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(Alzheimer’s Disease)
150,011 results
  • Copper Ion Uptake by Chitosan in the Presence of Amyloid-β and Histidine. [Journal Article]
    Appl Biochem Biotechnol 2019Mahl CRA, Taketa TB, … Beppu MM
  • Alzheimer's disease (AD) is related to the anomalous binding that occurs between amyloid-β peptide (Aβ) and copper ion, through imidazole ring of histidine (His), as stated in the literature. It is also known that high-affinity metal ion chelators can be pharmacologically used as a possible therapeutic approach. In this work, we tested the ability "in vitro" of chitosan (Chi) to reduce Aβ aggrega…
  • Docosahexaenoic acid,22:6n-3: its roles in the structure and function of the brain. [Review]
    Int J Dev Neurosci 2019Mallick R, Basak S, Duttaroy AK
  • Docosahexaenoic acid,22:6n-3 (DHA) and its metabolites are vital for the structure and functional brain development of the fetus and infants, and also for maintenance of healthy brain function of adults. DHA is thought to be an essential nutrient required throughout the life cycle for the maintenance of overall brain health. The mode of actions of DHA and its derivatives at both cellular and mole…
  • Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer's disease. [Review]
    Curr Opin Struct Biol 2019; 61:1-8Zhou R, Yang G, Shi Y
  • Proteolysis of amyloid precursor protein (APP), first extracellularly by β-secretase and then within the membrane by γ-secretase, produces β-amyloid peptides (Aβ). Aβ accumulates in the brain to form amyloid plaques, a hallmark of Alzheimer's disease (AD). Mutations in APP and presenilin (the catalytic subunit of γ-secretase) result in early onset of AD. Cryogenic electron microscopy (cryo-EM) st…
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