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Unbound Medicine.
(Amebic meningoencephalitis primary)
6,913 results
  • Laboratory Diagnosis of Primary Amoebic Meningoencephalitis. [Journal Article]
    Lab Med. 2023 Jan 13 [Online ahead of print]Rojo JU, Rajendran R, Salazar JH
  • Primary amebic meningoencephalitis (PAM) is a fulminant fatal human disease caused by the free-living amoeba Naegleria fowleri. Infection occurs after inhalation of water containing the amoeba, typically after swimming in bodies of warm freshwater. N. fowleri migrates to the brain where it incites meningoencephalitis and cerebral edema leading to death of the patient 7 to 10 days postinfection. A…
  • Population-specific positive selection on low CR1 expression in malaria-endemic regions. [Journal Article]
    PLoS One. 2023; 18(1):e0280282.Lorenzini PA, Gusareva ES, … Kim HL
  • Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe form of the disease. Here, we study the history of adaptation against malaria by analyzing selection s…
  • Anti-amoebic effects of synthetic acridine-9(10H)-one against brain-eating amoebae. [Journal Article]
    Acta Trop. 2023 Jan 04; 239:106824.Ahmed U, Manzoor M, … Anwar A
  • Pathogenic A. castellanii and N. fowleri are opportunistic free-living amoebae. Acanthamoeba spp. are the causative agents of granulomatous amebic encephalitis (GAE) and amebic keratitis (AK), whereas Naegleria fowleri causes a very rare but severe brain infection called primary amebic meningoencephalitis (PAM). Acridinone is an important heterocyclic scaffold and both synthetic and naturally occ…
  • Parasite infections, neuroinflammation, and potential contributions of gut microbiota. [Review]
    Front Immunol. 2022; 13:1024998.Alloo J, Leleu I, … Pied S
  • Many parasitic diseases (including cerebral malaria, human African trypanosomiasis, cerebral toxoplasmosis, neurocysticercosis and neuroschistosomiasis) feature acute or chronic brain inflammation processes, which are often associated with deregulation of glial cell activity and disruption of the brain blood barrier's intactness. The inflammatory responses of astrocytes and microglia during paras…
  • Using Malarial Retinopathy to Improve the Diagnosis of Pediatric Cerebral Malaria. [Journal Article]
    Am J Trop Med Hyg. 2023 01 11; 108(1):69-75.Lin Y, Tebulo A, … Zhang B
  • In malaria endemic areas, a high proportion of children have detectable parasitemia but show no clinical symptoms. When comatose from a cause other than malaria, this group confounds the cerebral malaria (CM) definition, making accurate diagnosis challenging. One important biomarker of CM is malarial retinopathy, a set of specific features visible in the ocular fundus. In this study, we quantifie…
  • Plasmodium vivax cerebral malaria with pancytopenia in the peruvian amazon: case report. [Case Reports]
    Rev Peru Med Exp Salud Publica. 2022 Apr-Jun; 39(2):241-244.Paredes-Obando M, Moreno A, … Casapía-Morales M
  • Plasmodium vivax causes 81% of all malaria cases and is the most common species in the Peruvian Amazon. We present the case of a male patient with cerebral malaria caused by Plasmodium vivax, who had general malaise and fever, and then presented seizures more than twice a day with loss of consciousness and motor functional limitation. Plasmodium vivax trophozoites were detected by thick blood sme…
  • Congenital toxoplasmosis with severe neurological disease in a referral hospital in Peru. [Review]
    Rev Peru Med Exp Salud Publica. 2022 Apr-Jun; 39(2):208-213.Maquera-Afaray J, Luna-Vilchez M, … López JW
  • The aim of this study was to describe the epidemiological, clinical, and therapeutic characteristics of patients diagnosed with congenital toxoplasmosis (CT) with severe neurological disease. We reviewed the medical records of patients under 1 year of age with positive IgM test for Toxoplasma gondii and brain, eye, and/or hearing involvement. This study was carried out at the Instituto Nacional d…
  • Imaging of Central Nervous System Parasitic Infections. [Review]
    Neuroimaging Clin N Am. 2023 Feb; 33(1):125-146.Vasconcelos Miranda TA, Tsuchiya K, Lucato LT
  • Parasitic infections of the central nervous system (CNS) constitute a wide range of diseases, some quite prevalent across the world, some exceedingly rare. Causative parasites can be divided into two groups: unicellular protozoa and multicellular helminthic worms. This includes diseases such as neurotoxoplasmosis and neurocysticercosis, which represent a major cause of pathology among certain pop…
  • Is the incidence of congenital toxoplasmosis declining? [Review]
    Trends Parasitol. 2023 Jan; 39(1):26-37.Milne GC, Webster JP, Walker M
  • Prenatal infection with the protozoan parasite Toxoplasma gondii can cause congenital toxoplasmosis (CT), an often fatal or lifelong-disabling condition. Several studies of human populations have reported temporal decreases in seroprevalence, suggesting declining CT incidence. However, the consistency of this trend among diverse populations remains unclear, as does its implication for prenatal sc…
  • HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset. [Meta-Analysis]
    Malar J. 2022 Nov 17; 21(1):342.Hamilton F, Mitchell R, … Timpson NJ
  • CONCLUSIONS: Meta-analysis suggested that increasing HMOX1 STR length is unlikely to be reliably associated with severe malaria. It cannot be ruled out that repeat length may alter risk in specific populations, although whether this is due to chance variation, or true variation due to underlying biology (e.g., gene vs environment interaction) remains unanswered.
  • Dissecting the mechanisms of pathogenesis in cerebral malaria. [Journal Article]
    PLoS Pathog. 2022 11; 18(11):e1010919.Ramachandran A, Sharma A
  • Cerebral malaria (CM) is one of the leading causes of death due to malaria. It is characterised by coma, presence of asexual parasites in blood smear, and absence of any other reason that can cause encephalopathy. The fatality rate for CM is high, and those who survive CM often experience long-term sequelae, including cognitive and motor dysfunctions. It is unclear how parasites sequestered in th…
  • The IL-33/ST2 Pathway in Cerebral Malaria. [Review]
    Int J Mol Sci. 2022 Nov 03; 23(21)Glineur C, Leleu I, Pied S
  • Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord tissues where it acts as a key cytokine to coordinate the exchange between the immune and central nervous system (CNS). In this review, we report the recent advances to our knowledge regarding the role of IL-33 and of…
  • Concomitant giant purely intradiploic cavernous haemangioma and multifocal neurotoxoplasmosis. [Case Reports]
    BMJ Case Rep. 2022 Nov 01; 15(11)Costanzo R, Scalia G, … Nicoletti G
  • Purely calvarial or intradiploic cavernous haemangiomas (PICHs) are rare benign tumours accounting for 0.2% of all bone tumours and 10% of benign skull tumours. They are generally small, slow-growing and asymptomatic lesions. Here the authors described an immunocompromised patient with concomitant giant intradiploic ossified globular cavernous angioma and multifocal neurotoxoplasmosis that underw…
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