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25,956 results
  • Carbon Dioxide Potentiates Flucytosine Susceptibility in Cryptococcus neoformans. [Journal Article]
    Microbiol Spectr. 2023 Jan 31 [Online ahead of print]Jezewski AJ, Ristow LC, Krysan DJ
  • Cryptococcal meningoencephalitis remains a global health threat with limited treatment options. Currently, the most effective treatment regimens are based on a combination therapy of flucytosine with either amphotericin B or fluconazole. Slow but steady progress is being made toward universal access to flucytosine-based therapies. The broadening access to flucytosine combination therapies will be…
  • Case Report: Amphotericin B and Mefloquine as a Salvage Treatment of Alveolar Echinococcosis. [Case Reports]
    Am J Trop Med Hyg. 2023 Jan 30 [Online ahead of print]Jelicic K, Papic N, … Vince A
  • Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therapy, there are no alternatives. Here, we present a patient with advanced alveolar echinococcosis who …
  • Cinnamic acid and lactobionic acid based nanoformulations as a potential antiamoebic therapeutics. [Journal Article]
    Exp Parasitol. 2023 Jan 25; 246:108474.Akbar N, Kawish M, … Siddiqui R
  • Acanthamoeba castellanii causes granulomatous amoebic encephalitis, an uncommon but severe brain infection and sight-threatening Acanthamoeba keratitis. Most of the currently used anti-amoebic treatments are not always effective, due to persistence of the cyst stage, and recurrence can occur. Here in this study we synthesize cinnamic acid and lactobionic acid-based magnetic nanoparticles (MNPs) u…
  • Cu(II)-Triggered Ion Channel Properties of a 2,2'-Bipyridine-Modified Amphotericin B. [Journal Article]
    ACS Appl Bio Mater. 2023 Jan 28 [Online ahead of print]Komaki K, Kasuya S, … Koshiyama T
  • The development of stimuli-responsive synthetic channels that open and close in response to physical and chemical changes in the surrounding environment has attracted attention because of their potential bioapplications such as sensing, drug release, antibiotics, and molecular manipulation tools to control membrane transport in cells. Metal coordination is ideal as a stimulus for stimuli-responsi…
  • Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient. [Case Reports]
    Med Mycol Case Rep. 2023 Mar; 39:26-30.Kinch A, Furebring M, … Hallböök H
  • We report for the first time a case of disseminated infection caused by Peziza ostracoderma, a mold not previously associated with invasive infections in humans. P. ostracoderma occurs in natural and sterilized soil and may cause hypersensitivity pneumonitis in greenhouse workers. The immunocompromised patient presented with neutropenic fever that did not respond to broad-spectrum antibiotics and…
  • Prevention of acquired invasive fungal infection with decontamination regimen in mechanically ventilated ICU patients: a pre/post observational study. [Journal Article]
    Infect Dis (Lond). 2023 Jan 24 [Online ahead of print]Massart N, Reizine F, … Fillatre P
  • CONCLUSIONS: Acquired fungal infection is a rare event, but accounts for a large proportion of ICU-acquired infections. Our study showed a preventive effect of decontamination against acquired fungal infection, especially candidemia.Take home messageAcquired fungal infection (AFI) incidence is close to 4% in mechanically ventilated patients without antifungal prophylaxis (3% for pulmonary aspergillosis and 1% for candidemia).Aspergillosis accounts for 14% of ventilator-associated pneumonia and candidemia for 9% of acquired bloodstream infections.Immunocompromised patients, those infected with SARS-COV 2 or influenza virus, males and patients admitted during the fall season are at higher risk of AFI.Mechanically ventilated patients receiving multiple site decontamination (MSD) have a lower risk of AFI.
  • C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences. [Journal Article]
    Clin Chem Lab Med. 2023 Jan 25 [Online ahead of print]Delanghe JR, Himpe J, … Verbeke F
  • CONCLUSIONS: In vitro experiments are suggestive of a complexation between CRP and liposomes in plasma. Interpretation of CRP values following administration of AmBisome® might be impaired due to this complexation. In vivo formation of complexes between liposomes and CRP might contribute, or even lead, to intravascular microembolisation. Similar effects have been described following the administration of Intralipid® and other phosphocholine-containing liposomes.
  • Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis. [Review]
    Future Microbiol. 2023 Jan 23 [Online ahead of print]Alves V, Araújo GR, Frases S
  • Cryptococcosis is an opportunistic mycosis that mainly affects immunosuppressed patients. The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and fluconazole. However, these drugs have many disadvantages, such as high nephrotoxicity, marketing bans in some countries and fungal resistance. One of the solutions to find possible new drugs is pharmacological repos…
  • Cerebral mucormycosis masquerading as brain metastasis from lung cancer: A case report. [Case Reports]
    Heliyon. 2023 Jan; 9(1):e12761.Cai Y, Wu Q, … Liu Z
  • We report a rare case of concurrent pulmonary and cerebral mucormycosis initially misdiagnosed as a metastatic tumor. A 66-year-old man with a complaint of progressive right-sided limb weakness for 3 days. Head MRI showed a left parietal occupying lesion with severe edema, and a chest CT scan showed a parenchymal mass with speculation and pleural invasion in his left lung. The patient was initial…
  • Study of Clinicoepidemiology and Surgical Complications in Acute Invasive Fungal Rhinosinusitis. [Journal Article]
    Indian J Otolaryngol Head Neck Surg. 2023 Jan 13 [Online ahead of print]Chaurpagar R, Chiplunkar B, … Athawale N
  • To study clinicoepidemiology and surgical complications in acute invasive fungal rhinosinusitis. Retrospective observational study carried in GMC Akola from February 2021 to April 2022. Detailed history and clinical examination, nasal endoscopic biopsy or swab for KOH and fungal culture was taken. CECT/MRI PNS + Orbit + Brain was done. All patients underwent surgery and tissue sample send for his…
  • Anti-fungal therapy: An overview for maxillofacial surgeons in post-covid-19 fungal infections. [Review]
    Natl J Maxillofac Surg. 2022 Sep-Dec; 13(3):330-336.Datarkar A, Bhawalkar A, … Walkey D
  • India is well known as the diabetes "capital" of the world but now it is also becoming the mucormycosis "capital" of the world. Indian Council of Medical Research has formed an "Evidence-Based Advisory in The Time of COVID-19 on Screening, Diagnosis, and Management of Mucormycosis." As per this advisory, an oral and maxillofacial surgeon forms an integral part of the team dedicated to fight this …
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