Free PDF
- Serological Screening of Patients Diagnosed with Alveolar Echinococcus Disease in Their Home Regions. [Journal Article]
- CONCLUSIONS: AE continues to threaten public health in the region. In families where AE is detected positive, the reason for disease is based on nutrition; thus, it will be proper to check up all family members in the terms of infection.
- PMC Free PDF
- Implementing deep learning models for the classification of Echinococcus multilocularis infection in human liver tissue. [Journal Article]
- CONCLUSIONS: Deep learning models achieved a high predictive performance in classifying E. multilocularis liver lesions. A possible next step could be to validate the model using other datasets and test it against other pathologic entities as well, such as, for example, Echinococcus granulosus infection.
- PMC Free PDF
- [Diagnostic delaying factors in hepatic alveolar echinococcosis]. [Journal Article]Dtsch Med Wochenschr. 2023 Jan 23 [Online ahead of print]DM
- CONCLUSIONS: The diagnostic clarification process of AE patients is lengthy and stressful. The psychological burden of a questionable malignant diagnosis is considerable. Early use of contrast-enhanced sonography and, if necessary, puncture of unclear hepatic masses helps to shorten the difficult diagnostic process.
- Publisher Full Text (DOI)
- Correlation between systemic immune inflammatory index and prognosis of patients with hepatic alveolar hydatid disease and establishment of a nomogram prediction model. [Journal Article]
- CONCLUSIONS: SII has a clear correlation to the prognosis of patients with alveolar echinococcosis. The nomogram prediction model constructed on this basis is beneficial to the clinically individualized analysis of the patient's prognosis.
- PMC Free PDF
- Alveolar Echinococcosis in a Patient with Presumed Autoimmune Hepatitis and Primary Sclerosing Cholangitis: An Unexpected Finding after Liver Transplantation. [Case Reports]
- Primary sclerosing cholangitis is an important reason for liver transplantation. Hepatic alveolar echinococcosis (AE) is caused by Echinococcus multilocularis and presents characteristic calcified conglomerates detected by ultrasound or computed tomography scan of the liver. Symptoms of AE only occur after a long period of infection when cholestasis or cholangitis becomes apparent. Here, we repor…
- PMC Free PDF
- Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation. [Journal Article]
- As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E. multilocularis has developed complex strategies to escape host immune attack and survive within a host. However, the mechanisms underlying immune evasion remain unclear. Here we investigated the binding activity…
- PMC Free PDF
- Diagnostic and Management Perspectives in Alveolar Echinococcosis: Review of Literature. [Journal Article]Eurasian J Med. 2022 Dec; 54(Suppl1):10-15.EJ
- Alveolar echinococcosis is a life-threatening zoonotic disease caused by Echinococcus multilocularis. The disease usually primarily involves the liver and shows tumor-like growth. Early diagnosis of alveolar echinococcosis is difficult because the disease is usually asymptomatic in the early stages. Untreated cases are fatal and result in death within 10 years of liver involvement. In the diagnos…
- Publisher Full Text (DOI)
- A rare disease: a single-center experience of cerebral alveolar echinococcosis in 12 operated patients. [Journal Article]Eur Rev Med Pharmacol Sci. 2023 Jan; 27(1):426-430.ER
- CONCLUSIONS: AE of the brain is a rare but life-threatening parasitic disease. Wherever the primary focus is, surgery for cerebral involvement of AE is challenging but safe with appropriate surgical techniques and the help of radiological examination.
- Publisher Full Text (DOI)
- Diffuse alveolar echinococcosis. [Journal Article]Med Clin (Barc). 2023 Jan 14 [Online ahead of print]MC
- Publisher Full Text (DOI)
- [Prevalence of Echinococcus infection in small mammals captured from Shiqu County, Sichuan Province from 2015 to 2020]. [Journal Article]Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2023 Jan 06; 34(6):611-615.ZX
- CONCLUSIONS: M. fuscus and P. pika were dominant species of small mammals in Shiqu County, Sichuan Province from 2015 to 2020, and E. multilocularis infection was mainly found in M. fuscus and E. shiquicus infection mainly found in P. pika. The prevalence of Echinococcus infection appeared a tendency towards a decline in both M. fuscus and P. pika year by year during the period from 2015 to 2020.
- Publisher Full Text (DOI)
- A Muskrat (Ondatra zibethicus) with alveolar echinococcosis bitten to death by a dog - a challenge for the forensic pathologist as an expert witness. [Case Reports]J Comp Pathol. 2023 Jan; 200:12-17.JC
- We present a case that illustrates the complex contexts in which forensic veterinary pathology examinations may be carried out. A wild muskrat (Ondatra zibethicus) had died after a putative bite attack from a domestic dog. Bite attacks by privately owned dogs on wild animals in Switzerland violate the Swiss civil (and/or hunting) laws, and dog owners are generally punished with a monetary fine; h…
- Publisher Full Text (DOI)
- Improvement of Antialveolar echinococcosis efficacy of novel Albendazole-Bile acids Derivatives with Enhanced Oral Bioavailability. [Journal Article]
- Alveolar echinococcosis (AE) is a chronic and fatal infectious parasitic disease, which has not been well-researched. Current recommended therapies for AE by the World Health Organization include complete removal of the infected tissue followed by two years of albendazole (ABZ), administered orally, which is the only effective first-line anti-AE drug. Unfortunately, in most cases, complete resect…
- PMC Free PDF
- Feasibility analysis and study of an intrahepatic portal vein infection hepatic alveolar echinococcosis C57 mouse model. [Journal Article]
- CONCLUSIONS: The intrahepatic portal vein infection HAE mouse model was successfully established.
- PMC Free PDF
- Alveolar echinococcosis in immunocompromised hosts. [Review]Clin Microbiol Infect. 2022 Dec 15 [Online ahead of print]CM
- CONCLUSIONS: Patients who live in endemic areas should benefit from serology before onset of a long-term immunosuppressive therapy, even if the cost-benefit ratio has to be evaluated. Physicians should explain AE to immunocompromised patients and think about AE when finding a liver lesion. Further research should address gaps in knowledge of AE/IS. Especially, extensive and accurate records of AE cases have to be collected by multinational registries.
- Publisher Full Text (DOI)
- Assessment of risk, landscape epidemiology and management strategies to combat alveolar echinococcosis in the rural communities of Hunza, Pakistan. [Journal Article]
- CONCLUSIONS: Knowledge of AE is poor among the residents of Hunza, Pakistan. Our study demands continued and strengthened awareness of the changes to lifestyle and practices associated with AE, not only in the study locality but throughout other areas of Pakistan.
- PMC Free PDF
- Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience. [Journal Article]
- CONCLUSIONS: For patients suffering from advanced hepatic AE with insufficient FLRV, PVE and TSH are safe and feasible in promoting hepatic lobe hyperplasia.
- PMC Free PDF
- 7T Small Animal MRI Research for Hepatic Alveolar Echinococcosis. [Journal Article]Top Magn Reson Imaging. 2022 Dec 01; 31(6):53-59.TM
- CONCLUSIONS: Polyvesicular structure is a characteristic manifestation of hepatic alveolar echinococcosis in mice. The noninvasive monitoring of liver HAE in mice by 7T small animal MRI provides a visual basis for the diagnosis and treatment integration of HAE.
- Publisher Full Text (DOI)
- Suppressive effect of pseudolaric acid B on Echinococcus multilocularis involving regulation of TGF-β1 signaling in vitro and in vivo. [Journal Article]
- Echinococcus multilocularis, the causative agent of alveolar echinococcosis (AE), severely threats human health and livestock farming. The first line of chemotherapeutic drug for AE is albendazole, which limits rapid extension of E. multilocularis metacestodes, but is rarely curative for AE, with severe side effects in long-term use, thus development of new anti-echinococcal drugs is mandated. Ps…
- PMC Free PDF
- Indoleamine 2,3-dioxygenase 1 signaling orchestrates immune tolerance in Echinococcus multilocularis-infected mice. [Journal Article]
- The cestode Echinococcus multilocularis larva infection causes lethal zoonotic alveolar echinococcosis (AE), a disease posing a great threat to the public health worldwide. This persistent hepatic tumor-like disease in AE patients has been largely attributed to aberrant T cell responses, of which Th1 responses are impeded, whilst Th2 and regulatory T cell responses are elevated, creating an immun…
- PMC Free PDF
- Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. [Review]Lancet Infect Dis. 2022 Nov 22 [Online ahead of print]LI
- The neglected zoonosis cystic echinococcosis affects mainly pastoral and rural communities in both low-income and upper-middle-income countries. In Europe, it should be regarded as an orphan and rare disease. Although human cystic echinococcosis is a notifiable parasitic infectious disease in most European countries, in practice it is largely under-reported by national health systems. To fill thi…
- Publisher Full Text (DOI)
- Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces. [Journal Article]
- The dataset presented here is related to a previous research article titled "Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts"[1]. In this report, data were collected from aerobic and anaerobic culture assays of E. multilocularis protoscoleces in the presence of three an…
- PMC Free PDF
- First detection of Echinococcus multilocularis in Bosnia and Herzegovina. [Journal Article]
- Echinococcus multilocularis has been spreading through Central Eastern Europe but has not yet been reported in Bosnia and Herzegovina (B&H). Recently, this parasite is confirmed in Croatia suggesting the movement of the parasite's distribution limit further south. Given that there is no surveillance or monitoring system for echinococcosis in B&H, our study was designed as a pilot study of E. mult…
- PMC Free PDF
- In vitro efficacy of albendazole-loaded β-cyclodextrin against protoscoleces of Echinococcus granulosus sensu stricto. [Journal Article]Exp Parasitol. 2022 Dec; 243:108428.EP
- CONCLUSIONS: In the present study, a significant scolicidal rate, apoptosis intensity and treatment efficacy was observed in PSCs treated with 400 μg/mL ABZ-β-CD compared to ABZ alone. This provides new insights into the use of nanostructured β-CD carriers with ABZ as a promising candidate to improve the treatment of CE in in vivo models.
- Publisher Full Text (DOI)
- Robotic Liver Surgery for Alveolar Echinococcosis: A Single-Centre Experience. [Journal Article]
- Alveolar echinococcosis (AE) is a rare disease caused by Echinococcosis multilocularis, which usually requires multidisciplinary management including surgery as the only curative approach. In recent years, minimally invasive strategies have been increasingly adopted for liver surgery. In particular, robotic surgery enables surgeons to perform even complex liver resections using a minimally invasi…
- PMC Free PDF
- Research progress in the proteomics of Echinococcus multilocularis and alveolar echinococcosis. [Letter]Asian J Surg. 2022 Nov 02 [Online ahead of print]AJ
- Publisher Full Text (DOI)