- Prevalence of Indicators of Low Energy Availability in Elite Female Sprinters. [Journal Article]
- IJInt J Sport Nutr Exerc Metab 2018 May 14; :1-22
- Low energy availability (LEA), and subsequent relative energy deficiency in sport (RED-S), has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athle...
Low energy availability (LEA), and subsequent relative energy deficiency in sport (RED-S), has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athletes in short-burst activities such as sprinting. We examined prevalence of signs and symptoms of LEA in elite female sprinters at the start of the training season (PRE), and at the end of a 5-month indoor training period (POST). Four of 13 female sprinters (31%) presented at PRE testing with at least one primary (amenorrhea, low BMD, low FSH, LH, or estradiol, RMR ≤ 29kcal/kg FFM, Low Energy Availability in Females Questionnaire (LEAF-Q) score ≥8) and one secondary indicator of LEA (fasting blood glucose < 4mmol/L, free triiodothyronine < 3.5pmol/L, ferritin < 25μg/L, LDL-cholesterol > 3.0mmol/L, fasting insulin < 20pmol/L, low insulin-like growth factor-1 (IGF-1), SBP < 90 and/or DBP < 60mm Hg). At POST, 7/13 athletes (54%) presented with at least one primary and one secondary indicator of LEA, three of whom had also presented with indicators of LEA at PRE. Five out of 13 (39%) athletes had previous stress fracture history, though this was not associated with current indicators of LEA (PRE: r = 0.52, P = 0.07; POST r = -0.07, P = 0.82). In conclusion, elite female sprinters may present with signs and symptoms of LEA, even after off-season rest. Medical and coaching staff should be aware of the signs and symptoms of LEA and RED-S and should include appropriate screening and intervention strategies when working with sprinters.
- Low trabecular bone score in adolescent female inpatients with anorexia nervosa. [Journal Article]
- CNClin Nutr 2018 Apr 26
- CONCLUSIONS: TBS of adolescent females with AN was found to be lower than TBS of healthy adolescents. Prospective longitudinal studies should be undertaken to investigate whether recovery may result in correction of bone microarchitecture.
- Successful Management of Abdominal Pregnancy: Two Case Reports. [Journal Article]
- OMOman Med J 2018; 33(2):171-175
- Abdominal pregnancy is a rare, life-threatening condition defined as pregnancy in the peritoneal cavity exclusive of tubal, ovarian, or intraligamentary locations. It can be primarily located in the ...
Abdominal pregnancy is a rare, life-threatening condition defined as pregnancy in the peritoneal cavity exclusive of tubal, ovarian, or intraligamentary locations. It can be primarily located in the peritoneal cavity or secondary to a ruptured ectopic pregnancy or tubal abortion. We present two cases of abdominal pregnancy, one primary and another secondary, both diagnosed and successfully managed in our institution. The first patient, a para 2 at 14 weeks gestation, presented with abdominal pain, distension, and dizziness, which had started four days prior. The initial radiological scan reported an intrauterine pregnancy with ascites, but a bedside ultrasound revealed an empty uterus and a viable pregnancy located in the Pouch of Douglas (POD). This was a secondary abdominal pregnancy managed successfully by laparotomy. The second patient, a para 3 + 4 miscarriages with seven weeks amenorrhea was admitted with an initial diagnosis of pregnancy of unknown location. She had a beta human chorionic gonadotropin level of 14 444 mIU/mL. Diagnostic laparoscopy revealed a hemoperitoneum, bulky uterus, normal looking right and left adnexa, and a dense irregular bleeding tissue of around 3 × 4 cm firmly attached to the POD. The histopathology report of the tissue retrieved from the POD confirmed products of conception. This case report supports the importance of awareness and high clinical suspicion for such a life-threatening condition to avoid maternal morbidity and mortality. To the best of our knowledge, no previous cases of abdominal pregnancy have been reported in the UAE to date.
- Extremely Rare Case of Bilateral Pure Primary Non-Gestational Ovarian Choriocarcinoma. [Journal Article]
- PJPol J Radiol 2017; 82:547-550
- CONCLUSIONS: The imaging findings were found to be specific for bilateral non-gestational pure primary ovarian choriocarcinoma.
- Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy among patients with idiopathic and functional hypothalamic amenorrhea: a systematic review of the literature and a meta-analysis. [Journal Article]
- FSFertil Steril 2018; 109(4):708-719.e8
- CONCLUSIONS: The high OvRs leading to a high rate of singleton pregnancies and the low likelihood of OHSS render the pGnRH treatment modality both effective and safe for the treatment of women with HA of either primary or secondary origin.
- Estrogen deprivation and cardiovascular disease risk in primary ovarian insufficiency. [Journal Article]
- FSFertil Steril 2018; 109(4):594-600.e1
- CONCLUSIONS: Prolonged E deprivation is associated with an increased estimated risk of CVD, whereas prolonged E exposure is associated with a reduced estimated risk. These results support the policy of early and continued use of E replacement therapy in women with POI.
- A rare cause of congenital adrenal hyperplasia: Clinical and genetic findings and follow-up characteristics of six patients with 17- hydroxylase deficiency and two novel mutations. [Journal Article]
- JCJ Clin Res Pediatr Endocrinol 2018 Mar 29
- CONCLUSIONS: 17OHD, a rare cause of CAH, should be kept in mind in patients with pubertal delay and/or hypertension. Patients with 46,XY who are raised as females need gonadectomy. Due to late diagnosis psychological problems, gender selection, hypertension and osteoporosis are important health prob-lems among these patients. Key Words: Congenital adrenal hyperplasia, CYP17A1, disorder of sex development, hypertension, primary amenorrhea.
- About a case of traumatic separation of the cervix from the uterine corpus, diagnosed in a context of infertility. [Journal Article]
- JGJ Gynecol Obstet Hum Reprod 2018 Mar 21
- This article reports a case of cervico-isthmic disjunction unnoticed during childhood, diagnosed in a context of primary infertility and endometriosis, and surgically treated. It is an uncommon condi...
This article reports a case of cervico-isthmic disjunction unnoticed during childhood, diagnosed in a context of primary infertility and endometriosis, and surgically treated. It is an uncommon condition. The diagnosis is most often made as part of an assessment of primary amenorrhea in a young woman with a history of severe pelvic trauma. It is suspected after imaging assessment and confirmed intraoperatively. The treatment consists in an anastomosis between the cervix and the uterine body, after individualizing these two structures, around a drain guiding healing. After this surgery, multiple pregnancies have been successfully carried out.
- Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. [Journal Article]
- HMHum Mol Genet 2018 Mar 16
- Primary ovarian insufficiency (POI) is characterized by amenorrhea and loss or dysfunction of ovarian follicles prior to the age of 40. POI has been associated with autosomal recessive mutations in g...
Primary ovarian insufficiency (POI) is characterized by amenorrhea and loss or dysfunction of ovarian follicles prior to the age of 40. POI has been associated with autosomal recessive mutations in genes involving hormonal signaling and folliculogenesis, however the genetic etiology of POI most often remains unknown. Here we report MRPS22 homozygous missense variants c.404G>A (p.R135Q) and c.605G>A (p.R202H) identified in four females from two independent consanguineous families as a novel genetic cause of POI in adolescents. Both missense mutations identified in MRPS22 are rare, occurred in highly evolutionarily conserved residues, and are predicted to be deleterious to protein function. In contrast to prior reports of mutations in MRPS22 associated with severe mitochondrial disease, the POI phenotype is far less severe. Consistent with this genotype - phenotype correlation, mitochondrial defects in oxidative phosphorylation or rRNA levels were not detected in fibroblasts derived from the POI patients, suggesting a non-bioenergetic or tissue specific mitochondrial defect. Furthermore, we demonstrate in a Drosophila model that mRpS22 deficiency specifically in somatic cells of the ovary had no effect on fertility, whereas flies with mRpS22 deficiency specifically in germ cells were infertile and agametic, demonstrating a cell autonomous requirement for mRpS22 in germ cell development. These findings collectively identify that MRPS22, a component of the small mitochondrial ribosome subunit, is critical for ovarian development and may therefore provide insight into the pathophysiology and treatment of ovarian dysfunction.
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- A CASE REPORT OF PREMENARCHIAL TRANSVERSE VAGINAL SEPTUM AT THE UNIVERSITY COLLEGE HOSPITAL, IBADAN. [Journal Article]
- AIAnn Ib Postgrad Med 2017; 15(2):130-132
- Premenarchial Transverse vaginal septum is a benign condition. The septum may be found in the upper, middle or lower vagina. A case report of a premenarchial girl with transverse vaginal septum manag...
Premenarchial Transverse vaginal septum is a benign condition. The septum may be found in the upper, middle or lower vagina. A case report of a premenarchial girl with transverse vaginal septum managed at the university college hospital, Ibadan, in January 2009. Diagnosis was made following a history of primary amenorrhea, cyclical low abdominal pain and pelvic examination which revealed a vaginal septum. She had surgical resection of the vaginal septum and a vaginal stent was left in-situ to keep the vagina patent during the healing process. The procedure was uneventful and she was able to achieve menstrual flow following surgery. Follow up visits were essentially unremarkable.