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Unbound Medicine.
(Alveolar hypoventilation primary)
432 results
  • StatPearls: Mechanical Ventilation [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)HickeySean M.SMMount Sinai HospitalGiwaAl O.AOIcahn School of Medicine at Mount SinaiBOOK
  • Although mechanical ventilation can be a complex and seemingly elusive topic, expectations are that physicians and healthcare professionals who deal with critically ill patients have a basic familiarity with the management of a patient on a ventilator. Additionally, providers must also understand how applying mechanical ventilation affects patient physiology and response to disease states. The fo…
  • Noninvasive ventilation in New Zealand: a national prevalence survey. [Journal Article]
    Intern Med J. 2022 Nov 03 [Online ahead of print]Neill A, Ingham TR, … Jones B
  • CONCLUSIONS: Home-based NIV provision has doubled since the previous survey, reflecting increased burden from OHS and obstructive pathologies and a disproportionate disease burden among Māori and Pacific populations. The large regional variations are concerning and highlight the urgent requirement for national service specifications, education and equipment provision. Further research is needed to address access equity.
  • APAP, BPAP, CPAP, and New Modes of Positive Airway Pressure Therapy. [Review]
    Adv Exp Med Biol. 2022; 1384:297-330.Johnson KG
  • Positive airway pressure (PAP) is the primary treatment of sleep-disordered breathing including obstructive sleep apnea, central sleep apnea, and sleep-related hypoventilation. Just as clinicians use pharmacological mechanism of action and pharmacokinetic data to optimize medication therapy for an individual, understanding how PAP works and choosing the right mode and device are critical to optim…
  • StatPearls: Oropharyngeal Airway [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)CastroDannyDBaylor College of Med, TX Children HospFreemanLori A.LAMercy Hospital St. LouisBOOK
  • Acute respiratory failure is caused by a wide range of etiologies.  Progression to cardiopulmonary arrest and ultimately death is likely in the absence of effective and timely airway management. Therefore, one of the primary goals of airway management is to provide adequate ventilation and oxygenation to avoid or halt the progression to cardiopulmonary arrest. Effective and timely airway manageme…
  • Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression. [Review]
    Sleep. 2022 11 09; 45(11)Olivares MJ, Toledo C, … Del Río R
  • The autonomic nervous system (ANS) plays an important role in the coordination of several physiological functions including sleep/wake process. Significant changes in ANS activity occur during wake-to-sleep transition maintaining the adequate cardiorespiratory regulation and brain activity. Since sleep is a complex homeostatic function, partly regulated by the ANS, it is not surprising that sleep…
  • The clinical use of impulse oscillometry in neuromuscular diseases. [Journal Article]
    Respir Med. 2022 Aug-Sep; 200:106931.Iliaz S, Yunisova G, … Oflazer P
  • CONCLUSIONS: Clinically reported dysphagia, a decreased capability of coughing, and shortness of breath in patients with NMD make Rrs increase in general, but Xrs parameters, which mainly express rib cage elasticity, turn more negative. In patients with NMD, IOS monitoring may help in evaluating the regression in respiratory functions, however, future studies are needed to understand more.
  • StatPearls: Respiratory Acidosis [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)PatelShivaniSNYITCOMSharmaSandeepSMery Fitzgerald HospitalBOOK
  • Respiratory acidosis is a state in which there is usually a failure of ventilation and an accumulation of carbon dioxide. The primary disturbance of elevated arterial PCO2 is the decreased ratio of arterial bicarbonate to arterial PCO2, which leads to a lowering of the pH. In the presence of alveolar hypoventilation, 2 features commonly are seen are respiratory acidosis and hypercapnia. To compen…
  • StatPearls: Central Sleep Apnea [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)RanaAbdul M.AMCMH Lahore Medical College, University of Health Sciences, Lahore, PakistanSankariAbdulghaniAWayne State UniversityBOOK
  • Central sleep apnea (CSA) is characterized by transient diminution or cessation of the respiratory rhythm generator located within the pontomedullary region of the brain. In general, CSA represents an array of sleep-disordered breathing (SDB) conditions due to the brief absence of ventilatory output during sleep. CSA manifests as a cyclical phenomenon/pattern during sleep; periods of apnea or hyp…
  • Metabolic Alkalosis Pathogenesis, Diagnosis, and Treatment: Core Curriculum 2022. [Review]
    Am J Kidney Dis. 2022 10; 80(4):536-551.Do C, Vasquez PC, Soleimani M
  • Metabolic alkalosis is a widespread acid-base disturbance, especially in hospitalized patients. It is characterized by the primary elevation of serum bicarbonate and arterial pH, along with a compensatory increase in Pco2 consequent to adaptive hypoventilation. The pathogenesis of metabolic alkalosis involves either a loss of fixed acid or a net accumulation of bicarbonate within the extracellula…
  • StatPearls: Stroke Anticoagulation [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AbbasMalakMBeaumont HealthMalickeDavid T.DTBeaumont HealthSchramskiJoseph T.JTBeaumont DearbornBOOK
  • Stroke is one of the leading causes of death and long-term disability worldwide.[1][2] As medical management advances, the incidence and mortality rate of stroke declines, with most strokes presenting as ischemic strokes vs. hemorrhagic strokes. As such, the focus of this article will be on ischemic strokes. Various etiologies lead to ischemic stroke, including both modifiable and non-modifiable …
  • The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with "Primary Mental Confusion" in Late 19th Century French Psychiatry. [Review]
    Front Biosci (Landmark Ed). 2022 04 01; 27(4):116.Kato R, Takenaka R, Matsumoto T
  • CONCLUSIONS: From the results, it is suggested that the phenomenological features understood as indicative of anti-NMDA receptor encephalitis include: (1) antecedent common cold-like symptoms (31.9%) in the prodromal phase, (2) delirium or acute confusional state (65.9%), (3) symptoms considered to be sudden personality changes (40.4%) in the psychotic phase, (4) central hypoventilation (14.9%) in the unresponsive phase, (5) motor disturbances (57.4%), and (6) autonomic symptoms, mainly without fluctuations (48.9%), in the hyperkinetic phase. These features were found to be similar to "primary mental confusion" (confusion mentale primitive) in French psychiatry in the late 19th century. We believe that classical psychiatry can contribute considerably to the interpretation of biological research results.
  • [When should and when should not use oxygen in neuromuscular diseases?] [Journal Article]
    Medicina (B Aires). 2022; 82(2):244-248.De Vito EL
  • Although the references warn about the adverse effects of adding O2 without ventilatory assistance in patients with neuromuscular diseases (NMD), patients are still to be admitted to intensive care units with severe hypercapnia and CO2 narcosis. It seems that the problem is rediscovered as the years and generations go by. Unfortunately, many patients and their network of formal and informal careg…
  • Clinical implications of opioid-induced ventilatory impairment. [Journal Article]
    Anaesth Intensive Care. 2022 Mar; 50(1-2):52-67.Pattullo GG
  • Opioid-induced ventilatory impairment is the primary mechanism of harm from opioid use. Opioids suppress the activity of the central respiratory centres and are sedating, leading to impairment of alveolar ventilation.Respiratory physiological changes induced with acute opioid use include depression of the hypercapnic ventilatory response and hypoxic ventilatory response. In chronic opioid use a c…
  • Congenital central hypoventilation syndrome: a life-threatening cause of neonatal apnoea. [Case Reports]
    BMJ Case Rep. 2021 Sep 20; 14(9)Castro C, Correia C, … Portela A
  • Congenital central hypoventilation syndrome (CCHS) is an uncommon genetic disease characterised by an autonomic nervous system dysfunction that affects ventilatory homeostasis. Involvement of other systems is also described, mainly cardiovascular, gastrointestinal and central nervous systems. We describe a rare case of CCHS diagnosed in a term newborn who presented with persistent apnoea in the f…
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