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Unbound Medicine.
(Amber)
8,333 results
  • Local Ugandan Production of Stable 0.2% Chlorhexidine Eye Drops. [Journal Article]
    Transl Vis Sci Technol. 2023 Jan 03; 12(1):27.Picken CAR, Brocchini S, … Mohamed-Ahmed AHA
  • CONCLUSIONS: Stable, sterile, buffered CHX eye drops (pH 6.75) were successfully prepared first in the United Kingdom and then reproducibly in Uganda. This eye drops can be prepared in a hospital or pharmacy setting with limited resources, thus providing a cost-effective treatment for fungal keratitis.
  • Evaluation of the fish acute toxicity test for pesticide registration. [Journal Article]
    Regul Toxicol Pharmacol. 2023 Jan 23 [Online ahead of print]Ceger P, Allen D, … Lowit M
  • The U.S. Environmental Protection Agency (USEPA) uses the in vivo fish acute toxicity test to assess potential risk of substances to non-target aquatic vertebrates. The test is typically conducted on a cold and a warm freshwater species and a saltwater species for a conventional pesticide registration, potentially requiring upwards of 200 or more fish. A retrospective data evaluation was conducte…
  • Mechanoregulatory role of TRPV4 in prenatal skeletal development. [Journal Article]
    Sci Adv. 2023 Jan 25; 9(4):eade2155.Khatib NS, Monsen J, … Nowlan NC
  • Biophysical cues are essential for guiding skeletal development, but the mechanisms underlying the mechanical regulation of cartilage and bone formation are unknown. TRPV4 is a mechanically sensitive ion channel involved in cartilage and bone cell mechanosensing, mutations of which lead to skeletal developmental pathologies. We tested the hypothesis that loading-driven prenatal skeletal developme…
  • Creation and stabilization of carbon dots in silica-confined compartments with high thermal stability. [Journal Article]
    Chem Commun (Camb). 2023 Jan 23 [Online ahead of print]Zhang HH, Wu CD
  • Inspired by the formation procedures and high stability of ambers, we report herein a facile approach for the in situ creation and stabilization of carbon dots (CDs) in confined silica compartments by a solvothermal reaction and subsequent thermal treatment, and the endowed CDs exhibit the initial photoluminescence (PL) properties at 400 °C, which could be used to fabricate highly thermal-stable …
  • Light Increases Astaxanthin Absorbance in Acetone Solution through Isomerization Reactions. [Journal Article]
    Molecules. 2023 Jan 14; 28(2)Virchenko O, Stefánsson T
  • Astaxanthin quantitative analysis is prone to high variability between laboratories. This study aimed to assess the effect of light on the spectrometric and high-performance liquid chromatography (HPLC) measurements of astaxanthin. The experiment was performed on four Haematococcus pluvialis-derived astaxanthin-rich oleoresin samples with different carotenoid matrices that were analyzed by UV/Vis…
  • Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles. [Journal Article]
    Cell Rep Med. 2023 Jan 17; 4(1):100899.Muñoz-Wolf N, Ward RW, … Lavelle EC
  • The non-canonical inflammasome sensor caspase-11 and gasdermin D (GSDMD) drive inflammation and pyroptosis, a type of immunogenic cell death that favors cell-mediated immunity (CMI) in cancer, infection, and autoimmunity. Here we show that caspase-11 and GSDMD are required for CD8+ and Th1 responses induced by nanoparticulate vaccine adjuvants. We demonstrate that nanoparticle-induced reactive ox…
  • Proximity-enhanced protein crosslinking through an alkene-tetrazine reaction. [Journal Article]
    Bioorg Chem. 2023 Jan 11; 132:106359.Ma B, Niu W, Guo J
  • The inverse electron demand Diels-Alder (iEDDA) reaction between a tetrazine and a strained alkene has been widely explored as useful bioorthogonal chemistry for selective labeling of biomolecules. In this work, we exploit the slow reaction between a non-conjugated terminal alkene and a tetrazine, and apply this reaction to achieving a proximity-enhanced protein crosslinking. In one protein subun…
  • New Surijokocixiidae (Insecta: Hemiptera: Fulgoromorpha) from the Middle Triassic of China. [Journal Article]
    Anat Rec (Hoboken). 2023 Jan 15 [Online ahead of print]Zhang Q, Szwedo J, … Zhang H
  • A new Middle Triassic (Ladinian) planthopper of the family Surijokocixiidae (Surijokocixioidea, Fulgoromorpha) from the Tongchuan Formation in Shaanxi, NW China is established as Sinosurijikocixius tongchuanensis gen. et sp. nov. All the known taxa assigned to Surijokocixiidae are reviewed and compared. The palaeogeographic distributional pattern of Surijokocixiidae from the middle Permian to Lat…
  • Bioprinting of structurally organized meniscal tissue within anisotropic melt electrowritten scaffolds. [Journal Article]
    Acta Biomater. 2023 Jan 10 [Online ahead of print]Barceló X, Eichholz KF, … Kelly DJ
  • The meniscus is characterised by an anisotropic collagen fibre network which is integral to its biomechanical functionality. The engineering of structurally organized meniscal grafts that mimic the anisotropy of the native tissue remains a significant challenge. In this study, inkjet bioprinting was used to deposit a cell-laden bioink into additively manufactured scaffolds of differing architectu…
  • The largest amber-preserved flower revisited. [Journal Article]
    Sci Rep. 2023 Jan 12; 13(1):17.Sadowski EM, Hofmann CC
  • Amber exquisitely preserves the delicate organs of fossil flowers for millions of years. However, flower inclusions can be rare and usually do not exceed 10 mm in size. Here we report an exceptionally large flower from late Eocene Baltic amber, measuring 28 mm across, which is about three times as large as most floral inclusions. This fossil was described over 150 years ago as Stewartia kowalewsk…
  • Novel Lennard-Jones Parameters for Cysteine and Selenocysteine in the AMBER Force Field. [Journal Article]
    J Chem Inf Model. 2023 Jan 23; 63(2):595-604.Pedron FN, Messias A, … Estrin DA
  • Cysteine is a common amino acid with a thiol group that plays a pivotal role in a variety of scenarios in redox biochemistry. In contrast, selenocysteine, the 21st amino acid, is only present in 25 human proteins. Classical force-field parameters for cysteine and selenocysteine are still scarce. In this context, we present a methodology to obtain Lennard-Jones parameters for cysteine and selenocy…
  • ACES: Optimized Alchemically Enhanced Sampling. [Journal Article]
    J Chem Theory Comput. 2023 Jan 11 [Online ahead of print]Lee TS, Tsai HC, … York DM
  • We present an alchemical enhanced sampling (ACES) method implemented in the GPU-accelerated AMBER free energy MD engine. The methods hinges on the creation of an "enhanced sampling state" by reducing or eliminating selected potential energy terms and interactions that lead to kinetic traps and conformational barriers while maintaining those terms that curtail the need to otherwise sample large vo…
  • AMBER Free Energy Tools: A New Framework for the Design of Optimized Alchemical Transformation Pathways. [Journal Article]
    J Chem Theory Comput. 2023 Jan 09 [Online ahead of print]Tsai HC, Lee TS, … York DM
  • We develop a framework for the design of optimized alchemical transformation pathways in free energy simulations using nonlinear mixing and a new functional form for so-called "softcore" potentials. We describe the implementation and testing of this framework in the GPU-accelerated AMBER software suite. The new optimized alchemical transformation pathways integrate a number of important features,…
  • Effect of sintering on the translucency of CAD-CAM lithium disilicate restorations: A comparative in vitro study. [Journal Article]
    J Prosthodont. 2023 Jan 07 [Online ahead of print]Jurado CA, Afrashtehfar KI, … Alhotan A
  • CONCLUSIONS: The translucency of chairside lithium disilicate single-unit full-coverage restorations manufactured with subtractive technology was significantly influenced by the brand and the number of sintering processes. The traditional presintered IPS e.max CAD and the fully crystallized glass-ceramic Straumann n!ce considerably increased the translucency after one additional firing process, whereas Amber Mill decreased its translucency.
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