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Unbound Medicine.
(Amanita mushroom poisoning)
760 results
  • Mechanism and treatment of α-amanitin poisoning. [Review]
    Arch Toxicol. 2023 01; 97(1):121-131.Xue J, Lou X, … Chen G
  • Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the nucleus, including the inhibition of the larges…
  • Silibinin: a toxicologist's herbal medicine? [Journal Article]
    Clin Toxicol (Phila). 2022 11; 60(11):1194-1197.Horowitz BZ
  • Silymarin is an herbal remedy, commonly called milk thistle, or St. Mary's Thistle, and has been used for over 2000 years. It has been available as a capsule of the plant extract in Europe since 1974 to treat hepatic disorders. To date toxicologists have relied on animal studies, human case series, or retrospective reviews to decide on its use. In the U.S. the ability to use IV silibinin, its pha…
  • Two Cases of Severe Amanita Muscaria Poisoning Including a Fatality. [Case Reports]
    Wilderness Environ Med. 2022 Dec; 33(4):412-416.Meisel EM, Morgan B, … Sahin A
  • Ingestion of Amanita muscaria mushrooms results in transient central nervous system excitation and depression mediated by its components, ibotenic acid and muscimol. The mushroom is distributed worldwide and ingestions occur with some frequency. Although these ingestions have traditionally been considered benign, serious complications can occur. We present 2 cases of serious toxicity, including a…
  • Results of diagnostics and treatment of amanita phalloides poisoning in Slovakia (2004-2020). [Journal Article]
    Toxicon. 2022 Nov; 219:106927.Dluholucký S, Snitková M, … Mydlová Z
  • CONCLUSIONS: Early diagnostics of amanitin intoxication based on mycological and clinical history and subsequent determination of urinary amanitin levels (ATOu) allows early initiation of treatment. The use of treatment protocol with antidotes of PNC and silibinin is of high therapeutic efficacy. The omission of PNC from the treatment protocol significantly worsens patients' prognosis.
  • Amanitin intoxication: effects of therapies on clinical outcomes - a review of 40 years of reported cases. [Review]
    Clin Toxicol (Phila). 2022 11; 60(11):1251-1265.Tan JL, Stam J, … Touw DJ
  • CONCLUSIONS: Based on data available, no statistical differences could be observed for the effects of NAC, PEN or SIL in proven poisonings with amanitin-containing mushrooms. However, monotherapy with SIL or PEN and combination therapy with NAC/SIL appear to be associated with higher survival rates compared to supportive care alone. AST, ALT, TSB, and INR values are possible predictors of potentially fatal outcomes.
  • [An investigation of a food poisoning incident caused by Amanita fuliginea]. [Journal Article]
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Aug 20; 40(8):607-609.Lu ZX, Li X, … Wang J
  • Mistakenly picking and eating poisonous mushrooms can cause acute poisoning. In August 2020, Qingdao Hospital of Traditional Chinese Medicine handled a poisonous mushroom poisoning incident, conducted epidemiological investigation on all poisoned patients, collected suspicious food, clinical manifestations, clinical test results and treatment conditions, and identified the mushrooms as Amanita fu…
  • Bibliometric Analysis of Mushroom Poisoning: From Diversity to Clinical Management. [Journal Article]
    Int J Med Mushrooms. 2022; 24(7):1-19.Tang JKS, Phan CW, … Bolhassan MH
  • The earliest publication related to mushroom poisoning dates back to 1837. To date, bibliometric analysis related to the field of mushroom poisoning has not been published. This study aimed to assess the most significant publications in this field as well as the associated trends and important drivers in the research related to mushroom poisoning. The Scopus database was screened to identify rele…
  • Draft Genomes of Six Wild Poisonous Mushrooms. [Journal Article]
    J Genomics. 2022; 10:57-60.Parnmen S, Nooron N, … Rangsiruji A
  • Foodborne illnesses caused by wild mushroom poisoning occur globally and have led to food safety concerns. Here, we reported de novo genome assemblies of the six most commonly encountered toxic mushrooms in Thailand. These comprised Amanita brunneitoxicaria, Cantharocybe virosa, Chlorophyllum molybdites, Entoloma mastoideum, Pseudosperma sp. and Russula subnigricans. The nuclear genome sizes of t…
  • Medical error in treatment of Amanita phalloides poisoning in pre-hospital care. [Case Reports]
    Scand J Trauma Resusc Emerg Med. 2022 Mar 19; 30(1):20.Smędra A, Wochna K, … Berent J
  • CONCLUSIONS: Mushroom poisoning is a particularly important problem not only in countries with a mushroom picking tradition, but also-due to the inflow of refugees-in countries where mushroom poisoning was very rare until recently. In such cases it is crucial to quickly implement the correct procedure, as this can prevent the need for liver transplant or even death. This is a particularly important consideration for the first medical professionals to contact the patient, especially in cases where the patient reports mushrooms consumption and presents alarming symptoms of the gastrointestinal tract. Such situations cannot be underestimated and ignored.
  • Occurrence and chemotaxonomical analysis of amatoxins in Lepiota spp. (Agaricales). [Journal Article]
    Phytochemistry. 2022 Mar; 195:113069.Sarawi S, Shi YN, … Piepenbring M
  • About 95% of fatal mushroom poisonings worldwide are caused by amatoxins and phallotoxins mostly produced by species of Amanita, Galerina, and Lepiota. The genus Lepiota is supposed to include a high number of species producing amatoxins. In this study, we investigated 16 species of Lepiota based on 48 recently collected specimens for the presence of amatoxins by liquid chromatography coupled to …
  • Drugs and Lactation Database (LactMed): Amanita Mushroom Poisoning [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Amatoxins are water soluble, heat stable polypeptides found in Amanita (most often Amanita phalloides ), Galerina and some Lepiota species. The main toxin from the species A. phalloides is alpha-amanitin, a cyclic octapeptide. It is a potent inhibitor of RNA polymerases that blocks the production of mRNA and protein synthesis in liver and kidney cells.[1] In one case, an infant developed elevated…
  • [Three cases of mushroom poisoning caused by lethal Amanita species]. [Journal Article]
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Oct 20; 39(10):787-788.Pu Y, Yao QM, … Yu CM
  • Mushroom poisoning with amatoxins can cause liver dysfunction in patients, and death in severe cases. The amatoxins detection by enzyme-linked immunosorbent assay (ELISA) can help early clinical diagnosis. Three patients were identified as α-amatoxin containing mushroom poisoning by ELISA. The first symptoms of patients was gastrointestinal symptoms, and liver function damage occured later. One p…
  • [Acute liver failure in a dog after mushroom intake, presumably of the genus Amanita]. [Journal Article]
    Tierarztl Prax Ausg K Kleintiere Heimtiere. 2021 Oct; 49(5):382-389.Runft S, Mischke R, … Hewicker-Trautwein M
  • A 4-year-old, neutered male Husky-mix dog weighing 29.4 kg that reportedly ingested a mushroom most likely of the genus Amanita one day prior to presentation exhibited signs of diarrhea, vomitus, inappetence and progressively worsening lethargy. Clinical chemistry revealed hypoglycemia, hyperbilirubinemia, decreased prothrombin and thromboplastin time, as well as increased liver enzyme activities…
  • Nephrotoxic Mushroom Poisoning: Global Epidemiology, Clinical Manifestations, and Management. [Review]
    Wilderness Environ Med. 2021 Dec; 32(4):537-544.Diaz JH
  • Because mushroom poisonings are increasing worldwide after ingestions of known, newly described, and formerly considered edible species, the objectives of this review are to describe the global epidemiology of nephrotoxic mushroom poisonings, to identify nephrotoxic mushrooms, to present a toxidromic approach to earlier diagnoses of nephrotoxic mushroom poisonings based on the onset of acute rena…
  • Mushroom Poisoning Outbreaks - China, 2020. [Journal Article]
    China CDC Wkly. 2021 Jan 15; 3(3):41-45.Li H, Zhang H, … Sun C
  • CONCLUSIONS: What is already known about this topic? Acute liver failure, rhabdomyolysis, acute renal failure, and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population. The most notorious lethal mushrooms are the species from genera Amanita, Lepiota, and Galerina that cause acute liver failure, and Russula subnigricans that leads to rhabdomyolysis.
  • [CME/Answers: Mushroom Poisoning in the Family Practice]. [Journal Article]
    Praxis (Bern 1994). 2021 Sep; 110(11):619-620.Schenk-Jäger K, Gessler M, Weiler S
  • CME/Answers: Mushroom Poisoning in the Family Practice Abstract. In the general medical practice, it is not trivial to distinguish between banal intolerances after consumption of edible mushrooms and the initial symptoms of poisoning with potentially fatal outcome. Nevertheless, there are some criteria that can be used as clinical guidance: A latency of six hours or more between the consumption o…
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