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Unbound Medicine.
(Alzheimer's disease)
195,270 results
  • Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress. [Journal Article]
    Life Sci Alliance. 2023 Apr; 6(4)Bodnar-Wachtel M, Huber AL, … Petrilli V
  • NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and cancer. Whereas its role in the context of cancer has been mostly explored in the immune compartment, whether NLRP3 exerts functions unrelated to imm…
  • DOPA pheomelanin is increased in nigral neuromelanin of Parkinson's disease. [Journal Article]
    Prog Neurobiol. 2023 Feb 04 [Online ahead of print]Cai W, Wakamatsu K, … Chen X
  • Neuromelanin (NM) in dopaminergic neurons of human substantia nigra (SN) has a melanic component that consists of pheomelanin and eumelanin moieties and has been proposed as a key factor contributing to dopaminergic neuron vulnerability in Parkinson's disease (PD). While eumelanin is considered as an antioxidant, pheomelanin and related oxidative stress are associated with compromised drug and me…
  • Transcriptional activation of CSTB gene expression by transcription factor Sp3. [Journal Article]
    Biochem Biophys Res Commun. 2023 Jan 30; 649:71-78.Zhu W, Dong X, … Song W
  • CSTB has been reported to be associated with the pathogenesis of many malignant tumors, especially hepatocellular carcinoma (HCC). However, how the expression of this gene is regulated is largely unknown. We initially cloned and analyzed the promoter region of the CSTB gene by luciferase assay and the Sp3 binding site (CCCCGCCCCGCG) was found in it. The results of electrophoretic mobility shift a…
  • Brain aerobic glycolysis and resilience in Alzheimer disease. [Journal Article]
    Proc Natl Acad Sci U S A. 2023 Feb 14; 120(7):e2212256120.Goyal MS, Blazey T, … Vlassenko AG
  • The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer disease (AD). Brain AG decreases with age, but the functional significance of this decrease with regard to the development of AD symptomatology is poorly understood. Using PET measurements of regional blood flow, …
  • Changes in Alcohol Consumption and Risk of Dementia in a Nationwide Cohort in South Korea. [Journal Article]
    JAMA Netw Open. 2023 Feb 01; 6(2):e2254771.Jeon KH, Han K, … Shin DW
  • CONCLUSIONS: In this cohort study of a Korean population, decreased risk of dementia was associated with maintaining mild to moderate alcohol consumption, reducing alcohol consumption from a heavy to a moderate level, and the initiation of mild alcohol consumption, suggesting that the threshold of alcohol consumption for dementia risk reduction is low.
  • Focused ultrasound: Innovation in use for neurologic conditions. [Journal Article]
    Trauma Emerg Med. 2022; 1(1):1-12.Hosseini M, Pierre K, … Lucke-Wold B
  • Focused ultrasound has emerged as a key tool for neurologic disorders. In this focused review, we discuss the utility in disrupting the blood brain barrier to maximize treatment. This can facilitate creating direct coagulative lesions and aid in the administration of chemotherapy. Furthermore, it can facilitate neuromodulation when used in pulse sequencing. The current literature regarding brain …
  • Digital Intervention For The Management Of Alzheimer's Disease. [Journal Article]
    Curr Alzheimer Res. 2023 Feb 06 [Online ahead of print]Manchanda N, Aggarwal A, … Talegaonkar S
  • Alzheimer's disease (AD) is a progressive, multifactorial, chronic, neurodegenerative disease with high prevalence and limited therapeutic options, making it a global health crisis. Being the most common cause of dementia, AD erodes the cognitive, functional, and social abilities of the individual and causes escalating medical and psychosocial needs. As yet, this disorder has no cure and current …
  • Sense of Purpose in Life and Beliefs and Knowledge of Alzheimer's Disease. [Journal Article]
    Arch Clin Neuropsychol. 2023 Feb 04 [Online ahead of print]Sutin AR, Stephan Y, … Terracciano A
  • CONCLUSIONS: Individuals with a sense of purpose are less concerned about risk of developing ad and believe modifiable factors reduce risk. These beliefs may support engagement in behaviors that reduce risk and be one psychological pathway through which purpose protects against ad.
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